BR9910672A - 1a-hidróxi-25-eno-vitamina d, análogos e seus usos - Google Patents
1a-hidróxi-25-eno-vitamina d, análogos e seus usosInfo
- Publication number
- BR9910672A BR9910672A BR9910672-8A BR9910672A BR9910672A BR 9910672 A BR9910672 A BR 9910672A BR 9910672 A BR9910672 A BR 9910672A BR 9910672 A BR9910672 A BR 9910672A
- Authority
- BR
- Brazil
- Prior art keywords
- ene
- analogues
- vitamin
- hydroxy
- treatment
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A61K31/592—9,10-Secoergostane derivatives, e.g. ergocalciferol, i.e. vitamin D2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Immunology (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
"1<244>-HIDRóXI - 25 - ENO - VITAMINA D, ANáLOGOS E SEUS USOS" A invenção apresenta compostos de 1<244>- hidroxivitamina D, emq eu a posição C - 25 ou equivalente da cadeia colateral C - 17 tem uma dupla ligação, e seu uso no tratamento e profilaxia de hiperparatireoidismo e doenças hiperproliferativas, e na modulação das respostas imune e inflamatória, assim como no tratamento de distúrbios de depleção óssea.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/087,439 US5972917A (en) | 1998-05-29 | 1998-05-29 | 1 α-hydroxy-25-ene-vitamin D, analogs and uses thereof |
PCT/US1999/012062 WO1999061418A2 (en) | 1998-05-29 | 1999-05-28 | 1α-HYDROXY-25-ENE-VITAMIN D, ANALOGS AND USES THEREOF |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9910672A true BR9910672A (pt) | 2001-01-30 |
Family
ID=22205199
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9910672-8A BR9910672A (pt) | 1998-05-29 | 1999-05-28 | 1a-hidróxi-25-eno-vitamina d, análogos e seus usos |
Country Status (14)
Country | Link |
---|---|
US (1) | US5972917A (pt) |
EP (1) | EP1082298B1 (pt) |
JP (1) | JP2002516307A (pt) |
CN (1) | CN1238341C (pt) |
AT (1) | ATE253554T1 (pt) |
AU (1) | AU754211B2 (pt) |
BR (1) | BR9910672A (pt) |
CA (1) | CA2333270A1 (pt) |
DE (1) | DE69912598T2 (pt) |
DK (1) | DK1082298T3 (pt) |
ES (1) | ES2211107T3 (pt) |
IL (1) | IL139353A (pt) |
PT (1) | PT1082298E (pt) |
WO (1) | WO1999061418A2 (pt) |
Families Citing this family (51)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20020183288A1 (en) * | 1995-04-03 | 2002-12-05 | Bone Care International, Inc. | Method for treating and preventing hyperparathyroidism |
US6242434B1 (en) * | 1997-08-08 | 2001-06-05 | Bone Care International, Inc. | 24-hydroxyvitamin D, analogs and uses thereof |
US20040043971A1 (en) * | 1995-04-03 | 2004-03-04 | Bone Care International, Inc. | Method of treating and preventing hyperparathyroidism with active vitamin D analogs |
US20020128240A1 (en) * | 1996-12-30 | 2002-09-12 | Bone Care International, Inc. | Treatment of hyperproliferative diseases using active vitamin D analogues |
US20030129194A1 (en) * | 1997-02-13 | 2003-07-10 | Bone Care International, Inc. | Targeted therapeutic delivery of vitamin D compounds |
US6392071B1 (en) * | 1997-03-17 | 2002-05-21 | Wisconsin Alumni: Research Foundation | 26,27-homologated-20-EPI-2-alkylidene-19-nor-vitamin D compounds |
US6087350A (en) | 1997-08-29 | 2000-07-11 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Use of pretreatment chemicals to enhance efficacy of cytotoxic agents |
AUPP405098A0 (en) * | 1998-06-12 | 1998-07-02 | Access Pharmaceuticals Australia Pty Limited | Novel methods of preparation of vitamin b12 derivatives suitable for conjugation to pharmaceuticals |
DE60024118T2 (de) * | 1999-09-20 | 2006-07-27 | Eli Lilly And Co., Indianapolis | Verwendung einer parathyroidhormone zur reduktion des krebsrisikos |
WO2002006218A2 (en) * | 2000-07-18 | 2002-01-24 | Bone Care International, Inc. | STABILIZED 1α-HYDROXY VITAMIN D |
US6465446B1 (en) * | 2001-03-12 | 2002-10-15 | John C. Dykstra | Treatment of dermatitis by the topical application of Δ5-androstene-3β-ol-7,17 dione and metabolizable precursors thereof |
US7129230B2 (en) | 2001-03-12 | 2006-10-31 | Nestec S.A. | Method and product for treating cancer in pets |
WO2003047595A1 (en) * | 2001-12-03 | 2003-06-12 | Novacea, Inc. | Pharmaceutical compositions comprising active vitamin d compounds |
AU2002360015A1 (en) * | 2001-12-26 | 2003-07-15 | Chugai Seiyaku Kabushiki Kaisha | 2-substituted vitamin d derivatives |
NZ534863A (en) * | 2002-03-29 | 2005-05-27 | Wisconsin Alumni Res Found | Method of synthesizing 1 alpha-hydroxy-2-methylene-19-nor- vitamin D compounds |
US7148211B2 (en) * | 2002-09-18 | 2006-12-12 | Genzyme Corporation | Formulation for lipophilic agents |
US20040058895A1 (en) * | 2002-09-18 | 2004-03-25 | Bone Care International, Inc. | Multi-use vessels for vitamin D formulations |
US20040053895A1 (en) * | 2002-09-18 | 2004-03-18 | Bone Care International, Inc. | Multi-use vessels for vitamin D formulations |
MXPA05003499A (es) * | 2002-10-23 | 2005-06-17 | Leo Pharma As | Analogos de vitamina d, composiciones que los comprenden y su uso. |
WO2004047673A2 (en) * | 2002-11-21 | 2004-06-10 | Novacea, Inc. | Treatment of liver disease with active vitamin d compounds |
JP2007501865A (ja) * | 2003-06-11 | 2007-02-01 | ノバセア インコーポレイティッド | 放射線治療薬および放射線治療と併用した、活性ビタミンd化合物による癌の治療法 |
EP1631297A4 (en) * | 2003-06-11 | 2007-09-05 | Novacea Inc | TREATMENT OF IMMUNOSTIC DISEASES WITH ACTIVE VITAMIN D COMPOUNDS ALONE OR IN COMBINATION WITH OTHER THERAPEUTICS |
SG110107A1 (en) | 2003-09-24 | 2005-04-28 | Bioxell Spa | Compound and use in treatment |
US7214671B2 (en) * | 2004-02-19 | 2007-05-08 | Wisconsin Alumni Research Foundation | Use of 2-methylene-19-nor-20(S)-1α,25-dihydroxyvitamin D3 for the prophylaxis of bone diseases |
US7713951B2 (en) * | 2004-04-09 | 2010-05-11 | Wisconsin Alumni Research Foundation | 2-alkylidene-18,19-dinor-vitamin D compounds |
US20070275934A1 (en) * | 2004-05-10 | 2007-11-29 | Curd John G | Treatment of pancreatic cancer with active vitamin d compounds in combination with other treatments |
US7094775B2 (en) * | 2004-06-30 | 2006-08-22 | Bone Care International, Llc | Method of treating breast cancer using a combination of vitamin D analogues and other agents |
JP5449767B2 (ja) | 2005-04-25 | 2014-03-19 | サイトクロマ インコーポレイテッド | 1α,25−ジヒドロキシビタミンD3の低血漿カルシウム上昇性16,23−ジエン−25−オキシムアナログ |
JP5155170B2 (ja) * | 2005-10-06 | 2013-02-27 | ネステク ソシエテ アノニム | 免疫を改善するためのプロバイオティックエンテロコッカス |
US9386797B2 (en) | 2011-02-17 | 2016-07-12 | Purecircle Sdn Bhd | Glucosyl stevia composition |
US8257948B1 (en) | 2011-02-17 | 2012-09-04 | Purecircle Usa | Method of preparing alpha-glucosyl Stevia composition |
US9392799B2 (en) | 2011-02-17 | 2016-07-19 | Purecircle Sdn Bhd | Glucosyl stevia composition |
US8318459B2 (en) | 2011-02-17 | 2012-11-27 | Purecircle Usa | Glucosyl stevia composition |
US9107436B2 (en) | 2011-02-17 | 2015-08-18 | Purecircle Sdn Bhd | Glucosylated steviol glycoside as a flavor modifier |
US20100009949A1 (en) * | 2006-03-24 | 2010-01-14 | Bioxell S.P.A. | Novel method |
EA201691980A1 (ru) | 2009-01-27 | 2017-07-31 | БЕРГ ЭлЭлСи | Способы уменьшения побочных эффектов, связанных с химиотерапией |
SG178382A1 (en) | 2009-08-14 | 2012-04-27 | Berg Biosystems Llc | Vitamin d3 and analogs thereof for treating alopecia |
EP4108668A1 (en) | 2010-03-12 | 2022-12-28 | PureCircle USA Inc. | High-purity steviol glycosides |
US10696706B2 (en) | 2010-03-12 | 2020-06-30 | Purecircle Usa Inc. | Methods of preparing steviol glycosides and uses of the same |
KR102125424B1 (ko) * | 2010-03-29 | 2020-06-22 | 사이토크로마 인코포레이티드 | 부갑상선 수준을 낮추기 위한 방법 및 조성물 |
US9510611B2 (en) | 2010-12-13 | 2016-12-06 | Purecircle Sdn Bhd | Stevia composition to improve sweetness and flavor profile |
WO2012082587A2 (en) | 2010-12-13 | 2012-06-21 | Purecircle Usa | Highly soluble rebaudioside d |
WO2014179737A2 (en) | 2013-05-03 | 2014-11-06 | The General Hospital Corporation | Assays and methods of treatment relating to vitamin d insufficiency |
US9052308B2 (en) | 2011-01-07 | 2015-06-09 | The General Hospital Corporation | Assays and methods of treatment relating to vitamin D insufficiency |
EP2661632B1 (en) | 2011-01-07 | 2018-03-07 | The General Hospital Corporation | Assays and methods of treatment relating to vitamin d insufficiency |
WO2012108894A1 (en) | 2011-02-10 | 2012-08-16 | Purecircle Usa | Stevia composition |
US9474296B2 (en) | 2011-02-17 | 2016-10-25 | Purecircle Sdn Bhd | Glucosyl stevia composition |
DE102011112532B4 (de) | 2011-09-05 | 2019-03-21 | Audi Ag | Prüfeinrichtung und Verfahren zum Prüfen von Batteriezellen |
JP6346174B2 (ja) | 2012-05-22 | 2018-06-20 | ピュアサークル スンディリアン ブルハド | 高純度ステビオールグリコシド |
US9370527B2 (en) * | 2012-12-28 | 2016-06-21 | The Regents Of The University Of Michigan | Amelioration of intestinal fibrosis and treatment of Crohn's disease |
CN105492081A (zh) | 2013-05-29 | 2016-04-13 | 博格有限责任公司 | 使用维生素d预防或减轻化疗诱发的脱发 |
Family Cites Families (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4202829A (en) * | 1978-01-05 | 1980-05-13 | Wisconsin Alumni Research Foundation | Process for preparing 1α-hydroxylated compounds |
US4195027A (en) * | 1978-01-16 | 1980-03-25 | Wisconsin Alumni Research Foundation | Process for preparing 1α-hydroxylated compounds |
US4260549A (en) * | 1979-05-21 | 1981-04-07 | Wisconsin Alumni Research Foundation | Process for preparing 1α-hydroxylated compounds |
US4225596A (en) * | 1978-10-13 | 1980-09-30 | Wisconsin Alumni Research Foundation | Method for treating calcium imbalance and improving calcium absorption in mammals |
JPS5626820A (en) * | 1979-08-10 | 1981-03-16 | Chugai Pharmaceut Co Ltd | Immunosuppressing agent |
US4234495A (en) * | 1979-09-10 | 1980-11-18 | Wisconsin Alumni Research Foundation | Process for preparing 1α-hydroxyvitamin D compounds from 1α-hydroxy-3,5-cyclovitamin D compounds |
DK160817C (da) * | 1979-10-23 | 1991-10-07 | Teijin Ltd | Fremgangsmaade til fremstilling af vitamin d3 forbindelser |
JPS57149224A (en) * | 1981-03-13 | 1982-09-14 | Chugai Pharmaceut Co Ltd | Tumor-suppressing agent |
US4652405A (en) * | 1981-08-28 | 1987-03-24 | Hoffman-La Roche Inc. | Synthesis of 1α,25-dihydroxy-24R-fluorocholecalciferol and 1α,25-dihydroxy-24S-fluorocholecalciferol |
US4689180A (en) * | 1984-01-30 | 1987-08-25 | Wisconsin Alumni Research Foundation | 1α,25-dihydroxy-22Z-dehydroxyvitamin D compound |
US4481198A (en) * | 1984-02-13 | 1984-11-06 | Wisconsin Alumni Research Foundation | Vitamin D metabolism inhibitor |
US4554106A (en) * | 1984-11-01 | 1985-11-19 | Wisconsin Alumni Research Foundation | Method for preparing 1α-hydroxyvitamin D compounds |
US4555364A (en) * | 1984-11-01 | 1985-11-26 | Wisconsin Alumni Research Foundation | Method for preparing 1-hydroxyvitamin D compounds |
EP0184112B1 (en) * | 1984-11-27 | 1990-05-09 | Chugai Seiyaku Kabushiki Kaisha | Novel vitamin d derivatives and process for producing the same |
US4749710A (en) * | 1985-05-01 | 1988-06-07 | Hoffmann-La Roche Inc. | Immunosuppressive agents |
JP2711161B2 (ja) * | 1988-04-21 | 1998-02-10 | レオ・ファーマシューティカル・プロダクツ・リミテッド・エイ/エス(レーベンス・ケミスケ・ファブリック・プロデュクチオンスアクチーセルスカブ) | 新規ビタミンd類似体 |
US5250523A (en) * | 1988-04-29 | 1993-10-05 | Wisconsin Alumni Research Foundation | Side chain unsaturated 1α-hydroxyvitanim D homologs |
ATE90075T1 (de) * | 1988-12-12 | 1993-06-15 | Duphar Int Res | Verfahren zur photochemischen umwandlung von tachysterol-derivaten in praevitamin d-derivate und von transvitamin d-derivaten in cisvitamin d- derivate. |
US5098899A (en) * | 1989-03-06 | 1992-03-24 | Trustees Of Boston University | Method for therapeutically treating psoriatic arthritis using vitamin D analogues and metabolites |
CA1333616C (en) * | 1989-03-09 | 1994-12-20 | Hector F. Deluca | 19-nor-vitamin d compounds |
US5063221A (en) * | 1989-04-05 | 1991-11-05 | Chugai Seiyaku Kabushiki Kaisha | Treatment for hyperparathyroidism with use of vitamin d derivatives |
GB8915770D0 (en) * | 1989-07-10 | 1989-08-31 | Leo Pharm Prod Ltd | Chemical compounds |
US5518725A (en) * | 1989-09-25 | 1996-05-21 | University Of Utah Research Foundation | Vaccine compositions and method for induction of mucosal immune response via systemic vaccination |
JP2505313B2 (ja) * | 1989-09-25 | 1996-06-05 | ユニバーシティ オブ ユタ リサーチ ファウンデーション | T細胞リンフォカインの産生を誘発する組成物でのステロイドホルモンの使用 |
US5562910A (en) * | 1989-09-25 | 1996-10-08 | University Of Utah Research Foundation | Vaccine compositions and method for enhancing an immune response |
US5260290A (en) * | 1990-02-14 | 1993-11-09 | Wisconsin Alumni Research Foundation | Homologated vitamin D2 compounds and the corresponding 1α-hydroxylated derivatives |
GB9007236D0 (en) * | 1990-03-30 | 1990-05-30 | Leo Pharm Prod Ltd | Chemical compounds |
ES2073661T3 (es) * | 1990-04-27 | 1995-08-16 | Duphar Int Res | Metodo para la isomerizacion fotoquimica de compuestos organicos bajo la influencia de un fotosensibilizador. |
DE69327480T2 (de) * | 1992-02-27 | 2002-11-21 | Duphar International Research B.V., Weesp | Verfahren zur Herstellung 9-Beta,10-Alpha-5,7-Dien-Steroiden |
DE4220757A1 (de) * | 1992-06-24 | 1994-01-05 | Schering Ag | Derivate in der Vitamin D-Reihe mit Modifikationen in der 20-Position, Verfahren zu ihrer Herstellung, Zwischenprodukte für dieses Verfahren, diese Derivate enthaltende pharmazeutische Präparate sowie deren Verwendung zur Herstellung von Arzneimitteln |
GB9220439D0 (en) * | 1992-09-28 | 1992-11-11 | Leo Pharm Prod Ltd | Chemical compounds |
US5753638A (en) * | 1992-10-07 | 1998-05-19 | Hoffmann-La Roche Inc. | Method of treating hyperproliferative skin disease with Vitamin D3 fluorinated analogs |
GB9223061D0 (en) * | 1992-11-04 | 1992-12-16 | Leo Pharm Prod Ltd | Chemical compounds |
US5449668A (en) * | 1993-06-04 | 1995-09-12 | Duphar International Research B.V. | Vitamin D compounds and method of preparing these compounds |
US5665387A (en) * | 1994-09-01 | 1997-09-09 | K.U. Leuven Research & Development | Methods and compositions for primary and secondary prevention of autoimmune diabetes |
US5559107A (en) * | 1994-10-20 | 1996-09-24 | Gates; Stephen | Regulation of immune response |
NZ307549A (en) * | 1995-06-14 | 1999-11-29 | Schering Ag | Novel vitamin d derivatives with c-25 substituents, process for their preparation, intermediate products and their use in preparing medicaments |
GB9524812D0 (en) * | 1995-12-05 | 1996-02-07 | Leo Pharm Prod Ltd | Chemical compounds |
US5716946A (en) * | 1996-02-13 | 1998-02-10 | Wisconsin Alumni Research Foundation | Multiple sclerosis treatment |
-
1998
- 1998-05-29 US US09/087,439 patent/US5972917A/en not_active Expired - Fee Related
-
1999
- 1999-05-28 AU AU45445/99A patent/AU754211B2/en not_active Ceased
- 1999-05-28 DE DE69912598T patent/DE69912598T2/de not_active Expired - Lifetime
- 1999-05-28 CN CNB998067873A patent/CN1238341C/zh not_active Expired - Fee Related
- 1999-05-28 CA CA002333270A patent/CA2333270A1/en not_active Abandoned
- 1999-05-28 WO PCT/US1999/012062 patent/WO1999061418A2/en active IP Right Grant
- 1999-05-28 AT AT99928357T patent/ATE253554T1/de not_active IP Right Cessation
- 1999-05-28 JP JP2000550824A patent/JP2002516307A/ja active Pending
- 1999-05-28 EP EP99928357A patent/EP1082298B1/en not_active Expired - Lifetime
- 1999-05-28 DK DK99928357T patent/DK1082298T3/da active
- 1999-05-28 ES ES99928357T patent/ES2211107T3/es not_active Expired - Lifetime
- 1999-05-28 PT PT99928357T patent/PT1082298E/pt unknown
- 1999-05-28 BR BR9910672-8A patent/BR9910672A/pt not_active Application Discontinuation
- 1999-05-28 IL IL13935399A patent/IL139353A/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CA2333270A1 (en) | 1999-12-02 |
ES2211107T3 (es) | 2004-07-01 |
CN1303368A (zh) | 2001-07-11 |
EP1082298A2 (en) | 2001-03-14 |
DK1082298T3 (da) | 2004-02-16 |
CN1238341C (zh) | 2006-01-25 |
US5972917A (en) | 1999-10-26 |
IL139353A0 (en) | 2001-11-25 |
EP1082298B1 (en) | 2003-11-05 |
AU754211B2 (en) | 2002-11-07 |
AU4544599A (en) | 1999-12-13 |
PT1082298E (pt) | 2004-03-31 |
WO1999061418A2 (en) | 1999-12-02 |
WO1999061418A3 (en) | 2000-03-23 |
DE69912598D1 (de) | 2003-12-11 |
JP2002516307A (ja) | 2002-06-04 |
IL139353A (en) | 2005-08-31 |
DE69912598T2 (de) | 2004-09-23 |
ATE253554T1 (de) | 2003-11-15 |
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