BRPI0116757B8 - composição, formulação e produto contendo aztreonam e uso do mesmo para aplicação via inalatória - Google Patents
composição, formulação e produto contendo aztreonam e uso do mesmo para aplicação via inalatóriaInfo
- Publication number
- BRPI0116757B8 BRPI0116757B8 BRPI0116757A BR0116757A BRPI0116757B8 BR PI0116757 B8 BRPI0116757 B8 BR PI0116757B8 BR PI0116757 A BRPI0116757 A BR PI0116757A BR 0116757 A BR0116757 A BR 0116757A BR PI0116757 B8 BRPI0116757 B8 BR PI0116757B8
- Authority
- BR
- Brazil
- Prior art keywords
- composition
- treatment
- formulation
- infections caused
- aerosol
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 6
- 238000009472 formulation Methods 0.000 title abstract 3
- WZPBZJONDBGPKJ-UHFFFAOYSA-N Antibiotic SQ 26917 Natural products O=C1N(S(O)(=O)=O)C(C)C1NC(=O)C(=NOC(C)(C)C(O)=O)C1=CSC(N)=N1 WZPBZJONDBGPKJ-UHFFFAOYSA-N 0.000 title abstract 2
- WZPBZJONDBGPKJ-VEHQQRBSSA-N aztreonam Chemical compound O=C1N(S([O-])(=O)=O)[C@@H](C)[C@@H]1NC(=O)C(=N/OC(C)(C)C(O)=O)\C1=CSC([NH3+])=N1 WZPBZJONDBGPKJ-VEHQQRBSSA-N 0.000 title abstract 2
- 229960003644 aztreonam Drugs 0.000 title abstract 2
- 239000000047 product Substances 0.000 title 1
- 241000894006 Bacteria Species 0.000 abstract 2
- 241000589517 Pseudomonas aeruginosa Species 0.000 abstract 2
- 239000000443 aerosol Substances 0.000 abstract 2
- 208000015181 infectious disease Diseases 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 241001673062 Achromobacter xylosoxidans Species 0.000 abstract 1
- 241000589513 Burkholderia cepacia Species 0.000 abstract 1
- 241000588914 Enterobacter Species 0.000 abstract 1
- 241000588724 Escherichia coli Species 0.000 abstract 1
- 241000606768 Haemophilus influenzae Species 0.000 abstract 1
- 241000588749 Klebsiella oxytoca Species 0.000 abstract 1
- 241000588747 Klebsiella pneumoniae Species 0.000 abstract 1
- 208000032376 Lung infection Diseases 0.000 abstract 1
- 241000588770 Proteus mirabilis Species 0.000 abstract 1
- 241000607715 Serratia marcescens Species 0.000 abstract 1
- 241000122973 Stenotrophomonas maltophilia Species 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940047650 haemophilus influenzae Drugs 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- 230000002685 pulmonary effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Otolaryngology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Dispersion Chemistry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Plural Heterocyclic Compounds (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25842300P | 2000-12-27 | 2000-12-27 | |
| US60/258,423 | 2000-12-27 | ||
| PCT/US2001/050062 WO2002051356A2 (en) | 2000-12-27 | 2001-12-20 | Inhalable aztreonam for treatment and prevention of pulmonary bacterial infections |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BR0116757A BR0116757A (pt) | 2003-11-04 |
| BR0116757B1 BR0116757B1 (pt) | 2014-02-04 |
| BRPI0116757B8 true BRPI0116757B8 (pt) | 2021-05-25 |
Family
ID=22980480
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0116757A BRPI0116757B8 (pt) | 2000-12-27 | 2001-12-20 | composição, formulação e produto contendo aztreonam e uso do mesmo para aplicação via inalatória |
Country Status (19)
| Country | Link |
|---|---|
| US (6) | US6660249B2 (enExample) |
| EP (2) | EP2301524B1 (enExample) |
| JP (1) | JP4646489B2 (enExample) |
| AT (1) | ATE502623T1 (enExample) |
| AU (1) | AU2002231244B2 (enExample) |
| BE (1) | BE2011C029I2 (enExample) |
| BR (1) | BRPI0116757B8 (enExample) |
| CA (2) | CA2708703C (enExample) |
| CY (2) | CY1111571T1 (enExample) |
| DE (2) | DE60144291D1 (enExample) |
| DK (2) | DK1353647T3 (enExample) |
| ES (2) | ES2406405T3 (enExample) |
| FR (1) | FR11C0030I2 (enExample) |
| IL (3) | IL156596A0 (enExample) |
| LU (1) | LU91851I2 (enExample) |
| NL (1) | NL300492I2 (enExample) |
| NO (3) | NO329643B1 (enExample) |
| PT (2) | PT2301524E (enExample) |
| WO (1) | WO2002051356A2 (enExample) |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7214364B2 (en) | 2000-12-27 | 2007-05-08 | Corus Pharma, Inc. | Inhalable aztreonam lysinate formulation for treatment and prevention of pulmonary bacterial infections |
| US6660249B2 (en) * | 2000-12-27 | 2003-12-09 | Salus Pharma, Inc. | Inhalable dry powder aztreonam for treatment and prevention of pulmonary bacterial infections |
| US7138419B2 (en) * | 2000-12-27 | 2006-11-21 | Corus Pharma, Inc. | Process for manufacturing bulk solutions and a lyophilized pure α-aztreonam lysinate |
| US20030133925A1 (en) * | 2001-09-28 | 2003-07-17 | Shawar Ribhi M. | Monobactam compositions and methods of use thereof |
| US20040009126A1 (en) * | 2002-03-05 | 2004-01-15 | Transave, Inc. | Inhalation system for prevention and treatment of intracellular infections |
| US7607436B2 (en) | 2002-05-06 | 2009-10-27 | The Research Foundation Of State University Of New York | Methods, devices and formulations for targeted endobronchial therapy |
| WO2004013133A1 (en) | 2002-08-05 | 2004-02-12 | TEVA Gyógyszergyár Részvénytársaság | Preparation of aztreonam |
| AU2002356646A1 (en) * | 2002-12-11 | 2004-06-30 | Pari Gmbh | Pharmaceutical compositions for the pulmonary delivery of aztreonam |
| US20060147389A1 (en) * | 2004-04-14 | 2006-07-06 | Vectura Ltd. | Devices and pharmaceutical compositions for enhancing dosing efficiency |
| EP1617820B1 (en) | 2003-04-14 | 2018-03-21 | Vectura Limited | Dry power inhaler devices and dry power formulations for enhancing dosing efficiency |
| US20040204439A1 (en) * | 2003-04-14 | 2004-10-14 | Staniforth John Nicholas | Composition, device, and method for treating sexual dysfunction via inhalation |
| WO2004103999A1 (en) | 2003-05-15 | 2004-12-02 | TEVA Gyógyszergyár Részvénytársaság | AZTREONAM β POLYMORPH WITH VERY LOW RESIDUAL SOLVENT CONTENT |
| US7883031B2 (en) * | 2003-05-20 | 2011-02-08 | James F. Collins, Jr. | Ophthalmic drug delivery system |
| JP4741487B2 (ja) * | 2003-07-02 | 2011-08-03 | コーラス ファーマ,インコーポレイティド | アズトレオナムl−リジン及びそれを調製するための方法 |
| AU2004257632C1 (en) * | 2003-07-03 | 2010-04-15 | Gilead Sciences, Inc. | Inhalable aztreonam lysinate formulation for treatment and prevention of pulmonary bacterial infections |
| AU2014271333B2 (en) * | 2003-07-03 | 2016-10-27 | Gilead Sciences, Inc. | Inhalable aztreonam lysinate formulation for treatment and prevention of pulmonary bacterial infections |
| US7452523B2 (en) * | 2004-01-27 | 2008-11-18 | Gilead Sciences, Inc. | Targeted delivery of lidocaine and other local anesthetics and a method for treatment of cough and tussive attacks |
| US20050207983A1 (en) * | 2004-03-05 | 2005-09-22 | Pulmatrix, Inc. | Formulations decreasing particle exhalation |
| GB0425758D0 (en) | 2004-11-23 | 2004-12-22 | Vectura Ltd | Preparation of pharmaceutical compositions |
| US20060210483A1 (en) * | 2005-03-02 | 2006-09-21 | Kodsi Robert E | Non-systemic antibiotic formulations and related method of use and treatment of upper respiratory infections |
| JP2008505189A (ja) | 2005-05-09 | 2008-02-21 | シコール インコーポレイティド | アズトレオナムの製造方法 |
| WO2008039987A2 (en) * | 2006-09-28 | 2008-04-03 | Transave, Inc. | Methods of treating pulmonary distress |
| HUP0700007A2 (en) * | 2007-01-08 | 2008-10-28 | Asthma Rehabilitacios Ct Kft | Device and process for producing of natrium chloride aerosol for the disorders of the respiratory system |
| WO2009020481A2 (en) * | 2007-05-08 | 2009-02-12 | Rq Bioscience, Inc. | Therapeutic compositions and methods for treating gram-negative bacterial infections |
| GB0714134D0 (en) * | 2007-07-19 | 2007-08-29 | Norton Healthcare Ltd | Dry-powder medicament |
| BRPI0817636A2 (pt) * | 2007-10-01 | 2019-09-24 | Gilead Sciences Inc | aztreonam lisina inalada para o tratamento de déficits na qualidade de vida relacionada à saúde em doenças pulmonares |
| CN104189908B (zh) * | 2007-11-27 | 2017-01-11 | 阿尔吉法玛公司 | 包含藻酸盐低聚物的产品、包含无生命表面的产品和清创组合物 |
| EP2098219A1 (en) | 2008-03-05 | 2009-09-09 | PARI Pharma GmbH | Macrolide compositions having improved taste and stability |
| US20090271021A1 (en) * | 2008-04-28 | 2009-10-29 | Popp Shane M | Execution system for the monitoring and execution of insulin manufacture |
| EP2410981B2 (en) | 2009-03-26 | 2020-02-26 | Pulmatrix Operating Company, Inc. | Dry powder formulations and methods for treating pulmonary diseases |
| JP5202764B2 (ja) | 2009-06-03 | 2013-06-05 | アルギファルマ エーエス | 細菌における多剤耐性の克服に使用されるアルギネートオリゴマー |
| US10154923B2 (en) | 2010-07-15 | 2018-12-18 | Eyenovia, Inc. | Drop generating device |
| US9061352B2 (en) | 2010-08-30 | 2015-06-23 | Pulmatrix, Inc. | Dry powder formulations and methods for treating pulmonary diseases |
| US20120076859A1 (en) * | 2010-09-23 | 2012-03-29 | Activaero Gmbh | Targeted Lung Delivery of Citrulline and/or Another Nitric Oxide Precursor and a Method for Treatment of Pulmonary Deficiency of Nitric Oxide in Cystic Fibrosis and Other Pulmonary Diseases |
| CA2812417C (en) | 2010-09-29 | 2019-10-22 | Pulmatrix, Inc. | Cationic dry powders |
| CN107096014B (zh) | 2010-09-29 | 2022-07-15 | 普马特里克斯营业公司 | 吸入用单价金属阳离子干粉剂 |
| EP2804589A1 (en) * | 2012-01-16 | 2014-11-26 | Mahmut Bilgic | Pharmaceutical formulations comprising aztreonam |
| CN104487075A (zh) | 2012-02-29 | 2015-04-01 | 普马特里克斯公司 | 可吸入干粉剂 |
| CA2910825A1 (en) * | 2013-03-28 | 2014-10-02 | Pharmacaribe, Llc | Compositions, formulations and methods of bio-balancing the ph of sterile isotonic saline and hypertonic saline solutions |
| WO2014165303A1 (en) | 2013-04-01 | 2014-10-09 | Pulmatrix, Inc. | Tiotropium dry powders |
| CN104784159A (zh) * | 2015-04-15 | 2015-07-22 | 苏州惠仁生物科技有限公司 | 氨曲南粉雾剂的制备方法 |
| US11285284B2 (en) | 2016-05-03 | 2022-03-29 | Pneuma Respiratory, Inc. | Methods for treatment of pulmonary lung diseases with improved therapeutic efficacy and improved dose efficiency |
| WO2017192782A1 (en) * | 2016-05-03 | 2017-11-09 | Pneuma Respiratory, Inc. | Systems and methods comprising a droplet delivery device and a breathing assist device for therapeutic treatment |
| US11285274B2 (en) | 2016-05-03 | 2022-03-29 | Pneuma Respiratory, Inc. | Methods for the systemic delivery of therapeutic agents to the pulmonary system using a droplet delivery device |
| EP3452150B1 (en) | 2016-05-03 | 2024-01-17 | Pneuma Respiratory, Inc. | Droplet delivery device for delivery of fluids to the pulmonary system |
| EP4624054A3 (en) | 2016-05-03 | 2025-11-19 | Pneuma Respiratory, Inc. | Methods for generating and delivering droplets to the pulmonary system using a droplet delivery device |
| CA3064005C (en) | 2017-05-19 | 2023-03-07 | Pneuma Respiratory, Inc. | Dry powder delivery device and methods of use |
| CN115300226A (zh) | 2017-06-10 | 2022-11-08 | 艾诺维亚股份有限公司 | 用于将一体积的流体输送到眼睛的设备 |
| JP2020536614A (ja) | 2017-10-04 | 2020-12-17 | ニューマ・リスパイラトリー・インコーポレイテッド | 呼吸により電気的に作動するインライン液滴送達装置および使用方法 |
| US11458267B2 (en) | 2017-10-17 | 2022-10-04 | Pneuma Respiratory, Inc. | Nasal drug delivery apparatus and methods of use |
| CN111479604B (zh) | 2017-11-08 | 2022-12-30 | 精呼吸股份有限公司 | 具有小体积安瓿的电动呼吸致动直列液滴输送装置及使用方法 |
| CN110898040B (zh) * | 2018-09-18 | 2022-05-17 | 北京盈科瑞创新药物研究有限公司 | 一种吸入用氨曲南溶液用冻干粉及其制备方法 |
| US12208061B2 (en) * | 2019-02-28 | 2025-01-28 | Exorao Life Science S.R.L. | Sterile aztreonam package |
| AU2020399803A1 (en) | 2019-12-11 | 2022-06-23 | Eyenovia, Inc. | Systems and devices for delivering fluids to the eye and methods of use |
| CN111647537B (zh) * | 2020-06-18 | 2022-04-26 | 浙江工业大学 | 一种耐盐辣椒素降解菌、应用及餐厨垃圾处理方法 |
| EP4659870A2 (en) | 2021-06-22 | 2025-12-10 | Pneuma Respiratory, Inc. | Droplet delivery device with push ejection |
| US12161795B2 (en) | 2022-07-18 | 2024-12-10 | Pneuma Respiratory, Inc. | Small step size and high resolution aerosol generation system and method |
Family Cites Families (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9126A (en) * | 1852-07-13 | Marcus r | ||
| US572801A (en) * | 1896-12-08 | Telephone-exchange | ||
| US610824A (en) * | 1898-09-13 | Sleigh attachment for vehicles | ||
| US673739A (en) * | 1900-09-19 | 1901-05-07 | Frank B Stearns | Driving mechanism for vehicles. |
| US775670A (en) * | 1904-08-17 | 1904-11-22 | Thomas F Whittelsey | Air-brake safety device. |
| US946838A (en) * | 1909-08-17 | 1910-01-18 | George Dawson | Tempering compound. |
| US4775670A (en) | 1980-09-29 | 1988-10-04 | E. R. Squibb & Sons, Inc. | 2-oxo-1-azetidinesulfonic acid salts |
| WO1982001873A1 (en) * | 1980-12-05 | 1982-06-10 | Takeda Chemical Industries Ltd | 1-sulfo-2-oxoazetidine derivatives and process for their preparation |
| US4673739A (en) | 1980-12-05 | 1987-06-16 | Takeda Chemical Industries, Ltd. | 4-carbamoyloxymethyl-1-sulfo-2-oxoazetidine derivatives and their production |
| US4529698A (en) * | 1981-01-19 | 1985-07-16 | E. R. Squibb & Sons, Inc. | Process for preparing a 2-oxo-1-azetidinesulfonic acid salt |
| US4386034A (en) * | 1981-02-02 | 1983-05-31 | E. R. Squibb & Sons, Inc. | Sulfamated amino acid amides |
| US4625022A (en) * | 1981-02-02 | 1986-11-25 | E. R. Squibb & Sons, Inc. | Process for preparing (s)-3-amino-2-oxo-1-azetidinesulfonic acid salts |
| US4572801A (en) | 1981-04-30 | 1986-02-25 | Takeda Chemical Industries, Ltd. | 4-Carbamoyloxymethyl-1-sulfo-2-oxoazetidine derivatives and their production |
| CA1181075A (en) | 1981-07-13 | 1985-01-15 | David M. Floyd | CRYSTALLINE ANHYDROUS FORM OF [3-S-[3.alpha.(Z),4 .beta.]]-3-[[(2-AMINO-4-THIAZOLYL) [(1-CARBOXY-1-METHYLETHOXY)IMINO]ACETYL] AMINO]-4-METHYL-2-OXO-1-AZETIDINESULFONIC ACID |
| US4946838A (en) | 1981-07-13 | 1990-08-07 | E. R. Squibb & Sons, Inc. | Crystalline anhydrous aztreonam |
| US4752469A (en) * | 1984-01-09 | 1988-06-21 | E. R. Squibb & Sons, Inc. | Potentiators of beta-lactam antibiotics |
| US4826973A (en) * | 1984-07-20 | 1989-05-02 | E. R. Squibb & Sons, Inc. | Delta form of aztreonam and preparation thereof |
| US4610824A (en) | 1984-10-09 | 1986-09-09 | E. R. Squibb & Sons, Inc. | Hydrazide derivatives of monocyclic beta-lactam antibiotics |
| US4888998A (en) * | 1986-07-11 | 1989-12-26 | Beckman Instruments, Inc. | Sample handling system |
| CA1339136C (en) | 1987-07-01 | 1997-07-29 | Sailesh Amilal Varia | Amorphous form of aztreonam |
| US5194604A (en) * | 1990-06-29 | 1993-03-16 | E. R. Squibb & Sons, Inc. | Process and intermediates for beta-lactams having aminothiazole(iminooxyacetic acid)acetic acid sidechains |
| IL104068A (en) * | 1991-12-12 | 1998-10-30 | Glaxo Group Ltd | Surfactant-free pharmaceutical aerosol formulation comprising 1,1,1,2-tetrafluoroethane or 1,1,1,2,3,3,3-heptafluoro-n- propane as propellant |
| CA2105629A1 (en) * | 1992-09-14 | 1994-03-15 | Robert S. Becker | Potentiation of immunogenic response |
| AU703192B2 (en) * | 1994-01-14 | 1999-03-18 | Xoma Corporation | Anti-gram-positive bacterial methods and materials |
| US5508269A (en) * | 1994-10-19 | 1996-04-16 | Pathogenesis Corporation | Aminoglycoside formulation for aerosolization |
| US5662929A (en) * | 1994-12-23 | 1997-09-02 | Universite De Montreal | Therapeutic liposomal formulation |
| US5723495A (en) | 1995-11-16 | 1998-03-03 | The University Of North Carolina At Chapel Hill | Benzamidoxime prodrugs as antipneumocystic agents |
| US5875776A (en) * | 1996-04-09 | 1999-03-02 | Vivorx Pharmaceuticals, Inc. | Dry powder inhaler |
| US6180604B1 (en) | 1996-08-21 | 2001-01-30 | Micrologix Biotech Inc. | Compositions and methods for treating infections using analogues of indolicidin |
| AU725733B2 (en) | 1996-09-04 | 2000-10-19 | Takara Bio Inc. | Fungal antigens and process for producing the same |
| US5994340A (en) * | 1997-08-29 | 1999-11-30 | Synphar Laboratories, Inc. | Azetidinone derivatives as β-lactamase inhibitors |
| CA2410694A1 (en) | 1998-06-16 | 1999-12-16 | Serge Dea | Porcine reproductive and respiratory syndrome virus (prrsv) dna vaccines |
| CA2514899A1 (en) | 1998-08-31 | 2000-03-09 | Biogen, Inc. | Method of modulating memory effector t-cells and compositions |
| CN1348377A (zh) * | 1998-12-17 | 2002-05-08 | 希龙公司 | 用气溶胶化的抗生素治疗严重慢性支气管炎(支气管扩张症)的方法 |
| JP2003502292A (ja) | 1999-06-01 | 2003-01-21 | バイオジェン インコーポレイテッド | ヘッジホッグタンパク質のポリマー結合体及び利用 |
| US6576224B1 (en) * | 1999-07-06 | 2003-06-10 | Sinuspharma, Inc. | Aerosolized anti-infectives, anti-inflammatories, and decongestants for the treatment of sinusitis |
| EP1666028B1 (en) * | 1999-10-29 | 2010-03-24 | Novartis AG | Dry powder compositions having improved dispersivity |
| US6962151B1 (en) | 1999-11-05 | 2005-11-08 | Pari GmbH Spezialisten für effektive Inhalation | Inhalation nebulizer |
| DE19953317C1 (de) | 1999-11-05 | 2001-02-01 | Pari Gmbh | Inhalationsvernebler |
| US6660249B2 (en) * | 2000-12-27 | 2003-12-09 | Salus Pharma, Inc. | Inhalable dry powder aztreonam for treatment and prevention of pulmonary bacterial infections |
| US7138419B2 (en) * | 2000-12-27 | 2006-11-21 | Corus Pharma, Inc. | Process for manufacturing bulk solutions and a lyophilized pure α-aztreonam lysinate |
| US7214364B2 (en) * | 2000-12-27 | 2007-05-08 | Corus Pharma, Inc. | Inhalable aztreonam lysinate formulation for treatment and prevention of pulmonary bacterial infections |
| JP2005505441A (ja) * | 2001-10-08 | 2005-02-24 | カリフォルニア インスティテュート オブ テクノロジー | 微小加工レンズ、その製造の方法および応用 |
| EP1438019A1 (en) | 2001-10-24 | 2004-07-21 | PARI GmbH Spezialisten für effektive Inhalation | Kit for the preparation of a pharmaceutical composition |
| US20040009126A1 (en) | 2002-03-05 | 2004-01-15 | Transave, Inc. | Inhalation system for prevention and treatment of intracellular infections |
| EP1417958A1 (en) | 2002-11-08 | 2004-05-12 | Pari GmbH | Wet granulation process |
| AU2002356646A1 (en) | 2002-12-11 | 2004-06-30 | Pari Gmbh | Pharmaceutical compositions for the pulmonary delivery of aztreonam |
| JP4741487B2 (ja) | 2003-07-02 | 2011-08-03 | コーラス ファーマ,インコーポレイティド | アズトレオナムl−リジン及びそれを調製するための方法 |
| BRPI0817636A2 (pt) | 2007-10-01 | 2019-09-24 | Gilead Sciences Inc | aztreonam lisina inalada para o tratamento de déficits na qualidade de vida relacionada à saúde em doenças pulmonares |
-
2001
- 2001-12-20 US US10/027,113 patent/US6660249B2/en not_active Expired - Lifetime
- 2001-12-20 DK DK01991523.0T patent/DK1353647T3/da active
- 2001-12-20 EP EP10010411.6A patent/EP2301524B1/en not_active Revoked
- 2001-12-20 ES ES10010411T patent/ES2406405T3/es not_active Expired - Lifetime
- 2001-12-20 IL IL15659601A patent/IL156596A0/xx unknown
- 2001-12-20 EP EP01991523A patent/EP1353647B1/en not_active Expired - Lifetime
- 2001-12-20 AT AT01991523T patent/ATE502623T1/de active
- 2001-12-20 DE DE60144291T patent/DE60144291D1/de not_active Expired - Lifetime
- 2001-12-20 CA CA2708703A patent/CA2708703C/en not_active Expired - Lifetime
- 2001-12-20 PT PT100104116T patent/PT2301524E/pt unknown
- 2001-12-20 DE DE201112100043 patent/DE122011100043I1/de active Pending
- 2001-12-20 AU AU2002231244A patent/AU2002231244B2/en not_active Expired
- 2001-12-20 ES ES01991523T patent/ES2360692T3/es not_active Expired - Lifetime
- 2001-12-20 CA CA2433280A patent/CA2433280C/en not_active Expired - Lifetime
- 2001-12-20 PT PT01991523T patent/PT1353647E/pt unknown
- 2001-12-20 DK DK10010411.6T patent/DK2301524T3/da active
- 2001-12-20 BR BRPI0116757A patent/BRPI0116757B8/pt not_active IP Right Cessation
- 2001-12-20 JP JP2002552504A patent/JP4646489B2/ja not_active Expired - Lifetime
- 2001-12-20 WO PCT/US2001/050062 patent/WO2002051356A2/en not_active Ceased
-
2003
- 2003-06-23 IL IL156596A patent/IL156596A/en active Protection Beyond IP Right Term
- 2003-06-26 NO NO20032946A patent/NO329643B1/no not_active IP Right Cessation
- 2003-09-04 US US10/654,815 patent/US7208141B2/en not_active Expired - Lifetime
-
2007
- 2007-03-28 US US11/729,698 patent/US20080050439A1/en not_active Abandoned
-
2010
- 2010-10-05 NO NO20101377A patent/NO20101377L/no not_active Application Discontinuation
-
2011
- 2011-01-25 NO NO2011001C patent/NO2011001I2/no unknown
- 2011-06-16 CY CY20111100581T patent/CY1111571T1/el unknown
- 2011-08-03 LU LU91851C patent/LU91851I2/fr unknown
- 2011-08-05 NL NL300492C patent/NL300492I2/nl unknown
- 2011-08-16 FR FR11C0030C patent/FR11C0030I2/fr active Active
- 2011-08-22 CY CY2011012C patent/CY2011012I2/el unknown
- 2011-09-08 BE BE2011C029C patent/BE2011C029I2/fr unknown
- 2011-12-19 US US13/330,633 patent/US20120093890A1/en not_active Abandoned
-
2012
- 2012-07-19 IL IL221036A patent/IL221036A0/en unknown
-
2013
- 2013-10-04 US US14/046,539 patent/US9533000B2/en not_active Expired - Fee Related
-
2016
- 2016-11-15 US US15/352,364 patent/US20170296517A1/en not_active Abandoned
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BRPI0116757B8 (pt) | composição, formulação e produto contendo aztreonam e uso do mesmo para aplicação via inalatória | |
| CY1114621T1 (el) | Συνταγοποιηση εισπνευσιμης λυσινικης αζτρεοναμης για τη θεραπευτικη αγωγη και προληψη πνευμονικων βακτηριακων μολυνσεων | |
| NZ631469A (en) | Aerosol fluoroquinolone formulations for improved pharmacokinetics | |
| US8980226B2 (en) | Aerosolized fosfomycin/aminoglycoside combination for the treatment of bacterial respiratory infections | |
| AU2025256218A1 (en) | Method For Reducing Lung Infection | |
| Shah | Progress in the treatment of pulmonary disease in cystic fibrosis | |
| AR040420A1 (es) | Aztreonam inhalable para el tratamiento y la prevencion de infecciones bacterianas pulmonares | |
| AR054219A1 (es) | Formulacion de lisinato de aztreonam inhalable para el tratamiento y la prevencion de infecciones pulmonares bacteriales | |
| CY1114144T1 (el) | Εισπνευσιμη αζτρεοναμη για τη θεραπεια και την προληψη πνευμονικων βακτηριακων λοιμωξεων |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B25C | Requirement related to requested transfer of rights |
Owner name: SALUS PHARMA, INC. (US) Free format text: A FIM DE ATENDER O SOLICITADO NA PETICAO DE TRANSFERENCIA NO 004866/SP DE 18/03/2005, QUEIRA APRESENTAR DOCUMENTO DE CESSAO ONDE CONSTE O NUMERO DO PEDIDO BRASILEIRO A SER TRANSFERIDO, ASSINADO PELA CEDENTE, CESSIONARIA E DUAS TESTEMUNHAS, COM AS DEVIDAS ASSINATURAS NOTARIZADAS E COM A RESPECTIVA LEGALIZACAO CONSULAR. |
|
| B25B | Requested transfer of rights rejected |
Owner name: SALUS PHARMA, INC. (US) Free format text: INDEFERIDO O PEDIDO DE TRANSFERENCIA DE TITULAR SOLICITADO ATRAVES DA PETICAO NO 004866/SP DE 18/03/2005, POR NAO CUMPRIMENTO DE EXIGENCIA PUBLICADA NA RPI 1865 DE 03/10/2006. |
|
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B25A | Requested transfer of rights approved |
Owner name: CORUS PHARMA, INC. (US) Free format text: TRANSFERIDO POR FUSAO DE: SALUS PHARMA, INC. |
|
| B25A | Requested transfer of rights approved |
Owner name: GILEAD SCIENCES, INC. (US) Free format text: TRANSFERIDO POR FUSAO DE: CORUS PHARMA, INC. |
|
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B06H | Technical and formal requirements: requirement cancelled [chapter 6.8 patent gazette] |
Free format text: ANULACAO DA EXIGENCIA 6.6 POR TER SIDO INDEVIDA. REQUERENTE NAO APRESENTOU RESPOSTA A EXIGENCIA CONFORME DISPOE A RESOLUCAO 207 DE 24/04/2009, ENTRETANTO, A RESPOSTA CONSTA NA PETICAO INPI/DESP NO 018110035272 DE 12/09/2011 |
|
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 04/02/2014, OBSERVADAS AS CONDICOES LEGAIS. |
|
| B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 20/12/2001 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF |
|
| B21A | Patent or certificate of addition expired [chapter 21.1 patent gazette] |
Free format text: PATENTE EXTINTA EM 20/12/2021 |