BR9809183A - Médoto para prognóstico de doença inflamatória associada com polimorfismos de locais de gene il-1, conjunto de diagnóstico, método de determinação suscetibilidade aumentada a desordem inflamatória, e escada alélica - Google Patents

Médoto para prognóstico de doença inflamatória associada com polimorfismos de locais de gene il-1, conjunto de diagnóstico, método de determinação suscetibilidade aumentada a desordem inflamatória, e escada alélica

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Publication number
BR9809183A
BR9809183A BR9809183-2A BR9809183A BR9809183A BR 9809183 A BR9809183 A BR 9809183A BR 9809183 A BR9809183 A BR 9809183A BR 9809183 A BR9809183 A BR 9809183A
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inflammatory disorder
inflammatory
polymorphisms
prognosis
disease
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BR9809183-2A
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English (en)
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Gordon Duff
Angela Cox
Jane Nicola Camp
Saveiro Francesco De Giovine
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Interleukin Genetics Inc
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    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/172—Haplotypes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333—Saccharide [e.g., DNA, etc.]

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  • General Engineering & Computer Science (AREA)
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  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

<B>"MéTODO PARA PROGNóSTICO DE DOENçA INFLAMATóRIA ASSOCIADA COM POLIMORFISMOS DE LOCAIS DE GENE IL-1, CONJUNTO DE DIAGNóSTICO, MéTODO DE DETERMINAçãO DE SUSCETIBILIDADE AUMENTADA A DESORDEM INFLAMATóRIA, E ESCADA ALéLICA"<D> Métodos, análises e conjuntos são apresentados para detectar a suscetibilidade de um paciente a uma desordem inflamatória tal como doença da artéria coronária, osteoporose, nefropatia em diabetes melito, alopecia pelada, doença de Graves, lúpus eritematoso sistêmico, esclerose de líquen, colite ulcerativa, retinopatia diabética, doença peridental, artrite crónica juvenil, especialmente iridociclite crónica, psoríase, diabetes insulino dependente e outras doenças com um componente genético IL-1. O método compreende obter uma amostra biológica de um paciente e determinar a presença ou ausência de um haplótipo específico do agrupamento de gene IL-1 que está associado com uma desordem inflamatória. A detecção de pelo menos um dos alelos no haplótipo indica uma suscetibilidade para a desordem inflamatória.
BR9809183-2A 1997-05-29 1998-05-21 Médoto para prognóstico de doença inflamatória associada com polimorfismos de locais de gene il-1, conjunto de diagnóstico, método de determinação suscetibilidade aumentada a desordem inflamatória, e escada alélica BR9809183A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9711040.7A GB9711040D0 (en) 1997-05-29 1997-05-29 Prediction of inflammatory disease
PCT/GB1998/001481 WO1998054359A1 (en) 1997-05-29 1998-05-21 Prediction of inflammatory disease associated with il-1 geneloci polymorphisms

Publications (1)

Publication Number Publication Date
BR9809183A true BR9809183A (pt) 2000-08-01

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BR9809183-2A BR9809183A (pt) 1997-05-29 1998-05-21 Médoto para prognóstico de doença inflamatória associada com polimorfismos de locais de gene il-1, conjunto de diagnóstico, método de determinação suscetibilidade aumentada a desordem inflamatória, e escada alélica

Country Status (19)

Country Link
US (4) US6268142B1 (pt)
EP (1) EP0983385B1 (pt)
JP (1) JP2002500513A (pt)
CN (1) CN1177059C (pt)
AR (1) AR016754A1 (pt)
AT (1) ATE462800T1 (pt)
AU (1) AU755107B2 (pt)
BR (1) BR9809183A (pt)
CA (1) CA2291731A1 (pt)
DE (1) DE69841588D1 (pt)
EA (1) EA199901097A1 (pt)
ES (1) ES2342992T3 (pt)
GB (1) GB9711040D0 (pt)
IL (1) IL133128A0 (pt)
NO (1) NO995803L (pt)
PL (1) PL337080A1 (pt)
TW (1) TWI236502B (pt)
WO (1) WO1998054359A1 (pt)
ZA (1) ZA984490B (pt)

Families Citing this family (93)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6524795B1 (en) * 1997-03-10 2003-02-25 Interleukin Genetics, Inc. Diagnostics for cardiovascular disorders
US7820383B2 (en) 1997-03-10 2010-10-26 Interleukin Genetics, Inc. Method for diagnosing myocardial infarction
US6720141B1 (en) * 1999-11-01 2004-04-13 Interleukin Genetics, Inc. Diagnostics and therapeutics for restenosis
US20050282198A1 (en) * 1997-05-29 2005-12-22 Interleukin Genetics, Inc. Diagnostics and therapeutics for diseases associated with an IL-1 inflammatory haplotype
GB9723553D0 (en) * 1997-11-07 1998-01-07 Duff Gordon W Prediction of the risk of chronic obstructive airway disease
AU760856B2 (en) * 1997-05-29 2003-05-22 Interleukin Genetics, Inc. Diagnostics and therapeutics for chronic obstructive airway disease
GB9711040D0 (en) 1997-05-29 1997-07-23 Duff Gordon W Prediction of inflammatory disease
US6746839B1 (en) 1998-01-12 2004-06-08 Interleukin Genetics, Inc. Diagnostics and therapeutics for an obstructive airway disease
US20050032077A1 (en) * 1998-03-10 2005-02-10 Duff Gordon W. Detecting genetic predisposition to sight-threatening diabetic retinopathy
GB2336431B (en) * 1998-04-17 2003-06-25 Johnson & Johnson Medical Ltd Method of analysis of chronic wounds
US6733967B1 (en) 1998-04-21 2004-05-11 Interleukin Genetics, Inc. Fetal testing for prediction of low birth weight
IL139131A0 (en) * 1998-04-21 2001-11-25 Interleukin Genetics Inc Fetal testing for prediction of low birth weight
US6251598B1 (en) * 1998-10-30 2001-06-26 Interleukin Genetics, Inc. Methods for diagnosing sepsis
IL144492A0 (en) * 1999-02-10 2002-05-23 Interleukin Genetics Inc Therapeutics and diagnostics based on an il-1b mutation
CA2367294A1 (en) * 1999-04-02 2000-10-12 Interleukin Genetics, Inc. Prediction of risk of interstitial lung disease
WO2001000880A2 (en) * 1999-06-30 2001-01-04 Interleukin Genetics, Inc. Diagnostics and therapeutics for diseases associated with an il-1 inflammatory haplotype
US20090023147A1 (en) * 1999-08-30 2009-01-22 Kenneth Kornman Diagnostics and therapeutics for osteoporosis
ATE318328T1 (de) * 1999-08-30 2006-03-15 Interleukin Genetics Inc Diagnostika und therapeutika für osteoporose
US20030054002A1 (en) * 2000-05-17 2003-03-20 Board Of Regents, The University Of Texas System Isolation of genes within SLE-1B that mediate a break in immune tolerance
WO2002000933A2 (en) * 2000-06-23 2002-01-03 Interleukin Genetics, Inc. Screening assays for identifying modulators of the inflammatory or immune responses
US20020168639A1 (en) * 2000-09-22 2002-11-14 Muraca Patrick J. Profile array substrates
JP2002345500A (ja) * 2000-12-22 2002-12-03 Pfizer Prod Inc 炎症性障害を発展させる増加したリスクを検出するための方法および試薬
NZ545283A (en) * 2001-06-05 2008-01-31 Auckland Uniservices Ltd Methods and compositions for determining a subject's predisposition to developing impaired lung function
EP1409737A4 (en) * 2001-06-15 2005-10-12 Interleukin Genetics Inc METHODS OF DETECTING AND TREATING EARLY APPEARANCE OF CONDITIONS RELATED TO AGING
US20050202421A1 (en) * 2001-10-31 2005-09-15 Raphael Hirsch Method for diagnosis and treatment of rheumatoid arthritis
US20080311581A1 (en) * 2001-11-19 2008-12-18 David Wyllie Functional polymorphisms of the interleukin-1 locus affecting transcription and susceptibility to inflammatory and infectious diseases
KR101019131B1 (ko) 2001-11-19 2011-03-07 인터레우킨 제네틱스, 인코포레이티드 염증성 질환 및 감염성 질환에 대한 감수성 및 전사에영향을 미치는 인터루킨-1 좌의 기능적 다형성
US20070264645A1 (en) * 2002-01-25 2007-11-15 Kenneth Kornman IL-1 gene cluster and associated inflammatory polymorphisms and haplotypes
TWI346700B (en) * 2002-01-25 2011-08-11 Interleukin Genetics Inc The il-1 gene cluster and associated inflammatory polymorphisms and haplotypes
US20040048287A1 (en) * 2002-05-20 2004-03-11 Smith Lloyd M. Label-free detection of single nucleotide polymorphisms using surface plasmon resonance imaging
US9388459B2 (en) * 2002-06-17 2016-07-12 Affymetrix, Inc. Methods for genotyping
KR20040001552A (ko) * 2002-06-28 2004-01-07 주식회사 인투젠 디엔에이 결합 단백질 비에 대한 자가항체에 결합할 수있는 단백질을 유효 성분으로 함유하는 전신성 경화증진단용 조성물, 이를 이용한 상기 자가항체의 검출 방법및 전신성 경화증 진단 방법
US20040229228A1 (en) * 2002-07-25 2004-11-18 Northwestern University Il-1 genotype in early kidney allograft rejection
US7732134B2 (en) * 2002-09-30 2010-06-08 Novartis Ag Methods to predict cholesterol elevation during immunosuppressant therapy
CN1711361A (zh) * 2002-10-15 2005-12-21 诺瓦提斯公司 预测药物治疗副效应水肿的方法
US10229244B2 (en) * 2002-11-11 2019-03-12 Affymetrix, Inc. Methods for identifying DNA copy number changes using hidden markov model based estimations
US7424368B2 (en) * 2002-11-11 2008-09-09 Affymetix, Inc. Methods for identifying DNA copy number changes
US7822555B2 (en) 2002-11-11 2010-10-26 Affymetrix, Inc. Methods for identifying DNA copy number changes
WO2005013809A2 (en) 2003-08-08 2005-02-17 Interleukin Genetics, Inc. Diagnostic and therapeutics for osteoporosis
ES2523147T3 (es) * 2004-02-26 2014-11-21 Baylor Research Institute Composiciones y métodos para el tratamiento sistémico de la artritis
US7309589B2 (en) 2004-08-20 2007-12-18 Vironix Llc Sensitive detection of bacteria by improved nested polymerase chain reaction targeting the 16S ribosomal RNA gene and identification of bacterial species by amplicon sequencing
WO2006097388A2 (en) * 2005-02-08 2006-09-21 Innogenetics N.V. Nucleic acid variants in the c1qr1 gene associated with altered innate immunity.
EP1896607A4 (en) * 2005-05-10 2009-12-16 Synergenz Bioscience Ltd METHOD AND COMPOSITIONS FOR THE ASSESSMENT OF LUNG FUNCTION AND RESPIRATORY DISEASE
WO2006123955A2 (en) * 2005-05-19 2006-11-23 Synergenz Bioscience Limited Methods for the assesssment of risk of developing lung cancer using analysis of genetic polymorphisms
CA2608158A1 (en) * 2005-05-19 2006-11-23 Synergenz Bioscience Limited Methods and compositions for assessment of pulmonary function and disorders
US7933722B2 (en) * 2005-05-20 2011-04-26 Synergenz Bioscience Limited Methods of analysis of polymorphisms and uses thereof
US8202546B2 (en) 2005-08-04 2012-06-19 Vertical Pharmaceuticals, Inc. Nutritional supplement for use under physiologically stressful conditions
US8263137B2 (en) * 2005-08-04 2012-09-11 Vertical Pharmaceuticals, Inc. Nutritional supplement for women
US7998500B2 (en) * 2005-08-04 2011-08-16 Vertical Pharmaceuticals, Inc. Nutritional supplement for women
US7901710B2 (en) * 2005-08-04 2011-03-08 Vertical Pharmaceuticals, Inc. Nutritional supplement for use under physiologically stressful conditions
WO2007023148A2 (en) * 2005-08-22 2007-03-01 Innogenetics N.V. Nucleic acid variants in the lbp gene associated with altered innate immunity
WO2007022590A1 (en) * 2005-08-24 2007-03-01 Genetic Technologies Limited Identification of ancestral haplotypes and uses thereof
WO2007050794A2 (en) 2005-10-25 2007-05-03 Interleuken Genetics, Inc. The il-1 gene cluster and associated inflammatory polymorphisms and haplotypes
US11306351B2 (en) 2005-12-21 2022-04-19 Affymetrix, Inc. Methods for genotyping
US8338109B2 (en) 2006-11-02 2012-12-25 Mayo Foundation For Medical Education And Research Predicting cancer outcome
WO2008060627A2 (en) * 2006-11-15 2008-05-22 Interleukin Genetics, Inc. The il-1 gene cluster, insulin resistance and coronary artery disease associated polymorphisms and haplotypes and methods of using same
CN101230386B (zh) * 2007-04-28 2011-09-14 廖凌虹 检测CYP2E1基因的单核苷酸多态性位点rs2480256的引物在制造用于评估系统性红斑狼疮易感性的试剂盒的用途
US8200440B2 (en) 2007-05-18 2012-06-12 Affymetrix, Inc. System, method, and computer software product for genotype determination using probe array data
US20080293589A1 (en) * 2007-05-24 2008-11-27 Affymetrix, Inc. Multiplex locus specific amplification
WO2009135218A2 (en) * 2008-05-02 2009-11-05 Interleukin Genetics, Inc. Detecting genetic predisposition to osteoarthritis associated conditions
EP2291553A4 (en) 2008-05-28 2011-12-14 Genomedx Biosciences Inc SYSTEMS AND METHODS FOR THE EXPRESSION-BASED DISTINCTION OF DIFFERENT CLINICAL ILLICIT STADIAS IN PROSTATE CANCER
US10407731B2 (en) 2008-05-30 2019-09-10 Mayo Foundation For Medical Education And Research Biomarker panels for predicting prostate cancer outcomes
US10236078B2 (en) 2008-11-17 2019-03-19 Veracyte, Inc. Methods for processing or analyzing a sample of thyroid tissue
US9495515B1 (en) 2009-12-09 2016-11-15 Veracyte, Inc. Algorithms for disease diagnostics
US9074258B2 (en) 2009-03-04 2015-07-07 Genomedx Biosciences Inc. Compositions and methods for classifying thyroid nodule disease
CN103223177B (zh) * 2009-05-06 2016-08-10 库尔纳公司 通过针对脂质转运和代谢基因的天然反义转录物的抑制治疗脂质转运和代谢基因相关疾病
JP6078339B2 (ja) 2009-05-07 2017-02-08 ベラサイト インコーポレイテッド 甲状腺状態の診断のための方法および組成物
US10446272B2 (en) 2009-12-09 2019-10-15 Veracyte, Inc. Methods and compositions for classification of samples
ES2680545T3 (es) * 2010-02-26 2018-09-10 Qiagen Gmbh Proceso de aislamiento y/o purificación paralela de ARN y ADN
NZ612799A (en) 2010-12-09 2015-04-24 Interleukin Genetics Inc Improved method and kit for determining severity and progression of periodontal disease
CA2858581A1 (en) 2011-12-13 2013-06-20 Genomedx Biosciences, Inc. Cancer diagnostics using non-coding transcripts
CA2881627A1 (en) 2012-08-16 2014-02-20 Genomedx Biosciences Inc. Cancer diagnostics using biomarkers
EP3626308A1 (en) 2013-03-14 2020-03-25 Veracyte, Inc. Methods for evaluating copd status
US11976329B2 (en) 2013-03-15 2024-05-07 Veracyte, Inc. Methods and systems for detecting usual interstitial pneumonia
CN103397022A (zh) * 2013-07-17 2013-11-20 上海交通大学医学院附属瑞金医院 与Graves病或Graves眼病相关的核苷酸多态性标记及其应用
WO2016073768A1 (en) 2014-11-05 2016-05-12 Veracyte, Inc. Systems and methods of diagnosing idiopathic pulmonary fibrosis on transbronchial biopsies using machine learning and high dimensional transcriptional data
WO2017123696A1 (en) 2016-01-12 2017-07-20 Interleukin Genetics, Inc. Methods for predicting response to treatment
EP3504348B1 (en) 2016-08-24 2022-12-14 Decipher Biosciences, Inc. Use of genomic signatures to predict responsiveness of patients with prostate cancer to post-operative radiation therapy
US10337070B2 (en) 2017-01-12 2019-07-02 Cardioforecast Ltd. Methods and kits for treating cardiovascular disease
US11208697B2 (en) 2017-01-20 2021-12-28 Decipher Biosciences, Inc. Molecular subtyping, prognosis, and treatment of bladder cancer
WO2018165600A1 (en) 2017-03-09 2018-09-13 Genomedx Biosciences, Inc. Subtyping prostate cancer to predict response to hormone therapy
AU2018266733A1 (en) 2017-05-12 2020-01-16 Veracyte, Inc. Genetic signatures to predict prostate cancer metastasis and identify tumor aggressiveness
US11217329B1 (en) 2017-06-23 2022-01-04 Veracyte, Inc. Methods and systems for determining biological sample integrity
DE102018104133A1 (de) * 2018-02-23 2019-08-29 Klinikum der Universität München, Anstalt des öffentlichen Rechts Biomarker zur Feststellung einer möglichen Unverträglichkeit gegenüber Metallimplantaten
US20210140974A1 (en) * 2018-04-12 2021-05-13 Mayo Foundation For Medical Education And Research Methods for guiding therapy decisions in seizure disorders
CN109295211A (zh) * 2018-10-30 2019-02-01 深圳市万众基因转化医学研究院 一种人类斑秃相关基因突变筛查的组合引物及其应用
WO2020150633A1 (en) 2019-01-18 2020-07-23 Orthobio Therapeutics, Inc. Gene editing to improve joint function
WO2020215051A1 (en) * 2019-04-19 2020-10-22 Rpi Consulting Llc Treatments for pregnancy-related conditions
EP3980561A1 (en) 2019-06-06 2022-04-13 Sitokine Limited Compositions and methods for treating lung, colorectal and breast cancer
WO2021028469A1 (en) 2019-08-12 2021-02-18 Sitokine Limited Compositions and methods for treating cytokine release syndrome and neurotoxicity
WO2021205013A1 (en) 2020-04-09 2021-10-14 Sitokine Limited Compositions and methods for treating covid-19
CA3186119A1 (en) * 2020-07-16 2022-01-20 Orthobio Therapeutics, Inc. Gene editing to improve joint function
WO2023283021A1 (en) * 2021-07-08 2023-01-12 Martin Levine Devices, kits, and methods for determining increased susceptibility to and treatment and prevention of periodontitis, alzheimer's disease, and other conditions

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3587605T2 (de) * 1984-12-25 1994-03-17 Dainippon Pharmaceutical Co Interleukin-1 und dessen Derivat.
US5582979A (en) * 1989-04-21 1996-12-10 Marshfield Clinic Length polymorphisms in (dC-dA)n.(dG-dT)n sequences and method of using the same
US5780587A (en) * 1990-08-24 1998-07-14 President And Fellows Of Harvard College Compounds and methods for inhibiting β-protein filament formation and neurotoxicity
US5681940A (en) * 1994-11-02 1997-10-28 Icn Pharmaceuticals Sugar modified nucleosides and oligonucleotides
US5993817A (en) * 1995-01-23 1999-11-30 Xenotech Method to ameliorate osteolysis and metastasis
US5686246A (en) 1995-08-03 1997-11-11 Kornman; Kenneth S. Detecting genetic predisposition to periodontal disease
US5942390A (en) 1996-01-12 1999-08-24 Cedars-Sinai Medical Center Method of diagnosing predisposition for ulcerative colitis in Jewish population by detection of interleukin-1 receptor antagonist polymorphism
US5698399A (en) * 1996-04-05 1997-12-16 Duff; Gordon W. Detecting genetic predisposition for osteoporosis
GB9610281D0 (en) * 1996-05-16 1996-07-24 Ralston Stuart H Diagnostic method and apparatus
GB9621129D0 (en) 1996-10-10 1996-11-27 Duff Gordon W Detecting genetic predisposition to sight-threatening diabetic retinopathy
US6210877B1 (en) * 1997-03-10 2001-04-03 Interleukin Genetics, Inc. Prediction of coronary artery disease
GB9706359D0 (en) 1997-03-27 1997-05-14 Gemini International Holdings Polymorphisms of an il-1 receptor antagonist gene
GB9711040D0 (en) 1997-05-29 1997-07-23 Duff Gordon W Prediction of inflammatory disease
GB9723553D0 (en) * 1997-11-07 1998-01-07 Duff Gordon W Prediction of the risk of chronic obstructive airway disease
US6746839B1 (en) * 1998-01-12 2004-06-08 Interleukin Genetics, Inc. Diagnostics and therapeutics for an obstructive airway disease
US6733967B1 (en) * 1998-04-21 2004-05-11 Interleukin Genetics, Inc. Fetal testing for prediction of low birth weight
US6251598B1 (en) * 1998-10-30 2001-06-26 Interleukin Genetics, Inc. Methods for diagnosing sepsis
EP1409737A4 (en) * 2001-06-15 2005-10-12 Interleukin Genetics Inc METHODS OF DETECTING AND TREATING EARLY APPEARANCE OF CONDITIONS RELATED TO AGING
KR101019131B1 (ko) * 2001-11-19 2011-03-07 인터레우킨 제네틱스, 인코포레이티드 염증성 질환 및 감염성 질환에 대한 감수성 및 전사에영향을 미치는 인터루킨-1 좌의 기능적 다형성

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US20040152124A1 (en) 2004-08-05
US20020146700A1 (en) 2002-10-10
AU755107B2 (en) 2002-12-05
DE69841588D1 (de) 2010-05-12
IL133128A0 (en) 2001-03-19
US6706478B2 (en) 2004-03-16
ATE462800T1 (de) 2010-04-15
TWI236502B (en) 2005-07-21
ES2342992T3 (es) 2010-07-20
WO1998054359A1 (en) 1998-12-03
ZA984490B (en) 1998-12-02
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PL337080A1 (en) 2000-07-31
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NO995803L (no) 2000-01-18
GB9711040D0 (en) 1997-07-23
CA2291731A1 (en) 1998-12-03
AR016754A1 (es) 2001-08-01
US20080187920A1 (en) 2008-08-07
US6268142B1 (en) 2001-07-31
JP2002500513A (ja) 2002-01-08
CN1278868A (zh) 2001-01-03
CN1177059C (zh) 2004-11-24

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