BRPI0510852A - produtos medicinais em formulação aerossol com estabilidade quìmica aprimorada - Google Patents

produtos medicinais em formulação aerossol com estabilidade quìmica aprimorada

Info

Publication number
BRPI0510852A
BRPI0510852A BRPI0510852-7A BRPI0510852A BRPI0510852A BR PI0510852 A BRPI0510852 A BR PI0510852A BR PI0510852 A BRPI0510852 A BR PI0510852A BR PI0510852 A BRPI0510852 A BR PI0510852A
Authority
BR
Brazil
Prior art keywords
aerosol formulation
chemical stability
improved chemical
linking agent
butyl rubber
Prior art date
Application number
BRPI0510852-7A
Other languages
English (en)
Inventor
Brian Meakin
David Lewis
Robert Johnson
Tanya Church
Original Assignee
Chiesi Farma Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiesi Farma Spa filed Critical Chiesi Farma Spa
Publication of BRPI0510852A publication Critical patent/BRPI0510852A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4704—2-Quinolinones, e.g. carbostyril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Otolaryngology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)

Abstract

PRODUTOS MEDICINAIS EM FORMULAçãO AEROSSOL COM ESTABILIDADE QUìMICA APRIMORADA A presente invenção está relacionada a um produto medicinal em formulação aerossol com estabilidade química aprimorada, incluindo um inalador dosimetrado pressurizado com um reservatório de aerossol equipado com uma válvula reguladora com anéis e/ou juntas de vedação feitos de uma composição elastomérica vulcanizada de borracha butílica, um agente de ligação cruzada para a borracha butílica e um acelerador para o agente de ligação cruzada, em que o acelerador inclui um composto de polissulfeto derivado de um ácido ditiocarbónico substituído ou de um derivado deste, e no qual o inalador dosimetrado pressurizado contém, no reservatório do aerossol, uma formulação medicinal em aerossol contendo um <225>~ 2~-agonista de longa duração, um propelente de hidrofluorcarbono, um co-solvente e um ácido mineral como estabilizante para o ingrediente ativo.
BRPI0510852-7A 2004-05-13 2005-02-25 produtos medicinais em formulação aerossol com estabilidade quìmica aprimorada BRPI0510852A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04011425 2004-05-13
PCT/EP2005/002041 WO2005112902A2 (en) 2004-05-13 2005-02-25 Medicinal aerosol formulation products with improved chemical stability

Publications (1)

Publication Number Publication Date
BRPI0510852A true BRPI0510852A (pt) 2007-11-27

Family

ID=34960892

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0510852-7A BRPI0510852A (pt) 2004-05-13 2005-02-25 produtos medicinais em formulação aerossol com estabilidade quìmica aprimorada

Country Status (19)

Country Link
US (1) US20070086953A1 (pt)
EP (1) EP1746981B1 (pt)
JP (1) JP2007537170A (pt)
KR (1) KR20070010159A (pt)
CN (1) CN1950075A (pt)
AT (1) ATE404185T1 (pt)
AU (1) AU2005245248A1 (pt)
BR (1) BRPI0510852A (pt)
CA (1) CA2565747A1 (pt)
DE (1) DE602005008946D1 (pt)
EA (1) EA200602112A1 (pt)
ES (1) ES2309722T3 (pt)
IL (1) IL178739A0 (pt)
MA (1) MA28649B1 (pt)
MX (1) MXPA06013189A (pt)
NO (1) NO20065722L (pt)
TN (1) TNSN06334A1 (pt)
WO (1) WO2005112902A2 (pt)
ZA (1) ZA200608742B (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TN2016000261A1 (en) * 2013-12-30 2017-10-06 Chiesi Farm Spa Stable pressurised aerosol solution composition of glycopyrronium bromide and formoterol combination.
ES2666905T4 (es) 2013-12-30 2018-06-07 Chiesi Farmaceutici S.P.A. Composición en solución para aerosol estable presurizada de una combinación de bromuro de glicopirronio y formoterol
CN106620976B (zh) * 2016-12-28 2020-01-07 四川普锐特医药科技有限责任公司 一种丙酸氟替卡松定量吸入气雾剂
GB202001537D0 (en) * 2020-02-05 2020-03-18 Consort Medical Plc Pressurised dispensing container
US20230277451A1 (en) * 2020-10-09 2023-09-07 Chiesi Farmaceutici S.P.A. A pharmaceutical formulation for pressurised metered dose inhaler

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060257324A1 (en) * 2000-05-22 2006-11-16 Chiesi Farmaceutici S.P.A. Pharmaceutical solution formulations for pressurised metered dose inhalers
CZ303833B6 (cs) * 2000-05-22 2013-05-22 Chiesi Farmaceutici S.P.A. Aerosolový prostredek
MXPA04008372A (es) * 2002-03-01 2004-11-26 Chiesi Farma Spa Formulacion superfina de formoterol.
US20040126325A1 (en) * 2002-03-12 2004-07-01 David Lewis Medicinal aerosol solution formulation products with improved chemical stability
EP1485443B1 (en) * 2002-03-18 2007-01-03 Bespak Plc Seal material for a dispensing apparatus
IL177103A0 (en) * 2004-02-27 2006-12-10 Chiesi Farma Spa Stable pharmaceutical solution formulations for pressurized metered dose inhalers
EP1595531A1 (en) * 2004-05-13 2005-11-16 CHIESI FARMACEUTICI S.p.A. Stable pharmaceutical solution formulations for pressurized metered dose inhalers
EP1850831B1 (en) * 2005-02-25 2015-12-02 CHIESI FARMACEUTICI S.p.A. Pharmaceutical aerosol formulations for pressurized metered dose inhalers comprising a sequestering agent

Also Published As

Publication number Publication date
MA28649B1 (fr) 2007-06-01
MXPA06013189A (es) 2007-02-14
NO20065722L (no) 2006-12-12
WO2005112902A3 (en) 2006-05-04
IL178739A0 (en) 2007-02-11
US20070086953A1 (en) 2007-04-19
WO2005112902A2 (en) 2005-12-01
EP1746981A2 (en) 2007-01-31
ZA200608742B (en) 2008-07-30
AU2005245248A1 (en) 2005-12-01
CA2565747A1 (en) 2005-12-01
CN1950075A (zh) 2007-04-18
ES2309722T3 (es) 2008-12-16
EP1746981B1 (en) 2008-08-13
TNSN06334A1 (en) 2008-02-22
DE602005008946D1 (de) 2008-09-25
JP2007537170A (ja) 2007-12-20
ATE404185T1 (de) 2008-08-15
KR20070010159A (ko) 2007-01-22
EA200602112A1 (ru) 2007-04-27

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A E 6 ANUIDADE(S).

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2099 DE 29/03/2011.