BRPI0416360A - processo para o cultivo de microorganismos da espécie thraustochytriales com a utilização de um meio de baixo número otimizado - Google Patents
processo para o cultivo de microorganismos da espécie thraustochytriales com a utilização de um meio de baixo número otimizadoInfo
- Publication number
- BRPI0416360A BRPI0416360A BRPI0416360-5A BRPI0416360A BRPI0416360A BR PI0416360 A BRPI0416360 A BR PI0416360A BR PI0416360 A BRPI0416360 A BR PI0416360A BR PI0416360 A BRPI0416360 A BR PI0416360A
- Authority
- BR
- Brazil
- Prior art keywords
- medium
- microorganisms
- salts
- low
- optimized
- Prior art date
Links
- 244000005700 microbiome Species 0.000 title abstract 5
- 241001467333 Thraustochytriaceae Species 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 150000003839 salts Chemical class 0.000 abstract 5
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract 3
- 150000003841 chloride salts Chemical class 0.000 abstract 2
- 239000011734 sodium Substances 0.000 abstract 2
- 239000011780 sodium chloride Substances 0.000 abstract 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
- 239000000654 additive Substances 0.000 abstract 1
- 230000007613 environmental effect Effects 0.000 abstract 1
- 150000002500 ions Chemical class 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 235000020777 polyunsaturated fatty acids Nutrition 0.000 abstract 1
- 239000013535 sea water Substances 0.000 abstract 1
- 229910052708 sodium Inorganic materials 0.000 abstract 1
- 159000000000 sodium salts Chemical class 0.000 abstract 1
- 239000002351 wastewater Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6409—Fatty acids
- C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
- C12P7/6434—Docosahexenoic acids [DHA]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
- A23K10/37—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms from waste material
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
- A23L33/12—Fatty acids or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/12—Unicellular algae; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6436—Fatty acid esters
- C12P7/6445—Glycerides
- C12P7/6472—Glycerides containing polyunsaturated fatty acid [PUFA] residues, i.e. having two or more double bonds in their backbone
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Botany (AREA)
- Mycology (AREA)
- Food Science & Technology (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Cell Biology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Animal Husbandry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Fodder In General (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Edible Oils And Fats (AREA)
Abstract
PROCESSO PARA O CULTIVO DE MICROORGANISMOS DA ESPéCIE THRAUSTOCHYTRIALES COM A UTILIZAçãO DE UM MEIO DE BAIXO NúMERO OTIMIZADO. A presente invenção refere-se a um processo otimizado para o cultivo de microorganismos do gênero Thraustochytriales, no qual os microorganismos são cultivados em um meio de baixa salinidade sem adição de sais de sódio e sais de cloreto, com um teor de sal total de menos do que 3,5 g/l de sais totais (correspondentemente menos do que 10 % do teor de sal de água marinha) e isolamento subseqüente dos PUFAa dos microorganismos e/ou do meio. Especialmente são descritos novos meio otimizados com teor de sal total consideravelmente reduzido com teor de NaCI particularmente reduzido. Uma nova combinação de diversos sais como composição do meio não mais de 1,75 g/l de íons da Na¬ +¬ e CI¬ -¬ na soma das partes em peso, permite aperfeiçoar competentemente e simplificar consideravelmente a produção dos PUFAs. Além disso, o meio descrito é preferentemente inteiramente isento de aditivos de sais de sódio e cloreto, o que ajuda a evitar danos ambientais das águas residuais salinas.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2003152838 DE10352838A1 (de) | 2003-11-10 | 2003-11-10 | Verfahren zur Kultivierung von Mikroorganismen der Gattung Thraustochytriales unter Verwendung eines optimierten Niedrigsalzmediums |
| PCT/EP2004/012718 WO2005045003A2 (de) | 2003-11-10 | 2004-11-10 | Verfahren zur kultivierung von mikroorganismen der gattung thraustochytriales unter verwendung eines optimierten niedrigsalzmediums |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0416360A true BRPI0416360A (pt) | 2007-05-08 |
Family
ID=34559600
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0416360-5A BRPI0416360A (pt) | 2003-11-10 | 2004-11-10 | processo para o cultivo de microorganismos da espécie thraustochytriales com a utilização de um meio de baixo número otimizado |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US8900831B2 (pt) |
| EP (2) | EP2816104A1 (pt) |
| JP (1) | JP4791367B2 (pt) |
| KR (1) | KR101238613B1 (pt) |
| CN (2) | CN104073442A (pt) |
| AU (1) | AU2004287954B2 (pt) |
| BR (1) | BRPI0416360A (pt) |
| CA (1) | CA2545410A1 (pt) |
| DE (1) | DE10352838A1 (pt) |
| EA (1) | EA011858B1 (pt) |
| IL (1) | IL175520A (pt) |
| SG (1) | SG148157A1 (pt) |
| WO (1) | WO2005045003A2 (pt) |
| ZA (1) | ZA200603854B (pt) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100086979A1 (en) * | 2006-10-27 | 2010-04-08 | Thomas Kiy | Production of omega-3 fatty acids in microflora of thraustochytriales using modified media |
| EP2071019A1 (en) | 2007-12-15 | 2009-06-17 | Lonza AG | Method for the cultivation of microoranisms of the order thraustochytriales |
| EP2105506A1 (de) * | 2008-03-26 | 2009-09-30 | Lonza Ag | Verfahren zur Herstellung PUFAs enthaltender Öle unter Verwendung von Mikroorganismen der Ordnung Labyrinthulomycota |
| US8207363B2 (en) | 2009-03-19 | 2012-06-26 | Martek Biosciences Corporation | Thraustochytrids, fatty acid compositions, and methods of making and uses thereof |
| KR20120133381A (ko) | 2010-01-19 | 2012-12-10 | 디에스엠 아이피 어셋츠 비.브이. | 에이코사펜타엔산 생산 미생물, 지방산 조성물 및 이의 제조방법 및 용도 |
| CN108771240A (zh) | 2011-07-21 | 2018-11-09 | 帝斯曼知识产权资产管理有限公司 | 脂肪酸组合物 |
| KR101134324B1 (ko) * | 2011-10-07 | 2012-04-13 | 나윤경 | 미생물 대량 생산을 위한 분말 배지 |
| KR101418066B1 (ko) * | 2012-11-30 | 2014-07-09 | 롯데케미칼 주식회사 | 미세조류를 이용한 도코사헥사엔산 생산방법 |
| EP2826384A1 (de) | 2013-07-16 | 2015-01-21 | Evonik Industries AG | Verfahren zur Trocknung von Biomasse |
| FR3019559B1 (fr) * | 2014-04-03 | 2018-01-05 | Fermentalg | Procede de culture des microalgues du genre aurantiochytrium dans un milieu de culture a teneur reduite en sodium et en chlorure pour la production de dha |
| WO2015171151A1 (en) * | 2014-05-08 | 2015-11-12 | Smith Donald M | Selecting, producing, and feeding whole algae as a feed supplement for cattle and bison to produce meat high in omega 3's for human health |
| CN104004661B (zh) * | 2014-05-22 | 2017-12-15 | 广东省生物工程研究所（广州甘蔗糖业研究所） | 一种可提高鸡蛋品质的蛋鸡日粮 |
| AU2015263044B2 (en) * | 2014-05-22 | 2021-07-01 | MARA Renewables Corporation | Methods of oil production in microorganisms |
| CN104277975A (zh) * | 2014-09-28 | 2015-01-14 | 江苏科技大学 | 脱脂蚕蛹渣用于产油微生物培养的预处理方法及其产物和应用 |
| US11324234B2 (en) | 2014-10-02 | 2022-05-10 | Evonik Operations Gmbh | Method for raising animals |
| DK3200606T3 (da) | 2014-10-02 | 2021-06-21 | Evonik Operations Gmbh | Fremgangsmåde til fremstilling af et fodermiddel, der indeholder pufa'er, ved ekstrusion af en biomasse, der indeholder pufa'er, af typen labyrinthulomycetes |
| US20170295824A1 (en) | 2014-10-02 | 2017-10-19 | Evonik Degussa Gmbh | Process for producing a pufa-containing biomass which has high cell stability |
| DK180016B1 (da) | 2014-10-02 | 2020-01-22 | Evonik Degussa Gmbh | Feedstuff of high abrasion resistance and good stability in water, containing PUFAs |
| KR102405390B1 (ko) | 2016-07-13 | 2022-06-03 | 에보닉 오퍼레이션스 게엠베하 | 용해된 지질을 함유하는 바이오매스로부터 지질을 분리하는 방법 |
| KR102027632B1 (ko) * | 2016-12-06 | 2019-10-01 | 국립해양생물자원관 | 고온성 미생물 배양용 고체배지조성물 및 그 제조방법 |
| CN110462014A (zh) | 2016-12-27 | 2019-11-15 | 赢创德固赛有限公司 | 从含有脂质的生物质中分离脂质的方法 |
| EP3527664A1 (en) | 2018-02-15 | 2019-08-21 | Evonik Degussa GmbH | Method of isolating lipids from a lipids containing biomass |
| WO2019219443A1 (en) | 2018-05-15 | 2019-11-21 | Evonik Operations Gmbh | Method of isolating lipids from a lipids containing biomass with aid of hydrophobic silica |
| US11976253B2 (en) | 2018-05-15 | 2024-05-07 | Evonik Operations Gmbh | Method of isolating lipids from a lysed lipids containing biomass by emulsion inversion |
| CN114525312A (zh) * | 2020-11-06 | 2022-05-24 | 嘉必优生物技术（武汉）股份有限公司 | 一种使用裂殖壶菌发酵生产dha的方法 |
| SE2151489A1 (en) * | 2021-12-07 | 2023-06-08 | Mycorena Ab | A food product or food ingredient comprising fungi biomass with an increased intracellular fat content |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5130242A (en) | 1988-09-07 | 1992-07-14 | Phycotech, Inc. | Process for the heterotrophic production of microbial products with high concentrations of omega-3 highly unsaturated fatty acids |
| US5340742A (en) * | 1988-09-07 | 1994-08-23 | Omegatech Inc. | Process for growing thraustochytrium and schizochytrium using non-chloride salts to produce a microfloral biomass having omega-3-highly unsaturated fatty acids |
| US6451567B1 (en) | 1988-09-07 | 2002-09-17 | Omegatech, Inc. | Fermentation process for producing long chain omega-3 fatty acids with euryhaline microorganisms |
| US5407957A (en) | 1990-02-13 | 1995-04-18 | Martek Corporation | Production of docosahexaenoic acid by dinoflagellates |
| US6410281B1 (en) | 1992-07-10 | 2002-06-25 | Omegatech, Inc. | Reducing corrosion in a fermentor by providing sodium with a non-chloride sodium salt |
| DE69637953D1 (de) | 1995-04-17 | 2009-07-30 | Nat Inst Of Advanced Ind Scien | Hoch ungesättigte fettsäurenproduzierende mikroorganismen und verfahren zur herstellung von hoch ungesättigten fettsäuren durch verwendung dieser mikroorganismen |
| JP2764572B2 (ja) * | 1995-04-17 | 1998-06-11 | 工業技術院長 | ドコサヘキサエン酸生産能を有する新規微生物及びそれを用いたドコサヘキサエン酸の製造方法 |
| AU723553C (en) * | 1996-07-23 | 2005-04-14 | Nagase & Co., Ltd. | Process for preparing docosahexaenoic acid and docosapentaenoic acid |
| CN1187371C (zh) * | 2003-03-19 | 2005-02-02 | 中国科学院南海海洋研究所 | 海水藻蓝蛋白的制备方法 |
-
2003
- 2003-11-10 DE DE2003152838 patent/DE10352838A1/de not_active Withdrawn
-
2004
- 2004-11-10 EA EA200600947A patent/EA011858B1/ru not_active IP Right Cessation
- 2004-11-10 CA CA002545410A patent/CA2545410A1/en not_active Abandoned
- 2004-11-10 WO PCT/EP2004/012718 patent/WO2005045003A2/de active Application Filing
- 2004-11-10 SG SG200808208-3A patent/SG148157A1/en unknown
- 2004-11-10 EP EP20140002902 patent/EP2816104A1/de not_active Withdrawn
- 2004-11-10 CN CN201410052133.3A patent/CN104073442A/zh active Pending
- 2004-11-10 EP EP04818134A patent/EP1685241A2/de not_active Withdrawn
- 2004-11-10 JP JP2006538781A patent/JP4791367B2/ja not_active Expired - Fee Related
- 2004-11-10 CN CN200480035832.1A patent/CN1977038B/zh not_active Expired - Fee Related
- 2004-11-10 US US10/578,968 patent/US8900831B2/en not_active Expired - Fee Related
- 2004-11-10 AU AU2004287954A patent/AU2004287954B2/en not_active Ceased
- 2004-11-10 KR KR1020067011561A patent/KR101238613B1/ko not_active IP Right Cessation
- 2004-11-10 BR BRPI0416360-5A patent/BRPI0416360A/pt not_active Application Discontinuation
-
2006
- 2006-05-09 IL IL175520A patent/IL175520A/en not_active IP Right Cessation
- 2006-05-15 ZA ZA200603854A patent/ZA200603854B/en unknown
-
2014
- 2014-10-28 US US14/525,315 patent/US20150104557A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP2007510422A (ja) | 2007-04-26 |
| ZA200603854B (en) | 2007-11-28 |
| US20150104557A1 (en) | 2015-04-16 |
| US20070054384A1 (en) | 2007-03-08 |
| EP1685241A2 (de) | 2006-08-02 |
| AU2004287954A1 (en) | 2005-05-19 |
| CN104073442A (zh) | 2014-10-01 |
| EP2816104A1 (de) | 2014-12-24 |
| IL175520A (en) | 2014-08-31 |
| WO2005045003A2 (de) | 2005-05-19 |
| KR101238613B1 (ko) | 2013-02-28 |
| EA200600947A1 (ru) | 2007-02-27 |
| CA2545410A1 (en) | 2005-05-19 |
| DE10352838A1 (de) | 2005-07-07 |
| CN1977038B (zh) | 2014-12-24 |
| CN1977038A (zh) | 2007-06-06 |
| US8900831B2 (en) | 2014-12-02 |
| WO2005045003A3 (de) | 2005-08-04 |
| KR20070042115A (ko) | 2007-04-20 |
| SG148157A1 (en) | 2008-12-31 |
| IL175520A0 (en) | 2006-09-05 |
| AU2004287954B2 (en) | 2010-04-29 |
| EA011858B1 (ru) | 2009-06-30 |
| JP4791367B2 (ja) | 2011-10-12 |
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