BR9901208A - Derivados de ácido acético de fenóxi e de tetrazol de fenóximetila, tendo propriedades anti-tumor, que atuam como antagonistas de atividade mdm2.. - Google Patents

Derivados de ácido acético de fenóxi e de tetrazol de fenóximetila, tendo propriedades anti-tumor, que atuam como antagonistas de atividade mdm2..

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Publication number
BR9901208A
BR9901208A BR9901208-1A BR9901208A BR9901208A BR 9901208 A BR9901208 A BR 9901208A BR 9901208 A BR9901208 A BR 9901208A BR 9901208 A BR9901208 A BR 9901208A
Authority
BR
Brazil
Prior art keywords
group
alkyl
groups
hydrogen
formula
Prior art date
Application number
BR9901208-1A
Other languages
English (en)
Inventor
Roberto Di Domenico
Silke Hansen
Ernesto Menta
Brigitte Kaluza
Ralf Schumacher
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BR9901208A publication Critical patent/BR9901208A/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/62—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by hydrogenation of carbon-to-carbon double or triple bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
    • C07C45/74—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups combined with dehydration
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/82—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups
    • C07C49/83—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/82—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups
    • C07C49/835—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups having unsaturation outside an aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/90—Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
    • C07C69/708—Ethers
    • C07C69/712—Ethers the hydroxy group of the ester being etherified with a hydroxy compound having the hydroxy group bound to a carbon atom of a six-membered aromatic ring

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Patente de Invenção: <B>"DERIVADOS DE áCIDO ACéTICO DE FENóXI E DE TETRAZOL DE FENóXIMETILA, TENDO PROPRIEDADES ANTI-TUMOR, QUE ATUAM COMO ANTAGONISTAS DE ATIVIDADE MDM2"<D>. A presente invenção refere-se a derivados de ácido acético de fenóxi e de tetrazol de fenóximetila de fórmula (I): onde: - o grupo -O-C(R1)(R2)-(CH~ 2~)~ p~-A pode ser em posição orto, meta ou para; - A é selecionado de -COOH, -COO-(C~ 1~-C~ 4~)alquila, -CN ou um grupo de fórmula: em que R' é hidrogênio ou (C~ 1~-C~ 4~)alquila; ou o grupo A-(CH~ 2~)~ p~-C(R1)(R2)- é selecionado de fenila, benzila ou (indolil)metila, que pode ser substituído por grupos R4; - p é 0, 1 ou 2; - R1 e R2 são independentemente selecionados de hidrogênio ou (C~ 1~-C~ 8~)alquila ou eles formam, juntos com o átomo de carbono ao qual eles são ligados, um grupo (C~ 3~-C~ 7~)cicloalquila; - R4 são de 0 a 2 substituentes independentemente selecionados de cloro, bromo, iódo, flúor, grupos (C~ 1~-C~ 8~)alquila, hidróxi, (C~ 1~-C~ 4~) alcóxi, (C~ 1~-C~ 4~)acila, lineares ou ramificados; ou o grupo na fórmula (I) é um grupo naftila que por sua vez pode ser substituído por grupos R4; - n é um número inteiro de 1 a 4; - m é 0 ou 1; - B é selecionado de C~ 1~-C~ 10~ alquila linear ou ramificada, -CO-C(R3)=CH-R, -CH=C(R3)-CO-Ar, -CO-CH(R3)-CH~ 2~-R ou -CO-CH(R3)-CH~ 2~-NR5R6 quando m é 0, ou é -CH=C(R3)-CO-Ar quando m é 1; - R é selecionado de hidrogênio, <B>-Ar<D> ou -CO-<B>Ar<D>; - R3 é hidrogênio ou um grupo (C~ 1~-C~ 8~)alquila; -R5 e R6 são independentemente um grupo (C~ 1~-C~ 4~)alquila, ou eles formam, juntos com o átomo de nitrogênio ao qual eles são ligados, um grupo piperidino, piperazino, (C~ 1~-C~ 8~)alquilpiperazino, morfolino ou tiomorfolino; - <B>Ar<D> é um grupo fenila que pode ser não substituído ou substituído com de 1 a 3 grupos independentemente selecionados de cloro, bromo, iódo, flúor, grupos (C~ 1~-C~ 4~)alquila, hidróxi, (C~ 1~-C~ 4~) alcóxi, (C~ 1~-C~ 4~)acila, lineares ou ramificados, os estereoisómeros deles ou os sais deles com ácidos ou bases farmaceuticamente aceitáveis, para as preparação de um medicamento tendo atividade antagónica de MDM2, novos compostos da fórmula acima mencionada, e composições farmacêuticas contendo pelo menos um daqueles compostos.
BR9901208-1A 1998-03-30 1999-03-29 Derivados de ácido acético de fenóxi e de tetrazol de fenóximetila, tendo propriedades anti-tumor, que atuam como antagonistas de atividade mdm2.. BR9901208A (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP98105726A EP0947511A1 (en) 1998-03-30 1998-03-30 Derivatives of phenoxy acetic acid and of phenoxymethyl tetrazole having antitumor activity

Publications (1)

Publication Number Publication Date
BR9901208A true BR9901208A (pt) 2000-04-25

Family

ID=8231677

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9901208-1A BR9901208A (pt) 1998-03-30 1999-03-29 Derivados de ácido acético de fenóxi e de tetrazol de fenóximetila, tendo propriedades anti-tumor, que atuam como antagonistas de atividade mdm2..

Country Status (20)

Country Link
EP (1) EP0947511A1 (pt)
JP (1) JP2000063340A (pt)
KR (1) KR19990078366A (pt)
CN (1) CN1232028A (pt)
AR (1) AR018170A1 (pt)
AU (1) AU2250299A (pt)
BR (1) BR9901208A (pt)
CA (1) CA2267047A1 (pt)
HR (1) HRP990093A2 (pt)
HU (1) HUP9900804A3 (pt)
ID (1) ID22335A (pt)
IL (1) IL129191A0 (pt)
MA (1) MA26616A1 (pt)
NO (1) NO991526L (pt)
NZ (1) NZ334874A (pt)
PE (1) PE20000341A1 (pt)
PL (1) PL332273A1 (pt)
SG (1) SG81972A1 (pt)
TR (1) TR199900719A2 (pt)
ZA (1) ZA992407B (pt)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2841784B1 (fr) * 2002-07-08 2007-03-02 Composition a base de derives de 1,3-diphenylprop-2en-1-one substitues, preparation et utilisations
FR2841900B1 (fr) 2002-07-08 2007-03-02 Genfit S A Nouveaux derives de 1,3-diphenylprop-2-en-1-one substitues, preparation et utilisations
FR2857361B1 (fr) * 2003-07-08 2005-09-09 Genfit S A PREPARATION DE DERIVES DE 1,3-DIPHENYPROP-2-¼n-1-one
WO2005063774A1 (en) * 2003-12-22 2005-07-14 Johns Hopkins University Boronic acid aryl analogs
JP2007297283A (ja) * 2004-07-28 2007-11-15 Santen Pharmaceut Co Ltd 新規桂皮酸関連化合物
SG174107A1 (en) * 2006-08-30 2011-09-29 Univ Michigan New small molecule inhibitors of mdm2 and the uses thereof
DE602007006519D1 (de) 2006-09-21 2010-06-24 Hoffmann La Roche Oxindolderivate als antikrebsmittel
US7638548B2 (en) 2006-11-09 2009-12-29 Hoffmann-La Roche Inc. Spiroindolinone derivatives
US7553833B2 (en) 2007-05-17 2009-06-30 Hoffmann-La Roche Inc. 3,3-spiroindolinone derivatives
US7928233B2 (en) 2009-02-10 2011-04-19 Hoffmann-La Roche Inc. Spiroindolinone pyridine derivatives
US8217051B2 (en) 2009-02-17 2012-07-10 Hoffmann-La Roche Inc. Spiroindolinone derivatives
US8076482B2 (en) 2009-04-23 2011-12-13 Hoffmann-La Roche Inc. 3,3′-spiroindolinone derivatives
US8017607B2 (en) 2009-10-14 2011-09-13 Hoffmann-La Roche Inc. N-substituted-pyrrolidines as inhibitors of MDM2-P-53 interactions
US8088815B2 (en) 2009-12-02 2012-01-03 Hoffman-La Roche Inc. Spiroindolinone pyrrolidines
US8288431B2 (en) 2010-02-17 2012-10-16 Hoffmann-La Roche Inc. Substituted spiroindolinones
US8217044B2 (en) 2010-04-28 2012-07-10 Hoffmann-La Roche Inc. Spiroindolinone pyrrolidines

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3255241A (en) * 1961-01-19 1966-06-07 Merck & Co Inc (2-alkylidene acyl)phenoxy-and (2-alkylidene acyl)phenylmercaptocarboxylic acids
BE639727A (pt) * 1962-11-13
US3251064A (en) * 1962-11-13 1966-05-10 Everett M Schultz beta-aminoacylphenoxy-and beta-aminoacylphenylmercapto-derivatives of monocarboxylicacids
US3994955A (en) * 1975-01-20 1976-11-30 G. D. Searle & Co. Substituted phenoxydialkylacetic acids and esters
US4904697A (en) * 1987-04-09 1990-02-27 Merrell Dow Pharmaceuticals Inc. Controlling the growth of certain tumor tissue with chalcone derivatives
JPH0624975A (ja) * 1992-05-12 1994-02-01 Dainippon Ink & Chem Inc 制癌活性増強剤
DE4327365A1 (de) * 1993-08-14 1995-02-16 Boehringer Mannheim Gmbh Verwendung von Phenolen und Phenolderivaten als Arzneimittel mit fibrinogensenkender Wirkung

Also Published As

Publication number Publication date
PE20000341A1 (es) 2000-05-08
TR199900719A2 (xx) 1999-10-21
ID22335A (id) 1999-09-30
JP2000063340A (ja) 2000-02-29
SG81972A1 (en) 2001-07-24
CA2267047A1 (en) 1999-09-30
AR018170A1 (es) 2001-10-31
CN1232028A (zh) 1999-10-20
IL129191A0 (en) 2000-02-17
HUP9900804A3 (en) 2001-08-28
NO991526D0 (no) 1999-03-29
KR19990078366A (ko) 1999-10-25
AU2250299A (en) 1999-10-14
HUP9900804A2 (hu) 1999-11-29
EP0947511A1 (en) 1999-10-06
ZA992407B (en) 1999-09-30
PL332273A1 (en) 1999-10-11
HU9900804D0 (en) 1999-05-28
NZ334874A (en) 2000-08-25
HRP990093A2 (en) 2000-02-29
MA26616A1 (fr) 2004-12-20
NO991526L (no) 1999-10-01

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Legal Events

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FA10 Dismissal: dismissal - article 33 of industrial property law
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]