EA200700041A1 - Способ получения 3-(4-пиперидинил)-2,3,4,5-тетрагидро-1,3-бензодиазепин-2(1н)-она - Google Patents

Способ получения 3-(4-пиперидинил)-2,3,4,5-тетрагидро-1,3-бензодиазепин-2(1н)-она

Info

Publication number
EA200700041A1
EA200700041A1 EA200700041A EA200700041A EA200700041A1 EA 200700041 A1 EA200700041 A1 EA 200700041A1 EA 200700041 A EA200700041 A EA 200700041A EA 200700041 A EA200700041 A EA 200700041A EA 200700041 A1 EA200700041 A1 EA 200700041A1
Authority
EA
Eurasian Patent Office
Prior art keywords
benzodiazepin
piperidinyl
tetrahydro
producing
migraine
Prior art date
Application number
EA200700041A
Other languages
English (en)
Other versions
EA011260B1 (ru
Inventor
Юрген Шнаубельт
Вернер Ралль
Райнер Зойка
Норберт Бирк
Лудвиг Гутшера
Хейделоре Хеймрот
Томас Крюгер
Армин Прёлль
Original Assignee
Бёрингер Ингельхайм Интернациональ Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34925890&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA200700041(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Бёрингер Ингельхайм Интернациональ Гмбх filed Critical Бёрингер Ингельхайм Интернациональ Гмбх
Publication of EA200700041A1 publication Critical patent/EA200700041A1/ru
Publication of EA011260B1 publication Critical patent/EA011260B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

В заявке описан способ получения 3-(4-пиперидинил)-2,3,4,5-тетрагидро-1,3-бензодиазепин-2(1Н)-она формулы (I), представляющего собой структурный фрагмент CGRP-антагонистов, которые могут применяться прежде всего для терапии мигрени путем их приема внутрь.
EA200700041A 2004-07-23 2005-07-16 Способ получения 3-(4-пиперидинил)-2,3,4,5-тетрагидро-1,3-бензодиазепин-2(1h)-она EA011260B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04017424A EP1619187A1 (de) 2004-07-23 2004-07-23 Verfahren zur Herstellung von 3-(4-Piperidinyl)- 2,3,4,5-tetrahydro-1,3-benzodiazepin-2(1H)-on
PCT/EP2005/007778 WO2006010511A1 (de) 2004-07-23 2005-07-16 Verfahren zur herstellung 3-(4-piperidinyl)-2,3,4,5-tetrahydro-1,3-benzodiazepin-2(1h)-on

Publications (2)

Publication Number Publication Date
EA200700041A1 true EA200700041A1 (ru) 2007-08-31
EA011260B1 EA011260B1 (ru) 2009-02-27

Family

ID=34925890

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200700041A EA011260B1 (ru) 2004-07-23 2005-07-16 Способ получения 3-(4-пиперидинил)-2,3,4,5-тетрагидро-1,3-бензодиазепин-2(1h)-она

Country Status (19)

Country Link
US (1) US7141667B2 (ru)
EP (2) EP1619187A1 (ru)
JP (1) JP4516118B2 (ru)
KR (1) KR20070046881A (ru)
CN (2) CN1989114A (ru)
AR (1) AR050352A1 (ru)
AU (1) AU2005266579A1 (ru)
BR (1) BRPI0513468A (ru)
CA (1) CA2572811C (ru)
EA (1) EA011260B1 (ru)
EC (1) ECSP077190A (ru)
IL (1) IL180848A0 (ru)
MX (1) MX2007000906A (ru)
NO (1) NO20070366L (ru)
NZ (1) NZ553294A (ru)
TW (1) TW200613283A (ru)
UA (1) UA87507C2 (ru)
WO (1) WO2006010511A1 (ru)
ZA (1) ZA200609919B (ru)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101146799A (zh) 2005-03-23 2008-03-19 贝林格尔·英格海姆国际有限公司 Cgrp拮抗剂、其制备方法以及其作为药物的用途
US7473778B2 (en) * 2005-12-24 2009-01-06 Boehringer Ingelheim International Gmbh 3-(4-piperidinyl)-2,3,4,5-tetrahydro-1,3-benzodiazepin-2(1H)-one
DE102007038251A1 (de) 2007-08-13 2009-02-19 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neues Herstellverfahren
WO2009065919A2 (de) 2007-11-22 2009-05-28 Boehringer Ingelheim International Gmbh Organische verbindungen

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3474090A (en) * 1966-12-22 1969-10-21 American Cyanamid Co 3-aminoalkyl-1,3-benzodiazepin-2-ones
FR2518544A1 (fr) * 1981-12-22 1983-06-24 Lipha Benzodiazepines-1,3 thione-2, procede de preparation et medicament les contenant
DE19911039A1 (de) * 1999-03-12 2000-09-14 Boehringer Ingelheim Pharma Abgewandelte Aminosäureamide, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
FR2791021B1 (fr) * 1999-03-16 2001-05-11 France Design Arceau de protection pour vehicule decouvrable a toit repliable

Also Published As

Publication number Publication date
KR20070046881A (ko) 2007-05-03
JP2008507484A (ja) 2008-03-13
CN1989114A (zh) 2007-06-27
BRPI0513468A (pt) 2008-05-06
CA2572811A1 (en) 2006-02-02
ZA200609919B (en) 2008-07-30
MX2007000906A (es) 2007-04-13
AU2005266579A1 (en) 2006-02-02
IL180848A0 (en) 2007-07-04
EP1619187A1 (de) 2006-01-25
WO2006010511A1 (de) 2006-02-02
EA011260B1 (ru) 2009-02-27
AR050352A1 (es) 2006-10-18
US7141667B2 (en) 2006-11-28
US20060019946A1 (en) 2006-01-26
EP1773789A1 (de) 2007-04-18
NZ553294A (en) 2009-07-31
WO2006010511A8 (de) 2006-05-18
NO20070366L (no) 2007-02-06
CN102040590A (zh) 2011-05-04
UA87507C2 (en) 2009-07-27
TW200613283A (en) 2006-05-01
ECSP077190A (es) 2007-03-29
CA2572811C (en) 2012-09-11
JP4516118B2 (ja) 2010-08-04

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): BY RU