ES2175966T3 - Nuevo procedimiento de preparacion de productos intermedios de sintesis. - Google Patents

Nuevo procedimiento de preparacion de productos intermedios de sintesis.

Info

Publication number
ES2175966T3
ES2175966T3 ES99918034T ES99918034T ES2175966T3 ES 2175966 T3 ES2175966 T3 ES 2175966T3 ES 99918034 T ES99918034 T ES 99918034T ES 99918034 T ES99918034 T ES 99918034T ES 2175966 T3 ES2175966 T3 ES 2175966T3
Authority
ES
Spain
Prior art keywords
preparation
new procedure
intermediate synthesis
synthesis products
enzyme
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES99918034T
Other languages
English (en)
Inventor
Marie-Claude Bontoux
Olivier Favre-Bulle
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer CropScience SA
Original Assignee
Aventis CropScience SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis CropScience SA filed Critical Aventis CropScience SA
Application granted granted Critical
Publication of ES2175966T3 publication Critical patent/ES2175966T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C07D233/80—Two oxygen atoms, e.g. hydantoin with hetero atoms or acyl radicals directly attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids

Abstract

Procedimiento de preparación de ésteres de -fenilalanina sustancialmente enantiómeramente puros de fórmulas (I) y (II): **fórmula** en las que Alk representa un radica lalquilolinealo ramificado que tiene de1 a 6 átomos de carbono, caracterizado porque se pone en presencia una mezcla de enantiómeros de ésteres de -fenilalanina con una enzima que es una lipasa, una proteasa o una esterasa, con excepción de la enzima PLE (Pig Liver Esterase).
ES99918034T 1998-05-14 1999-05-10 Nuevo procedimiento de preparacion de productos intermedios de sintesis. Expired - Lifetime ES2175966T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9806339A FR2778671B1 (fr) 1998-05-14 1998-05-14 Nouveau procede de preparation d'intermediaires de synthese

Publications (1)

Publication Number Publication Date
ES2175966T3 true ES2175966T3 (es) 2002-11-16

Family

ID=9526525

Family Applications (1)

Application Number Title Priority Date Filing Date
ES99918034T Expired - Lifetime ES2175966T3 (es) 1998-05-14 1999-05-10 Nuevo procedimiento de preparacion de productos intermedios de sintesis.

Country Status (17)

Country Link
US (1) US6551816B1 (es)
EP (1) EP1076718B1 (es)
JP (1) JP4553485B2 (es)
KR (1) KR100576276B1 (es)
CN (1) CN1196795C (es)
AT (1) ATE217025T1 (es)
AU (1) AU3610299A (es)
BR (1) BR9910677A (es)
CA (1) CA2337269C (es)
DE (1) DE69901388T2 (es)
DK (1) DK1076718T3 (es)
ES (1) ES2175966T3 (es)
FR (1) FR2778671B1 (es)
HU (1) HU228080B1 (es)
IL (1) IL139600A0 (es)
PT (1) PT1076718E (es)
WO (1) WO1999058706A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6759551B1 (en) 2000-11-03 2004-07-06 Bayer Cropscience S.A. Chiral (s- or r-methylphenylglycine) amino acid crystal and method for preparing same
EP1483283A4 (en) 2002-03-13 2007-04-11 Signum Biosciences Inc MODULATION OF PROTEIN METHYLATION AND PHOSPHOPROTEIN PHOSPHATE
US7923041B2 (en) 2005-02-03 2011-04-12 Signum Biosciences, Inc. Compositions and methods for enhancing cognitive function
CA2601777A1 (en) * 2005-02-03 2006-08-10 Signum Biosciences, Inc. Compositions and methods for enhancing cognitive function
JP2008260755A (ja) * 2007-03-20 2008-10-30 Sumitomo Chemical Co Ltd Ｌ−ビフェニルアラニン化合物の塩の回収方法、およびそれを用いたビフェニルアラニンエステル化合物の回収方法
JP5607025B2 (ja) 2008-04-21 2014-10-15 シグナム バイオサイエンシーズ， インコーポレイテッド 化合物、組成物およびそれらを作製する方法
CN101555211B (zh) * 2009-05-13 2012-01-25 浙江九洲药业股份有限公司 2-酰基氨基-3-联苯基丙酸的化学合成方法
CN102321690B (zh) * 2011-07-27 2012-07-18 陆宏国 一种酯类手性胺化合物的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3438189A1 (de) * 1984-10-18 1986-04-24 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung aromatisch substituierter l-aminosaeuren
FR2706456B1 (fr) * 1993-06-18 1996-06-28 Rhone Poulenc Agrochimie Dérivés optiquement actifs de 2-imidazoline-5-ones et 2-imidazoline-5-thiones fongicides.
US5552317A (en) * 1995-05-26 1996-09-03 Industrial Technology Research Institute Method for preparing optically active homophenylalanine and esters thereof using lipase from wheat germ or Candida lipolytica
US5552318A (en) * 1995-05-26 1996-09-03 Industrial Technology Research Institute Method for preparing optically active amino acids and their esters using wheat germ lipase
FR2751327A1 (fr) * 1996-07-22 1998-01-23 Rhone Poulenc Agrochimie Intermediaires pour la preparation de 2-imidazoline-5-ones

Also Published As

Publication number Publication date
BR9910677A (pt) 2001-11-20
JP4553485B2 (ja) 2010-09-29
FR2778671A1 (fr) 1999-11-19
HUP0102348A3 (en) 2006-03-28
DE69901388T2 (de) 2002-08-29
CN1348500A (zh) 2002-05-08
PT1076718E (pt) 2002-09-30
CA2337269C (fr) 2007-04-10
US6551816B1 (en) 2003-04-22
EP1076718A1 (fr) 2001-02-21
DK1076718T3 (da) 2002-08-12
FR2778671B1 (fr) 2002-07-05
KR100576276B1 (ko) 2006-05-04
ATE217025T1 (de) 2002-05-15
CN1196795C (zh) 2005-04-13
DE69901388D1 (de) 2002-06-06
AU3610299A (en) 1999-11-29
WO1999058706A1 (fr) 1999-11-18
HUP0102348A2 (hu) 2001-10-28
HU228080B1 (en) 2012-10-29
EP1076718B1 (fr) 2002-05-02
KR20010025022A (ko) 2001-03-26
CA2337269A1 (fr) 1999-11-18
JP2002514436A (ja) 2002-05-21
IL139600A0 (en) 2002-02-10

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