BRPI0306644B8 - método para produzir um peptídeo modificado - Google Patents
método para produzir um peptídeo modificadoInfo
- Publication number
- BRPI0306644B8 BRPI0306644B8 BRPI0306644A BR0306644A BRPI0306644B8 BR PI0306644 B8 BRPI0306644 B8 BR PI0306644B8 BR PI0306644 A BRPI0306644 A BR PI0306644A BR 0306644 A BR0306644 A BR 0306644A BR PI0306644 B8 BRPI0306644 B8 BR PI0306644B8
- Authority
- BR
- Brazil
- Prior art keywords
- peptide
- producing
- modified
- amino acid
- side chain
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 3
- 108091005601 modified peptides Proteins 0.000 title abstract 2
- 108010033276 Peptide Fragments Proteins 0.000 abstract 3
- 102000007079 Peptide Fragments Human genes 0.000 abstract 3
- 125000000539 amino acid group Chemical group 0.000 abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 230000010933 acylation Effects 0.000 abstract 1
- 238000005917 acylation reaction Methods 0.000 abstract 1
- 238000003776 cleavage reaction Methods 0.000 abstract 1
- 238000006911 enzymatic reaction Methods 0.000 abstract 1
- 230000013595 glycosylation Effects 0.000 abstract 1
- 238000006206 glycosylation reaction Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000004048 modification Effects 0.000 abstract 1
- 238000012986 modification Methods 0.000 abstract 1
- 230000026731 phosphorylation Effects 0.000 abstract 1
- 238000006366 phosphorylation reaction Methods 0.000 abstract 1
- 230000006798 recombination Effects 0.000 abstract 1
- 239000011347 resin Substances 0.000 abstract 1
- 229920005989 resin Polymers 0.000 abstract 1
- 230000007017 scission Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/465—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from birds
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Endocrinology (AREA)
- Analytical Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
"método para produzir um peptídeo modificado". a presente invenção refere-se a um método para produzir um peptídeo ou uma proteína nos quais uma cadeia lateral contém um resíduo de aminoácido modificado, o qual compreende produzir quimicamente um fragmento de peptídeo contendo um resíduo de aminoácido apresentando uma cadeia lateral modificada utilizando uma resina de clivagem em ácido fraco, produzir um fragmento de peptídeo não contendo resíduos de aminoácidos apresentando uma cadeia lateral modificada utilizando um método de recombinação genética ou/e um método enzimático, e condensar os dois tipos de fragmentos de peptídeo resultantes e, de acordo com a presente invenção, podem ser efetivamente obtidos um peptídeo ou uma proteína contendo modificações tais como acilação, glicosilação e fosforilação de alta qualidade.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2002-109761 | 2002-04-11 | ||
| JP2002109761 | 2002-04-11 | ||
| PCT/JP2003/004590 WO2003084983A1 (fr) | 2002-04-11 | 2003-04-10 | Procede de production d'un peptide modifie |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BR0306644A BR0306644A (pt) | 2005-04-26 |
| BRPI0306644B1 BRPI0306644B1 (pt) | 2018-02-14 |
| BRPI0306644B8 true BRPI0306644B8 (pt) | 2021-05-25 |
Family
ID=28786604
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0306644A BRPI0306644B8 (pt) | 2002-04-11 | 2003-04-10 | método para produzir um peptídeo modificado |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7138489B2 (pt) |
| EP (1) | EP1493747B1 (pt) |
| KR (1) | KR101036524B1 (pt) |
| CN (1) | CN100491395C (pt) |
| AU (1) | AU2003236080B8 (pt) |
| BR (1) | BRPI0306644B8 (pt) |
| CA (1) | CA2472235C (pt) |
| ES (1) | ES2400703T3 (pt) |
| IL (2) | IL162780A0 (pt) |
| WO (1) | WO2003084983A1 (pt) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7357947B2 (en) * | 2001-09-10 | 2008-04-15 | Biomet, Inc. | Bone graft material incorporating demineralized bone matrix and lipids |
| IL162796A0 (en) * | 2002-05-21 | 2005-11-20 | Kenji Kangawa | Medicinal compositions containing ghrelin |
| CN1688696A (zh) * | 2002-09-18 | 2005-10-26 | 蒙特利尔大学医疗中心 | Ghrh类似物 |
| USRE46830E1 (en) | 2004-10-19 | 2018-05-08 | Polypeptide Laboratories Holding (Ppl) Ab | Method for solid phase peptide synthesis |
| US20070042501A1 (en) * | 2005-08-20 | 2007-02-22 | Institute Of Nuclear Energy Research | A novel technology for the purity assay of TRODAT-1 raw material |
| US7763707B2 (en) * | 2006-03-13 | 2010-07-27 | Liat Mintz | Use of ghrelin splice variant for treating cachexia and/or anorexia and/or anorexia-cachexia and/or malnutrition and/or lipodystrophy and/or muscle wasting and/or appetite-stimulation |
| KR20200108494A (ko) | 2012-10-24 | 2020-09-18 | 다이이찌 산쿄 가부시키가이샤 | 근위축성 측삭 경화증 치료제 |
| SG11201506885UA (en) | 2013-03-21 | 2015-09-29 | Sanofi Aventis Deutschland | Synthesis of cyclic imide containing peptide products |
| HUE034308T2 (en) | 2013-03-21 | 2018-02-28 | Sanofi Aventis Deutschland | Preparation of hydantoin-containing peptide products |
| RU2694051C2 (ru) * | 2014-03-04 | 2019-07-09 | Мотус Терапьютикс, Инк. | СПОСОБ ЖИДКОФАЗНОГО СИНТЕЗА H-Inp-(D)Bal-(D)Trp-Phe-Apc-NH2 И ЕГО ФАРМАЦЕВТИЧЕСКИ ПРИЕМЛЕМЫХ СОЛЕЙ |
| JP6554180B6 (ja) * | 2015-04-14 | 2019-09-11 | 成都先導薬物開発股▲フン▼有限公司 | Ｄｎａコード化化合物ライブラリーの固相合成方法 |
| EP3986919A1 (en) * | 2019-06-18 | 2022-04-27 | Fresenius Kabi iPSUM S.r.l. | Process for the manufacture of glucagon |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL118473A0 (en) | 1995-06-02 | 1996-09-12 | Suntory Ltd | Staphylococcus aureus V8 protease genes coding therefor and a method for the production thereof |
| CA2198968C (en) | 1996-03-04 | 2010-02-09 | Toyofumi Masuda | Process for production of secretory kex2 derivatives |
| CA2198966C (en) | 1996-03-04 | 2011-06-21 | Yuji Suzuki | Method for cleaving chimeric protein using processing enzyme |
| EP0978565B1 (en) | 1998-01-30 | 2007-10-10 | Asubio Pharma Co., Ltd. | Process for producing peptide with the use of accessory peptide |
| DE60040771D1 (de) * | 1999-03-04 | 2008-12-24 | Asubio Pharma Co Ltd | Verfahren zur kontrolle der spaltung mit ompt protease |
| ES2154590B1 (es) * | 1999-05-20 | 2001-11-01 | Lipotec Sa | Procedimiento de sintesis de peptidos en fase solida |
| ATE449174T1 (de) * | 1999-07-23 | 2009-12-15 | Kenji Kangawa | Neue peptide |
| AU2001250683B2 (en) * | 2000-04-12 | 2006-06-29 | Ge Healthcare As | Peptide-based compounds |
-
2003
- 2003-04-10 EP EP03723102A patent/EP1493747B1/en not_active Expired - Lifetime
- 2003-04-10 WO PCT/JP2003/004590 patent/WO2003084983A1/ja active Application Filing
- 2003-04-10 BR BRPI0306644A patent/BRPI0306644B8/pt not_active IP Right Cessation
- 2003-04-10 IL IL16278003A patent/IL162780A0/xx unknown
- 2003-04-10 KR KR1020047010361A patent/KR101036524B1/ko active IP Right Grant
- 2003-04-10 AU AU2003236080A patent/AU2003236080B8/en not_active Expired
- 2003-04-10 CA CA2472235A patent/CA2472235C/en not_active Expired - Lifetime
- 2003-04-10 CN CNB038019051A patent/CN100491395C/zh not_active Expired - Lifetime
- 2003-04-10 US US10/500,018 patent/US7138489B2/en not_active Expired - Lifetime
- 2003-04-10 ES ES03723102T patent/ES2400703T3/es not_active Expired - Lifetime
-
2004
- 2004-06-29 IL IL162780A patent/IL162780A/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| EP1493747A1 (en) | 2005-01-05 |
| AU2003236080B2 (en) | 2009-06-11 |
| KR20050012717A (ko) | 2005-02-02 |
| US7138489B2 (en) | 2006-11-21 |
| AU2003236080A1 (en) | 2003-10-20 |
| CA2472235C (en) | 2012-05-22 |
| IL162780A (en) | 2013-10-31 |
| CN1612891A (zh) | 2005-05-04 |
| BR0306644A (pt) | 2005-04-26 |
| CA2472235A1 (en) | 2003-10-16 |
| WO2003084983A1 (fr) | 2003-10-16 |
| EP1493747A4 (en) | 2007-11-28 |
| ES2400703T3 (es) | 2013-04-11 |
| IL162780A0 (en) | 2005-11-20 |
| EP1493747B1 (en) | 2012-12-19 |
| KR101036524B1 (ko) | 2011-05-24 |
| US20050131208A1 (en) | 2005-06-16 |
| CN100491395C (zh) | 2009-05-27 |
| BRPI0306644B1 (pt) | 2018-02-14 |
| AU2003236080B8 (en) | 2009-07-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BRPI0306644B8 (pt) | método para produzir um peptídeo modificado | |
| Sadler | Thrombomodulin structure and function | |
| AR016224A1 (es) | Fragmento aislado de acidos nucleicos que codifica una inositol 1,3,4-trifosfato 5/6 quinasa, gen quimerico, celula huesped transformada, polipeptido,metodo para alterar el nivel de expresion de dicha enzima, metodos para obtener dicho fragmento, productos obtenidos por dichos metodos | |
| EA199900939A1 (ru) | Остеопротегерин-связывающие белки и рецепторы | |
| DE60320362D1 (de) | Verfahren zur Herstellung von Dipeptiden | |
| PT1669463E (pt) | Hidrolisado de caseína, processo para produção do mesmo e sua utilização | |
| SG166001A1 (en) | Methods of generating and screening for proteases with altered specificity | |
| ATE462000T1 (de) | Verfahren zur herstellung von l-arginin, l- ornithin oder l-citrullin | |
| GB9821393D0 (en) | Protein profiling 2 | |
| Mann et al. | Isolation of ovocleidin-116 from chicken eggshells, correction of its amino acid sequence and identification of disulfide bonds and glycosylated Asn | |
| BR9802403A (pt) | Proteìna tendo atividade transglutaminase, dna, transformante, e, processo para produzir uma proteìna tendo uma atividade transglutaminase. | |
| ATE495247T1 (de) | Chromoprotein und fluoroproteine | |
| ES2113878T3 (es) | Proteina c hibrida. | |
| EP1132402A4 (en) | PEPTIDE FRAGMENTS WITH CELL DEATH PREVENTIVE ACTIVITY | |
| ATE362939T1 (de) | Dimere von thrombinpeptidderivaten | |
| CY1109946T1 (el) | Τροποποιημενα πεπτιδια και η χρηση τους για τη θεραπεια αυτοανοσων νοσων | |
| Meggio et al. | Location of the phosphorylation site for casein kinase-2 within the amino acid sequence of ornithine decarboxylase | |
| Akashi et al. | A determination of the positions of disulphide bonds in Paim I, α‐amylase inhibitor from Streptomyces corchorushii, using fast atom bombardment mass spectrometry | |
| Tsuji et al. | Molecular weight heterogeneity of bovine serum transferrin | |
| MXPA03011453A (es) | Acetilacion de fragmentos de gp41. | |
| Kunii et al. | Actinidain-hydrolyzed type I collagen reveals a crucial amino acid sequence in fibril formation | |
| Henschen et al. | Structure-function-evolution relationship in fibrinogen | |
| IL162133A0 (en) | Method of increasing protein expression, proteins and polynucleotides | |
| Mykles | Lobster muscle proteasome and the degradation of myofibrillar proteins | |
| ATE403873T1 (de) | Verfahren zur überwachung der typ-ii- kollagenabbau in knorpeln |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B25D | Requested change of name of applicant approved |
Owner name: KANGAWA, KENJI (JP) , DAIICHI ASUBIO PHARMA CO., L Free format text: ALTERADO DE: DAIICHI SUNTORY PHARMA CO., LTD. |
|
| B25I | Requirement for requested change of headquarter |
Owner name: KANGAWA, KENJI (JP) , DAIICHI ASUBIO PHARMA CO., L Free format text: A FIM DE ATENDER A SOLICITACAO CONSTANTE NA PETICAO NO 020050141056/RJ DE 05/12/2005, QUEIRA APRESENTAR A GUIA DE RECOLHIMENTO REFERENTE A ESTE ATO. |
|
| B25G | Requested change of headquarter approved |
Owner name: KANGAWA, KENJI (JP) , DAIICHI ASUBIO PHARMA CO., L Free format text: SEDE ALTERADA CONFORME SOLICITADO NA PETICAO NO 020050141056/RJ DE 05/12/2005. |
|
| B25D | Requested change of name of applicant approved |
Owner name: KANGAWA, KENJI (JP) , ASUBIO PHARMA CO., LTD. (JP) Free format text: ALTERADO DE: DAIICHI ASUBIO PHARMA CO., LTD. |
|
| B25A | Requested transfer of rights approved |
Owner name: KANGAWA, KENJI (JP) , DAIICHI SANKYO COMPANY, LIMI Free format text: TRANSFERIDO POR INCORPORACAO DE : ASUBIO PHARMA CO., LTD. |
|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] | ||
| B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 10/04/2003 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF |
|
| B21A | Patent or certificate of addition expired [chapter 21.1 patent gazette] |
Free format text: PATENTE EXTINTA EM 10/04/2023 |