BR9910677A - Processo de preparação de ésteres de<244>-fenilalanina substancialmenteenantiomericamente puros e utilização de umaenzima total ou parcialmente purificada de tipoprotease - Google Patents
Processo de preparação de ésteres de<244>-fenilalanina substancialmenteenantiomericamente puros e utilização de umaenzima total ou parcialmente purificada de tipoproteaseInfo
- Publication number
- BR9910677A BR9910677A BR9910677-9A BR9910677A BR9910677A BR 9910677 A BR9910677 A BR 9910677A BR 9910677 A BR9910677 A BR 9910677A BR 9910677 A BR9910677 A BR 9910677A
- Authority
- BR
- Brazil
- Prior art keywords
- preparation
- partially purified
- enantiomerically pure
- fully
- substantially enantiomerically
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title abstract 3
- 102000004190 Enzymes Human genes 0.000 title abstract 2
- 108090000790 Enzymes Proteins 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 102000004882 Lipase Human genes 0.000 abstract 1
- 239000004367 Lipase Substances 0.000 abstract 1
- 108090001060 Lipase Proteins 0.000 abstract 1
- 108091005804 Peptidases Proteins 0.000 abstract 1
- 239000004365 Protease Substances 0.000 abstract 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 235000019421 lipase Nutrition 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
- C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/72—Two oxygen atoms, e.g. hydantoin
- C07D233/80—Two oxygen atoms, e.g. hydantoin with hetero atoms or acyl radicals directly attached to ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
Abstract
"PROCESSO DE PREPARAçãO DE éSTERES DE<244>-FENILALANINA SUBSTANCIALMENTEENANTIOMERICAMENTE PUROS E UTILIZAçãO DE UMAENZIMA TOTAL OU PARCIALMENTE PURIFICADA DE TIPOPROTEASE". Processo de preparação de ésteres de<244>-fenilalanina substancialmente enatiomericamente puros defórmula (1) e (II) nas quais Alk representa um radical alquila linearou ramificado que comporta de 1 a 6 átomos de carbono,caracterizado pelo fato de colocarmos em presença uma misturade enanciómeros de ésteres da <244>-fenilalanina com uma lipase,uma protease, ou uma estearase.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9806339A FR2778671B1 (fr) | 1998-05-14 | 1998-05-14 | Nouveau procede de preparation d'intermediaires de synthese |
PCT/FR1999/001098 WO1999058706A1 (fr) | 1998-05-14 | 1999-05-10 | Nouveau procede de preparation d'intermediaires de synthese |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9910677A true BR9910677A (pt) | 2001-11-20 |
Family
ID=9526525
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9910677-9A BR9910677A (pt) | 1998-05-14 | 1999-05-10 | Processo de preparação de ésteres de<244>-fenilalanina substancialmenteenantiomericamente puros e utilização de umaenzima total ou parcialmente purificada de tipoprotease |
Country Status (17)
Country | Link |
---|---|
US (1) | US6551816B1 (pt) |
EP (1) | EP1076718B1 (pt) |
JP (1) | JP4553485B2 (pt) |
KR (1) | KR100576276B1 (pt) |
CN (1) | CN1196795C (pt) |
AT (1) | ATE217025T1 (pt) |
AU (1) | AU3610299A (pt) |
BR (1) | BR9910677A (pt) |
CA (1) | CA2337269C (pt) |
DE (1) | DE69901388T2 (pt) |
DK (1) | DK1076718T3 (pt) |
ES (1) | ES2175966T3 (pt) |
FR (1) | FR2778671B1 (pt) |
HU (1) | HU228080B1 (pt) |
IL (1) | IL139600A0 (pt) |
PT (1) | PT1076718E (pt) |
WO (1) | WO1999058706A1 (pt) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6759551B1 (en) | 2000-11-03 | 2004-07-06 | Bayer Cropscience S.A. | Chiral (s- or r-methylphenylglycine) amino acid crystal and method for preparing same |
US7794965B2 (en) | 2002-03-13 | 2010-09-14 | Signum Biosciences, Inc. | Method of identifying modulators of PP2A methylase |
US7923041B2 (en) | 2005-02-03 | 2011-04-12 | Signum Biosciences, Inc. | Compositions and methods for enhancing cognitive function |
WO2006084033A1 (en) * | 2005-02-03 | 2006-08-10 | Signum Biosciences, Inc. | Compositions and methods for enhancing cognitive function |
JP2008260755A (ja) * | 2007-03-20 | 2008-10-30 | Sumitomo Chemical Co Ltd | L−ビフェニルアラニン化合物の塩の回収方法、およびそれを用いたビフェニルアラニンエステル化合物の回収方法 |
EP2282735B1 (en) | 2008-04-21 | 2019-01-16 | Signum Biosciences, Inc. | Pp2a modulators for treating alzheimer, parkinson, diabetes |
CN101555211B (zh) * | 2009-05-13 | 2012-01-25 | 浙江九洲药业股份有限公司 | 2-酰基氨基-3-联苯基丙酸的化学合成方法 |
CN102321690B (zh) * | 2011-07-27 | 2012-07-18 | 陆宏国 | 一种酯类手性胺化合物的制备方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3438189A1 (de) * | 1984-10-18 | 1986-04-24 | Hoechst Ag, 6230 Frankfurt | Verfahren zur herstellung aromatisch substituierter l-aminosaeuren |
FR2706456B1 (fr) | 1993-06-18 | 1996-06-28 | Rhone Poulenc Agrochimie | Dérivés optiquement actifs de 2-imidazoline-5-ones et 2-imidazoline-5-thiones fongicides. |
US5552317A (en) * | 1995-05-26 | 1996-09-03 | Industrial Technology Research Institute | Method for preparing optically active homophenylalanine and esters thereof using lipase from wheat germ or Candida lipolytica |
US5552318A (en) * | 1995-05-26 | 1996-09-03 | Industrial Technology Research Institute | Method for preparing optically active amino acids and their esters using wheat germ lipase |
FR2751327A1 (fr) * | 1996-07-22 | 1998-01-23 | Rhone Poulenc Agrochimie | Intermediaires pour la preparation de 2-imidazoline-5-ones |
-
1998
- 1998-05-14 FR FR9806339A patent/FR2778671B1/fr not_active Expired - Fee Related
-
1999
- 1999-05-10 CN CNB998075256A patent/CN1196795C/zh not_active Expired - Lifetime
- 1999-05-10 JP JP2000548497A patent/JP4553485B2/ja not_active Expired - Lifetime
- 1999-05-10 ES ES99918034T patent/ES2175966T3/es not_active Expired - Lifetime
- 1999-05-10 US US09/700,379 patent/US6551816B1/en not_active Expired - Lifetime
- 1999-05-10 WO PCT/FR1999/001098 patent/WO1999058706A1/fr active IP Right Grant
- 1999-05-10 DE DE69901388T patent/DE69901388T2/de not_active Expired - Lifetime
- 1999-05-10 KR KR1020007012766A patent/KR100576276B1/ko not_active IP Right Cessation
- 1999-05-10 BR BR9910677-9A patent/BR9910677A/pt not_active Application Discontinuation
- 1999-05-10 DK DK99918034T patent/DK1076718T3/da active
- 1999-05-10 CA CA002337269A patent/CA2337269C/fr not_active Expired - Fee Related
- 1999-05-10 EP EP99918034A patent/EP1076718B1/fr not_active Expired - Lifetime
- 1999-05-10 PT PT99918034T patent/PT1076718E/pt unknown
- 1999-05-10 AU AU36102/99A patent/AU3610299A/en not_active Abandoned
- 1999-05-10 HU HU0102348A patent/HU228080B1/hu unknown
- 1999-05-10 IL IL13960099A patent/IL139600A0/xx not_active IP Right Cessation
- 1999-05-10 AT AT99918034T patent/ATE217025T1/de active
Also Published As
Publication number | Publication date |
---|---|
KR20010025022A (ko) | 2001-03-26 |
WO1999058706A1 (fr) | 1999-11-18 |
CA2337269A1 (fr) | 1999-11-18 |
DK1076718T3 (da) | 2002-08-12 |
CN1348500A (zh) | 2002-05-08 |
DE69901388T2 (de) | 2002-08-29 |
AU3610299A (en) | 1999-11-29 |
KR100576276B1 (ko) | 2006-05-04 |
ES2175966T3 (es) | 2002-11-16 |
HUP0102348A2 (hu) | 2001-10-28 |
FR2778671A1 (fr) | 1999-11-19 |
FR2778671B1 (fr) | 2002-07-05 |
DE69901388D1 (de) | 2002-06-06 |
JP2002514436A (ja) | 2002-05-21 |
US6551816B1 (en) | 2003-04-22 |
CA2337269C (fr) | 2007-04-10 |
JP4553485B2 (ja) | 2010-09-29 |
EP1076718A1 (fr) | 2001-02-21 |
CN1196795C (zh) | 2005-04-13 |
PT1076718E (pt) | 2002-09-30 |
HU228080B1 (en) | 2012-10-29 |
ATE217025T1 (de) | 2002-05-15 |
IL139600A0 (en) | 2002-02-10 |
HUP0102348A3 (en) | 2006-03-28 |
EP1076718B1 (fr) | 2002-05-02 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B25D | Requested change of name of applicant approved |
Owner name: BAYER CROPSCIENCE S.A. (FR) Free format text: NOME ALTERADO DE: AVENTIS CROPSCIENCE S.A. |
|
B25G | Requested change of headquarter approved |
Owner name: BAYER CROPSCIENCE S.A. (FR) Free format text: ENDERECO ALTERADO CONFORME SOLICITADO NA PETICAO NO 018100045262/SP DE 29/11/2010. |
|
B25A | Requested transfer of rights approved |
Owner name: BAYER SAS (FR) Free format text: TRANSFERIDO POR FUSAO DE: BAYER CROPSCIENCE S.A. |
|
B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: INDEFIRO O PEDIDO DE ACORDO COM O(S) ARTIGO(S) 8O C/C 11 E 13 DA LPI. |
|
B12B | Appeal against refusal [chapter 12.2 patent gazette] |