BRPI0506470A - produtos farmacêuticos esteroidal direcionado a helix 12, incluindo composto molecular da fórmula ou sal do mesmo; composição farmacêutica e método de tratamento - Google Patents
produtos farmacêuticos esteroidal direcionado a helix 12, incluindo composto molecular da fórmula ou sal do mesmo; composição farmacêutica e método de tratamentoInfo
- Publication number
- BRPI0506470A BRPI0506470A BRPI0506470-8A BRPI0506470A BRPI0506470A BR PI0506470 A BRPI0506470 A BR PI0506470A BR PI0506470 A BRPI0506470 A BR PI0506470A BR PI0506470 A BRPI0506470 A BR PI0506470A
- Authority
- BR
- Brazil
- Prior art keywords
- helix
- salt
- treatment method
- pharmaceutical composition
- molecular compound
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/08—Antiseborrheics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/26—Androgens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/28—Antiandrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Reproductive Health (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pregnancy & Childbirth (AREA)
- Cardiology (AREA)
- Neurology (AREA)
- Gynecology & Obstetrics (AREA)
- Heart & Thoracic Surgery (AREA)
- Nutrition Science (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
Abstract
"PRODUTOS FARMACêUTICOS ESTEROIDAL DIRECIONADO A HELIX 12, INCLUINDO COMPOSTO MOLECULAR DA FóRMULA OU SAL DO MESMO; COMPOSIçãO FARMACêUTICA E MéTODO DE TRATAMENTO". Compostos possuindo a estrutura ou seus sais são usados para o tratamento ou redução da probabilidade de adquirir doenças que dependem de andrógeno, tais como, câncer de próstata, hiperplasia prostática benigna, sindrome ovariana policística, acne, hirsutismo, seborréia, alopecia androgênica e males da calvície. Eles podem ser formulados juntos com diluentes ou condutores aceitáveis farmacêuticamente ou por outro lado feitos em qualquer forma de dosagem farmacêutica. Alguns destes compostos possuindo tecido específico de atividade antiandrogênica podem ser usados para tratar ou reduzir o risco do desenvolvimento das doenças referentes à perda da estimulação androgênica. Combinações com outros agentes farmacêuticos ativos, são também revelados.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US53512104P | 2004-01-07 | 2004-01-07 | |
PCT/CA2005/000011 WO2005066194A1 (en) | 2004-01-07 | 2005-01-06 | Helix 12 directed steroidal pharmaceutical products |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0506470A true BRPI0506470A (pt) | 2007-02-21 |
Family
ID=34749018
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0506470-8A BRPI0506470A (pt) | 2004-01-07 | 2005-01-06 | produtos farmacêuticos esteroidal direcionado a helix 12, incluindo composto molecular da fórmula ou sal do mesmo; composição farmacêutica e método de tratamento |
Country Status (16)
Country | Link |
---|---|
US (1) | US9090651B2 (pt) |
EP (1) | EP1704161A4 (pt) |
JP (1) | JP4866740B2 (pt) |
KR (2) | KR101536701B1 (pt) |
CN (2) | CN102358750B (pt) |
AU (2) | AU2005203922A1 (pt) |
BR (1) | BRPI0506470A (pt) |
CA (1) | CA2551737C (pt) |
HK (1) | HK1167657A1 (pt) |
IL (1) | IL176538A0 (pt) |
MY (1) | MY157898A (pt) |
NO (1) | NO20063564L (pt) |
RU (1) | RU2397176C2 (pt) |
TW (1) | TWI383993B (pt) |
WO (1) | WO2005066194A1 (pt) |
ZA (1) | ZA200605242B (pt) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2551737C (en) | 2004-01-07 | 2009-11-10 | Endorecherche, Inc. | Helix 12 directed steroidal pharmaceutical products |
CN102357248A (zh) | 2004-10-20 | 2012-02-22 | 恩多研究公司 | 单独的性甾体前体或与选择性雌激素受体调节剂联合用于防治绝经后女性的阴道疾病和病症 |
GB0428128D0 (en) * | 2004-12-22 | 2005-01-26 | Avecia Ltd | Process |
US7709516B2 (en) | 2005-06-17 | 2010-05-04 | Endorecherche, Inc. | Helix 12 directed non-steroidal antiandrogens |
US9284345B2 (en) | 2007-04-12 | 2016-03-15 | Endorecherche, Inc. | 17alpha-substituted steroids as systemic antiandrogens and selective androgen receptor modulators |
US8268806B2 (en) | 2007-08-10 | 2012-09-18 | Endorecherche, Inc. | Pharmaceutical compositions |
US8067448B2 (en) | 2008-02-22 | 2011-11-29 | Radius Health, Inc. | Selective androgen receptor modulators |
US8268872B2 (en) * | 2008-02-22 | 2012-09-18 | Radius Health, Inc. | Selective androgen receptor modulators |
US20090285893A1 (en) * | 2008-05-19 | 2009-11-19 | The Procter & Gamble Company | Treatment of heart failure in women |
GB2461037A (en) * | 2008-06-17 | 2009-12-23 | Elias Bouras | A method of treating alopecia using a composition comprising a cardiac glycoside |
EP2419400A1 (en) | 2009-04-15 | 2012-02-22 | Research Triangle Institute | Monoamine reuptake inhibitors |
CA2788907A1 (en) | 2010-02-04 | 2011-08-11 | Radius Health, Inc. | Selective androgen receptor modulators |
WO2011143469A1 (en) | 2010-05-12 | 2011-11-17 | Radius Health,Inc | Therapeutic regimens |
WO2011151423A1 (en) | 2010-06-04 | 2011-12-08 | Exonhit S.A. | Substituted isoquinolines and their use as tubulin polymerization inhibitors |
US8642632B2 (en) | 2010-07-02 | 2014-02-04 | Radius Health, Inc. | Selective androgen receptor modulators |
ES2550319T3 (es) | 2010-09-28 | 2015-11-06 | Radius Health, Inc | Moduladores selectivos del receptor de andrógenos |
CN102746360B (zh) * | 2012-06-19 | 2014-07-02 | 广西民族大学 | 四种喜树碱-甾体缀合物的合成及其应用 |
US9682960B2 (en) | 2013-12-19 | 2017-06-20 | Endorecherche, Inc. | Non-steroidal antiandrogens and selective androgen receptor modulators with a pyridyl moiety |
CN105237605B (zh) * | 2014-07-11 | 2019-01-25 | 上海迪赛诺生物医药有限公司 | 一种用于合成孕二烯酮的中间体及其制备方法和应用 |
CN105237606B (zh) * | 2014-07-11 | 2018-08-24 | 上海创诺制药有限公司 | 一种用于合成去氧孕烯的中间体及其制备方法和应用 |
MX2017013802A (es) | 2015-04-29 | 2018-08-15 | Radius Pharmaceuticals Inc | Métodos para tratar el cáncer. |
EP4066827A1 (en) | 2016-06-22 | 2022-10-05 | Ellipses Pharma Ltd | Ar+ breast cancer treatment methods |
MX2019007748A (es) | 2017-01-05 | 2019-09-09 | Radius Pharmaceuticals Inc | Formas polimorficas de rad1901-2hcl. |
CN108822175B (zh) * | 2018-04-26 | 2021-01-05 | 昆明理工大学 | 3,16-雄甾烯二酮类化合物及其应用 |
SG11202013177WA (en) | 2018-07-04 | 2021-01-28 | Radius Pharmaceuticals Inc | Polymorphic forms of rad 1901-2hcl |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3797494A (en) | 1969-04-01 | 1974-03-19 | Alza Corp | Bandage for the administration of drug by controlled metering through microporous materials |
US3742951A (en) | 1971-08-09 | 1973-07-03 | Alza Corp | Bandage for controlled release of vasodilators |
DE3333240A1 (de) | 1983-09-12 | 1985-03-28 | Schering AG, 1000 Berlin und 4709 Bergkamen | Mittel zur transdermalen applikation von arzneimittelwirkstoffen |
US4568343A (en) | 1984-10-09 | 1986-02-04 | Alza Corporation | Skin permeation enhancer compositions |
EP0254341B1 (en) * | 1986-07-23 | 1990-01-03 | Akzo N.V. | Novel 18-phenyloestrane derivatives |
US4816258A (en) | 1987-02-26 | 1989-03-28 | Alza Corporation | Transdermal contraceptive formulations |
US5064654A (en) | 1989-01-11 | 1991-11-12 | Ciba-Geigy Corporation | Mixed solvent mutually enhanced transdermal therapeutic system |
US5071644A (en) | 1990-08-07 | 1991-12-10 | Mediventures, Inc. | Topical drug delivery with thermo-irreversible gels |
US6060503A (en) | 1991-12-02 | 2000-05-09 | Endorecherche, Inc. | Benzopyran-containing compounds and method for their use |
WO1995018821A2 (en) * | 1994-01-06 | 1995-07-13 | Sri International | Novel antiandrogenic agents and related pharmaceutical compositions and methods of use |
US6124115A (en) | 1995-09-22 | 2000-09-26 | Endorecherche Inc. | Production and use of isolated type 5 17β-hydroxysteroid dehydrogenase |
EP1094798A2 (en) | 1998-03-11 | 2001-05-02 | Endorecherche Inc. | INHIBITORS OF TYPE 5 AND TYPE 3 17beta-HYDROXYSTEROID DEHYDROGENASE AND METHODS FOR THEIR USE |
AU2001288213B2 (en) | 2000-06-28 | 2005-04-14 | Bristol-Myers Squibb Company | Selective androgen receptor modulators and methods for their identification, design and use |
JP3908162B2 (ja) * | 2000-06-30 | 2007-04-25 | 中外製薬株式会社 | 新規な抗アンドロゲン剤 |
NZ530810A (en) | 2001-09-06 | 2006-05-26 | Schering Corp | 17beta-hydroxysteroid dehydrogenase type 3 inhibitors for the treatment of androgen dependent diseases |
DE60309667D1 (de) * | 2002-02-15 | 2006-12-28 | Endorech Inc | Biphenylderivate und ihre verwendung als antiandrogene |
JP4516316B2 (ja) * | 2002-03-13 | 2010-08-04 | メルク・シャープ・エンド・ドーム・コーポレイション | アンドロゲン受容体モジュレーターとしてのフッ化4−アザステロイド誘導体 |
EP1501512A4 (en) * | 2002-04-30 | 2009-11-18 | Merck & Co Inc | 4-AZASTEROID DERIVATIVES AS ANDROGEN RECEPTOR MODULATORS |
CA2551737C (en) | 2004-01-07 | 2009-11-10 | Endorecherche, Inc. | Helix 12 directed steroidal pharmaceutical products |
US7709516B2 (en) | 2005-06-17 | 2010-05-04 | Endorecherche, Inc. | Helix 12 directed non-steroidal antiandrogens |
US9284345B2 (en) | 2007-04-12 | 2016-03-15 | Endorecherche, Inc. | 17alpha-substituted steroids as systemic antiandrogens and selective androgen receptor modulators |
-
2005
- 2005-01-06 CA CA002551737A patent/CA2551737C/en not_active Expired - Fee Related
- 2005-01-06 BR BRPI0506470-8A patent/BRPI0506470A/pt not_active IP Right Cessation
- 2005-01-06 KR KR1020067015954A patent/KR101536701B1/ko not_active IP Right Cessation
- 2005-01-06 WO PCT/CA2005/000011 patent/WO2005066194A1/en active Search and Examination
- 2005-01-06 CN CN201110251554.5A patent/CN102358750B/zh not_active Expired - Fee Related
- 2005-01-06 EP EP05700249A patent/EP1704161A4/en not_active Withdrawn
- 2005-01-06 CN CNA200580007350XA patent/CN1930181A/zh active Pending
- 2005-01-06 AU AU2005203922A patent/AU2005203922A1/en not_active Abandoned
- 2005-01-06 KR KR1020137024835A patent/KR20130124576A/ko not_active Application Discontinuation
- 2005-01-06 TW TW094100344A patent/TWI383993B/zh not_active IP Right Cessation
- 2005-01-06 JP JP2006548053A patent/JP4866740B2/ja not_active Expired - Fee Related
- 2005-01-06 RU RU2006128574/04A patent/RU2397176C2/ru not_active IP Right Cessation
- 2005-01-07 US US11/030,850 patent/US9090651B2/en active Active
- 2005-01-07 MY MYPI20050071A patent/MY157898A/en unknown
-
2006
- 2006-06-25 IL IL176538A patent/IL176538A0/en unknown
- 2006-06-26 ZA ZA200605242A patent/ZA200605242B/en unknown
- 2006-08-07 NO NO20063564A patent/NO20063564L/no not_active Application Discontinuation
-
2009
- 2009-05-22 AU AU2009202038A patent/AU2009202038A1/en not_active Abandoned
-
2012
- 2012-08-22 HK HK12108245.2A patent/HK1167657A1/zh not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP1704161A1 (en) | 2006-09-27 |
RU2397176C2 (ru) | 2010-08-20 |
AU2009202038A1 (en) | 2009-06-11 |
KR101536701B1 (ko) | 2015-07-14 |
MY157898A (en) | 2016-08-15 |
IL176538A0 (en) | 2006-10-05 |
CA2551737A1 (en) | 2005-07-21 |
CA2551737C (en) | 2009-11-10 |
HK1167657A1 (zh) | 2012-12-07 |
RU2006128574A (ru) | 2008-02-20 |
US9090651B2 (en) | 2015-07-28 |
JP4866740B2 (ja) | 2012-02-01 |
WO2005066194A1 (en) | 2005-07-21 |
CN102358750A (zh) | 2012-02-22 |
NO20063564L (no) | 2006-10-09 |
AU2009202038A2 (en) | 2009-08-06 |
CN102358750B (zh) | 2015-11-25 |
KR20130124576A (ko) | 2013-11-14 |
CN1930181A (zh) | 2007-03-14 |
JP2007519635A (ja) | 2007-07-19 |
TWI383993B (zh) | 2013-02-01 |
US20050250749A1 (en) | 2005-11-10 |
TW200530264A (en) | 2005-09-16 |
AU2005203922A1 (en) | 2005-07-21 |
KR20070003851A (ko) | 2007-01-05 |
EP1704161A4 (en) | 2011-06-08 |
ZA200605242B (en) | 2007-10-31 |
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