BR9901551B1 - processo para preparação de ácido 13-cis -retinóico. - Google Patents
processo para preparação de ácido 13-cis -retinóico.Info
- Publication number
- BR9901551B1 BR9901551B1 BRPI9901551-0A BR9901551A BR9901551B1 BR 9901551 B1 BR9901551 B1 BR 9901551B1 BR 9901551 A BR9901551 A BR 9901551A BR 9901551 B1 BR9901551 B1 BR 9901551B1
- Authority
- BR
- Brazil
- Prior art keywords
- cis
- retinoic acid
- preparing
- vinyl
- ionol
- Prior art date
Links
- SHGAZHPCJJPHSC-NUEINMDLSA-N Isotretinoin Chemical compound OC(=O)C=C(C)/C=C/C=C(C)C=CC1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-NUEINMDLSA-N 0.000 title abstract 2
- 229960005280 isotretinoin Drugs 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- PZGYHDPZANRCSM-PKNBQFBNSA-N (1e)-3-methyl-1-(2,6,6-trimethylcyclohexen-1-yl)penta-1,4-dien-3-ol Chemical compound CC1=C(\C=C\C(C)(O)C=C)C(C)(C)CCC1 PZGYHDPZANRCSM-PKNBQFBNSA-N 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 229910001385 heavy metal Inorganic materials 0.000 abstract 1
- 229930002839 ionone Natural products 0.000 abstract 1
- 150000002499 ionone derivatives Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 150000004794 vinyl magnesium halides Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
- C07C403/20—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by carboxyl groups or halides, anhydrides, or (thio)esters thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/09—Geometrical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT98MI001093A IT1299582B1 (it) | 1998-05-19 | 1998-05-19 | Procedimento per la preparazione dell'acido 13-cis-retinoico |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR9901551A BR9901551A (pt) | 2000-05-30 |
| BR9901551B1 true BR9901551B1 (pt) | 2010-10-19 |
Family
ID=11380052
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI9901551-0A BR9901551B1 (pt) | 1998-05-19 | 1999-05-19 | processo para preparação de ácido 13-cis -retinóico. |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US6177579B1 (enExample) |
| EP (1) | EP0959069B1 (enExample) |
| JP (1) | JP4418048B2 (enExample) |
| AT (1) | ATE226190T1 (enExample) |
| BR (1) | BR9901551B1 (enExample) |
| CA (1) | CA2272439C (enExample) |
| DE (1) | DE69903498T2 (enExample) |
| DK (1) | DK0959069T3 (enExample) |
| ES (1) | ES2185263T3 (enExample) |
| HU (1) | HU229518B1 (enExample) |
| IN (1) | IN188476B (enExample) |
| IT (1) | IT1299582B1 (enExample) |
| NO (1) | NO317759B1 (enExample) |
| PL (1) | PL192958B1 (enExample) |
| SG (1) | SG80628A1 (enExample) |
| ZA (1) | ZA993395B (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008102375A2 (en) * | 2007-02-20 | 2008-08-28 | Ipca Laboratories Limited | A process for preparation of highly pure isotretinoin |
| CN104447459A (zh) * | 2014-11-28 | 2015-03-25 | 重庆华邦制药有限公司 | 异维a酸的新晶型及其制备方法与应用 |
| CN111454141A (zh) * | 2020-04-26 | 2020-07-28 | 上海新华联制药有限公司 | 一种异维a酸缩合物及其制备方法和应用 |
| CN116283495B (zh) * | 2021-12-01 | 2024-12-03 | 万华化学集团股份有限公司 | 一种乙烯基-β-紫罗兰醇的制备方法 |
| CN116462621B (zh) * | 2023-02-20 | 2025-05-27 | 湖北恒安芙林药业股份有限公司 | 一种维a酸的制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3200231A1 (de) | 1982-01-07 | 1983-07-21 | Basf Ag, 6700 Ludwigshafen | (alpha)-pyrone und verfahren zur herstellung von polyencarbonsaeuren |
| DE4313089A1 (de) | 1993-04-22 | 1994-10-27 | Basf Ag | Verfahren zur Herstellung von 13-(Z)-Retinsäure |
| IT1289528B1 (it) | 1996-12-27 | 1998-10-15 | Lab Mag Spa | Procedimento per la preparazione dell'acido 13,cis-retinoico |
-
1998
- 1998-05-19 IT IT98MI001093A patent/IT1299582B1/it active IP Right Grant
-
1999
- 1999-05-17 CA CA2272439A patent/CA2272439C/en not_active Expired - Lifetime
- 1999-05-17 US US09/313,028 patent/US6177579B1/en not_active Expired - Lifetime
- 1999-05-18 AT AT99109784T patent/ATE226190T1/de active
- 1999-05-18 ES ES99109784T patent/ES2185263T3/es not_active Expired - Lifetime
- 1999-05-18 EP EP99109784A patent/EP0959069B1/en not_active Expired - Lifetime
- 1999-05-18 DK DK99109784T patent/DK0959069T3/da active
- 1999-05-18 PL PL333200A patent/PL192958B1/pl unknown
- 1999-05-18 ZA ZA9903395A patent/ZA993395B/xx unknown
- 1999-05-18 IN IN566MA1999 patent/IN188476B/en unknown
- 1999-05-18 DE DE69903498T patent/DE69903498T2/de not_active Expired - Lifetime
- 1999-05-19 HU HU9901651A patent/HU229518B1/hu unknown
- 1999-05-19 JP JP13890999A patent/JP4418048B2/ja not_active Expired - Lifetime
- 1999-05-19 SG SG9902501A patent/SG80628A1/en unknown
- 1999-05-19 NO NO992396A patent/NO317759B1/no not_active IP Right Cessation
- 1999-05-19 BR BRPI9901551-0A patent/BR9901551B1/pt not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ATE226190T1 (de) | 2002-11-15 |
| DE69903498D1 (de) | 2002-11-21 |
| EP0959069B1 (en) | 2002-10-16 |
| SG80628A1 (en) | 2001-05-22 |
| DE69903498T2 (de) | 2003-02-27 |
| JP2000034275A (ja) | 2000-02-02 |
| CA2272439A1 (en) | 1999-11-19 |
| JP4418048B2 (ja) | 2010-02-17 |
| ITMI981093A1 (it) | 1999-11-19 |
| PL333200A1 (en) | 1999-11-22 |
| NO992396L (no) | 1999-11-22 |
| NO992396D0 (no) | 1999-05-19 |
| IT1299582B1 (it) | 2000-03-16 |
| EP0959069A1 (en) | 1999-11-24 |
| NO317759B1 (no) | 2004-12-13 |
| PL192958B1 (pl) | 2006-12-29 |
| DK0959069T3 (da) | 2003-02-24 |
| HU229518B1 (hu) | 2014-01-28 |
| ZA993395B (en) | 1999-11-18 |
| IN188476B (enExample) | 2002-09-28 |
| ES2185263T3 (es) | 2003-04-16 |
| BR9901551A (pt) | 2000-05-30 |
| HUP9901651A3 (en) | 2000-06-28 |
| CA2272439C (en) | 2010-05-11 |
| US6177579B1 (en) | 2001-01-23 |
| HUP9901651A2 (hu) | 1999-12-28 |
| HU9901651D0 (en) | 1999-07-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B15K | Others concerning applications: alteration of classification |
Free format text: ALTERADA DA INT.CL C07C 51/00, C07C 403/20, A61P 17/10 Ipc: C07C 51/00 (2009.01), C07C 403/20 (2009.01), A61P |
|
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 19/10/2010, OBSERVADAS AS CONDICOES LEGAIS. |
|
| B25G | Requested change of headquarter approved | ||
| B25A | Requested transfer of rights approved | ||
| B25D | Requested change of name of applicant approved | ||
| B25A | Requested transfer of rights approved | ||
| B25A | Requested transfer of rights approved | ||
| B21A | Patent or certificate of addition expired [chapter 21.1 patent gazette] |
Free format text: PATENTE EXTINTA EM 19.10.2020 |