BR9811166A - Processo para a preparação de um triéster de fosforotioato, h-fosfonato, e, processo para a produção de um oligonucleotìdeo h-fosfonato - Google Patents
Processo para a preparação de um triéster de fosforotioato, h-fosfonato, e, processo para a produção de um oligonucleotìdeo h-fosfonatoInfo
- Publication number
- BR9811166A BR9811166A BR9811166-3A BR9811166A BR9811166A BR 9811166 A BR9811166 A BR 9811166A BR 9811166 A BR9811166 A BR 9811166A BR 9811166 A BR9811166 A BR 9811166A
- Authority
- BR
- Brazil
- Prior art keywords
- phosphonate
- preparation
- production
- triester
- phosphorothioate
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 6
- -1 phosphorothioate triester Chemical class 0.000 title abstract 6
- 108091034117 Oligonucleotide Proteins 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- UEZVMMHDMIWARA-UHFFFAOYSA-M phosphonate Chemical compound [O-]P(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-M 0.000 abstract 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000011230 binding agent Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 238000011065 in-situ storage Methods 0.000 abstract 1
- 239000002777 nucleoside Substances 0.000 abstract 1
- 125000003835 nucleoside group Chemical group 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
- C07D265/32—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings with oxygen atoms directly attached to ring carbon atoms
- C07D265/33—Two oxygen atoms, in positions 3 and 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
- C07D207/48—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/16—Esters of thiophosphoric acids or thiophosphorous acids
- C07F9/165—Esters of thiophosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/16—Esters of thiophosphoric acids or thiophosphorous acids
- C07F9/165—Esters of thiophosphoric acids
- C07F9/18—Esters of thiophosphoric acids with hydroxyaryl compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
- C07H11/04—Phosphates; Phosphites; Polyphosphates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9717158.1A GB9717158D0 (en) | 1997-08-13 | 1997-08-13 | Solution synthesis of oligonucleotides and their phosphorothioate analogues |
| PCT/GB1998/002407 WO1999009041A2 (en) | 1997-08-13 | 1998-08-10 | Solution phase synthesis of oligonucleotides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9811166A true BR9811166A (pt) | 2000-07-25 |
Family
ID=10817430
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9811166-3A BR9811166A (pt) | 1997-08-13 | 1998-08-10 | Processo para a preparação de um triéster de fosforotioato, h-fosfonato, e, processo para a produção de um oligonucleotìdeo h-fosfonato |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US6506894B1 (enFirst) |
| EP (2) | EP1325927A3 (enFirst) |
| JP (1) | JP2001515086A (enFirst) |
| KR (1) | KR20010022840A (enFirst) |
| CN (1) | CN1231492C (enFirst) |
| AT (1) | ATE236916T1 (enFirst) |
| BR (1) | BR9811166A (enFirst) |
| CA (1) | CA2300874A1 (enFirst) |
| DE (1) | DE69813243T2 (enFirst) |
| DK (1) | DK1003758T3 (enFirst) |
| EA (1) | EA003091B1 (enFirst) |
| ES (1) | ES2197491T3 (enFirst) |
| GB (1) | GB9717158D0 (enFirst) |
| HU (1) | HUP0002684A3 (enFirst) |
| IL (1) | IL134517A (enFirst) |
| IN (1) | IN190784B (enFirst) |
| NO (1) | NO20000690L (enFirst) |
| NZ (1) | NZ502684A (enFirst) |
| PL (1) | PL338888A1 (enFirst) |
| TR (1) | TR200000384T2 (enFirst) |
| WO (1) | WO1999009041A2 (enFirst) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9924285D0 (en) * | 1999-10-14 | 1999-12-15 | Avecia Ltd | Process |
| GB0004889D0 (en) * | 2000-03-01 | 2000-04-19 | Avecia Ltd | Synthesis of oligonucleotides |
| WO2003045969A1 (en) * | 2001-11-21 | 2003-06-05 | Avecia Biotechnology Inc. | Coupling reagent for h-phosphonate chemistry |
| US6894158B2 (en) * | 2002-02-22 | 2005-05-17 | Honeywell International Inc. | Methods of producing phosphitylated compounds |
| GB0209539D0 (en) | 2002-04-26 | 2002-06-05 | Avecia Ltd | Monomer Polymer and process |
| WO2005077966A1 (en) * | 2004-02-10 | 2005-08-25 | Isis Pharmaceuticals, Inc. | Substituted pixyl protecting groups for oligonucleotide synthesis |
| US9394333B2 (en) | 2008-12-02 | 2016-07-19 | Wave Life Sciences Japan | Method for the synthesis of phosphorus atom modified nucleic acids |
| US8272150B2 (en) * | 2008-12-12 | 2012-09-25 | Speedplay, Inc. | Shoe sole mounting standard for bicycle cleat |
| CA2747999A1 (en) | 2008-12-23 | 2010-07-01 | Girindus America, Inc. | Sulfurizing reagents and their use for oligonucleotides synthesis |
| MX342945B (es) | 2009-07-06 | 2016-10-18 | Ontorii Inc * | Profármacos de ácido nucleico novedosos y métodos de uso de los mismos. |
| WO2012001126A1 (en) | 2010-06-30 | 2012-01-05 | Girindus America, Inc. | A new method of using n-thio compounds for oligonucleotide synthesis |
| DK2620428T3 (da) | 2010-09-24 | 2019-07-01 | Wave Life Sciences Ltd | Asymmetrisk hjælpegruppe |
| US9605019B2 (en) | 2011-07-19 | 2017-03-28 | Wave Life Sciences Ltd. | Methods for the synthesis of functionalized nucleic acids |
| US20140179875A1 (en) | 2011-07-29 | 2014-06-26 | Girindus America, Inc. | Sulfurization reagents on solid supports |
| SG11201500243WA (en) | 2012-07-13 | 2015-04-29 | Shin Nippon Biomedical Lab Ltd | Chiral nucleic acid adjuvant |
| SG11201500239VA (en) | 2012-07-13 | 2015-03-30 | Wave Life Sciences Japan | Asymmetric auxiliary group |
| KR20240148947A (ko) | 2012-07-13 | 2024-10-11 | 웨이브 라이프 사이언시스 리미티드 | 키랄 제어 |
| WO2014085471A1 (en) * | 2012-11-28 | 2014-06-05 | Prognosdx Health, Inc. | Acid-activated compositions for the treatment of cancers, methods of their use and methods of their preparation |
| WO2015108047A1 (ja) | 2014-01-15 | 2015-07-23 | 株式会社新日本科学 | 免疫誘導活性を有するキラル核酸アジュバンド及び免疫誘導活性剤 |
| EP3095460A4 (en) | 2014-01-15 | 2017-08-23 | Shin Nippon Biomedical Laboratories, Ltd. | Chiral nucleic acid adjuvant having anti-allergic activity, and anti-allergic agent |
| WO2015108048A1 (ja) | 2014-01-15 | 2015-07-23 | 株式会社新日本科学 | 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤 |
| ES2917473T3 (es) | 2014-01-16 | 2022-07-08 | Wave Life Sciences Ltd | Diseño quiral |
| WO2018215049A1 (en) * | 2017-05-23 | 2018-11-29 | F. Hoffmann-La Roche Ag | Process for galnac oligonucleotide conjugates |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3444300A (en) * | 1964-05-05 | 1969-05-13 | Chevron Res | N-polyhaloalkylthio compounds as fungicidal agents |
| FR1519704A (fr) * | 1967-02-14 | 1968-04-05 | Roussel Uclaf | Nouveaux composés dithiocarbamiques hétérocycliques et procédé de préparation |
| US3546185A (en) | 1968-03-20 | 1970-12-08 | Monsanto Co | Inhibiting premature vulcanization of diene rubbers |
| US5149798A (en) * | 1989-04-06 | 1992-09-22 | Worcester Foundation For Experimental Biology | Process for synthesizing oligonucleotides and their analogs adaptable to large scale syntheses |
| JPH08507752A (ja) | 1993-01-08 | 1996-08-20 | ハイブライドン インコーポレイテッド | 二量体ブロックの合成と二量体ブロックを使ったオリゴヌクレオチド結合法 |
| GB9501465D0 (en) | 1995-01-25 | 1995-03-15 | King S College London | Nucleoside phosphorothioate derivatives,synthesis and use thereof |
| GB0004889D0 (en) * | 2000-03-01 | 2000-04-19 | Avecia Ltd | Synthesis of oligonucleotides |
-
1997
- 1997-08-13 GB GBGB9717158.1A patent/GB9717158D0/en active Pending
-
1998
- 1998-08-10 IL IL13451798A patent/IL134517A/en active IP Right Grant
- 1998-08-10 DE DE69813243T patent/DE69813243T2/de not_active Expired - Fee Related
- 1998-08-10 KR KR1020007001442A patent/KR20010022840A/ko not_active Abandoned
- 1998-08-10 HU HU0002684A patent/HUP0002684A3/hu unknown
- 1998-08-10 EP EP03007651A patent/EP1325927A3/en not_active Withdrawn
- 1998-08-10 TR TR2000/00384T patent/TR200000384T2/xx unknown
- 1998-08-10 ES ES98938782T patent/ES2197491T3/es not_active Expired - Lifetime
- 1998-08-10 BR BR9811166-3A patent/BR9811166A/pt not_active IP Right Cessation
- 1998-08-10 WO PCT/GB1998/002407 patent/WO1999009041A2/en not_active Ceased
- 1998-08-10 CA CA002300874A patent/CA2300874A1/en not_active Abandoned
- 1998-08-10 EA EA200000211A patent/EA003091B1/ru not_active IP Right Cessation
- 1998-08-10 EP EP98938782A patent/EP1003758B1/en not_active Expired - Lifetime
- 1998-08-10 CN CNB988099314A patent/CN1231492C/zh not_active Expired - Fee Related
- 1998-08-10 NZ NZ502684A patent/NZ502684A/xx unknown
- 1998-08-10 PL PL98338888A patent/PL338888A1/xx unknown
- 1998-08-10 US US09/485,606 patent/US6506894B1/en not_active Expired - Lifetime
- 1998-08-10 AT AT98938782T patent/ATE236916T1/de not_active IP Right Cessation
- 1998-08-10 DK DK98938782T patent/DK1003758T3/da active
- 1998-08-10 JP JP2000509720A patent/JP2001515086A/ja active Pending
- 1998-08-12 IN IN2353DE1998 patent/IN190784B/en unknown
-
2000
- 2000-02-11 NO NO20000690A patent/NO20000690L/no not_active Application Discontinuation
-
2002
- 2002-11-15 US US10/294,794 patent/US7019127B2/en not_active Expired - Lifetime
-
2005
- 2005-06-28 US US11/167,145 patent/US20050240015A1/en not_active Abandoned
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR9811166A (pt) | Processo para a preparação de um triéster de fosforotioato, h-fosfonato, e, processo para a produção de um oligonucleotìdeo h-fosfonato | |
| Shibahara et al. | Site-directed cleavage of RNA | |
| Kuimelis et al. | Ribozyme-mediated cleavage of a substrate analogue containing an internucleotide-bridging 5 ‘-phosphorothioate: evidence for the single-metal model | |
| MX9700270A (es) | Composicion que contiene acidos nucleicos, preparacion y utilizacion. | |
| DE69521517D1 (de) | Prodrug-oligonukleotide | |
| BR0108771A (pt) | Processos para a preparação de um triéster de fosforotioato, e de oligonucleotìdeo desprotegido, fosforotioato de oligonucleotìdeo, ou oligonucleotìdeo/fosforotioato de oligonucleotìdeo mistos | |
| ATE196912T1 (de) | Propargylethoxyamino nucleotide | |
| BR9803010A (pt) | Composição compreendendo sìlica pirogenada, utilização de uma sìlica pirogenada, processo de tratamento cosmético e processo de maquilagem. | |
| DE69619141D1 (en) | Festphasensynthese von oligonucleotid n3'-p5'-phosphoramidaten | |
| BR9707529A (pt) | Oligunucleotìdeo especificamente hibridizável com dna ou rna. | |
| BR9810369A (pt) | Processo de transferência de ácido nucleico para o interior de um ou mais músculos estriados, in vivo, composição, ácido mucleico e campo elétrico, e, produto de combinação | |
| BR9908930A (pt) | Compósito e artigo absorvente | |
| BR8506001A (pt) | Processo para produzir um alcool superior a partir de uma carga de alimentacao olefinica e de uma com c6 a c12,e residuo hof | |
| FI980862A7 (fi) | Kiraalisia metyylifenyylioksatsolidinoneja | |
| NO983979L (no) | FremgangsmÕte ved nedsettelse av det totale syretall i rÕolje | |
| BR9611356A (pt) | Composição líquida aquosa e processo para formar um revestimento de conversão por fosfato | |
| BR9807253A (pt) | Ligação seletiva e método de ampliação | |
| BR9801643A (pt) | Compostos precursores de fragâncias. | |
| BR0007982A (pt) | Processo para a preparação de um composto, e,composto | |
| BR9813712A (pt) | Derivados de n-fenilamida e n-piridilamida, método para preparação dos mesmos e composições farmacêuticas contendo os mesmos | |
| BR9809158A (pt) | Processo para a preparação de 5'- deóxi-5-fluorouridina | |
| BR0107211A (pt) | Agente para tratar hepatite c | |
| BR0209212A (pt) | Processo de etapa única para a preparação de derivados de tolueno | |
| BR9803582A (pt) | Processo para preparar tebuconazol | |
| ES2188857T3 (es) | Procedimiento para la preparacion de difluorometano. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AO NAO RECOLHIMENTO DA(S) 9A E 10A ANUIDADE(S). |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 DA RPI 1986 DE 27/03/2009. |