BR9906356A - Sistema de diagnostico e metodo para determinacao da presenca de um composto genotoxico numa amostra. - Google Patents

Sistema de diagnostico e metodo para determinacao da presenca de um composto genotoxico numa amostra.

Info

Publication number
BR9906356A
BR9906356A BR9906356-5A BR9906356A BR9906356A BR 9906356 A BR9906356 A BR 9906356A BR 9906356 A BR9906356 A BR 9906356A BR 9906356 A BR9906356 A BR 9906356A
Authority
BR
Brazil
Prior art keywords
reporter
diagnostic system
organism
sample
determining
Prior art date
Application number
BR9906356-5A
Other languages
English (en)
Inventor
Daniel Van Der Lelie
Luc Agnes Louis Jean Regniers
Safiyh Taghavi
Philippe Gilbert Ghi Corbisier
Luc Phillipine Edou Verschaeve
Original Assignee
Vlaamse Instelling Voour Techn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vlaamse Instelling Voour Techn filed Critical Vlaamse Instelling Voour Techn
Publication of BR9906356A publication Critical patent/BR9906356A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

"SISTEMA DE DIAGNóSTICO E MéTODO PARA DETERMINAçãO DA PRESENçA DE UM COMPOSTO GENOTóXICO NUMA AMOSTRA". O presente invento respeita a um sistema de diagnóstico feito de: um microrganismo transformado capaz de uma elevada atividade informativa quando exposto a uma agressão ambiental, microrganismo esse possuindo uma sequência promotora induzida pela tensão, sendo operativamente ligado a uma sequência informativa codificadora de ácidos nucleicos codificando uma molécula informativa que resulta num sinal que pode ser analisado; e de um microrganismo transformado tendo uma sequência constitutiva e promotora não induzida pela tensão, sendo operativamente ligada a uma sequência informativa codificadora de ácidos nucleicos codificando uma molécula informativa que resulta num sinal que pode ser analisado.
BR9906356-5A 1998-04-14 1999-04-12 Sistema de diagnostico e metodo para determinacao da presenca de um composto genotoxico numa amostra. BR9906356A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98870081A EP0950717A1 (en) 1998-04-14 1998-04-14 Diagnostic system and method for determining the presence of a genotoxic compound in a sample
PCT/BE1999/000049 WO1999053092A1 (en) 1998-04-14 1999-04-12 Diagnostic system and method for determining the presence of a genotoxic compound in a sample

Publications (1)

Publication Number Publication Date
BR9906356A true BR9906356A (pt) 2000-09-19

Family

ID=8237025

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9906356-5A BR9906356A (pt) 1998-04-14 1999-04-12 Sistema de diagnostico e metodo para determinacao da presenca de um composto genotoxico numa amostra.

Country Status (13)

Country Link
US (1) US6472152B1 (pt)
EP (2) EP0950717A1 (pt)
JP (1) JP4272265B2 (pt)
CN (1) CN1227367C (pt)
AT (1) ATE351922T1 (pt)
AU (1) AU3694499A (pt)
BR (1) BR9906356A (pt)
CA (1) CA2290354C (pt)
DE (1) DE69934847T2 (pt)
DK (1) DK0977896T3 (pt)
ES (1) ES2281173T3 (pt)
PT (1) PT977896E (pt)
WO (1) WO1999053092A1 (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6642057B1 (en) * 1989-03-30 2003-11-04 Solomon Zaromb Methods for the detection of harmful substances or traces thereof
AUPP438598A0 (en) 1998-06-29 1998-07-23 Garvan Institute Of Medical Research NPY-Y7 receptor gene
DE10061872A1 (de) * 2000-12-12 2002-06-20 Lichtenberg Frate Hella Hefestamm zur Prüfung der Geno- und Zytotoxizität komplexer Umweltkontaminationen
US7455375B2 (en) 2001-08-23 2008-11-25 Hewlett-Packard Development Company, L.P. Removable media storage method and device for a data storage system
KR20030040923A (ko) * 2001-11-17 2003-05-23 광주과학기술원 산화적 손상과 관련된 유해성 탐지를 위한 재조합발광박테리아 대장균ＤＨ5@/ｐＳｏｄａＬｕｘ（ＥＢＨＪ1）［ＫＣＴＣ10098ＢＰ］
GB0415963D0 (en) * 2004-07-16 2004-08-18 Cxr Biosciences Ltd Detection of cellular stress
DE602005023517D1 (de) 2004-11-24 2010-10-21 Hoffmann La Roche Verfahren zur bestimmung von genotoxizität

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2117665T5 (es) * 1991-03-01 2002-11-16 Vito Genes fusionados y su utilizacion para determinar la presencia de metales o de compuestos xenobioticos.
JP3456703B2 (ja) * 1992-07-06 2003-10-14 プレジデント アンド フェローズ オブ ハーバード カレッジ リポーター遺伝子に融合した細菌のストレスプロモーターを用いる毒性を測定するための方法および診断用キット
IL107815A (en) * 1992-12-04 2003-12-10 Du Pont Genetic constructs comprising a stress-responsive promoter linked to a lux reporter operon and methods of use in environmental testing
EP0649905B1 (en) * 1993-10-22 1998-09-23 Kabushiki Kaisha Toyota Chuo Kenkyusho Methods of detection of mutagens using luminescence gene
WO1996016187A1 (en) * 1994-11-23 1996-05-30 E.I. Du Pont De Nemours And Company Lyophilized bioluminescent bacterial reagent for the detection of toxicants
EP0907748B1 (en) * 1996-04-25 2013-06-12 "VLAAMSE INSTELLING VOOR TECHNOLOGISCH ONDERZOEK", afgekort "V.I.T.O." Recombinant nucleic acid sequences and methods for determining both genotoxicity and mutagenicity of a sample and the kinetics of the genetoxicity

Also Published As

Publication number Publication date
CN1227367C (zh) 2005-11-16
CA2290354C (en) 2009-09-22
DE69934847D1 (de) 2007-03-08
JP2002509446A (ja) 2002-03-26
JP4272265B2 (ja) 2009-06-03
EP0977896A1 (en) 2000-02-09
ATE351922T1 (de) 2007-02-15
CN1263561A (zh) 2000-08-16
US6472152B1 (en) 2002-10-29
ES2281173T3 (es) 2007-09-16
CA2290354A1 (en) 1999-10-21
DK0977896T3 (da) 2007-05-21
EP0950717A1 (en) 1999-10-20
PT977896E (pt) 2007-04-30
AU3694499A (en) 1999-11-01
DE69934847T2 (de) 2007-11-08
EP0977896B1 (en) 2007-01-17
WO1999053092A1 (en) 1999-10-21

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