AR050352A1 - Procedimiento para obtener 3-(4-piperidinil)-2,3,4,5-tetrahidro-1,3-benzodiazepin-2(1h)-ona - Google Patents

Procedimiento para obtener 3-(4-piperidinil)-2,3,4,5-tetrahidro-1,3-benzodiazepin-2(1h)-ona

Info

Publication number
AR050352A1
AR050352A1 ARP050103035A ARP050103035A AR050352A1 AR 050352 A1 AR050352 A1 AR 050352A1 AR P050103035 A ARP050103035 A AR P050103035A AR P050103035 A ARP050103035 A AR P050103035A AR 050352 A1 AR050352 A1 AR 050352A1
Authority
AR
Argentina
Prior art keywords
phenylmethyl
piperidinyl
benzodiazepin
tetrahydro
compound
Prior art date
Application number
ARP050103035A
Other languages
English (en)
Inventor
Juergen Schnaubelt
Werner Rall
Rainer Soyka
Norbert Birk
Ludwig Gutschera
Heiderole Heimroth
Thomas Krueger
Armin Proell
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34925890&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR050352(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of AR050352A1 publication Critical patent/AR050352A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Es objeto de la presente un procedimiento para la preparacion del compuesto 3-(4-piperidinil)-2,3,4,5-tetrahidro-1,3-benzo-diazepin-2(1H)-ona de la formula (1) que se ha de encontrar como elemento estructural en antagonistas de CGRP que son apropiados sobre todo para la terapia oral de la migrana. Reivindicacion 1: Procedimiento para la preparacion del compuesto de la formula (1) caracterizado porque (a) se hace reaccionar ácido 2-nitrofenilacético en presencia de agentes de condensacion con 4-amino-N-fenil-metilpiperidina; (b) se transforma el grupo carbonilo de la 2-nitro-N-[1-(fenilmetil)-4-piperidinil]-fenilacetamida obtenida por adicion de un agente de reduccion en un grupo metileno; (c) se cicla el producto intermediario N-[2-(2-nitro-fenil)etil]-1-(fenilmetil)-4-amino-piperidina obtenido después de la reduccion el grupo nitro en presencia de un catalizador de níquel Raney por adicion de agentes de condensacion en 3-[1-(fenilmetil)-4-piperidinil]- 2,3,4,5-tetrahidro-1,3-benzodiazepin-2(1H)-ona, y (d) se transforma la 3-[1-(fenilmetil)-4-piperidinil]-2,3,4,5-tetrahidro-1,3-benzodiazepin-2-(1H)-ona por separacion del grupo protector bencilo en le compuesto de la formula (1).
ARP050103035A 2004-07-23 2005-07-22 Procedimiento para obtener 3-(4-piperidinil)-2,3,4,5-tetrahidro-1,3-benzodiazepin-2(1h)-ona AR050352A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP04017424A EP1619187A1 (de) 2004-07-23 2004-07-23 Verfahren zur Herstellung von 3-(4-Piperidinyl)- 2,3,4,5-tetrahydro-1,3-benzodiazepin-2(1H)-on

Publications (1)

Publication Number Publication Date
AR050352A1 true AR050352A1 (es) 2006-10-18

Family

ID=34925890

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP050103035A AR050352A1 (es) 2004-07-23 2005-07-22 Procedimiento para obtener 3-(4-piperidinil)-2,3,4,5-tetrahidro-1,3-benzodiazepin-2(1h)-ona

Country Status (19)

Country Link
US (1) US7141667B2 (es)
EP (2) EP1619187A1 (es)
JP (1) JP4516118B2 (es)
KR (1) KR20070046881A (es)
CN (2) CN1989114A (es)
AR (1) AR050352A1 (es)
AU (1) AU2005266579A1 (es)
BR (1) BRPI0513468A (es)
CA (1) CA2572811C (es)
EA (1) EA011260B1 (es)
EC (1) ECSP077190A (es)
IL (1) IL180848A0 (es)
MX (1) MX2007000906A (es)
NO (1) NO20070366L (es)
NZ (1) NZ553294A (es)
TW (1) TW200613283A (es)
UA (1) UA87507C2 (es)
WO (1) WO2006010511A1 (es)
ZA (1) ZA200609919B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101146799A (zh) 2005-03-23 2008-03-19 贝林格尔·英格海姆国际有限公司 Cgrp拮抗剂、其制备方法以及其作为药物的用途
US7473778B2 (en) * 2005-12-24 2009-01-06 Boehringer Ingelheim International Gmbh 3-(4-piperidinyl)-2,3,4,5-tetrahydro-1,3-benzodiazepin-2(1H)-one
DE102007038251A1 (de) 2007-08-13 2009-02-19 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neues Herstellverfahren
CA2705405A1 (en) 2007-11-22 2009-05-28 Boehringer Ingelheim International Gmbh New compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3474090A (en) * 1966-12-22 1969-10-21 American Cyanamid Co 3-aminoalkyl-1,3-benzodiazepin-2-ones
FR2518544A1 (fr) * 1981-12-22 1983-06-24 Lipha Benzodiazepines-1,3 thione-2, procede de preparation et medicament les contenant
DE19911039A1 (de) * 1999-03-12 2000-09-14 Boehringer Ingelheim Pharma Abgewandelte Aminosäureamide, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
FR2791021B1 (fr) * 1999-03-16 2001-05-11 France Design Arceau de protection pour vehicule decouvrable a toit repliable

Also Published As

Publication number Publication date
NO20070366L (no) 2007-02-06
US20060019946A1 (en) 2006-01-26
US7141667B2 (en) 2006-11-28
CN1989114A (zh) 2007-06-27
UA87507C2 (en) 2009-07-27
EP1773789A1 (de) 2007-04-18
EA200700041A1 (ru) 2007-08-31
MX2007000906A (es) 2007-04-13
EP1619187A1 (de) 2006-01-25
JP2008507484A (ja) 2008-03-13
TW200613283A (en) 2006-05-01
CN102040590A (zh) 2011-05-04
WO2006010511A8 (de) 2006-05-18
WO2006010511A1 (de) 2006-02-02
KR20070046881A (ko) 2007-05-03
IL180848A0 (en) 2007-07-04
CA2572811A1 (en) 2006-02-02
NZ553294A (en) 2009-07-31
AU2005266579A1 (en) 2006-02-02
ECSP077190A (es) 2007-03-29
CA2572811C (en) 2012-09-11
BRPI0513468A (pt) 2008-05-06
JP4516118B2 (ja) 2010-08-04
EA011260B1 (ru) 2009-02-27
ZA200609919B (en) 2008-07-30

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