BRPI0414191A - tienoimidazóis substituìdos, processo para sua preparação, seu uso como medicamento ou diagnóstico bem como medicamento contendo os mesmos - Google Patents

tienoimidazóis substituìdos, processo para sua preparação, seu uso como medicamento ou diagnóstico bem como medicamento contendo os mesmos

Info

Publication number
BRPI0414191A
BRPI0414191A BRPI0414191-1A BRPI0414191A BRPI0414191A BR PI0414191 A BRPI0414191 A BR PI0414191A BR PI0414191 A BRPI0414191 A BR PI0414191A BR PI0414191 A BRPI0414191 A BR PI0414191A
Authority
BR
Brazil
Prior art keywords
diseases
well
medicine
treatment
substituted
Prior art date
Application number
BRPI0414191-1A
Other languages
English (en)
Inventor
Hans-Jochen Lang
Uwe Heinelt
Klaus Wirth
Thomas Licher
Original Assignee
Sanofi Aventis Deutschland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland
Publication of BRPI0414191A publication Critical patent/BRPI0414191A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Psychiatry (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

"TIENOIMIDAZóIS SUBSTITUìDOS, PROCESSO PARA SUA PREPARAçãO, SEU USO COMO MEDICAMENTO OU DIAGNóSTICO BEM COMO MEDICAMENTO CONTENDO OS MESMOS". A presente invenção refere-se a tienoimidazóis substituídos da fórmula (I) ou (II) em que R1 até R4 possuem os significados dados nas reivindicações. Medicamentos contendo compostos deste tipo são úteis na prevenção ou tratamento de diversas doenças. Assim, os compostos podem ser usados, entre outros, para o tratamento de distúrbios respiratórios e do ronco, bem como para o aperfeiçoamento do estímulo respiratório, para o tratamento de doenças agudas e crónicas dos rins e intestino, doenças causadas por casos isquêmicos e/ou de reperfusão bem como por doenças proliferativas ou fibróticas, para o tratamento ou profilaxia de doenças do sistema nervoso central, do metabolismo graxo e do diabetes, da coagulação sangüínea e da infestação por parasitas.
BRPI0414191-1A 2003-09-08 2004-09-03 tienoimidazóis substituìdos, processo para sua preparação, seu uso como medicamento ou diagnóstico bem como medicamento contendo os mesmos BRPI0414191A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10341240A DE10341240A1 (de) 2003-09-08 2003-09-08 Substituierte Thienoimidazole, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
PCT/EP2004/009836 WO2005026173A1 (de) 2003-09-08 2004-09-03 Substituierte thienoimidazole, verfahren zu ihrer herstellung, ihre verwendung als medikament oder diagnostikum sowie sie enthaltendes medikament

Publications (1)

Publication Number Publication Date
BRPI0414191A true BRPI0414191A (pt) 2006-10-31

Family

ID=34258478

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0414191-1A BRPI0414191A (pt) 2003-09-08 2004-09-03 tienoimidazóis substituìdos, processo para sua preparação, seu uso como medicamento ou diagnóstico bem como medicamento contendo os mesmos

Country Status (23)

Country Link
US (1) US7179830B2 (pt)
EP (1) EP1664058B1 (pt)
JP (1) JP2007505035A (pt)
KR (1) KR20060069489A (pt)
CN (1) CN1845926A (pt)
AR (1) AR045600A1 (pt)
AT (1) ATE378343T1 (pt)
AU (1) AU2004272225A1 (pt)
BR (1) BRPI0414191A (pt)
CA (1) CA2537695A1 (pt)
DE (2) DE10341240A1 (pt)
GT (1) GT200400148A (pt)
IL (1) IL173918A0 (pt)
MA (1) MA28026A1 (pt)
MX (1) MXPA06001830A (pt)
NO (1) NO20061559L (pt)
PA (1) PA8611401A1 (pt)
PE (1) PE20050571A1 (pt)
RU (1) RU2006111467A (pt)
SV (1) SV2005001872A (pt)
TW (1) TW200521130A (pt)
WO (1) WO2005026173A1 (pt)
ZA (1) ZA200601001B (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2725209C (en) * 2008-05-09 2016-09-20 Norbert Beier Pharmaceutical composition comprising rimeporide for treating diseases associated with insulin resistance and beta-cell dysfunction
FR2993780B1 (fr) * 2012-07-26 2015-02-13 Assist Publ Hopitaux De Paris Methode de traitement de la sclerose en plaque
CN102964354B (zh) * 2012-11-16 2014-08-13 江苏先声药业有限公司 一类噻吩并咪唑衍生物及其应用
TR201910305T4 (tr) * 2014-04-17 2019-07-22 Pasteur Institut Korea Viral enfeksiyonları tedavi etmek için bileşikler.
CN106536502B (zh) 2014-07-25 2019-03-05 大正制药株式会社 被杂芳基取代的苯基四氢异喹啉化合物

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE754935A (fr) 1969-08-13 1971-02-17 Hoechst Ag 2-(thienyl-3'-amino)-1,3-diazacycloalcenes et leur preparation
AU636066B2 (en) * 1990-10-30 1993-04-08 Takeda Chemical Industries Ltd. Thienoimidazole derivatives, their production and use
DE4034728A1 (de) * 1990-10-30 1992-05-07 Schering Ag Neue thienoimidazolderivate, verfahren zu ihrer herstellung und ihre pharmazeutische verwendung
DE19633966A1 (de) 1996-08-22 1998-02-26 Hoechst Ag Phenylsubstituierte Alkenylcarbonsäure-guanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19945302A1 (de) 1999-09-22 2001-03-29 Merck Patent Gmbh Biphenylderivate als NHE-3-Inhibitoren
DE10015248A1 (de) 2000-03-28 2001-10-04 Merck Patent Gmbh Bisamidino-Verbindungen als NHE-3 Inhibitoren
DE10019062A1 (de) 2000-04-18 2001-10-25 Merck Patent Gmbh 2-Guanidino-4-aryl-chinazoline als NHE-3 Inhibitoren
DE10060292A1 (de) 2000-12-05 2002-06-20 Aventis Pharma Gmbh Verwendung substituierter Benzimidazole zur Herstellung eines Medikaments zur Behandlung von Krankheiten, welche durch Inhibierung des Na+/H+-Austauschers beeinflusst werden können und sie enthaltendes Medikament
DE10163239A1 (de) * 2001-12-21 2003-07-10 Aventis Pharma Gmbh Substituierte Imidazolidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie enthaltendes Medikament

Also Published As

Publication number Publication date
AR045600A1 (es) 2005-11-02
CN1845926A (zh) 2006-10-11
RU2006111467A (ru) 2006-08-10
MXPA06001830A (es) 2006-05-31
SV2005001872A (es) 2005-03-09
NO20061559L (no) 2006-04-06
IL173918A0 (en) 2006-07-05
EP1664058B1 (de) 2007-11-14
AU2004272225A1 (en) 2005-03-24
US7179830B2 (en) 2007-02-20
EP1664058A1 (de) 2006-06-07
PE20050571A1 (es) 2005-12-02
WO2005026173A1 (de) 2005-03-24
US20050075385A1 (en) 2005-04-07
JP2007505035A (ja) 2007-03-08
DE10341240A1 (de) 2005-04-07
DE502004005522D1 (de) 2007-12-27
ZA200601001B (en) 2007-03-28
PA8611401A1 (es) 2005-03-28
ATE378343T1 (de) 2007-11-15
KR20060069489A (ko) 2006-06-21
CA2537695A1 (en) 2005-03-24
TW200521130A (en) 2005-07-01
GT200400148A (es) 2007-03-22
MA28026A1 (fr) 2006-07-03

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]