BR9910723A - Composição farmacêutica oral, estável, contendo um composto de piridilsulfinil benzimidazol substituìdo - Google Patents

Composição farmacêutica oral, estável, contendo um composto de piridilsulfinil benzimidazol substituìdo

Info

Publication number
BR9910723A
BR9910723A BR9910723-6A BR9910723A BR9910723A BR 9910723 A BR9910723 A BR 9910723A BR 9910723 A BR9910723 A BR 9910723A BR 9910723 A BR9910723 A BR 9910723A
Authority
BR
Brazil
Prior art keywords
pharmaceutical composition
substituted pyridyl
vinyl pyrrolidone
polymer
stable pharmaceutical
Prior art date
Application number
BR9910723-6A
Other languages
English (en)
Inventor
Dilipkumar Thacharodi
Ashok Rampal
Original Assignee
Ranbaxy Lab Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ranbaxy Lab Ltd filed Critical Ranbaxy Lab Ltd
Publication of BR9910723A publication Critical patent/BR9910723A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4891—Coated capsules; Multilayered drug free capsule shells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

<B>"COMPOSIçãO FARMACêUTICA ORAL, ESTáVEL, CONTENDO UM COMPOSTO DE PIRIDILSULFINIL BENZIMIDAZOL SUBSTITUìDO"<D>. A presente invenção se refere a uma composição farmacêutica que é estável e adequada para administração oral a um paciente, que compreende uma mistura de um composto de piridilsulfinil benzimidazol substituído tendo atividade inibidora de secreção de ácido gástrico (tal como omeprazol, lansoprazol ou pantoprazol) e um veículo farmaceuticamente aceitável. O veículo compreende um polímero tendo unidades monoméricas de vinilpirrolidona, tal como polivinilpirrolidona ou um copolímero de vinilpirrolidona - acetato de vinila. Surpreendentemente, foi agora descoberto que o polímero de vinilpirrolidona atua como um excipiente de estabilização no composto de piridilsulfinil benzimidazol substituído, de modo que a composição não necessita incluir quaisquer componentes alcalinos para evitar a degradação do ingrediente ativo. Numa modalidade preferida, a composição se apresenta na forma de uma cápsula, em que a mistura do composto de piridilsulfinil benzimidazol substituído e do polímero de vinilpirrolidona na forma de uma mistura em pó ou em grânulos, é contida dentro de uma casca de cápsula, cuja casca de cápsula é feita de um material entérico ou é revestida com um material entérico.
BR9910723-6A 1998-05-28 1999-01-26 Composição farmacêutica oral, estável, contendo um composto de piridilsulfinil benzimidazol substituìdo BR9910723A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8622498A 1998-05-28 1998-05-28
PCT/IB1999/000139 WO1999061022A1 (en) 1998-05-28 1999-01-26 A stable oral pharmaceutical composition containing a substituted pyridylsulfinyl benzimidazole

Publications (1)

Publication Number Publication Date
BR9910723A true BR9910723A (pt) 2001-06-12

Family

ID=22197118

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9910723-6A BR9910723A (pt) 1998-05-28 1999-01-26 Composição farmacêutica oral, estável, contendo um composto de piridilsulfinil benzimidazol substituìdo

Country Status (11)

Country Link
US (1) US20020128293A1 (pt)
EP (1) EP0960620B1 (pt)
CN (1) CN1136850C (pt)
AT (1) ATE315396T1 (pt)
AU (1) AU1979699A (pt)
BR (1) BR9910723A (pt)
DE (1) DE69833157T2 (pt)
ES (1) ES2256910T3 (pt)
RU (1) RU2216321C2 (pt)
WO (1) WO1999061022A1 (pt)
ZA (1) ZA9810765B (pt)

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MY148805A (en) * 2002-10-16 2013-05-31 Takeda Pharmaceutical Controlled release preparation
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PE20050150A1 (es) 2003-05-08 2005-03-22 Altana Pharma Ag Una forma de dosificacion que contiene (s)-pantoprazol como ingrediente activo
WO2004112756A1 (en) 2003-06-26 2004-12-29 Isa Odidi Proton pump-inhibitor-containing capsules which comprise subunits differently structured for a delayed release of the active ingredient
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CA2570916C (en) 2004-06-16 2013-06-11 Tap Pharmaceutical Products, Inc. Pulsed release dosage form of a ppi
US8394409B2 (en) 2004-07-01 2013-03-12 Intellipharmaceutics Corp. Controlled extended drug release technology
US10624858B2 (en) 2004-08-23 2020-04-21 Intellipharmaceutics Corp Controlled release composition using transition coating, and method of preparing same
CN101111233A (zh) 2004-12-23 2008-01-23 兰贝克赛实验室有限公司 稳定的口服苯并咪唑组合物及其制备方法
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US9561188B2 (en) 2006-04-03 2017-02-07 Intellipharmaceutics Corporation Controlled release delivery device comprising an organosol coat
US10960077B2 (en) 2006-05-12 2021-03-30 Intellipharmaceutics Corp. Abuse and alcohol resistant drug composition
AU2007266574A1 (en) * 2006-06-01 2007-12-06 Dexcel Pharma Technologies Ltd. Multiple unit pharmaceutical formulation
KR101464771B1 (ko) * 2006-06-01 2014-11-26 머크 샤프 앤드 돔 코포레이션 페닐에프린의 지속 방출용 약제학적 조성물
CN102014638A (zh) 2007-10-12 2011-04-13 武田制药北美公司 与食物摄入无关的治疗胃肠病症的方法
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Also Published As

Publication number Publication date
ES2256910T3 (es) 2006-07-16
CN1136850C (zh) 2004-02-04
DE69833157T2 (de) 2006-08-31
DE69833157D1 (de) 2006-04-06
EP0960620A1 (en) 1999-12-01
US20020128293A1 (en) 2002-09-12
AU1979699A (en) 1999-12-13
RU2216321C2 (ru) 2003-11-20
WO1999061022A1 (en) 1999-12-02
ATE315396T1 (de) 2006-02-15
EP0960620B1 (en) 2006-01-11
CN1237415A (zh) 1999-12-08
ZA9810765B (en) 1999-08-06

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Legal Events

Date Code Title Description
FA10 Dismissal: dismissal - article 33 of industrial property law
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]