BRPI0406647A - Método para transportar um composto através da barreira sanguìnea do cérebro - Google Patents
Método para transportar um composto através da barreira sanguìnea do cérebroInfo
- Publication number
- BRPI0406647A BRPI0406647A BR0406647-2A BRPI0406647A BRPI0406647A BR PI0406647 A BRPI0406647 A BR PI0406647A BR PI0406647 A BRPI0406647 A BR PI0406647A BR PI0406647 A BRPI0406647 A BR PI0406647A
- Authority
- BR
- Brazil
- Prior art keywords
- blood
- transporting
- brain barrier
- carrier
- compound
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 230000004888 barrier function Effects 0.000 title 1
- 239000008280 blood Substances 0.000 title 1
- 210000004369 blood Anatomy 0.000 title 1
- 210000004556 brain Anatomy 0.000 title 1
- 230000008499 blood brain barrier function Effects 0.000 abstract 8
- 210000001218 blood-brain barrier Anatomy 0.000 abstract 8
- 239000003795 chemical substances by application Substances 0.000 abstract 6
- 239000003814 drug Substances 0.000 abstract 2
- 229940079593 drug Drugs 0.000 abstract 2
- 238000012377 drug delivery Methods 0.000 abstract 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Immunology (AREA)
- Psychology (AREA)
- Psychiatry (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Child & Adolescent Psychology (AREA)
- Vascular Medicine (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43798603P | 2003-01-06 | 2003-01-06 | |
| PCT/CA2004/000011 WO2004060403A2 (en) | 2003-01-06 | 2004-01-05 | Aprotinin and anglos as carriers across the blood-brain barrier |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0406647A true BRPI0406647A (pt) | 2005-12-06 |
Family
ID=32713262
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0406647-2A BRPI0406647A (pt) | 2003-01-06 | 2004-01-05 | Método para transportar um composto através da barreira sanguìnea do cérebro |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US9221867B2 (enExample) |
| EP (2) | EP2260874A1 (enExample) |
| JP (2) | JP4903036B2 (enExample) |
| CN (2) | CN1747747B (enExample) |
| AT (1) | ATE512674T1 (enExample) |
| AU (2) | AU2004203682B2 (enExample) |
| BR (1) | BRPI0406647A (enExample) |
| CA (1) | CA2516056C (enExample) |
| CY (1) | CY1111844T1 (enExample) |
| DK (1) | DK1583562T3 (enExample) |
| ES (1) | ES2368941T3 (enExample) |
| MX (1) | MXPA05007322A (enExample) |
| PT (1) | PT1583562E (enExample) |
| SI (1) | SI1583562T1 (enExample) |
| WO (1) | WO2004060403A2 (enExample) |
Families Citing this family (73)
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| US20090016959A1 (en) * | 2005-02-18 | 2009-01-15 | Richard Beliveau | Delivery of antibodies to the central nervous system |
| BRPI0520032A2 (pt) * | 2005-02-18 | 2009-04-14 | Angiochem Inc | moléculas para transportar um composto através da barreira hematoencefálica |
| DK2233156T3 (da) * | 2005-07-15 | 2013-08-05 | Angiochem Inc | Anvendelse af aprotininpolypeptider som bærere i farmaceutiske konjugater |
| JP4945766B2 (ja) * | 2006-01-24 | 2012-06-06 | 国立大学法人 鹿児島大学 | 脳神経細胞への薬物の標的化剤 |
| US20090239942A1 (en) * | 2006-09-15 | 2009-09-24 | Cloyd James C | Topiramate Compositions and Methods of Making and Using the Same |
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| PT2164866E (pt) * | 2007-05-29 | 2014-08-04 | Angiochem Inc | Polipéptidos de tipo aprotinina para administrar agentes conjugados com os mesmos aos tecidos |
| CA2688344C (en) | 2007-05-29 | 2019-09-03 | Angiochem, Inc. | Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues |
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| AU2012351967A1 (en) | 2011-12-16 | 2014-07-17 | Massachusetts Institute Of Technology | Alpha-aminoamidine polymers and uses thereof |
| WO2013120107A1 (en) | 2012-02-09 | 2013-08-15 | University Of Rochester | Methods and compositions for treating a subject to inhibit hearing loss |
| EP2819686A4 (en) | 2012-03-02 | 2016-05-25 | Icahn School Med Mount Sinai | PROTHYMOSIN ALPHA VARIANTS AND METHODS OF USE |
| JP6042527B2 (ja) | 2012-04-04 | 2016-12-14 | ハロザイム インコーポレイテッド | 抗ヒアルロナン剤と腫瘍標的タキサンの組み合わせ治療 |
| EP2841107B1 (en) | 2012-04-26 | 2021-11-03 | Yale University | Cytotoxic-drug delivering molecules targeting hiv (cdm-hs), cytotoxic activity against the human immunodeficiency virus and methods of use |
| CN104662151A (zh) | 2012-06-15 | 2015-05-27 | 安吉奥开米公司 | 靶向的艾杜糖醛酸酶化合物 |
-
2004
- 2004-01-05 DK DK04700102.9T patent/DK1583562T3/da active
- 2004-01-05 EP EP10009847A patent/EP2260874A1/en not_active Withdrawn
- 2004-01-05 CN CN2004800035448A patent/CN1747747B/zh not_active Expired - Fee Related
- 2004-01-05 BR BR0406647-2A patent/BRPI0406647A/pt not_active Application Discontinuation
- 2004-01-05 CA CA2516056A patent/CA2516056C/en not_active Expired - Lifetime
- 2004-01-05 WO PCT/CA2004/000011 patent/WO2004060403A2/en not_active Ceased
- 2004-01-05 PT PT04700102T patent/PT1583562E/pt unknown
- 2004-01-05 CN CN2012102486937A patent/CN102775472A/zh active Pending
- 2004-01-05 AU AU2004203682A patent/AU2004203682B2/en not_active Ceased
- 2004-01-05 US US10/541,304 patent/US9221867B2/en active Active
- 2004-01-05 SI SI200431732T patent/SI1583562T1/sl unknown
- 2004-01-05 ES ES04700102T patent/ES2368941T3/es not_active Expired - Lifetime
- 2004-01-05 AT AT04700102T patent/ATE512674T1/de active
- 2004-01-05 JP JP2006500425A patent/JP4903036B2/ja not_active Expired - Fee Related
- 2004-01-05 MX MXPA05007322A patent/MXPA05007322A/es active IP Right Grant
- 2004-01-05 EP EP04700102A patent/EP1583562B1/en not_active Expired - Lifetime
-
2009
- 2009-12-29 AU AU2009251223A patent/AU2009251223B2/en not_active Ceased
-
2011
- 2011-09-15 CY CY20111100889T patent/CY1111844T1/el unknown
- 2011-10-28 JP JP2011237203A patent/JP2012031197A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CY1111844T1 (el) | 2015-10-07 |
| EP1583562B1 (en) | 2011-06-15 |
| US9221867B2 (en) | 2015-12-29 |
| MXPA05007322A (es) | 2006-02-17 |
| WO2004060403A3 (en) | 2004-11-18 |
| CA2516056C (en) | 2012-05-29 |
| EP2260874A1 (en) | 2010-12-15 |
| AU2009251223A1 (en) | 2010-01-28 |
| JP2006515363A (ja) | 2006-05-25 |
| US20060182684A1 (en) | 2006-08-17 |
| SI1583562T1 (sl) | 2011-10-28 |
| JP4903036B2 (ja) | 2012-03-21 |
| AU2004203682A8 (en) | 2009-09-17 |
| ES2368941T3 (es) | 2011-11-23 |
| CN1747747A (zh) | 2006-03-15 |
| AU2004203682A1 (en) | 2004-07-22 |
| JP2012031197A (ja) | 2012-02-16 |
| DK1583562T3 (da) | 2011-09-19 |
| CN1747747B (zh) | 2012-09-05 |
| ATE512674T1 (de) | 2011-07-15 |
| EP1583562A2 (en) | 2005-10-12 |
| CA2516056A1 (en) | 2004-07-22 |
| WO2004060403A2 (en) | 2004-07-22 |
| CN102775472A (zh) | 2012-11-14 |
| AU2004203682B2 (en) | 2009-10-01 |
| PT1583562E (pt) | 2011-09-19 |
| AU2009251223B2 (en) | 2012-02-09 |
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Ipc: C07H 21/00 (2006.01), A61K 47/64 (2017.01), C07K 1 |