BR9911152A - Inibidores de transcrição de fator nf-kb - Google Patents
Inibidores de transcrição de fator nf-kbInfo
- Publication number
- BR9911152A BR9911152A BR9911152-7A BR9911152A BR9911152A BR 9911152 A BR9911152 A BR 9911152A BR 9911152 A BR9911152 A BR 9911152A BR 9911152 A BR9911152 A BR 9911152A
- Authority
- BR
- Brazil
- Prior art keywords
- sym
- present
- disease
- activation
- diseases
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/58—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/64—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Vascular Medicine (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Urology & Nephrology (AREA)
- AIDS & HIV (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
"INIBIDORES DE TRANSCRIçãO DE FATOR NF-<sym>B" A presente invenção provê composições farmacêuticas de salicil anilida inibidoras de fator de transcrição NF-<sym>B, e processos para tratamento de doenças nas quais ativação de NF-<sym>B está implicada. Mais especificamente, a presente invenção provê processos de tratamento de uma variedade de doenças associadas com ativação de NF-<sym>B incluindo desordens inflamatórias; particularmente artrite reumatóide, doença inflamatória de intestino e asma; dermatose, incluíndo psoríase e dermatite atópica; doenças autoimunes; rejeição de tecido e órgão; mal de Alzheimer, acidente vascular cerebral, aterosclerose, restenose, câncer, incluindo doença de Hodgkin, certas infecções virais, incluindo AIDS, osteoartrite, osteoporose, e Ataxia Telangiestasia através de administração a um paciente em sua necessidade, de um composto da presente invenção.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US8982798P | 1998-06-19 | 1998-06-19 | |
PCT/US1999/013652 WO1999065449A2 (en) | 1998-06-19 | 1999-06-18 | INHIBITORS OF TRANSCRIPTION FACTOR NF-λB |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9911152A true BR9911152A (pt) | 2001-03-06 |
Family
ID=22219773
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9911152-7A BR9911152A (pt) | 1998-06-19 | 1999-06-18 | Inibidores de transcrição de fator nf-kb |
Country Status (21)
Country | Link |
---|---|
US (3) | US6492425B1 (pt) |
EP (1) | EP1085848B1 (pt) |
JP (1) | JP2002518307A (pt) |
KR (1) | KR20010052991A (pt) |
CN (1) | CN1311629A (pt) |
AR (1) | AR019692A1 (pt) |
AT (1) | ATE383769T1 (pt) |
AU (1) | AU4690099A (pt) |
BR (1) | BR9911152A (pt) |
CA (1) | CA2335294A1 (pt) |
CO (1) | CO5021213A1 (pt) |
CZ (1) | CZ20004761A3 (pt) |
DE (1) | DE69937997T2 (pt) |
ES (1) | ES2299251T3 (pt) |
HU (1) | HUP0102782A3 (pt) |
IL (1) | IL140328A0 (pt) |
NO (1) | NO20006451D0 (pt) |
PL (1) | PL348969A1 (pt) |
TR (1) | TR200003781T2 (pt) |
WO (1) | WO1999065449A2 (pt) |
ZA (1) | ZA200007447B (pt) |
Families Citing this family (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2371962A3 (en) | 1996-12-23 | 2011-12-21 | Immunex Corporation | Receptor activator of NF-KAPPA B, receptor is member of TNF receptor superfamily |
US6316408B1 (en) | 1997-04-16 | 2001-11-13 | Amgen Inc. | Methods of use for osetoprotegerin binding protein receptors |
AU762574B2 (en) | 1998-05-14 | 2003-06-26 | Immunex Corporation | Method of inhibiting osteoclast activity |
GB9930616D0 (en) * | 1999-12-24 | 2000-02-16 | Mathilda & Terence Kennedy Ins | Activation and inhibition of the immune system |
EP1134221A1 (en) * | 2000-03-15 | 2001-09-19 | Aventis Pharma Deutschland GmbH | Substituted beta-carbolines as lkB kinase inhibitors |
FR2813315B1 (fr) * | 2000-08-23 | 2002-10-18 | Genfit S A | Procede d'identification de substances utiles pour le traitement de l'inflammation mettant en oeuvre l'element de reponse du recepteur ror du gene ikbalpha |
JP4224566B2 (ja) * | 2000-12-18 | 2009-02-18 | 株式会社医薬分子設計研究所 | 炎症性サイトカイン産生遊離抑制剤 |
WO2003039545A2 (en) * | 2001-11-07 | 2003-05-15 | Millennium Pharmaceuticals, Inc. | Carboline derivatives as inhibitors of ikb in the treatment of multiple myeloma and others cancers |
US7119120B2 (en) | 2001-12-26 | 2006-10-10 | Genzyme Corporation | Phosphate transport inhibitors |
EP1510207A4 (en) * | 2002-06-05 | 2008-12-31 | Inst Med Molecular Design Inc | THERAPEUTIC MEDICAMENT AGAINST DIABETES |
WO2003103658A1 (ja) * | 2002-06-05 | 2003-12-18 | 株式会社医薬分子設計研究所 | 免疫関連プロテインキナーゼ阻害剤 |
EP1514544A4 (en) * | 2002-06-06 | 2009-01-07 | Inst Med Molecular Design Inc | HYPO-ALLERGENIC |
EA009051B1 (ru) * | 2002-06-06 | 2007-10-26 | Инститьют Оф Медисинал Молекьюлар Дизайн. Инк. | О-замещенные гидроксиарильные производные |
TW200307535A (en) * | 2002-06-10 | 2003-12-16 | Inst Med Molecular Design Inc | Therapeutic agent for cancer |
AU2003242098B2 (en) * | 2002-06-10 | 2008-11-20 | Institute Of Medicinal Molecular Design, Inc | Inhibitors against activation of NFkappaB |
CA2488979A1 (en) * | 2002-06-11 | 2003-12-18 | Institute Of Medicinal Molecular Design, Inc. | Medicament for treatment of neurodegenerative diseases |
US7324455B2 (en) | 2003-03-14 | 2008-01-29 | International Business Machines Corporation | Transfer of error-analysis and statistical data in a fibre channel input/output system |
US7981915B2 (en) * | 2003-04-30 | 2011-07-19 | Beth Israel Deaconess Medical Center | Methods for modulating PPAR biological activity for the treatment of diseases caused by mutations in the CFTR gene |
WO2004098510A2 (en) * | 2003-04-30 | 2004-11-18 | Beth Israel Deaconess Medical Center | Cystic fibrosis therapy |
US20050256132A1 (en) * | 2003-04-30 | 2005-11-17 | Wyeth | Use of ER selective NF-kB inhibitors for the treatment of sepsis |
US20050004164A1 (en) * | 2003-04-30 | 2005-01-06 | Caggiano Thomas J. | 2-Cyanopropanoic acid amide and ester derivatives and methods of their use |
EP1653968A4 (en) * | 2003-07-23 | 2006-09-06 | Synta Pharmaceuticals Corp | METHOD FOR MODULATING CALCIUMION RELIEF ACTIVATED CALCIUMION CHANNELS |
US7425580B2 (en) | 2004-05-19 | 2008-09-16 | Wyeth | (Diaryl-methyl)-malononitriles and their use as estrogen receptor ligands |
WO2006117660A2 (en) * | 2005-05-04 | 2006-11-09 | Clio Pharmaceutical Corporation | Method for treating cancer, coronary, inflammatory and macular disease, combining the modulation of zinc- and/or copper dependent proteins |
CN100418532C (zh) * | 2005-06-17 | 2008-09-17 | 吕志民 | 治疗多种疾病的NF-κB化合物抑制剂 |
US7671058B2 (en) * | 2006-06-21 | 2010-03-02 | Institute Of Medicinal Molecular Design, Inc. | N-(3,4-disubstituted phenyl) salicylamide derivatives |
RU2010120675A (ru) | 2007-10-23 | 2011-11-27 | Инститьют Оф Медисинал Молекьюлар Дизайн, Инк. (Jp) | Ингибитор продуцирования pai-1 |
EP2987495A1 (en) | 2007-10-25 | 2016-02-24 | Yale University | Use of phy906 as treatment for inflammatory bowel disease and/or irritable bowel syndrome |
WO2009089277A2 (en) * | 2008-01-08 | 2009-07-16 | The Trustees Of The University Of Pennsylvania | Rel inhibitors and methods of use thereof |
US20090264514A1 (en) * | 2008-04-18 | 2009-10-22 | The Research Foundation Of State University Of New York | SPHINGOMYELIN SYNTHASE 2 (SMS2) DEFICIENCY ATTENUATES NFkB ACTIVATION, A POTENTIAL ANTI-ATHEROGENIC PROPERTY |
US10640457B2 (en) | 2009-12-10 | 2020-05-05 | The Trustees Of Columbia University In The City Of New York | Histone acetyltransferase activators and uses thereof |
CN103347392B (zh) * | 2010-12-22 | 2016-10-12 | 纽约市哥伦比亚大学理事会 | 组蛋白乙酰转移酶调节剂和其用途 |
TWI492920B (zh) * | 2012-04-18 | 2015-07-21 | Nat Defense Medical Ct | 水楊酸苯胺衍生小分子之醫藥組合物及其製備與醫藥用途 |
WO2014113467A1 (en) * | 2013-01-15 | 2014-07-24 | Board Of Regents, The University Of Texas System | Stat3 inhibitor |
AU2014308699C1 (en) | 2013-08-21 | 2022-06-02 | Board Of Regents, The University Of Texas System | Compositions and methods for targeting connexin hemichannels |
CN106604913A (zh) * | 2014-03-31 | 2017-04-26 | 纽约哥伦比亚大学理事会 | 组蛋白乙酰基转移酶激活剂及其用途 |
AU2015314287B2 (en) | 2014-09-12 | 2019-04-18 | UNION therapeutics A/S | Antibacterial use of halogenated salicylanilides |
CN105797154B (zh) * | 2014-12-31 | 2020-03-10 | 中国科学院上海生命科学研究院 | 软骨干细胞的分离及其应用 |
GB201509326D0 (en) | 2015-05-29 | 2015-07-15 | Antibio Tx Aps | Novel use |
WO2017122209A2 (en) * | 2016-01-12 | 2017-07-20 | Yeda Research And Development Co. Ltd. | NF-kappaB INHIBITORS |
CN116672445A (zh) | 2016-02-26 | 2023-09-01 | 德克萨斯大学体系董事会 | 连接蛋白(Cx)43半通道结合抗体及其用途 |
GB201604484D0 (en) * | 2016-03-16 | 2016-04-27 | Antibiotx Aps And Københavns Uni University Of Copenhagen | Topical antibacterial compositions |
MX2019011287A (es) | 2017-03-21 | 2019-12-19 | Novalead Pharma Inc | Agente terapéutico para la inhibición de fosfodiesterasas y sus trastornos relacionados. |
US11419834B2 (en) | 2019-02-25 | 2022-08-23 | Rhode Island Hospital | Methods for treating diseases or infections caused by or associated with H. pylori using a halogenated salicylanilide |
BR112022009457A2 (pt) * | 2019-11-18 | 2022-08-16 | Univ California | Inibidores duplos de receptor androgênico/akr1c3 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1079177A (en) * | 1963-06-11 | 1967-08-16 | Stecker Internat S P A | Improvements in pesticide composition for destroying internal worm parasites in animals |
GB1079178A (en) * | 1966-07-27 | 1967-08-16 | Stecker Internat S P A | Improvements in pesticide compositions for destroying internal worm parasites in animals |
US4742083A (en) * | 1983-08-24 | 1988-05-03 | Lever Brothers Company | Method of relieving pain and inflammatory conditions employing substituted salicylamides |
US4803279A (en) * | 1985-05-23 | 1989-02-07 | Smithkline Beckman Corporation | 1.4-dihydro-4-pyridyl-substituted imidazo (2,1-b) thiazoles and the corresponding thiazines. |
WO1992003451A1 (en) | 1990-08-21 | 1992-03-05 | The Upjohn Company | Bisphosphonic acid derivatives as anti-arthritic agents |
WO1992020795A1 (en) * | 1991-05-17 | 1992-11-26 | Cetus Oncology Corporation | INHIBITOR OF NF-λB TRANSCRIPTIONAL ACTIVATOR AND USES THEREOF |
US5466715A (en) * | 1991-12-31 | 1995-11-14 | Sterling Winthrop Inc. | 3,4-disubstituted phenols-immunomodulating agents |
DE4200534A1 (de) * | 1992-01-11 | 1993-07-15 | Henkel Kgaa | Neue n-benzyl-4-aminophenole und deren verwendung als entwicklerkomponente in oxidationshaarfaerbemitteln |
DE69432985D1 (de) * | 1993-06-15 | 2003-09-04 | Australian Nat University Acto | Synergistische anthelmintische zusammensetzungen gegen fasciola hepatica und andere fascola spezien |
JP2001513503A (ja) * | 1997-08-06 | 2001-09-04 | スミスクライン・ビーチャム・コーポレイション | 心臓血管系の疾病の治療に用いられるマクロファージスカベンジャー受容体アンタゴニスト |
-
1998
- 1998-06-19 HU HU0102782A patent/HUP0102782A3/hu unknown
-
1999
- 1999-06-18 TR TR2000/03781T patent/TR200003781T2/xx unknown
- 1999-06-18 CA CA002335294A patent/CA2335294A1/en not_active Abandoned
- 1999-06-18 CO CO99038264A patent/CO5021213A1/es unknown
- 1999-06-18 US US09/720,018 patent/US6492425B1/en not_active Expired - Fee Related
- 1999-06-18 CZ CZ20004761A patent/CZ20004761A3/cs unknown
- 1999-06-18 AU AU46900/99A patent/AU4690099A/en not_active Abandoned
- 1999-06-18 JP JP2000554329A patent/JP2002518307A/ja not_active Withdrawn
- 1999-06-18 WO PCT/US1999/013652 patent/WO1999065449A2/en active IP Right Grant
- 1999-06-18 PL PL99348969A patent/PL348969A1/xx unknown
- 1999-06-18 KR KR1020007014386A patent/KR20010052991A/ko not_active Application Discontinuation
- 1999-06-18 EP EP99930345A patent/EP1085848B1/en not_active Expired - Lifetime
- 1999-06-18 IL IL14032899A patent/IL140328A0/xx unknown
- 1999-06-18 AR ARP990102955A patent/AR019692A1/es unknown
- 1999-06-18 AT AT99930345T patent/ATE383769T1/de not_active IP Right Cessation
- 1999-06-18 DE DE69937997T patent/DE69937997T2/de not_active Expired - Fee Related
- 1999-06-18 BR BR9911152-7A patent/BR9911152A/pt not_active Application Discontinuation
- 1999-06-18 CN CN99807571A patent/CN1311629A/zh active Pending
- 1999-06-18 ES ES99930345T patent/ES2299251T3/es not_active Expired - Lifetime
-
2000
- 2000-12-13 ZA ZA200007447A patent/ZA200007447B/en unknown
- 2000-12-18 NO NO20006451A patent/NO20006451D0/no not_active Application Discontinuation
-
2002
- 2002-07-31 US US10/210,560 patent/US20030092771A1/en not_active Abandoned
-
2005
- 2005-10-03 US US11/242,572 patent/US20060035979A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
NO20006451L (no) | 2000-12-18 |
IL140328A0 (en) | 2002-02-10 |
AR019692A1 (es) | 2002-03-13 |
DE69937997T2 (de) | 2009-02-19 |
PL348969A1 (en) | 2002-06-17 |
ZA200007447B (en) | 2002-02-13 |
WO1999065449A3 (en) | 2000-03-30 |
US20030092771A1 (en) | 2003-05-15 |
HUP0102782A3 (en) | 2002-12-28 |
ES2299251T3 (es) | 2008-05-16 |
US6492425B1 (en) | 2002-12-10 |
EP1085848A2 (en) | 2001-03-28 |
WO1999065449A2 (en) | 1999-12-23 |
DE69937997D1 (pt) | 2008-03-06 |
AU4690099A (en) | 2000-01-05 |
US20060035979A1 (en) | 2006-02-16 |
WO1999065449A8 (en) | 2001-03-08 |
CA2335294A1 (en) | 1999-12-23 |
EP1085848A4 (en) | 2004-09-08 |
NO20006451D0 (no) | 2000-12-18 |
KR20010052991A (ko) | 2001-06-25 |
EP1085848B1 (en) | 2008-01-16 |
CZ20004761A3 (cs) | 2001-08-15 |
TR200003781T2 (tr) | 2001-07-23 |
HUP0102782A2 (hu) | 2001-12-28 |
JP2002518307A (ja) | 2002-06-25 |
CN1311629A (zh) | 2001-09-05 |
CO5021213A1 (es) | 2001-03-27 |
ATE383769T1 (de) | 2008-02-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR9911152A (pt) | Inibidores de transcrição de fator nf-kb | |
BRPI0509340A (pt) | formulação compreendendo inibidores de histona desacetilase | |
MXPA04005376A (es) | Composiciones farmaceuticas y sus usos. | |
UY27993A1 (es) | Derivados de 4-pirrolidino-fenil-bencil eter | |
MX352614B (es) | Nuevos agentes anti-inflamatorios. | |
CY1112370T1 (el) | Παραγωγα σουλφοναμιδης και χρηση αυτων στη ρυθμιση των μεταλλοπρωτεϊνασων | |
EP2037739A4 (en) | POSITIVE ALLOSTERIC EFFECTORS OF BENZYL-SUBSTITUTED QUINOLONE M1 RECEPTOR | |
BR9912179A (pt) | Composição neuroprotetora para a prevenção e/ou tratamento de alterações nervosas e do comportamento devido a estados de ansiedade ou depressão | |
CY1109194T1 (el) | Παραγωγα ν-υδροξυαμιδιου και η χρηση του | |
ECSP034518A (es) | Nuevos retinoides para el tratamiento de enfisema | |
ITMI20031311A1 (it) | Formulazioni per il trattamento di disturbi artrosici. | |
BR9911151A (pt) | Inibidores do fator de transcrição nf-kb | |
CR6606A (es) | 5-cloro-3-(4-metanosulfonilfenil)-6-metil[2,3 ]-bipiridinil en forma cristalina pura y proceso para su sintesis | |
BR0312780A (pt) | Compostos de tiofeno-carboxamida substituìda para o tratamento de inflamação | |
Bas et al. | New insight into the inhibition of the inflammatory response to experimental delayed-type hypersensitivity reactions in mice by scropolioside A | |
Zunino et al. | Resveratrol alters proliferative responses and apoptosis in human activated B lymphocytes in vitro | |
Torshin et al. | Toll-like receptors as a part of osteoarthritis pathophysiology: anti-inflammatory, analgesic and neuroprotective effects | |
WO2003077832A3 (en) | Dexanabinol and dexanabinol analogs regulate inflammation related genes | |
MA30665B1 (fr) | Traitement de maladies rhumatoïdes avec des glucocorticoïdes a liberation retardee. | |
Duarte-Celada et al. | Bilateral carotid dissection due to Eagle syndrome in a young female | |
EP1201240A3 (en) | Heterocyclic derivatives useful as pharmaceutical agents | |
GB0113663D0 (en) | Use of organic compounds | |
CA2462276A1 (en) | 3,4-methylenedioxy-substituted chalcones as therapeutic agents | |
Chaithanya et al. | Anti-inflammatory activity of bioactive flavonoid mesuaferrin-A from Mesua ferrea L. on Lipopolysaccharide-induced pro-inflammatory cytokines in raw 264.7 cells | |
Fridman et al. | Spontaneous urinary voiding of a metallic implant after operative fixation of the pubic symphysis: a case report |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA10 | Dismissal: dismissal - article 33 of industrial property law | ||
B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |