BRPI0414317A - métodos para indentificar alfa-agonistas não sedantes aprimorados - Google Patents

métodos para indentificar alfa-agonistas não sedantes aprimorados

Info

Publication number
BRPI0414317A
BRPI0414317A BRPI0414317-5A BRPI0414317A BRPI0414317A BR PI0414317 A BRPI0414317 A BR PI0414317A BR PI0414317 A BRPI0414317 A BR PI0414317A BR PI0414317 A BRPI0414317 A BR PI0414317A
Authority
BR
Brazil
Prior art keywords
methods
conditions
alpha agonists
enhanced non
brimonidine
Prior art date
Application number
BRPI0414317-5A
Other languages
English (en)
Inventor
Daniel W Gil
John E Donello
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allergan Inc filed Critical Allergan Inc
Publication of BRPI0414317A publication Critical patent/BRPI0414317A/pt

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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
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  • Health & Medical Sciences (AREA)
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  • Epidemiology (AREA)
  • Virology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Hematology (AREA)
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Abstract

"MéTODOS PARA IDENTIFICAR ALFA AGONISTAS NãO SEDANTES APRIMORADOS". A presente invenção proporciona métodos para prevenir ou aliviar condições reforçadas simpaticamente, condições neutológicas, condições oculares e dor crónica sem sedação concomitante administrando perifericamente a um indivíduo uma quantidade eficaz de um <244>-2A/<244>-1A agonista seletivo, deste modo prevenindo ou aliviando a condição ou dor crónica sem sedação concomitante, onde o agonista seletivo tem uma eficácia para <244>-1A menor do que a da brimonidina ou uma proporção de potência de <244>-1A/<244>-2A maior do que a da brimonidina.
BRPI0414317-5A 2003-09-12 2004-08-19 métodos para indentificar alfa-agonistas não sedantes aprimorados BRPI0414317A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US50284003P 2003-09-12 2003-09-12
US10/891,740 US20050059664A1 (en) 2003-09-12 2004-07-15 Novel methods for identifying improved, non-sedating alpha-2 agonists
PCT/US2004/027170 WO2005034849A2 (en) 2003-09-12 2004-08-19 Methods for identifying improved, non-sedating alpha-2 agonists

Publications (1)

Publication Number Publication Date
BRPI0414317A true BRPI0414317A (pt) 2006-10-31

Family

ID=34278886

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0414317-5A BRPI0414317A (pt) 2003-09-12 2004-08-19 métodos para indentificar alfa-agonistas não sedantes aprimorados

Country Status (10)

Country Link
US (1) US20050059664A1 (pt)
EP (1) EP1663207A2 (pt)
JP (1) JP2007505112A (pt)
KR (1) KR20070005911A (pt)
AU (1) AU2004279333A1 (pt)
BR (1) BRPI0414317A (pt)
CA (1) CA2538430A1 (pt)
MX (1) MXPA06002726A (pt)
TW (1) TWI353835B (pt)
WO (1) WO2005034849A2 (pt)

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