BRPI0308706B8 - hidrato de darifenacina, e processo para sua preparação - Google Patents
hidrato de darifenacina, e processo para sua preparaçãoInfo
- Publication number
- BRPI0308706B8 BRPI0308706B8 BRPI0308706A BR0308706A BRPI0308706B8 BR PI0308706 B8 BRPI0308706 B8 BR PI0308706B8 BR PI0308706 A BRPI0308706 A BR PI0308706A BR 0308706 A BR0308706 A BR 0308706A BR PI0308706 B8 BRPI0308706 B8 BR PI0308706B8
- Authority
- BR
- Brazil
- Prior art keywords
- bladder
- urinary
- hydrate
- treatment
- receptor antagonist
- Prior art date
Links
- HXGBXQDTNZMWGS-RUZDIDTESA-N darifenacin Chemical compound C=1C=CC=CC=1C([C@H]1CN(CCC=2C=C3CCOC3=CC=2)CC1)(C(=O)N)C1=CC=CC=C1 HXGBXQDTNZMWGS-RUZDIDTESA-N 0.000 title 1
- 229960002677 darifenacin Drugs 0.000 title 1
- 206010020853 Hypertonic bladder Diseases 0.000 abstract 2
- 229940121948 Muscarinic receptor antagonist Drugs 0.000 abstract 2
- 239000003149 muscarinic antagonist Substances 0.000 abstract 2
- 206010056948 Automatic bladder Diseases 0.000 abstract 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 abstract 1
- 208000012258 Diverticular disease Diseases 0.000 abstract 1
- 206010013554 Diverticulum Diseases 0.000 abstract 1
- 208000000289 Esophageal Achalasia Diseases 0.000 abstract 1
- 208000018522 Gastrointestinal disease Diseases 0.000 abstract 1
- 206010021639 Incontinence Diseases 0.000 abstract 1
- 206010027566 Micturition urgency Diseases 0.000 abstract 1
- 208000000693 Neurogenic Urinary Bladder Diseases 0.000 abstract 1
- 206010029279 Neurogenic bladder Diseases 0.000 abstract 1
- 206010030136 Oesophageal achalasia Diseases 0.000 abstract 1
- 208000009722 Overactive Urinary Bladder Diseases 0.000 abstract 1
- 206010036018 Pollakiuria Diseases 0.000 abstract 1
- 206010046543 Urinary incontinence Diseases 0.000 abstract 1
- 201000000621 achalasia Diseases 0.000 abstract 1
- 208000029162 bladder disease Diseases 0.000 abstract 1
- 206010013990 dysuria Diseases 0.000 abstract 1
- 230000002496 gastric effect Effects 0.000 abstract 1
- 208000013403 hyperactivity Diseases 0.000 abstract 1
- 208000002551 irritable bowel syndrome Diseases 0.000 abstract 1
- 201000003890 low compliance bladder Diseases 0.000 abstract 1
- 230000001272 neurogenic effect Effects 0.000 abstract 1
- 208000020629 overactive bladder Diseases 0.000 abstract 1
- 230000002040 relaxant effect Effects 0.000 abstract 1
- 210000000329 smooth muscle myocyte Anatomy 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 abstract 1
- 208000011580 syndromic disease Diseases 0.000 abstract 1
- 208000026533 urinary bladder disease Diseases 0.000 abstract 1
- 230000002485 urinary effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
"hidrato estável de um antagonista de receptor muscarínico". a presente invenção refere-se a um hidrato sólido estável de um antagonista de receptor muscarínico que é útil no tratamento de síndrome de intestino irritável, doença diverticular, acalasia esofageal, doença de vias aéreas obstrutivas crônica, bexiga super ativa incluindo sintomas de incontinência, urgência e freqüência, incontinência urinária, urgência urinária neurogênica ou polaquiúria, tratamento de distúrbio funcional de bexiga, vazamento urinário, micção difícil ou dolorosa causada por bexiga neurogênica, bexiga hipertônica ou espástica, síndrome de bexiga disfuncional, distúrbios gastrointestinais incluindo hiperatividade gastrointestinal, e efeito relaxante sobre células de músculo liso.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0207104.1A GB0207104D0 (en) | 2002-03-26 | 2002-03-26 | Stable hydrate of a muscarinic receptor antagonist |
GB0207104.1 | 2002-03-26 | ||
PCT/IB2003/001043 WO2003080599A1 (en) | 2002-03-26 | 2003-03-17 | Stable hydrate of a muscarinic receptor antagonist |
Publications (3)
Publication Number | Publication Date |
---|---|
BR0308706A BR0308706A (pt) | 2005-01-04 |
BRPI0308706B1 BRPI0308706B1 (pt) | 2018-07-10 |
BRPI0308706B8 true BRPI0308706B8 (pt) | 2021-05-25 |
Family
ID=9933731
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0308706A BRPI0308706B8 (pt) | 2002-03-26 | 2003-03-17 | hidrato de darifenacina, e processo para sua preparação |
BR122018000397A BR122018000397B8 (pt) | 2002-03-26 | 2003-03-17 | solvato de darifenacina, e processo para sua preparação |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR122018000397A BR122018000397B8 (pt) | 2002-03-26 | 2003-03-17 | solvato de darifenacina, e processo para sua preparação |
Country Status (23)
Country | Link |
---|---|
US (3) | US6930188B2 (pt) |
EP (2) | EP1490357B1 (pt) |
JP (2) | JP2005524678A (pt) |
KR (4) | KR20120098888A (pt) |
CN (1) | CN100345840C (pt) |
AR (1) | AR042608A1 (pt) |
AT (1) | ATE495169T1 (pt) |
AU (1) | AU2003209921A1 (pt) |
BR (2) | BRPI0308706B8 (pt) |
CA (1) | CA2480287C (pt) |
CY (2) | CY1111200T1 (pt) |
DE (1) | DE60335711D1 (pt) |
DK (2) | DK2336124T3 (pt) |
ES (2) | ES2358644T3 (pt) |
GB (1) | GB0207104D0 (pt) |
HK (2) | HK1080847A1 (pt) |
PA (1) | PA8569701A1 (pt) |
PT (2) | PT1490357E (pt) |
SI (2) | SI2336124T1 (pt) |
SV (1) | SV2003001515A (pt) |
TW (1) | TW200306816A (pt) |
UY (1) | UY27735A1 (pt) |
WO (1) | WO2003080599A1 (pt) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0207104D0 (en) * | 2002-03-26 | 2002-05-08 | Pfizer Ltd | Stable hydrate of a muscarinic receptor antagonist |
US7244765B2 (en) * | 2004-06-25 | 2007-07-17 | Cytokine Pharmasciences, Inc | Guanylhydrazone salts, compositions, processes of making and methods of using |
AU2006239941A1 (en) * | 2005-04-24 | 2006-11-02 | Wyeth | Methods for modulating bladder function |
US20070197630A1 (en) * | 2005-12-27 | 2007-08-23 | Valeriano Merli | Pure darifenacin hydrobromide substantially free of oxidized darifenacin and salts thereof and processes for the preparation thereof |
EP2109601A2 (en) * | 2007-01-05 | 2009-10-21 | Dr. Reddy's Laboratories Ltd. | Preparation of darifenacin and its salts |
RU2452728C2 (ru) * | 2007-02-23 | 2012-06-10 | Тереванс, Инк. | Четвертичные аммониевые дифенилметилсоединения, применимые в качестве антагонистов мускариновых рецепторов |
WO2008144602A1 (en) * | 2007-05-18 | 2008-11-27 | Auspex Pharmaceuticals, Inc. | Deuterated zamifenacin derivatives |
WO2009007853A2 (en) * | 2007-06-08 | 2009-01-15 | Actavis Group Ptc Ehf | Novel polymorphs of darifenacin free base and its hydrobromide salt |
US20090005431A1 (en) * | 2007-06-30 | 2009-01-01 | Auspex Pharmaceuticals, Inc. | Substituted pyrrolidines |
AR068322A1 (es) * | 2007-07-13 | 2009-11-11 | Medichem Sa | Forma amorfa de hidrobromuro de darifenacina y procedimientos para su preparacion |
CZ200845A3 (cs) | 2008-01-28 | 2009-09-02 | Zentiva, A. S. | Zpusob prípravy Darifenacinu |
WO2009125426A2 (en) * | 2008-02-08 | 2009-10-15 | Neuland Laboratories Ltd | NOVEL PROCESS FOR THE PREPARATION OF (3SM-[2-(2 J-DIHYDRO-5- BENZOFURANYLϊETHYL]-α.α -DIPHENYL-3-PYRROLIDINEACETAMIDE HYDROBROMIDE |
EP2261205A4 (en) | 2008-04-02 | 2012-06-06 | Kaneka Corp | PROCESS FOR PRODUCING (S) -3- (1-CYANO-1,1-DIPHENYLMETHYL) -PYRROLIDINE |
WO2010032225A2 (en) * | 2008-09-22 | 2010-03-25 | Watson Pharma Private Limited | Process for preparation of darifenacin and intermediates used in the process |
EP2236509A1 (en) | 2009-04-01 | 2010-10-06 | Ragactives, S.L. | Method for obtaining 1,3-difunctionalized pyrrolidine derivatives |
WO2011070419A1 (en) | 2009-12-10 | 2011-06-16 | Aurobindo Pharma Limited | An improved process for the preparation of darifenacin hydrobromide |
JP6440625B2 (ja) | 2012-11-14 | 2018-12-19 | ザ・ジョンズ・ホプキンス・ユニバーシティー | 精神分裂病を処置するための方法および組成物 |
AU2016371762A1 (en) * | 2015-12-14 | 2018-06-21 | Cyclerion Therapeutics, Inc. | Use of sGC stimulators for the treatment of gastrointestinal sphincter dysfunction |
DK3497075T3 (da) * | 2016-08-12 | 2020-08-31 | Bayer Cropscience Ag | Fremgangsmåde til fremstilling af substituerede styren-derivater |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5233053A (en) * | 1989-03-17 | 1993-08-03 | Pfizer Inc. | Pyrrolidine derivatives |
GB8906166D0 (en) | 1989-03-17 | 1989-05-04 | Pfizer Ltd | Therapeutic agents |
US5376645A (en) | 1990-01-23 | 1994-12-27 | University Of Kansas | Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof |
KR0166088B1 (ko) | 1990-01-23 | 1999-01-15 | . | 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도 |
GB9400600D0 (en) * | 1994-01-14 | 1994-03-09 | Pfizer Ltd | Treatment of motion seckness |
GB9518953D0 (en) * | 1995-09-15 | 1995-11-15 | Pfizer Ltd | Pharmaceutical formulations |
GB9612710D0 (en) * | 1996-06-18 | 1996-08-21 | Pfizer Ltd | Method of treatment |
AU4421697A (en) * | 1996-09-19 | 1998-04-14 | American Home Products Corporation | Method of treating urinary incontinence |
GB9711643D0 (en) | 1997-06-05 | 1997-07-30 | Janssen Pharmaceutica Nv | Glass thermoplastic systems |
GB0207104D0 (en) * | 2002-03-26 | 2002-05-08 | Pfizer Ltd | Stable hydrate of a muscarinic receptor antagonist |
-
2002
- 2002-03-26 GB GBGB0207104.1A patent/GB0207104D0/en not_active Ceased
-
2003
- 2003-03-17 EP EP03744716A patent/EP1490357B1/en not_active Expired - Lifetime
- 2003-03-17 AU AU2003209921A patent/AU2003209921A1/en not_active Abandoned
- 2003-03-17 KR KR1020127018787A patent/KR20120098888A/ko not_active Application Discontinuation
- 2003-03-17 DK DK10177716.7T patent/DK2336124T3/da active
- 2003-03-17 BR BRPI0308706A patent/BRPI0308706B8/pt not_active IP Right Cessation
- 2003-03-17 SI SI200332215T patent/SI2336124T1/sl unknown
- 2003-03-17 BR BR122018000397A patent/BR122018000397B8/pt not_active IP Right Cessation
- 2003-03-17 KR KR1020117027931A patent/KR101212908B1/ko active IP Right Grant
- 2003-03-17 CA CA2480287A patent/CA2480287C/en not_active Expired - Lifetime
- 2003-03-17 AT AT03744716T patent/ATE495169T1/de active
- 2003-03-17 DK DK03744716.6T patent/DK1490357T3/da active
- 2003-03-17 PT PT03744716T patent/PT1490357E/pt unknown
- 2003-03-17 ES ES03744716T patent/ES2358644T3/es not_active Expired - Lifetime
- 2003-03-17 KR KR1020047015243A patent/KR101026283B1/ko active IP Right Grant
- 2003-03-17 DE DE60335711T patent/DE60335711D1/de not_active Expired - Lifetime
- 2003-03-17 SI SI200331973T patent/SI1490357T1/sl unknown
- 2003-03-17 JP JP2003578353A patent/JP2005524678A/ja not_active Withdrawn
- 2003-03-17 ES ES10177716T patent/ES2394067T3/es not_active Expired - Lifetime
- 2003-03-17 WO PCT/IB2003/001043 patent/WO2003080599A1/en active Application Filing
- 2003-03-17 KR KR1020107018853A patent/KR20100101182A/ko not_active Application Discontinuation
- 2003-03-17 CN CNB038070847A patent/CN100345840C/zh not_active Expired - Lifetime
- 2003-03-17 PT PT101777167T patent/PT2336124E/pt unknown
- 2003-03-17 EP EP10177716A patent/EP2336124B1/en not_active Expired - Lifetime
- 2003-03-20 PA PA20038569701A patent/PA8569701A1/es unknown
- 2003-03-24 AR ARP030101017A patent/AR042608A1/es unknown
- 2003-03-25 TW TW092106635A patent/TW200306816A/zh unknown
- 2003-03-25 UY UY27735A patent/UY27735A1/es not_active Application Discontinuation
- 2003-03-25 SV SV2003001515A patent/SV2003001515A/es not_active Application Discontinuation
- 2003-03-25 US US10/396,887 patent/US6930188B2/en not_active Expired - Lifetime
-
2005
- 2005-07-13 US US11/180,433 patent/US20050245597A1/en not_active Abandoned
-
2006
- 2006-01-18 HK HK06100807A patent/HK1080847A1/xx not_active IP Right Cessation
-
2008
- 2008-03-17 US US12/049,660 patent/US7696357B2/en not_active Expired - Lifetime
-
2010
- 2010-06-02 JP JP2010126865A patent/JP2010195828A/ja active Pending
-
2011
- 2011-02-22 CY CY20111100213T patent/CY1111200T1/el unknown
- 2011-10-17 HK HK11111039.7A patent/HK1156626A1/xx not_active IP Right Cessation
-
2012
- 2012-11-29 CY CY20121101165T patent/CY1113433T1/el unknown
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Legal Events
Date | Code | Title | Description |
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B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B25A | Requested transfer of rights approved |
Owner name: ASPEN GLOBAL INCORPORATED (MR) |
|
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B25G | Requested change of headquarter approved |
Owner name: ASPEN GLOBAL INCORPORATED (MR) |
|
B65X | Notification of requirement for priority examination of patent application | ||
B65Y | Grant of priority examination of the patent application (request complies with dec. 132/06 of 20061117) | ||
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] | ||
B17A | Notification of administrative nullity (patentee has 60 days time to reply to this notification) |
Free format text: REQUERENTE DA NULIDADE: ZODIAC PRODUTOS FARMACEUTICOS S.A. - PETICAO NO870190002945 DE 10/01/2019. |
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B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 17/03/2003 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF |
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B21A | Patent or certificate of addition expired [chapter 21.1 patent gazette] |
Free format text: PATENTE EXTINTA EM 17/03/2023 |