BR9908186A - Processo para produzir endostatina - Google Patents

Processo para produzir endostatina

Info

Publication number
BR9908186A
BR9908186A BR9908186-5A BR9908186A BR9908186A BR 9908186 A BR9908186 A BR 9908186A BR 9908186 A BR9908186 A BR 9908186A BR 9908186 A BR9908186 A BR 9908186A
Authority
BR
Brazil
Prior art keywords
endostatin
producing
presented
processes
producing endostatin
Prior art date
Application number
BR9908186-5A
Other languages
English (en)
Inventor
Elizabeth I Harding
Bernard N Violand
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Publication of BR9908186A publication Critical patent/BR9908186A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Analytical Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

"PROCESSO PARA PRODUZIR ENDOSTATINA" Apresentam-se processos para produzir endostatina de camundongos e humana. Processos para reduplicar e purificar a endostatina dos corpos de inclusão expressos em bactérias e ácidos nucleicos codificando as formas de comprimento completo e truncadas de endostatina são também apresentados.
BR9908186-5A 1998-02-23 1999-02-19 Processo para produzir endostatina BR9908186A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7558798P 1998-02-23 1998-02-23
PCT/US1999/003271 WO1999042486A1 (en) 1998-02-23 1999-02-19 Method of producing mouse and human endostatin

Publications (1)

Publication Number Publication Date
BR9908186A true BR9908186A (pt) 2000-10-24

Family

ID=22126741

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9908186-5A BR9908186A (pt) 1998-02-23 1999-02-19 Processo para produzir endostatina

Country Status (15)

Country Link
US (1) US6653098B1 (pt)
EP (1) EP1056780A1 (pt)
JP (1) JP2002504494A (pt)
KR (1) KR20010034529A (pt)
CN (1) CN1295580A (pt)
AU (1) AU766154C (pt)
BR (1) BR9908186A (pt)
CA (1) CA2321958A1 (pt)
CZ (1) CZ20003058A3 (pt)
IL (1) IL137995A0 (pt)
NO (1) NO20004170L (pt)
NZ (1) NZ506466A (pt)
PL (1) PL342495A1 (pt)
RU (1) RU2225728C2 (pt)
WO (1) WO1999042486A1 (pt)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6346510B1 (en) * 1995-10-23 2002-02-12 The Children's Medical Center Corporation Therapeutic antiangiogenic endostatin compositions
US7153943B2 (en) * 1997-07-14 2006-12-26 Bolder Biotechnology, Inc. Derivatives of growth hormone and related proteins, and methods of use thereof
AU4182300A (en) * 1999-03-30 2000-10-16 Merck & Co., Inc. Soluble recombinant endostatin
WO2001060839A2 (en) * 2000-02-18 2001-08-23 The United States Of America, As Represented By Secretary Of The Department Of Health And Human Services Method for refolding recombinant endostatin
CA2408851C (en) * 2000-05-16 2011-07-12 Bolder Biotechnology, Inc. Methods for refolding proteins containing free cysteine residues
US7276580B2 (en) 2001-03-12 2007-10-02 Biogen Idec Ma Inc. Neurotrophic factors
CA2864810A1 (en) 2003-04-18 2004-11-04 Biogen Idec Ma, Inc. Polymer-conjugated glycosylated neublastin
US7524811B2 (en) * 2003-08-29 2009-04-28 Children's Medical Center Corporation Anti-angiogenic peptides from the N-terminus of endostatin
CA2537236A1 (en) * 2003-08-29 2005-05-12 Children's Medical Center Corporation Anti-angiogenic peptides for treating or preventing endometriosis
AU2005277227B2 (en) 2004-08-19 2011-10-06 Biogen Ma Inc. Refolding transforming growth factor beta family proteins
BRPI0514534A (pt) 2004-08-19 2008-06-17 Biogen Idec Inc variantes de neublastina
WO2007130154A2 (en) 2005-12-22 2007-11-15 Genentech, Inc. Recombinant production of heparin binding proteins
TWI501774B (zh) 2006-02-27 2015-10-01 Biogen Idec Inc 神經性病症之治療
CN100398557C (zh) * 2006-04-05 2008-07-02 中国药科大学 血管生成抑制多肽及其制备方法和应用
AU2007272412B2 (en) * 2006-07-14 2013-11-07 Genentech, Inc. Refolding of recombinant proteins
BRPI0605212B8 (pt) * 2006-12-12 2021-05-25 Univ Rio De Janeiro processo de produção de endostatina dimerizada ou oligomerizada, endostatina dimerizada ou oligomerizada e composição farmacêutica
WO2008076933A2 (en) 2006-12-14 2008-06-26 Bolder Biotechnology, Inc. Long acting proteins and peptides and methods of making and using the same
US8329655B2 (en) 2007-05-01 2012-12-11 Biogen Idec Ma Inc. Methods for increasing vascularization
EP2445923B1 (en) * 2009-06-22 2018-09-05 Amgen, Inc Refolding proteins using a chemically controlled redox state
EP2445924B2 (en) 2009-06-25 2023-12-13 Amgen Inc. Capture purification processes for proteins expressed in a non-mammalian system
US20130095558A1 (en) * 2011-07-19 2013-04-18 Wenlin Huang Process for producing recombinant human endostatin adenovirus
CN103992400B (zh) * 2014-05-29 2017-01-04 江苏吴中医药集团有限公司苏州中凯生物制药厂 重组人血管内皮抑素的复性液及其制备、使用方法
JP6742300B2 (ja) * 2014-07-14 2020-08-19 ジェンノヴァ バイオファーマシューティカルズ リミテッド ｒＨｕ−ＧＣＳＦの精製のための新規プロセス
CN106008702B (zh) * 2016-07-22 2019-11-26 江苏江山聚源生物技术有限公司 一种规模化分离纯化重组人源胶原蛋白的方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3537708A1 (de) 1985-10-23 1987-04-23 Boehringer Mannheim Gmbh Verfahren zur aktivierung von t-pa nach expression in prokaryonten
JPH01132598A (ja) 1987-10-14 1989-05-25 Pitman Moore Inc 変性剤溶液中に含まれる組換え蛋白質における分子内ジスルフィド結合の生成を促進する方法
US5789547A (en) 1995-06-07 1998-08-04 Celtrix Pharmaceuticals, Inc. Method of producing insulin-like growth factor-I (IGF-I) and insulin-like growth factor binding protein-3 (IGFBP-3) with correct folding and disulfide bonding
CZ117798A3 (cs) 1995-10-23 1998-08-12 The Children's Medical Center Corporation Antiangiogenní kompozice a způsoby léčby
US5854205A (en) * 1995-10-23 1998-12-29 The Children's Medical Center Corporation Therapeutic antiangiogenic compositions and methods
SE9504019D0 (sv) 1995-11-13 1995-11-13 Pharmacia Ab Method for production of proteins

Also Published As

Publication number Publication date
CZ20003058A3 (cs) 2001-09-12
NZ506466A (en) 2003-10-31
KR20010034529A (ko) 2001-04-25
EP1056780A1 (en) 2000-12-06
RU2225728C2 (ru) 2004-03-20
AU766154C (en) 2004-05-20
JP2002504494A (ja) 2002-02-12
CA2321958A1 (en) 1999-08-26
AU766154B2 (en) 2003-10-09
US6653098B1 (en) 2003-11-25
NO20004170D0 (no) 2000-08-21
IL137995A0 (en) 2001-10-31
PL342495A1 (en) 2001-06-04
NO20004170L (no) 2000-10-23
WO1999042486A1 (en) 1999-08-26
AU3294599A (en) 1999-09-06
CN1295580A (zh) 2001-05-16

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 8A,9A E 10A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 1990 DE 25/02/2009.