BRPI0515451A - quinolinas substituìdas com tiazolinona na posição 2 - Google Patents

quinolinas substituìdas com tiazolinona na posição 2

Info

Publication number
BRPI0515451A
BRPI0515451A BRPI0515451-0A BRPI0515451A BRPI0515451A BR PI0515451 A BRPI0515451 A BR PI0515451A BR PI0515451 A BRPI0515451 A BR PI0515451A BR PI0515451 A BRPI0515451 A BR PI0515451A
Authority
BR
Brazil
Prior art keywords
thiazolinone
substituted
substituted quinolines
derivatives
quinolines
Prior art date
Application number
BRPI0515451-0A
Other languages
English (en)
Inventor
Li Chen
Shaoqing Chen
Christophe Michoud
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BRPI0515451A publication Critical patent/BRPI0515451A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D521/00—Heterocyclic compounds containing unspecified hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

"QUINOLINAS SUBSTITUìDAS COM TIAZOLINONA NA POSIçãO 2". A presente invenção fornece derivados de quinolina substituídos com tiazolina, onde o anel quinolina é substituido na posição 2, da fórmula I derivados estes que demostram atividade antiproliferativa de CDK1 e são, portanto úteis como agentes anticâncer, composições farmacêuticas que contêm os ditos compostos, bem como processos para sua fabricação.
BRPI0515451-0A 2004-09-17 2005-09-15 quinolinas substituìdas com tiazolinona na posição 2 BRPI0515451A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US61076704P 2004-09-17 2004-09-17
PCT/EP2005/009927 WO2006029863A1 (en) 2004-09-17 2005-09-15 Thiazolinone 2-substituted quinolines

Publications (1)

Publication Number Publication Date
BRPI0515451A true BRPI0515451A (pt) 2008-07-29

Family

ID=35427233

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0515451-0A BRPI0515451A (pt) 2004-09-17 2005-09-15 quinolinas substituìdas com tiazolinona na posição 2

Country Status (11)

Country Link
US (1) US7241893B2 (pt)
EP (1) EP1791836A1 (pt)
JP (1) JP2008513398A (pt)
KR (2) KR20090031797A (pt)
CN (1) CN101018785A (pt)
AU (1) AU2005284294A1 (pt)
BR (1) BRPI0515451A (pt)
CA (1) CA2579348A1 (pt)
MX (1) MX2007002721A (pt)
RU (1) RU2395509C2 (pt)
WO (1) WO2006029863A1 (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008545690A (ja) * 2005-05-23 2008-12-18 スミスクライン・ビーチャム・コーポレイション 新規化合物
WO2010112545A1 (en) 2009-04-01 2010-10-07 Basf Se Isoxazoline compounds for combating invertebrate pests
WO2014080345A2 (en) * 2012-11-20 2014-05-30 Shasun Pharmaceuticals Limited Improved process for the preparation of pregabalin
RU2521390C1 (ru) * 2013-03-14 2014-06-27 Общество с ограниченной ответственностью "Тиацен" Производное роданина и средство для профилактики опухолевых заболеваний
CN103539781B (zh) * 2013-09-09 2015-09-30 苏州东南药业股份有限公司 一种wnt信号通路抑制剂的合成方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ503788A (en) * 1997-10-27 2002-11-26 Agouron Pharma 4-aminothiazole derivatives and their use as inhibitors of cyclin-dependent kinases
EP1215208B1 (en) 1997-10-27 2006-07-12 Agouron Pharmaceuticals, Inc. 4-Aminothiazole derivatives, their preparation and their use as inhibitors of cyclin-dependent kinases
MXPA05000453A (es) * 2002-07-10 2005-03-23 Applied Research Systems Derivados de benceno fusionados a azolidinona-vinilo.
WO2004006916A1 (en) * 2002-07-10 2004-01-22 Applied Research Systems Ars Holding Nv Use of compounds for increasing spermatozoa motility
UA80572C2 (en) * 2002-11-22 2007-10-10 Smithkline Beecham Corp THIAZOLIDINE DERIVATIVES AS hYAK3 INHIBITORS
US8106214B2 (en) 2003-07-28 2012-01-31 Merck Serono Sa 2-imino-4-(thio) oxo-5-polycyclovinylazolines for use as PI3 kinase inhibitors

Also Published As

Publication number Publication date
RU2007114126A (ru) 2008-10-27
RU2395509C2 (ru) 2010-07-27
WO2006029863A1 (en) 2006-03-23
JP2008513398A (ja) 2008-05-01
US7241893B2 (en) 2007-07-10
AU2005284294A1 (en) 2006-03-23
US20060063804A1 (en) 2006-03-23
KR20070043886A (ko) 2007-04-25
EP1791836A1 (en) 2007-06-06
MX2007002721A (es) 2007-04-23
KR20090031797A (ko) 2009-03-27
CN101018785A (zh) 2007-08-15
CA2579348A1 (en) 2006-03-23
KR100901091B1 (ko) 2009-06-08

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2167 DE 17/07/2012.