BR9811926A - Complexo de neutralização de carga de eprosartan arginila e um processo para a sua produção e formulação - Google Patents

Complexo de neutralização de carga de eprosartan arginila e um processo para a sua produção e formulação

Info

Publication number
BR9811926A
BR9811926A BR9811926-5A BR9811926A BR9811926A BR 9811926 A BR9811926 A BR 9811926A BR 9811926 A BR9811926 A BR 9811926A BR 9811926 A BR9811926 A BR 9811926A
Authority
BR
Brazil
Prior art keywords
production
formulation
charge neutralization
neutralization complex
eprosartan
Prior art date
Application number
BR9811926-5A
Other languages
English (en)
Inventor
Manga R Gudipati
John M Jushchyshyn
Nageswara R Palepu
Gopadi M Venkatesh
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of BR9811926A publication Critical patent/BR9811926A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Abstract

"COMPLEXO DE NEUTRALIZAçãO DE CARGA DE EPROSARTAN ARGINILA E UM PROCESSO PARA A SUA PRODUçãO E FORMULAçãO" A invenção relaciona-se ao complexo de neutralização de carga de ácido (E)-<244>-[2-n-butil-1-[(4-carboxifenil)metil]-1H-imidazol-5-il]metileno- 2-tiofenopropiónico arginila, a um processo para a sua produção, às composições contendo o composto e aos métodos de usar o composto para bloquear os receptores para angiotensina II e para tratar a hipertensão, a insuficiência cardíaca congestiva e a insuficiência renal.
BR9811926-5A 1997-08-06 1998-08-04 Complexo de neutralização de carga de eprosartan arginila e um processo para a sua produção e formulação BR9811926A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5499097P 1997-08-06 1997-08-06
PCT/US1998/016245 WO1999007365A1 (en) 1997-08-06 1998-08-04 Eprosartan arginyl charge-neutralization-complex and a process for its production and formulation

Publications (1)

Publication Number Publication Date
BR9811926A true BR9811926A (pt) 2000-08-22

Family

ID=21994861

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9811926-5A BR9811926A (pt) 1997-08-06 1998-08-04 Complexo de neutralização de carga de eprosartan arginila e um processo para a sua produção e formulação

Country Status (27)

Country Link
EP (1) EP1027047B1 (pt)
JP (1) JP4463975B2 (pt)
KR (1) KR100508044B1 (pt)
CN (1) CN1276724A (pt)
AR (1) AR015930A1 (pt)
AT (1) ATE341325T1 (pt)
AU (1) AU739295B2 (pt)
BR (1) BR9811926A (pt)
CA (1) CA2299470C (pt)
CO (1) CO4960666A1 (pt)
CY (1) CY1105851T1 (pt)
CZ (1) CZ296274B6 (pt)
DE (1) DE69836095T2 (pt)
DK (1) DK1027047T3 (pt)
ES (1) ES2273433T3 (pt)
HK (1) HK1031688A1 (pt)
HU (1) HUP0201624A3 (pt)
IL (1) IL134378A (pt)
NO (1) NO317771B1 (pt)
NZ (1) NZ502644A (pt)
PL (1) PL198875B1 (pt)
PT (1) PT1027047E (pt)
SA (1) SA98190592B1 (pt)
TR (1) TR200000350T2 (pt)
TW (1) TW570921B (pt)
WO (1) WO1999007365A1 (pt)
ZA (1) ZA987018B (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA991922B (en) * 1998-03-11 1999-09-13 Smithkline Beecham Corp Novel compositions of eprosartan.
EP1197223B1 (en) * 1999-04-28 2005-02-16 Takeda Pharmaceutical Company Limited Preventives / remedies / progression inhibitors for simplex retinopathy or preproliferating retinopathy
BRPI0406987A (pt) 2003-01-31 2006-01-10 Sankyo Co Medicamento para a prevenção e/ou tratamento de arteriosclerose, medicamentos para a inibição de proliferação de células do músculo liso vascular, de formação de neoìntima dos vasos sanguìneos e de remodelação vascular, medicamento para a prevenção de restenose que segue intervenção coronária percutânea, e, medicamentos para a profilaxia e/ou tratamento de hipertensão ou doenças causadas por hipertensão ou doenças causadas por hipertensão, de doenças cardìacas, de angina do peito, de infarto miocárdico, de arritmia, de morte súbita, de insuficiência cardìaca, de hipertrofia cardìaca, de doenças renais, de nefropatia diabética, de glomerulonefrite, de nefrosclerose, de doenças cerebrovasculares, de infarto cerebral, e de hemorragia cerebral
NO323391B1 (no) 2005-09-28 2007-04-23 Hts Hans Torgersen & Sonn As Barnepose
EP2167047A2 (en) * 2007-06-06 2010-03-31 Dexcel Ltd. Process for forming solid oral dosage forms of angiotensin ii receptor antagonists
JP5476782B2 (ja) * 2009-04-21 2014-04-23 大正製薬株式会社 アルギニン含有錠剤の製造方法
JP5446716B2 (ja) * 2009-10-21 2014-03-19 大正製薬株式会社 アルギニン及びカルニチン含有錠剤の製造方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5185351A (en) * 1989-06-14 1993-02-09 Smithkline Beecham Corporation Imidazolyl-alkenoic acids useful as angiotensin II receptor antagonists
NZ239161A (en) * 1990-07-31 1994-01-26 Smithkline Beecham Corp Substituted [1h-imidazol-5-yl] alkanoic acid derivatives; medicaments,
DE69131021T2 (de) * 1990-12-14 1999-08-12 Smithkline Beecham Corp Angiotensin-ii-rezeptor blockierende zusammensetzungen
JP3214856B2 (ja) * 1990-12-14 2001-10-02 スミスクライン・ビーチャム・コーポレイション イミダゾリル−アルケン酸
US5187159A (en) * 1991-10-07 1993-02-16 Merck & Co., Inc. Angiotensin II antagonists incorporating a substituted 1,3-benzodioxole or 1,3-benzodithiole
DE4208052A1 (de) * 1992-03-13 1993-09-16 Bayer Ag Imidazolyl substituierte phenylessigsaeureamide
FR2688781B1 (fr) * 1992-03-23 1994-07-01 Sanofi Elf Imidazolines n-substituees par un groupement biphenylmethyle, leur preparation, les compositions pharmaceutiques en contenant.
DE4210787A1 (de) * 1992-04-01 1993-10-07 Bayer Ag Cycloalkyl- und Heterocyclyl substituierte Imidazolylpropensäurederivate
JPH0841053A (ja) * 1994-07-28 1996-02-13 Nkk Corp ヘテロアリールアルキル基を有するピリミジン誘導体及 び該誘導体を有効成分として含有するアンジオテンシン ｉｉ拮抗剤
US5645839A (en) * 1995-06-07 1997-07-08 Trustees Of Boston University Combined use of angiotensin inhibitors and nitric oxide stimulators to treat fibrosis
WO1997021707A1 (en) * 1995-12-14 1997-06-19 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone

Also Published As

Publication number Publication date
EP1027047A4 (en) 2002-09-18
CZ296274B6 (cs) 2006-02-15
TR200000350T2 (tr) 2000-12-21
JP4463975B2 (ja) 2010-05-19
WO1999007365A1 (en) 1999-02-18
CY1105851T1 (el) 2011-02-02
EP1027047B1 (en) 2006-10-04
JP2001513498A (ja) 2001-09-04
IL134378A0 (en) 2001-04-30
AU739295B2 (en) 2001-10-11
NO20000577D0 (no) 2000-02-04
AU8768898A (en) 1999-03-01
CZ2000406A3 (cs) 2000-09-13
NO317771B1 (no) 2004-12-13
HUP0201624A2 (hu) 2002-12-28
ES2273433T3 (es) 2007-05-01
CA2299470C (en) 2010-01-26
NZ502644A (en) 2002-03-01
PL198875B1 (pl) 2008-07-31
DE69836095D1 (de) 2006-11-16
CO4960666A1 (es) 2000-09-25
HUP0201624A3 (en) 2003-03-28
CA2299470A1 (en) 1999-02-18
KR100508044B1 (ko) 2005-08-17
DE69836095T2 (de) 2007-04-12
ATE341325T1 (de) 2006-10-15
PT1027047E (pt) 2007-01-31
EP1027047A1 (en) 2000-08-16
AR015930A1 (es) 2001-05-30
HK1031688A1 (en) 2001-06-22
KR20010022582A (ko) 2001-03-26
TW570921B (en) 2004-01-11
DK1027047T3 (da) 2007-01-29
SA98190592B1 (ar) 2006-06-20
NO20000577L (no) 2000-02-29
IL134378A (en) 2004-02-19
ZA987018B (en) 1999-02-08
PL341562A1 (en) 2001-04-23
CN1276724A (zh) 2000-12-13

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PEDIDO DE PATENTE COM BASE NOS ARTIGO 25 DA LPI NO 9.279 DE 14/05/1996