BRPI0416105A - uso da bh4 para o tratamento de doença respiratórias - Google Patents
uso da bh4 para o tratamento de doença respiratóriasInfo
- Publication number
- BRPI0416105A BRPI0416105A BRPI0416105-0A BRPI0416105A BRPI0416105A BR PI0416105 A BRPI0416105 A BR PI0416105A BR PI0416105 A BRPI0416105 A BR PI0416105A BR PI0416105 A BRPI0416105 A BR PI0416105A
- Authority
- BR
- Brazil
- Prior art keywords
- treatment
- respiratory disease
- derivatives
- tetrahydrobiopterin
- copd
- Prior art date
Links
- 208000023504 respiratory system disease Diseases 0.000 title 1
- FNKQXYHWGSIFBK-RPDRRWSUSA-N sapropterin Chemical compound N1=C(N)NC(=O)C2=C1NC[C@H]([C@@H](O)[C@@H](O)C)N2 FNKQXYHWGSIFBK-RPDRRWSUSA-N 0.000 abstract 4
- 239000004475 Arginine Substances 0.000 abstract 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 abstract 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000000241 respiratory effect Effects 0.000 abstract 1
- 229960004617 sapropterin Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Otolaryngology (AREA)
- Neurology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
"USO DA BH4 PARA O TRATAMENTO DE DOENçAS RESPIRATóRIAS". A invenção descreve o uso de tetrahidrobiopterina (BH4) ou de derivados da mesma no tratamento de COPD. Em uma modalidade preferida, a BH4 ou os derivados da mesma são combinados com a arginina ou com derivados da mesma.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP03024844 | 2003-10-31 | ||
PCT/EP2004/052725 WO2005041975A1 (en) | 2003-10-31 | 2004-10-29 | Use of bh4 for the treatment of respiratory diseases |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0416105A true BRPI0416105A (pt) | 2007-01-02 |
Family
ID=34530659
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0416105-0A BRPI0416105A (pt) | 2003-10-31 | 2004-10-29 | uso da bh4 para o tratamento de doença respiratórias |
Country Status (13)
Country | Link |
---|---|
US (1) | US20070049599A1 (pt) |
EP (1) | EP1682148A1 (pt) |
JP (1) | JP2007509909A (pt) |
KR (1) | KR20060120147A (pt) |
CN (1) | CN1871011A (pt) |
AU (1) | AU2004285300A1 (pt) |
BR (1) | BRPI0416105A (pt) |
CA (1) | CA2543252A1 (pt) |
IL (1) | IL174589A0 (pt) |
MX (1) | MXPA06004687A (pt) |
NO (1) | NO20062384L (pt) |
WO (1) | WO2005041975A1 (pt) |
ZA (1) | ZA200602536B (pt) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2007013766A (es) * | 2005-05-11 | 2008-01-28 | Nycomed Gmbh | Combinacion de inhibidor pde4 de roflumilast y un derivado de tetrahidrobiopterina. |
WO2013055954A1 (en) * | 2011-10-11 | 2013-04-18 | The Regents Of The University Of California | Biomarker for abdominal aortic aneurysm |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5877176A (en) * | 1991-12-26 | 1999-03-02 | Cornell Research Foundation, Inc. | Blocking induction of tetrahydrobiopterin to block induction of nitric oxide synthesis |
US5830461A (en) * | 1992-11-25 | 1998-11-03 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Methods for promoting wound healing and treating transplant-associated vasculopathy |
DE4418097A1 (de) * | 1994-05-24 | 1995-11-30 | Cassella Ag | Verwendung von Tetrahydropteridin-Derivaten als Hemmstoffe der NO-Synthase |
US5859058A (en) * | 1994-07-14 | 1999-01-12 | Glaxo Wellcome Inc. | Nitric oxide synthase inhibitors for inhibiting the production of airway mucas |
WO1998008516A1 (fr) * | 1996-08-30 | 1998-03-05 | Suntory Limited | Preparations servant a la prevention et au traitement de maladies provoquees par une hypofonction de l'oxyde nitrique synthase |
SE0000307D0 (sv) * | 2000-01-31 | 2000-01-31 | Univ Zuerich | Method and formulation för treatment of vasoconstriction |
US6544994B2 (en) * | 2000-06-07 | 2003-04-08 | Eprov Ag | Pharmaceutical preparation for treating or preventing cardiovascular or neurological disorders by modulating of the activity of nitric oxide synthase |
JP2005532321A (ja) * | 2002-05-16 | 2005-10-27 | ファルマシア コーポレーション | 呼吸器の疾患および状態の、選択的iNOS阻害剤とPDE阻害剤による治療方法、ならびにそのための組成物 |
US20040097467A1 (en) * | 2002-08-22 | 2004-05-20 | Vijaya Juturu | Arginine silicate inositol complex and use thereof |
-
2004
- 2004-10-29 AU AU2004285300A patent/AU2004285300A1/en not_active Abandoned
- 2004-10-29 US US10/576,712 patent/US20070049599A1/en not_active Abandoned
- 2004-10-29 JP JP2006537307A patent/JP2007509909A/ja not_active Withdrawn
- 2004-10-29 CA CA002543252A patent/CA2543252A1/en not_active Abandoned
- 2004-10-29 WO PCT/EP2004/052725 patent/WO2005041975A1/en active Application Filing
- 2004-10-29 KR KR1020067010236A patent/KR20060120147A/ko not_active Application Discontinuation
- 2004-10-29 CN CNA2004800311062A patent/CN1871011A/zh active Pending
- 2004-10-29 MX MXPA06004687A patent/MXPA06004687A/es not_active Application Discontinuation
- 2004-10-29 EP EP04817396A patent/EP1682148A1/en not_active Withdrawn
- 2004-10-29 BR BRPI0416105-0A patent/BRPI0416105A/pt not_active IP Right Cessation
-
2006
- 2006-03-27 IL IL174589A patent/IL174589A0/en unknown
- 2006-03-28 ZA ZA200602536A patent/ZA200602536B/en unknown
- 2006-05-24 NO NO20062384A patent/NO20062384L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
KR20060120147A (ko) | 2006-11-24 |
JP2007509909A (ja) | 2007-04-19 |
EP1682148A1 (en) | 2006-07-26 |
CN1871011A (zh) | 2006-11-29 |
US20070049599A1 (en) | 2007-03-01 |
NO20062384L (no) | 2006-05-24 |
MXPA06004687A (es) | 2006-06-27 |
WO2005041975A1 (en) | 2005-05-12 |
ZA200602536B (en) | 2007-06-27 |
CA2543252A1 (en) | 2005-05-12 |
IL174589A0 (en) | 2006-08-20 |
AU2004285300A1 (en) | 2005-05-12 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B15K | Others concerning applications: alteration of classification |
Free format text: PARA:INT.CI. 461K 31/519, A61K 31/195, A61P 11/00 Ipc: A61K 31/519 (2011.01), A61K 31/195 (2011.01), A61P |
|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7A ANUIDADE. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2158 DE 15/05/2012. |