BRPI0406489A - Método para a preparação de 2-difenilmetilsulfinilacetato de metila (mdmsa) e método para a preparação de modafinil - Google Patents

Método para a preparação de 2-difenilmetilsulfinilacetato de metila (mdmsa) e método para a preparação de modafinil

Info

Publication number
BRPI0406489A
BRPI0406489A BR0406489-5A BRPI0406489A BRPI0406489A BR PI0406489 A BRPI0406489 A BR PI0406489A BR PI0406489 A BRPI0406489 A BR PI0406489A BR PI0406489 A BRPI0406489 A BR PI0406489A
Authority
BR
Brazil
Prior art keywords
preparation
methyl
diphenylmethylsulfinylacetate
mdmsa
modafinil
Prior art date
Application number
BR0406489-5A
Other languages
English (en)
Inventor
Sebastien Rose
Dominique Klein
Original Assignee
Organisation De Synthese Mondi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Organisation De Synthese Mondi filed Critical Organisation De Synthese Mondi
Publication of BRPI0406489A publication Critical patent/BRPI0406489A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/02—Preparation of sulfones; Preparation of sulfoxides by formation of sulfone or sulfoxide groups by oxidation of sulfides, or by formation of sulfone groups by oxidation of sulfoxides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

"MéTODO PARA A PREPARAçãO DE 2-DIFENILMETILSULFINILACETATO DE METILA (MDMSA) E MéTODO PARA A PREPARAçãO DE MODAFINIL". Trata-se de um método para a preparação de 2-difenilmetilsulfinilacetato de metila (MDMSA), o qual compreende as etapas de: (I) conversão de benzidrol em difenilmetiltioacetato do metila; e (II) conversão de difenilmetiltioacetato de metila em 2-difenilmetilsulfinilacetato de metila através de oxidação.
BR0406489-5A 2003-01-13 2004-01-08 Método para a preparação de 2-difenilmetilsulfinilacetato de metila (mdmsa) e método para a preparação de modafinil BRPI0406489A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP20030290082 EP1437345A1 (en) 2003-01-13 2003-01-13 Novel method for preparing methyl 2-diphenylmethylsulfinylacetate
PCT/IB2004/000002 WO2004063149A1 (en) 2003-01-13 2004-01-08 Method for preparing methyl 2-diphenylmethylsulfinylacetate

Publications (1)

Publication Number Publication Date
BRPI0406489A true BRPI0406489A (pt) 2005-12-06

Family

ID=32479973

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0406489-5A BRPI0406489A (pt) 2003-01-13 2004-01-08 Método para a preparação de 2-difenilmetilsulfinilacetato de metila (mdmsa) e método para a preparação de modafinil

Country Status (20)

Country Link
US (1) US7211684B2 (pt)
EP (2) EP1437345A1 (pt)
JP (1) JP4690304B2 (pt)
KR (1) KR101062281B1 (pt)
CN (1) CN100516035C (pt)
AR (1) AR042842A1 (pt)
AU (1) AU2004203975B2 (pt)
BR (1) BRPI0406489A (pt)
CA (1) CA2512084C (pt)
EA (1) EA010381B1 (pt)
IL (1) IL169517A (pt)
IS (1) IS7958A (pt)
MX (1) MXPA05007419A (pt)
NO (1) NO331507B1 (pt)
NZ (1) NZ541089A (pt)
PL (1) PL212412B1 (pt)
TW (1) TWI323250B (pt)
UA (1) UA80598C2 (pt)
WO (1) WO2004063149A1 (pt)
ZA (1) ZA200505381B (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1437345A1 (en) 2003-01-13 2004-07-14 Organisation de Synthese Mondiale Orsymonde Novel method for preparing methyl 2-diphenylmethylsulfinylacetate
US7368591B2 (en) 2003-09-19 2008-05-06 Cephalon France Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation
EP1516869A1 (en) 2003-09-19 2005-03-23 Cephalon France Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation
CN100393699C (zh) * 2005-03-10 2008-06-11 浙江工业大学 2-（二苯基甲基亚硫酰基）乙酰胺的合成方法
EP1702915A1 (en) * 2005-03-14 2006-09-20 Cephalon France Process for enantioselective synthesis of single enantiomers of thio-substituted arylmethanesulfinyl derivatives by asymmetric oxidation
WO2007103221A2 (en) * 2006-03-01 2007-09-13 Teva Pharmaceutical Industries Ltd. An improved process for the preparation of armodafinil
CN104059004A (zh) * 2014-06-25 2014-09-24 江苏斯威森生物医药工程研究中心有限公司 一种2-[(4,4’-二卤-二苯基甲基)巯基]乙酸酯的制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE198165C (pt)
GB1520812A (en) * 1975-10-02 1978-08-09 Lafon Labor Benzhydrylsulphinyl derivatives
GB1584462A (en) * 1977-03-31 1981-02-11 Lafon Labor N-diaryl-malonamide and diarylmethyl-sulphinyl-acetamide derivatives and pharmaceutical compositions containing them
DE2812542A1 (de) 1978-03-22 1979-10-04 Thomae Gmbh Dr K Neue schwefelhaltige fluorenyl-und phenanthryl-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
FR2528041A1 (fr) * 1982-06-04 1983-12-09 Lafon Labor Acides halogenobenzhydrylsulfinylacetohydroxamiques, procede de preparation et utilisation en therapeutique
FR2528038B2 (fr) * 1982-06-04 1985-08-09 Lafon Labor Derives de benzhydrylsulfinylacetamide et leur utilisation en therapeutique
US4964893A (en) * 1986-04-17 1990-10-23 Monsanto Company Benzhydryl compounds as herbicide antidotes
JP3233806B2 (ja) * 1995-01-23 2001-12-04 ユーシービージャパン株式会社 スルフェニル酢酸誘導体の製造法
US5571825A (en) * 1995-03-31 1996-11-05 Warner-Lambert Company Method of selectively inhibiting prostaglandin G/H synthase-2
EP1437345A1 (en) 2003-01-13 2004-07-14 Organisation de Synthese Mondiale Orsymonde Novel method for preparing methyl 2-diphenylmethylsulfinylacetate

Also Published As

Publication number Publication date
CA2512084C (en) 2012-03-20
WO2004063149A1 (en) 2004-07-29
TW200420530A (en) 2004-10-16
CN1735591A (zh) 2006-02-15
IS7958A (is) 2005-07-26
CA2512084A1 (en) 2004-07-29
CN100516035C (zh) 2009-07-22
MXPA05007419A (es) 2005-09-12
AR042842A1 (es) 2005-07-06
NZ541089A (en) 2008-05-30
PL377822A1 (pl) 2006-02-20
EA010381B1 (ru) 2008-08-29
US20060235237A1 (en) 2006-10-19
IL169517A (en) 2012-06-28
EP1437345A1 (en) 2004-07-14
ZA200505381B (pt) 2006-04-26
KR101062281B1 (ko) 2011-09-06
PL212412B1 (pl) 2012-09-28
AU2004203975B2 (en) 2010-07-01
EP1583739A1 (en) 2005-10-12
AU2004203975A1 (en) 2004-07-29
KR20050091085A (ko) 2005-09-14
NO331507B1 (no) 2012-01-16
US7211684B2 (en) 2007-05-01
NO20053602L (no) 2005-07-22
JP2006516560A (ja) 2006-07-06
JP4690304B2 (ja) 2011-06-01
UA80598C2 (en) 2007-10-10
TWI323250B (en) 2010-04-11
EA200501125A1 (ru) 2005-12-29

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Owner name: CEPHALON EUROPE (FR)

B25A Requested transfer of rights approved

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