WO2006032216A3 - Peptidos y derivados tipo apl de la hsp60 y composiciones farmacéuticas - Google Patents
Peptidos y derivados tipo apl de la hsp60 y composiciones farmacéuticas Download PDFInfo
- Publication number
- WO2006032216A3 WO2006032216A3 PCT/CU2005/000008 CU2005000008W WO2006032216A3 WO 2006032216 A3 WO2006032216 A3 WO 2006032216A3 CU 2005000008 W CU2005000008 W CU 2005000008W WO 2006032216 A3 WO2006032216 A3 WO 2006032216A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- peptides
- pharmaceutical compositions
- hsp60
- apl
- mechanisms
- Prior art date
Links
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 4
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 102000006303 Chaperonin 60 Human genes 0.000 title 1
- 108010058432 Chaperonin 60 Proteins 0.000 title 1
- 230000007246 mechanism Effects 0.000 abstract 3
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 2
- 206010011968 Decreased immune responsiveness Diseases 0.000 abstract 1
- 102000002812 Heat-Shock Proteins Human genes 0.000 abstract 1
- 108010004889 Heat-Shock Proteins Proteins 0.000 abstract 1
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 230000002093 peripheral effect Effects 0.000 abstract 1
- 210000003289 regulatory T cell Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Transplantation (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
Priority Applications (15)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020077008682A KR101054332B1 (ko) | 2004-09-24 | 2005-09-22 | Hsp60의 펩티드 및 이들의 유도형 apl 및 약학적조성물 |
EP05794474A EP1803732B1 (en) | 2004-09-24 | 2005-09-22 | Peptides and apl-type derivatives of hsp60 and pharmaceutical compositions |
MX2007003624A MX2007003624A (es) | 2004-09-24 | 2005-09-22 | Peptidos y derivados tipo peptido ligando alterado de la hsp60 y composiciones farmaceuticas. |
ES05794474T ES2386498T3 (es) | 2004-09-24 | 2005-09-22 | Péptidos y derivados tipo APL de Hsp60 y composiciones farmacéuticas |
BRPI0515893A BRPI0515893B8 (pt) | 2004-09-24 | 2005-09-22 | peptídeos da proteína humana de estresse térmico, composição farmacêutica, e, uso do peptídeo e da composição farmacêutica. |
BR122018077204A BR122018077204B8 (pt) | 2004-09-24 | 2005-09-22 | peptídeos da proteína humana de estresse térmico, composição farmacêutica, e, uso do peptídeo e da composição farmacêutica |
DK05794474.6T DK1803732T3 (da) | 2004-09-24 | 2005-09-22 | Peptider og derivater af APL-TYPE af HSP60 og famaceutiske sammensætninger |
AT05794474T ATE546462T1 (de) | 2004-09-24 | 2005-09-22 | Peptide und derivate vom apl-typ von hsp60 und pharmazeutische zusammensetzungen |
AU2005287757A AU2005287757B2 (en) | 2004-09-24 | 2005-09-22 | Peptides and APL-type derivatives of Hsp60 and pharmaceutical compositions |
JP2007532752A JP4755649B2 (ja) | 2004-09-24 | 2005-09-22 | Hsp60のペプチド及びapl型誘導体並びに医薬組成物 |
CN2005800403891A CN101065398B (zh) | 2004-09-24 | 2005-09-22 | Hsp60的肽和apl型衍生物及药物组合物 |
CA2581110A CA2581110C (en) | 2004-09-24 | 2005-09-22 | Peptides and apl-type derivatives of hsp60 and pharmaceutical compositions |
US11/663,603 US8383771B2 (en) | 2004-09-24 | 2005-09-22 | Altered peptide ligand derived from HSP60 and pharmaceutical compositions |
US12/649,687 US8324164B2 (en) | 2004-09-24 | 2009-12-30 | Peptides and altered peptide ligands derived from HSP60 and pharmaceutical compositions |
AU2010219312A AU2010219312B2 (en) | 2004-09-24 | 2010-09-06 | Peptides and APL-type derivatives of HSP60 and pharmaceutical compositions |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CU20040207A CU23504A1 (es) | 2004-09-24 | 2004-09-24 | Péptidos y derivados tipo apl de la hsp60 y composiciones farmacéuticas |
CU2004-0207 | 2004-09-24 |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US11/663,603 A-371-Of-International US8383771B2 (en) | 2004-09-24 | 2005-09-22 | Altered peptide ligand derived from HSP60 and pharmaceutical compositions |
US12/649,687 Division US8324164B2 (en) | 2004-09-24 | 2009-12-30 | Peptides and altered peptide ligands derived from HSP60 and pharmaceutical compositions |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2006032216A2 WO2006032216A2 (es) | 2006-03-30 |
WO2006032216A3 true WO2006032216A3 (es) | 2007-05-18 |
Family
ID=40273413
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/CU2005/000008 WO2006032216A2 (es) | 2004-09-24 | 2005-09-22 | Peptidos y derivados tipo apl de la hsp60 y composiciones farmacéuticas |
Country Status (17)
Country | Link |
---|---|
US (2) | US8383771B2 (es) |
EP (2) | EP1803732B1 (es) |
JP (1) | JP4755649B2 (es) |
KR (2) | KR101035283B1 (es) |
CN (2) | CN101065398B (es) |
AR (2) | AR051928A1 (es) |
AT (1) | ATE546462T1 (es) |
AU (2) | AU2005287757B2 (es) |
BR (2) | BR122018077204B8 (es) |
CA (2) | CA2797769C (es) |
CU (1) | CU23504A1 (es) |
DK (2) | DK1803732T3 (es) |
ES (2) | ES2445707T3 (es) |
MX (1) | MX2007003624A (es) |
RU (1) | RU2361877C2 (es) |
WO (1) | WO2006032216A2 (es) |
ZA (1) | ZA200702938B (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2450369A1 (en) * | 2007-01-30 | 2012-05-09 | Epivax, Inc. | Regulatory t cell epitopes, compositions and uses thereof |
CU23701A1 (es) * | 2008-12-29 | 2011-09-21 | Ct Ingenieria Genetica Biotech | Método de tratamiento de enfermedades inflamatorias intestinales y diabetes tipo i |
US8680241B2 (en) * | 2009-09-06 | 2014-03-25 | Protab Ltd. | Humanized antibodies specific for HSP65-derived peptide-6 methods and uses thereof |
WO2011059758A2 (en) * | 2009-10-28 | 2011-05-19 | Argentis Pharmaceuticals, Llc | Apls for treating arthritis |
CU24508B1 (es) * | 2017-12-29 | 2021-04-07 | Centro De Ingenieria Genetica Y Biotecnologia Biocubafarma | Composición farmacéutica que comprende péptido tipo apl |
CU20200026A7 (es) * | 2020-04-13 | 2021-11-04 | Ct Ingenieria Genetica Biotecnologia | Péptido para el tratamiento del síndrome de la tormenta de citocinas |
CN111870697B (zh) * | 2020-09-18 | 2022-09-09 | 山东鲁抗医药股份有限公司 | 糖类物质在提高apl型衍生肽稳定性中的应用和冻干组合物 |
KR102333645B1 (ko) | 2021-07-27 | 2021-12-02 | (주)문화전기 | 각도조절이 용이한 엘이디조명시스템 |
CN115671253B (zh) * | 2021-07-30 | 2024-02-27 | 河北菲尼斯生物技术有限公司 | Se-dr亲和肽在制备治疗风湿疾病的药物中的用途 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997011966A1 (en) * | 1995-09-27 | 1997-04-03 | Peptide Therapeutic Limited | Polypeptides and their use in treatment and prophylaxis of auto-immune disease |
WO2001043691A2 (en) * | 1999-12-15 | 2001-06-21 | Peptor Ltd. | Fragments and antagonists of heat shock protein 60 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL8701163A (nl) | 1986-09-09 | 1988-04-05 | Nederlanden Staat | Gebruik van een peptide voor de bereiding van preparaten voor het verlichten, het behandelen en de diagnose van autoimmuunziekten, in het bijzonder arthritische toestanden, verbindingen die met dit peptide verwant zijn, alsmede farmaceutische en diagnostische preparaten en testkits. |
NL8703107A (nl) | 1987-12-22 | 1989-07-17 | Nederlanden Staat | Polypeptiden en derivaten daarvan, alsmede de toepassing daarvan in farmaceutische en diagnostische preparaten. |
US5773570A (en) | 1994-05-20 | 1998-06-30 | The Regents Of The University Of California | Vaccine compositions and methods useful in inducing immune protection against arthritogenic peptides involved in the pathogenesis of rheumatoid arthritis |
GB9419553D0 (en) | 1994-09-27 | 1994-11-16 | Univ Bristol | Polypeptides and their use in the treatment of auto-immune disease |
US6180103B1 (en) | 1994-12-21 | 2001-01-30 | Yeda Research And Development Co., Ltd. | Peptide p277 analogs, and pharmaceutical compositions comprising them for treatment or diagnosis of diabetes |
US5993803A (en) | 1996-08-30 | 1999-11-30 | Yeda Research And Development Co., Ltd. | Method of reducing the severity of host vs graft reaction by down-regulating hsp60 autoimmunity |
GB9911772D0 (en) | 1999-05-21 | 1999-07-21 | Semmelweis University Of Medic | Diagnosis and treatment of atherosclerosis |
US20020169302A1 (en) * | 1999-08-23 | 2002-11-14 | Genesis Research And Development Corp. Ltd. | Compositions isolated from bovine mammary gland and methods for their use |
AU2002247004A1 (en) | 2001-01-19 | 2002-07-30 | Cambridge Scientific, Inc. | Methods of diagnosis and treatment of osteoporosis |
-
2004
- 2004-09-24 CU CU20040207A patent/CU23504A1/es active IP Right Grant
-
2005
- 2005-09-21 AR ARP050103950A patent/AR051928A1/es active IP Right Grant
- 2005-09-22 BR BR122018077204A patent/BR122018077204B8/pt active IP Right Grant
- 2005-09-22 MX MX2007003624A patent/MX2007003624A/es active IP Right Grant
- 2005-09-22 CN CN2005800403891A patent/CN101065398B/zh active Active
- 2005-09-22 DK DK05794474.6T patent/DK1803732T3/da active
- 2005-09-22 JP JP2007532752A patent/JP4755649B2/ja active Active
- 2005-09-22 AT AT05794474T patent/ATE546462T1/de active
- 2005-09-22 CA CA2797769A patent/CA2797769C/en active Active
- 2005-09-22 KR KR1020107001135A patent/KR101035283B1/ko active IP Right Grant
- 2005-09-22 EP EP05794474A patent/EP1803732B1/en active Active
- 2005-09-22 RU RU2007115411/04A patent/RU2361877C2/ru active
- 2005-09-22 AU AU2005287757A patent/AU2005287757B2/en not_active Ceased
- 2005-09-22 ES ES10189769.2T patent/ES2445707T3/es active Active
- 2005-09-22 KR KR1020077008682A patent/KR101054332B1/ko active IP Right Grant
- 2005-09-22 DK DK10189769.2T patent/DK2371847T3/da active
- 2005-09-22 CN CN2010100038161A patent/CN101935345B/zh active Active
- 2005-09-22 EP EP10189769.2A patent/EP2371847B1/en active Active
- 2005-09-22 CA CA2581110A patent/CA2581110C/en active Active
- 2005-09-22 BR BRPI0515893A patent/BRPI0515893B8/pt active IP Right Grant
- 2005-09-22 WO PCT/CU2005/000008 patent/WO2006032216A2/es active Application Filing
- 2005-09-22 ES ES05794474T patent/ES2386498T3/es active Active
- 2005-09-22 US US11/663,603 patent/US8383771B2/en active Active
-
2007
- 2007-04-10 ZA ZA200702938A patent/ZA200702938B/xx unknown
-
2009
- 2009-12-28 AR ARP090105137A patent/AR074924A2/es active IP Right Grant
- 2009-12-30 US US12/649,687 patent/US8324164B2/en active Active
-
2010
- 2010-09-06 AU AU2010219312A patent/AU2010219312B2/en not_active Ceased
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997011966A1 (en) * | 1995-09-27 | 1997-04-03 | Peptide Therapeutic Limited | Polypeptides and their use in treatment and prophylaxis of auto-immune disease |
WO2001043691A2 (en) * | 1999-12-15 | 2001-06-21 | Peptor Ltd. | Fragments and antagonists of heat shock protein 60 |
Non-Patent Citations (9)
Title |
---|
CHOI J-I ET AL: "Epitope mapping of Porphyromonas gingivalis heat-shock protein and human heat-shock protein in human atherosclerosis.", JOURNAL OF DENTAL RESEARCH. DEC 2004, vol. 83, no. 12, December 2004 (2004-12-01), pages 936 - 940, XP002371464, ISSN: 0022-0345 * |
JOOSTEN I ET AL: "DIRECT BINDING OF AUTOIMMUNE DISEASE RELATED T CELL EPITOPES TO PURIFIED LEWIS RAT MHC CLASS II MOLECULES", 1 May 1994, INTERNATIONAL IMMUNOLOGY, OXFORD UNIVERSITY PRESS, GB, PAGE(S) 751-759, ISSN: 0953-8178, XP000590812 * |
KAMPHUIS S S ET AL: "V1.2. recognition of multiple hsp60 epitopes in patients with juvenile idiopathic arthritis opens the way for antigen-specific immunotherapy.", ANNALS OF THE RHEUMATIC DISEASES. OCT 2001, vol. 60 Suppl 2, October 2001 (2001-10-01), pages II7 - II15, XP002371476, ISSN: 0003-4967 * |
KAMPHUIS SYLVIA ET AL: "Tolerogenic immune responses to novel T-cell epitopes from heat-shock protein 60 in juvenile idiopathic arthritis.", LANCET. 2005 JUL 2-8, vol. 366, no. 9479, 2 July 2005 (2005-07-02), pages 50 - 56, XP002371481, ISSN: 1474-547X * |
PRAKKEN BERENT J ET AL: "Epitope-specific immunotherapy induces immune deviation of proinflammatory T cells in rheumatoid arthritis.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 23 MAR 2004, vol. 101, no. 12, 23 March 2004 (2004-03-23), pages 4228 - 4233, XP002371463, ISSN: 0027-8424 * |
QUINTANA FRANCISCO J ET AL: "DNA fragments of the human 60-kDa heat shock protein (HSP60) vaccinate against adjuvant arthritis: identification of a regulatory HSP60 peptide.", JOURNAL OF IMMUNOLOGY (BALTIMORE, MD. : 1950) 1 OCT 2003, vol. 171, no. 7, 1 October 2003 (2003-10-01), pages 3533 - 3541, XP002371462, ISSN: 0022-1767 * |
RAMMENSEE HANS-GEORG ET AL: "SYFPEITHI: Database for MHC ligands and peptide motifs", IMMUNOGENETICS, SPRINGER VERLAG, BERLIN, DE, vol. 50, no. 3-4, November 1999 (1999-11-01), pages 213 - 219, XP002183663, ISSN: 0093-7711 * |
REIZIS B ET AL: "The peptide binding specificity of the MHC class II I-A molecule of the Lewis rat, RT1.BI.", INTERNATIONAL IMMUNOLOGY DEC 1996, vol. 8, no. 12, December 1996 (1996-12-01), pages 1825 - 1832, XP002421975, ISSN: 0953-8178 * |
SINGH H ET AL: "ProPred: prediction of HLA-DR binding sites.", BIOINFORMATICS (OXFORD, ENGLAND) DEC 2001, vol. 17, no. 12, December 2001 (2001-12-01), pages 1236 - 1237, XP002371461, ISSN: 1367-4803 * |
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