BRPI0407234A - Heterociclos substituìdos - Google Patents
Heterociclos substituìdosInfo
- Publication number
- BRPI0407234A BRPI0407234A BR0407234-0A BRPI0407234A BRPI0407234A BR PI0407234 A BRPI0407234 A BR PI0407234A BR PI0407234 A BRPI0407234 A BR PI0407234A BR PI0407234 A BRPI0407234 A BR PI0407234A
- Authority
- BR
- Brazil
- Prior art keywords
- substituted heterocycles
- heterocycles
- substituted
- medicaments
- asthma
- Prior art date
Links
- 125000000623 heterocyclic group Chemical group 0.000 title abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/10—Nitrogen as only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
- C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/465—Streptomyces
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyrrole Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03003495 | 2003-02-14 | ||
| EP03007594 | 2003-04-02 | ||
| PCT/EP2004/001097 WO2004071382A2 (en) | 2003-02-14 | 2004-02-06 | Substituted heterocycles |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0407234A true BRPI0407234A (pt) | 2006-01-31 |
Family
ID=32870763
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0407234-0A BRPI0407234A (pt) | 2003-02-14 | 2004-02-06 | Heterociclos substituìdos |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US20060229353A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1597262B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP4795931B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR20050098928A (cg-RX-API-DMAC7.html) |
| CN (1) | CN1845925B (cg-RX-API-DMAC7.html) |
| AT (1) | ATE448232T1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU2004212296B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI0407234A (cg-RX-API-DMAC7.html) |
| CA (1) | CA2515940C (cg-RX-API-DMAC7.html) |
| DE (1) | DE602004024037D1 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2336562T3 (cg-RX-API-DMAC7.html) |
| IL (1) | IL169897A0 (cg-RX-API-DMAC7.html) |
| IN (1) | IN228043B (cg-RX-API-DMAC7.html) |
| MX (1) | MX272108B (cg-RX-API-DMAC7.html) |
| WO (1) | WO2004071382A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2002243228B2 (en) * | 2000-11-16 | 2007-08-02 | The Regents Of The University Of California | Marine actinomycete taxon for drug and fermentation product discovery |
| US7176232B2 (en) | 2002-06-24 | 2007-02-13 | The Regents Of The University Of California | Salinosporamides and methods for use thereof |
| CN101791306A (zh) * | 2003-06-20 | 2010-08-04 | 加利福尼亚大学董事会 | 盐孢菌酰胺及其使用方法 |
| DE602004031614D1 (de) * | 2003-06-20 | 2011-04-14 | Nereus Pharmaceuticals Inc | Verwendung von (3.2.0) heterocyclischen verbindungen und ihren analoga zur behandlung von krebs |
| WO2005099687A2 (en) | 2004-04-09 | 2005-10-27 | President And Fellows Of Harvard College | Analogs of salinosporamide a |
| US7579371B2 (en) | 2004-04-30 | 2009-08-25 | Nereus Pharmaceuticals, Inc. | Methods of using [3.2.0] heterocyclic compounds and analogs thereof |
| JP2007535559A (ja) | 2004-04-30 | 2007-12-06 | ネレアス ファーマシューティカルズ インコーポレイテッド | ［３．２．０］複素環式化合物及びその使用法 |
| KR20070041742A (ko) * | 2004-07-12 | 2007-04-19 | 바이엘 크롭사이언스 아게 | 살진균제 및 살충제로서의 치환된 2-피롤리돈 유도체 |
| WO2006060809A2 (en) * | 2004-12-03 | 2006-06-08 | Nereus Pharmaceuticals, Inc. | Methods of using [3.2.0] heterocyclic compounds and analogs thereof |
| SG157365A1 (en) * | 2004-12-03 | 2009-12-29 | Dana Farber Cancer Inst Inc | Compositions and methods for treating neoplastic diseases |
| WO2006118973A2 (en) * | 2005-04-29 | 2006-11-09 | Nereus Pharmaceuticals, Inc. | Methods of using heterobyclic compounds for treatment of rectal cancer |
| US7465720B2 (en) | 2005-09-12 | 2008-12-16 | President And Fellows Of Harvard College | Proteasome inhibiting β-lactam compounds |
| NZ572026A (en) | 2006-04-06 | 2011-12-22 | Nereus Pharmaceuticals Inc | Total synthesis of salinosporamide a and analogs thereof |
| WO2008095195A2 (en) | 2007-02-02 | 2008-08-07 | Nereus Pharmaceuticals, Inc. | Lyophilized formulations of salinosporamide a |
| WO2008137780A2 (en) * | 2007-05-04 | 2008-11-13 | Nereus Pharmaceuticals, Inc. | Use of [3.2.0] heterocyclic compounds and analogs thereof for treating infectious diseases |
| US8394816B2 (en) * | 2007-12-07 | 2013-03-12 | Irene Ghobrial | Methods of using [3.2.0] heterocyclic compounds and analogs thereof in treating Waldenstrom's Macroglobulinemia |
| EP2088205A1 (en) | 2008-02-11 | 2009-08-12 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | PSMB10: A diagnosis marker and therapeutic target of chronic rejection. |
| AU2009241635A1 (en) | 2008-03-07 | 2009-11-05 | Nereus Pharmaceuticals, Inc. | Total synthesis of Salinosporamide A and analogs thereof |
| EP2276765A4 (en) * | 2008-05-12 | 2011-10-19 | Nereus Pharmaceuticals Inc | SALINOSPORAMIDE DERIVATIVES AS PROTEASOMAL HEMMER |
| US20120190565A1 (en) | 2009-02-20 | 2012-07-26 | Pangea Biosciences, Inc. | Method Of Diagnosis Or Prognosis Of A Neoplasm Comprising Determining The Level Of Expression Of A Protein In Stromal Cells Adjacent To The Neoplasm |
| US9126997B1 (en) | 2010-09-07 | 2015-09-08 | Northwestern University | Synergistic effect of glucocorticoid receptor agonists in combination with proteosome inhibitors for treating leukemia and myeloma |
| ES2776144T3 (es) | 2011-10-28 | 2020-07-29 | Millennium Pharm Inc | Biomarcadores de respuesta a inhibidores de NAE |
| JP6286358B2 (ja) | 2011-11-11 | 2018-02-28 | ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | プロテアソーム阻害剤に応答するバイオマーカー |
| EP2810066B1 (en) | 2012-01-24 | 2019-07-31 | Millennium Pharmaceuticals, Inc. | Methods of treatment of cancer |
| WO2013112881A1 (en) | 2012-01-27 | 2013-08-01 | Thomas Jefferson University | Mct protein inhibitor-related prognostic and therapeutic methods |
| JP6486826B2 (ja) | 2012-10-01 | 2019-03-20 | ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | 阻害剤に対する応答を予測するためのバイオマーカーおよび方法、ならびにそれらの使用 |
| US10022372B2 (en) | 2013-04-19 | 2018-07-17 | Thomas Jefferson University | Caveolin-1 related methods for treating glioblastoma with temozolomide |
| EP3339291A1 (en) | 2016-12-22 | 2018-06-27 | Vita Api | Proteasome inhibiting ss-lactam prodrugs useful for the treatment of cancer and neurodegenerative disorders |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6335358B1 (en) * | 1995-04-12 | 2002-01-01 | President And Fellows Of Harvard College | Lactacystin analogs |
| AU2002243228B2 (en) * | 2000-11-16 | 2007-08-02 | The Regents Of The University Of California | Marine actinomycete taxon for drug and fermentation product discovery |
-
2004
- 2004-02-06 BR BR0407234-0A patent/BRPI0407234A/pt not_active IP Right Cessation
- 2004-02-06 DE DE602004024037T patent/DE602004024037D1/de not_active Expired - Lifetime
- 2004-02-06 WO PCT/EP2004/001097 patent/WO2004071382A2/en not_active Ceased
- 2004-02-06 ES ES04708731T patent/ES2336562T3/es not_active Expired - Lifetime
- 2004-02-06 IN IN3350DE2005 patent/IN228043B/en unknown
- 2004-02-06 KR KR1020057014935A patent/KR20050098928A/ko not_active Abandoned
- 2004-02-06 EP EP04708731A patent/EP1597262B1/en not_active Expired - Lifetime
- 2004-02-06 MX MXPA05008478 patent/MX272108B/es active IP Right Grant
- 2004-02-06 CN CN2004800093759A patent/CN1845925B/zh not_active Expired - Fee Related
- 2004-02-06 US US10/545,449 patent/US20060229353A1/en not_active Abandoned
- 2004-02-06 CA CA2515940A patent/CA2515940C/en not_active Expired - Fee Related
- 2004-02-06 AT AT04708731T patent/ATE448232T1/de not_active IP Right Cessation
- 2004-02-06 AU AU2004212296A patent/AU2004212296B2/en not_active Ceased
- 2004-02-06 JP JP2006501755A patent/JP4795931B2/ja not_active Expired - Fee Related
-
2005
- 2005-07-26 IL IL169897A patent/IL169897A0/en unknown
-
2009
- 2009-01-08 US US12/350,696 patent/US20110015248A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1597262B1 (en) | 2009-11-11 |
| IN2005DE03350A (cg-RX-API-DMAC7.html) | 2007-06-01 |
| JP2006517934A (ja) | 2006-08-03 |
| CN1845925A (zh) | 2006-10-11 |
| EP1597262A2 (en) | 2005-11-23 |
| WO2004071382A3 (en) | 2005-01-06 |
| MX272108B (es) | 2009-11-25 |
| CA2515940A1 (en) | 2004-08-26 |
| CN1845925B (zh) | 2010-11-03 |
| IL169897A0 (en) | 2007-07-04 |
| AU2004212296A1 (en) | 2004-08-26 |
| HK1096392A1 (en) | 2007-06-01 |
| DE602004024037D1 (de) | 2009-12-24 |
| MXPA05008478A (es) | 2005-10-18 |
| KR20050098928A (ko) | 2005-10-12 |
| AU2004212296B2 (en) | 2010-06-17 |
| CA2515940C (en) | 2011-12-06 |
| ES2336562T3 (es) | 2010-04-14 |
| JP4795931B2 (ja) | 2011-10-19 |
| ATE448232T1 (de) | 2009-11-15 |
| US20110015248A1 (en) | 2011-01-20 |
| US20060229353A1 (en) | 2006-10-12 |
| IN228043B (cg-RX-API-DMAC7.html) | 2009-02-13 |
| WO2004071382A2 (en) | 2004-08-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B08L | Patent application lapsed because of non payment of annual fee [chapter 8.12 patent gazette] |
Free format text: REFERENTE AO NAO RECOLHIMENTO DAS 9A E 10A ANUIDADES. |
|
| B08I | Publication cancelled [chapter 8.9 patent gazette] |
Free format text: ANULADA A PUBLICACAO CODIGO 8.12 NA RPI NO 2257 DE 08/04/2014 POR TER SIDO INDEVIDA. |
|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 9A, 10A, 11A, 12A, 13A, 14A, 15A E 16A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2602 DE 17-11-2020 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |