BRPI0515562A - métodos e composições para avaliação do prognóstico do cáncer de mama - Google Patents

métodos e composições para avaliação do prognóstico do cáncer de mama

Info

Publication number
BRPI0515562A
BRPI0515562A BRPI0515562-2A BRPI0515562A BRPI0515562A BR PI0515562 A BRPI0515562 A BR PI0515562A BR PI0515562 A BRPI0515562 A BR PI0515562A BR PI0515562 A BRPI0515562 A BR PI0515562A
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BR
Brazil
Prior art keywords
methods
prognosis
compositions
breast cancer
computer program
Prior art date
Application number
BRPI0515562-2A
Other languages
English (en)
Inventor
Timothy J Fischer
Clark M Whitehead
Douglas P Malinowski
Raphael Marcelpoil
Didier Morel
Original Assignee
Tripath Imaging Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tripath Imaging Inc filed Critical Tripath Imaging Inc
Publication of BRPI0515562A publication Critical patent/BRPI0515562A/pt

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57415—Specifically defined cancers of breast
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Evolutionary Biology (AREA)
  • Medical Informatics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Theoretical Computer Science (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus For Radiation Diagnosis (AREA)

Abstract

"MéTODOS E COMPOSIçõES PARA AVALIAçãO DO DIAGNóSTICO DO CáNCER DE MAMA". São fornecidos métodos e composições para avaliação do prognóstico de um paciente com câncer de mama, particularmente um paciente com câncer de mama em estágio inicial. Os métodos da invenção compreendem a detecção da expressão de pelo menos um, mais particularmente pelo menos dois biomarcadores em uma amostra corporal, em que a superexpressão do biomarcador ou uma combinação de bimarcadores é indicativa do prognóstico do câncer de mama. Em algumas modalidades, a amostra corporal é uma amostra de tecido mamário, particularmente uma amostra de tumor primário da mama. Os biomarcadores da invenção são proteínas e/ou genes cuja superexpressão é indicativa de um prognóstico bom ou ruim do câncer. Biomarcadores de interesse incluem proteínas e genes envolvidos na regulação do ciclo celular, replicação de DNA, transcrição, transdução de sinal, proliferação celular, invasão, proteólise ou metástase. Em alguns aspectos da invenção, a superexpressão de um biomarcador de interesse é detectada no nível protéico usando anticorpos específicos para o biomarcador ou no nível de ácido nucléico usando técnicas de hibridização de ácido nucléico.
BRPI0515562-2A 2004-09-22 2005-09-22 métodos e composições para avaliação do prognóstico do cáncer de mama BRPI0515562A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US61207304P 2004-09-22 2004-09-22
US61196504P 2004-09-22 2004-09-22
PCT/US2005/034152 WO2006036788A2 (en) 2004-09-22 2005-09-22 Methods and compositions for evaluating breast cancer prognosis

Publications (1)

Publication Number Publication Date
BRPI0515562A true BRPI0515562A (pt) 2008-07-29

Family

ID=35695736

Family Applications (2)

Application Number Title Priority Date Filing Date
BRPI0515562-2A BRPI0515562A (pt) 2004-09-22 2005-09-22 métodos e composições para avaliação do prognóstico do cáncer de mama
BRPI0515581-9A BRPI0515581A (pt) 2004-09-22 2005-09-22 métodos e produtos de programa de computador para análise e otimização de candidatos marcadores para prognóstico de cáncer

Family Applications After (1)

Application Number Title Priority Date Filing Date
BRPI0515581-9A BRPI0515581A (pt) 2004-09-22 2005-09-22 métodos e produtos de programa de computador para análise e otimização de candidatos marcadores para prognóstico de cáncer

Country Status (11)

Country Link
US (3) US20060063190A1 (pt)
EP (2) EP1800130B1 (pt)
JP (2) JP5184087B2 (pt)
KR (2) KR20070061893A (pt)
AT (1) ATE520988T1 (pt)
AU (2) AU2005289756B2 (pt)
BR (2) BRPI0515562A (pt)
CA (2) CA2580795A1 (pt)
IL (2) IL182062A0 (pt)
MX (1) MX2007003502A (pt)
WO (2) WO2006036788A2 (pt)

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US20060078926A1 (en) 2006-04-13
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