BRPI0513468A - método de produção de 3-(4-piperidinil)-2,3,4,5-tetrahidro-1,3-benzodia-zepin-2 (1h)-ona - Google Patents

método de produção de 3-(4-piperidinil)-2,3,4,5-tetrahidro-1,3-benzodia-zepin-2 (1h)-ona

Info

Publication number
BRPI0513468A
BRPI0513468A BRPI0513468-4A BRPI0513468A BRPI0513468A BR PI0513468 A BRPI0513468 A BR PI0513468A BR PI0513468 A BRPI0513468 A BR PI0513468A BR PI0513468 A BRPI0513468 A BR PI0513468A
Authority
BR
Brazil
Prior art keywords
piperidinyl
tetrahydro
benzodiazepin
production method
compound
Prior art date
Application number
BRPI0513468-4A
Other languages
English (en)
Inventor
Juergen Schnaubelt
Werner Rall
Rainer Soyka
Norbert Birk
Ludwig Gutschera
Heidelore Heimroth
Thomas Krueger
Armin Pr Ll
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34925890&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0513468(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of BRPI0513468A publication Critical patent/BRPI0513468A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

MéTODO DE PRODUçãO DE 3 - (4-PIPERIDINIL)-2,3,4,5 - TETRAHIDRO - 1,3 - BENZODIA - ZEPIN - 2 (1H) - ONA. A presente invenção refere-se a um método de produção de um composto de 3 - (4 - piperidinil) 2,3,4,5 - tetrahidro 1,3 - benzodiazepin - 2 (1H) - ona de fórmula (I), no qual o referido composto é um elemento estrutural dos antagonistas do CGRP que são particularmente adequados para o tratamento oral da enxaqueca.
BRPI0513468-4A 2004-07-23 2005-07-16 método de produção de 3-(4-piperidinil)-2,3,4,5-tetrahidro-1,3-benzodia-zepin-2 (1h)-ona BRPI0513468A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04017424A EP1619187A1 (de) 2004-07-23 2004-07-23 Verfahren zur Herstellung von 3-(4-Piperidinyl)- 2,3,4,5-tetrahydro-1,3-benzodiazepin-2(1H)-on
PCT/EP2005/007778 WO2006010511A1 (de) 2004-07-23 2005-07-16 Verfahren zur herstellung 3-(4-piperidinyl)-2,3,4,5-tetrahydro-1,3-benzodiazepin-2(1h)-on

Publications (1)

Publication Number Publication Date
BRPI0513468A true BRPI0513468A (pt) 2008-05-06

Family

ID=34925890

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0513468-4A BRPI0513468A (pt) 2004-07-23 2005-07-16 método de produção de 3-(4-piperidinil)-2,3,4,5-tetrahidro-1,3-benzodia-zepin-2 (1h)-ona

Country Status (19)

Country Link
US (1) US7141667B2 (pt)
EP (2) EP1619187A1 (pt)
JP (1) JP4516118B2 (pt)
KR (1) KR20070046881A (pt)
CN (2) CN102040590A (pt)
AR (1) AR050352A1 (pt)
AU (1) AU2005266579A1 (pt)
BR (1) BRPI0513468A (pt)
CA (1) CA2572811C (pt)
EA (1) EA011260B1 (pt)
EC (1) ECSP077190A (pt)
IL (1) IL180848A0 (pt)
MX (1) MX2007000906A (pt)
NO (1) NO20070366L (pt)
NZ (1) NZ553294A (pt)
TW (1) TW200613283A (pt)
UA (1) UA87507C2 (pt)
WO (1) WO2006010511A1 (pt)
ZA (1) ZA200609919B (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101146799A (zh) 2005-03-23 2008-03-19 贝林格尔·英格海姆国际有限公司 Cgrp拮抗剂、其制备方法以及其作为药物的用途
US7473778B2 (en) 2005-12-24 2009-01-06 Boehringer Ingelheim International Gmbh 3-(4-piperidinyl)-2,3,4,5-tetrahydro-1,3-benzodiazepin-2(1H)-one
DE102007038251A1 (de) 2007-08-13 2009-02-19 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neues Herstellverfahren
EP2225223B1 (de) 2007-11-22 2017-01-11 Boehringer Ingelheim International GmbH Organische verbindungen

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3474090A (en) * 1966-12-22 1969-10-21 American Cyanamid Co 3-aminoalkyl-1,3-benzodiazepin-2-ones
FR2518544A1 (fr) * 1981-12-22 1983-06-24 Lipha Benzodiazepines-1,3 thione-2, procede de preparation et medicament les contenant
DE19911039A1 (de) * 1999-03-12 2000-09-14 Boehringer Ingelheim Pharma Abgewandelte Aminosäureamide, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
FR2791021B1 (fr) * 1999-03-16 2001-05-11 France Design Arceau de protection pour vehicule decouvrable a toit repliable

Also Published As

Publication number Publication date
US7141667B2 (en) 2006-11-28
TW200613283A (en) 2006-05-01
AU2005266579A1 (en) 2006-02-02
ECSP077190A (es) 2007-03-29
MX2007000906A (es) 2007-04-13
CN102040590A (zh) 2011-05-04
JP4516118B2 (ja) 2010-08-04
EA011260B1 (ru) 2009-02-27
WO2006010511A8 (de) 2006-05-18
UA87507C2 (en) 2009-07-27
CN1989114A (zh) 2007-06-27
AR050352A1 (es) 2006-10-18
NO20070366L (no) 2007-02-06
WO2006010511A1 (de) 2006-02-02
EA200700041A1 (ru) 2007-08-31
NZ553294A (en) 2009-07-31
US20060019946A1 (en) 2006-01-26
JP2008507484A (ja) 2008-03-13
CA2572811C (en) 2012-09-11
EP1773789A1 (de) 2007-04-18
IL180848A0 (en) 2007-07-04
KR20070046881A (ko) 2007-05-03
ZA200609919B (en) 2008-07-30
EP1619187A1 (de) 2006-01-25
CA2572811A1 (en) 2006-02-02

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: NAO APRESENTADA A GUIA DE CUMPRIMENTO DE EXIGENCIA. REFERENTE A 7A ANUIDADE.