BRPI0409078A - composto, métodos para o tratamento ou prevenção de distúrbios, doenças ou condições responsivas à ativação do receptor de melanocortina-4, para o tratamento ou prevenção de obesidade, para o tratamento ou prevenção de um distúrbio relacionado com a obesidade, para o tratamento ou prevenção de diabete melito, para o tratamento ou prevenção da disfunção sexual masculina ou feminina e para o tratamento ou prevenção de disfunção erétil, composição farmacêutica, métodos para o tratamento de disfução erétil em um mamìfero, para o tratamento de diabete em um mamìfero e para o tratamento de obesidade em um mamìfero, e, uso de um composto - Google Patents
composto, métodos para o tratamento ou prevenção de distúrbios, doenças ou condições responsivas à ativação do receptor de melanocortina-4, para o tratamento ou prevenção de obesidade, para o tratamento ou prevenção de um distúrbio relacionado com a obesidade, para o tratamento ou prevenção de diabete melito, para o tratamento ou prevenção da disfunção sexual masculina ou feminina e para o tratamento ou prevenção de disfunção erétil, composição farmacêutica, métodos para o tratamento de disfução erétil em um mamìfero, para o tratamento de diabete em um mamìfero e para o tratamento de obesidade em um mamìfero, e, uso de um compostoInfo
- Publication number
- BRPI0409078A BRPI0409078A BRPI0409078-0A BRPI0409078A BRPI0409078A BR PI0409078 A BRPI0409078 A BR PI0409078A BR PI0409078 A BRPI0409078 A BR PI0409078A BR PI0409078 A BRPI0409078 A BR PI0409078A
- Authority
- BR
- Brazil
- Prior art keywords
- treatment
- treating
- preventing
- obesity
- prevention
- Prior art date
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/20—Spiro-condensed ring systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Obesity (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Physical Education & Sports Medicine (AREA)
- Reproductive Health (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Child & Adolescent Psychology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Pulmonology (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Gynecology & Obstetrics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
"COMPOSTO, MéTODOS PARA O TRATAMENTO OU PREVENçãO DE DISTúRBIOS, DOENçAS OU CONDIçõES RESPONSIVAS à ATIVAçãO DO RECEPTOR DE MELANOCORTINA-4, PARA O TRATAMENTO OU PREVENçãO DE OBESIDADE, PARA O TRATAMENTO OU PREVENçãO DE UM DISTúRBIO RELACIONADO COM A OBESIDADE, PARA O TRATAMENTO OU PREVENçãO DE DIABETE MELITO, PARA O TRATAMENTO OU PREVENçãO DA DISFUNçãO SEXUAL MASCULINA OU FEMININA E PARA O TRATAMENTO OU PREVENçãO DE DISFUNçãO ERéTIL, COMPOSIçãO FARMACêUTICA, MéTODOS PARA O TRATAMENTO DE DISFUNçãO ERéTIL EM UM MAMìFERO, PARA O TRATAMENTO DE DIABETE EM UM MAMìFERO E PARA O TRATAMENTO DE OBESIDADE EM UM MAMìFERO, E, USO DE UM COMPOSTO". Certos derivados de espiropiperidina N-acilados novos são agonistas do(s) receptor(es) de melanocortina humano(s) e, em particular, são agonistas seletivos do receptor melanocortina-4 humano (MC-4R). eles são portanto úteis para o tratamento, controle ou prevenção de doenças e distúrbios responsivos para a ativação de MC-4R, tais como obesidade, diabetes, disfunção sexual, incluindo disfunção erétil e disfunção sexual feminina.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US46029303P | 2003-04-04 | 2003-04-04 | |
PCT/US2004/009751 WO2004089307A2 (en) | 2003-04-04 | 2004-03-31 | Acylated spiropiperidine derivatives as melanocortin-4 receptor agonists |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0409078A true BRPI0409078A (pt) | 2006-04-18 |
Family
ID=33159758
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0409078-0A BRPI0409078A (pt) | 2003-04-04 | 2004-03-31 | composto, métodos para o tratamento ou prevenção de distúrbios, doenças ou condições responsivas à ativação do receptor de melanocortina-4, para o tratamento ou prevenção de obesidade, para o tratamento ou prevenção de um distúrbio relacionado com a obesidade, para o tratamento ou prevenção de diabete melito, para o tratamento ou prevenção da disfunção sexual masculina ou feminina e para o tratamento ou prevenção de disfunção erétil, composição farmacêutica, métodos para o tratamento de disfução erétil em um mamìfero, para o tratamento de diabete em um mamìfero e para o tratamento de obesidade em um mamìfero, e, uso de um composto |
Country Status (17)
Country | Link |
---|---|
US (1) | US7329673B2 (pt) |
EP (1) | EP1613601A4 (pt) |
JP (1) | JP3856815B2 (pt) |
KR (1) | KR20050120773A (pt) |
CN (2) | CN101108825A (pt) |
AU (1) | AU2004227835B2 (pt) |
BR (1) | BRPI0409078A (pt) |
CA (1) | CA2520114A1 (pt) |
EC (1) | ECSP056073A (pt) |
HR (1) | HRP20050876A2 (pt) |
IS (1) | IS8039A (pt) |
MA (1) | MA27752A1 (pt) |
MX (1) | MXPA05010724A (pt) |
NO (1) | NO20055166L (pt) |
RU (1) | RU2005134230A (pt) |
WO (1) | WO2004089307A2 (pt) |
ZA (1) | ZA200507638B (pt) |
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WO2007076070A2 (en) * | 2005-12-22 | 2007-07-05 | Vertex Pharmaceuticals Incorporated | Modulators of muscarinic receptors |
KR20080094964A (ko) * | 2006-02-22 | 2008-10-27 | 버텍스 파마슈티칼스 인코포레이티드 | 무스카린성 수용체의 조절제 |
KR20080098070A (ko) * | 2006-02-22 | 2008-11-06 | 버텍스 파마슈티칼스 인코포레이티드 | 무스카린성 수용체의 조절제로서의 스피로 축합된 피페리딘 |
JP2009542670A (ja) * | 2006-06-29 | 2009-12-03 | バーテックス ファーマシューティカルズ インコーポレイテッド | ムスカリン受容体の調節剤 |
AU2007284548A1 (en) * | 2006-08-15 | 2008-02-21 | Vertex Pharmaceuticals Incorporated | Modulators of muscarinic receptors |
JP2010501561A (ja) | 2006-08-18 | 2010-01-21 | バーテックス ファーマシューティカルズ インコーポレイテッド | ムスカリン受容体の調節剤 |
EP2698157B1 (en) | 2006-09-22 | 2015-05-20 | Merck Sharp & Dohme Corp. | Method of treatment using fatty acid synthesis inhibitors |
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CN101108825A (zh) * | 2003-04-04 | 2008-01-23 | 麦克公司 | 作为黑皮质素-4受体激动剂的酰化螺哌啶衍生物 |
WO2005030210A1 (en) | 2003-09-26 | 2005-04-07 | Pfizer Products Inc. | Treatment of neurological disorders related to rapid eye movement (rem) sleep disturbances with npy y5 receptor antagonists |
EP1682136A4 (en) | 2003-11-04 | 2009-06-03 | Elixir Pharmaceuticals Inc | THERAPEUTIC COMPOUNDS AND CORRESPONDING USES THEREOF |
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2004
- 2004-03-31 CN CNA2007101410037A patent/CN101108825A/zh active Pending
- 2004-03-31 RU RU2005134230/04A patent/RU2005134230A/ru not_active Application Discontinuation
- 2004-03-31 KR KR1020057018731A patent/KR20050120773A/ko not_active Application Discontinuation
- 2004-03-31 AU AU2004227835A patent/AU2004227835B2/en not_active Ceased
- 2004-03-31 CA CA002520114A patent/CA2520114A1/en not_active Abandoned
- 2004-03-31 BR BRPI0409078-0A patent/BRPI0409078A/pt not_active Application Discontinuation
- 2004-03-31 WO PCT/US2004/009751 patent/WO2004089307A2/en active IP Right Grant
- 2004-03-31 EP EP04749540A patent/EP1613601A4/en not_active Withdrawn
- 2004-03-31 CN CNA2004800091486A patent/CN1768041A/zh active Pending
- 2004-03-31 MX MXPA05010724A patent/MXPA05010724A/es unknown
- 2004-03-31 US US10/548,350 patent/US7329673B2/en not_active Expired - Fee Related
- 2004-03-31 JP JP2006509489A patent/JP3856815B2/ja not_active Expired - Fee Related
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2005
- 2005-09-21 ZA ZA200507638A patent/ZA200507638B/xx unknown
- 2005-09-22 IS IS8039A patent/IS8039A/is unknown
- 2005-09-30 MA MA28527A patent/MA27752A1/fr unknown
- 2005-10-03 EC EC2005006073A patent/ECSP056073A/es unknown
- 2005-10-03 HR HR20050876A patent/HRP20050876A2/hr not_active Application Discontinuation
- 2005-11-03 NO NO20055166A patent/NO20055166L/no unknown
Also Published As
Publication number | Publication date |
---|---|
JP3856815B2 (ja) | 2006-12-13 |
WO2004089307A8 (en) | 2005-06-23 |
KR20050120773A (ko) | 2005-12-23 |
RU2005134230A (ru) | 2006-05-10 |
NO20055166L (no) | 2005-12-30 |
HRP20050876A2 (en) | 2006-06-30 |
ECSP056073A (es) | 2006-03-01 |
US20060183904A1 (en) | 2006-08-17 |
NO20055166D0 (no) | 2005-11-03 |
CN1768041A (zh) | 2006-05-03 |
AU2004227835A1 (en) | 2004-10-21 |
ZA200507638B (en) | 2006-08-30 |
MXPA05010724A (es) | 2005-12-15 |
JP2006522132A (ja) | 2006-09-28 |
WO2004089307A3 (en) | 2005-03-31 |
CN101108825A (zh) | 2008-01-23 |
IS8039A (is) | 2005-09-22 |
MA27752A1 (fr) | 2006-02-01 |
CA2520114A1 (en) | 2004-10-21 |
AU2004227835B2 (en) | 2007-06-14 |
US7329673B2 (en) | 2008-02-12 |
EP1613601A4 (en) | 2007-05-02 |
EP1613601A2 (en) | 2006-01-11 |
WO2004089307A2 (en) | 2004-10-21 |
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