BR9810616A - Inibidores de farnesil transferase em combinação com inibidores de hmg coa redutase para o tratamento do cancer - Google Patents
Inibidores de farnesil transferase em combinação com inibidores de hmg coa redutase para o tratamento do cancerInfo
- Publication number
- BR9810616A BR9810616A BR9810616-3A BR9810616A BR9810616A BR 9810616 A BR9810616 A BR 9810616A BR 9810616 A BR9810616 A BR 9810616A BR 9810616 A BR9810616 A BR 9810616A
- Authority
- BR
- Brazil
- Prior art keywords
- inhibitors
- combination
- coa reductase
- hmg coa
- cancer treatment
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Patente de Invenção: <B>''INIBIDORES DE FARNESIL TRANSFERASE EM COMBINAçãO COM INIBIDORES DE HMG CoA REDUTASE PARA O TRATAMENTO DO CANCER"<D>. A presente invenção refere-se a um método para o tratamento do câncer num mamífero, incluindo um ser humano, por administração ao mamífero de um inibidor de FTase em combinação com um inibidor de HMG CoA redutase.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4963897P | 1997-06-16 | 1997-06-16 | |
PCT/IB1998/000881 WO1998057633A1 (en) | 1997-06-16 | 1998-06-05 | FARNESYL TRANSFERASE INHIBITORS IN COMBINATION WITH HMG CoA REDUCTASE INHIBITORS FOR THE TREATMENT OF CANCER |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9810616A true BR9810616A (pt) | 2000-09-12 |
Family
ID=21960890
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9810616-3A BR9810616A (pt) | 1997-06-16 | 1998-06-05 | Inibidores de farnesil transferase em combinação com inibidores de hmg coa redutase para o tratamento do cancer |
Country Status (37)
Country | Link |
---|---|
EP (1) | EP0986387B1 (pt) |
JP (1) | JP3713051B2 (pt) |
KR (1) | KR100392573B1 (pt) |
CN (1) | CN1259868A (pt) |
AP (1) | AP9801261A0 (pt) |
AR (1) | AR013090A1 (pt) |
AT (1) | ATE235905T1 (pt) |
BG (1) | BG103946A (pt) |
BR (1) | BR9810616A (pt) |
CA (1) | CA2294399C (pt) |
CO (1) | CO4950607A1 (pt) |
DE (1) | DE69812933T2 (pt) |
DK (1) | DK0986387T3 (pt) |
DZ (1) | DZ2518A1 (pt) |
EA (1) | EA199901043A1 (pt) |
ES (1) | ES2196559T3 (pt) |
GT (1) | GT199800081A (pt) |
HN (1) | HN1998000091A (pt) |
HR (1) | HRP980328B1 (pt) |
HU (1) | HUP0004624A3 (pt) |
ID (1) | ID23014A (pt) |
IL (1) | IL132765A0 (pt) |
IS (1) | IS5259A (pt) |
MA (1) | MA24569A1 (pt) |
NO (1) | NO996206L (pt) |
NZ (1) | NZ500662A (pt) |
OA (1) | OA11231A (pt) |
PA (1) | PA8453601A1 (pt) |
PE (1) | PE82899A1 (pt) |
PL (1) | PL337651A1 (pt) |
PT (1) | PT986387E (pt) |
SK (1) | SK169699A3 (pt) |
TN (1) | TNSN98088A1 (pt) |
TR (1) | TR199903074T2 (pt) |
UA (1) | UA57081C2 (pt) |
WO (1) | WO1998057633A1 (pt) |
ZA (1) | ZA985182B (pt) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EE200000660A (et) * | 1998-05-12 | 2002-04-15 | Warner-Lambert Company | Valk farnesüültransferaasi ja HMG CoA reduktaasi inhibiitorite kombinatsioonid ja nende kasutamine vähi raviks |
AU6256499A (en) * | 1998-09-24 | 2000-04-10 | Merck & Co., Inc. | A method of treating cancer |
EP1006113A1 (en) | 1998-12-02 | 2000-06-07 | Pfizer Products Inc. | Derivatives of 2-(2-oxo-ethylidene)-imidazolidin-4-one and their use to inhibit abnormal cell growth |
AU4988100A (en) * | 1999-05-07 | 2000-11-21 | Brigham And Women's Hospital | Use of hmgcoa reductase inhibitors in the prevention of diseases whose pathogenesis is dependent on neovascularization |
US6710058B2 (en) | 2000-11-06 | 2004-03-23 | Bristol-Myers Squibb Pharma Company | Monocyclic or bicyclic carbocycles and heterocycles as factor Xa inhibitors |
CA2632091C (en) | 2000-12-19 | 2011-03-22 | Pfizer Products Inc. | Crystal forms of 6-[(4-chloro-phenyl)-hydroxy-(3-methyl-3h-imidazol-4-yl)-methyl]-4-(3-ethynyl-phenyl)-1-methyl-1h-quinolin-2-one, 2,3-dihydroxybutanedioate salts and method of production |
JP4092203B2 (ja) | 2000-12-21 | 2008-05-28 | ニトロメッド,インク. | 新規のシクロオキシゲナーゼ2選択的阻害剤としての置換アリール化合物、組成物、および使用方法 |
US20020151563A1 (en) * | 2001-03-29 | 2002-10-17 | Pfizer Inc. | Farnesyl transferase inhibitors in combination with HMG CoA reductase inhibitors for the inhibition of abnormal cell growth |
US6740757B2 (en) | 2001-08-29 | 2004-05-25 | Pfizer Inc | Enantiomers of 6-[(4-chloro-phenyl)-hydroxy-(3-methyl-3h-imidazol-4-yl)-methyl]-4-[3-(3-hydroxy-3-methyl-but-1-ynyl)-phenyl]-1-methyl-1h-quinolin-2-one and salts thereof, useful in the treatment of cancer |
JP2005200419A (ja) * | 2004-01-16 | 2005-07-28 | National Health Research Inst | 癌治療法 |
US8168667B2 (en) | 2006-05-31 | 2012-05-01 | Galapagos Nv | Imidazolidine derivatives, uses therefor, preparation thereof and compositions comprising such |
GB2463514C (en) | 2008-09-11 | 2018-09-26 | Galapagos Nv | Imidazolidine compounds and uses therefor |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0856315B1 (en) * | 1995-08-09 | 2005-08-24 | Banyu Pharmaceutical Co., Ltd. | Protein-farnesyltransferase inhibitors in combination with hmgcoa-reductase-inhibitors for the treatment of aids |
-
1998
- 1998-05-06 UA UA99126842A patent/UA57081C2/uk unknown
- 1998-06-05 PL PL98337651A patent/PL337651A1/xx unknown
- 1998-06-05 ES ES98921688T patent/ES2196559T3/es not_active Expired - Lifetime
- 1998-06-05 CN CN98805968A patent/CN1259868A/zh active Pending
- 1998-06-05 KR KR10-1999-7011860A patent/KR100392573B1/ko not_active IP Right Cessation
- 1998-06-05 SK SK1696-99A patent/SK169699A3/sk unknown
- 1998-06-05 AT AT98921688T patent/ATE235905T1/de not_active IP Right Cessation
- 1998-06-05 NZ NZ500662A patent/NZ500662A/en unknown
- 1998-06-05 CA CA002294399A patent/CA2294399C/en not_active Expired - Fee Related
- 1998-06-05 EP EP98921688A patent/EP0986387B1/en not_active Expired - Lifetime
- 1998-06-05 WO PCT/IB1998/000881 patent/WO1998057633A1/en not_active Application Discontinuation
- 1998-06-05 DK DK98921688T patent/DK0986387T3/da active
- 1998-06-05 BR BR9810616-3A patent/BR9810616A/pt not_active Application Discontinuation
- 1998-06-05 EA EA199901043A patent/EA199901043A1/ru unknown
- 1998-06-05 TR TR1999/03074T patent/TR199903074T2/xx unknown
- 1998-06-05 DE DE69812933T patent/DE69812933T2/de not_active Expired - Fee Related
- 1998-06-05 ID IDW991597A patent/ID23014A/id unknown
- 1998-06-05 HU HU0004624A patent/HUP0004624A3/hu unknown
- 1998-06-05 PT PT98921688T patent/PT986387E/pt unknown
- 1998-06-05 JP JP50403099A patent/JP3713051B2/ja not_active Expired - Fee Related
- 1998-06-05 IL IL13276598A patent/IL132765A0/xx unknown
- 1998-06-09 HN HN1998000091A patent/HN1998000091A/es unknown
- 1998-06-11 AP APAP/P/1998/001261A patent/AP9801261A0/en unknown
- 1998-06-12 AR ARP980102812A patent/AR013090A1/es unknown
- 1998-06-12 PE PE1998000500A patent/PE82899A1/es not_active Application Discontinuation
- 1998-06-15 PA PA19988453601A patent/PA8453601A1/es unknown
- 1998-06-15 DZ DZ980128A patent/DZ2518A1/xx active
- 1998-06-15 GT GT199800081A patent/GT199800081A/es unknown
- 1998-06-15 MA MA25114A patent/MA24569A1/fr unknown
- 1998-06-15 ZA ZA9805182A patent/ZA985182B/xx unknown
- 1998-06-15 TN TNTNSN98088A patent/TNSN98088A1/fr unknown
- 1998-06-16 HR HR980328A patent/HRP980328B1/xx not_active IP Right Cessation
- 1998-06-16 CO CO98034148A patent/CO4950607A1/es unknown
-
1999
- 1999-11-19 IS IS5259A patent/IS5259A/is unknown
- 1999-12-03 BG BG103946A patent/BG103946A/bg unknown
- 1999-12-10 OA OA9900276A patent/OA11231A/en unknown
- 1999-12-15 NO NO996206A patent/NO996206L/no not_active Application Discontinuation
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: INDEFIRO O PRESENTE PEDIDO DE PATENTE DE ACORDO COM ARTIGO 8O DA LPI |