BR9808147A - Clone de ácido nucleico do vìrus da hepatite c (hcv) geneticamente engenheirado, clone plasmìdeo que abriga uma cdna do hcv de tamanho natural, dna ou rna do hcv transcrito do cdna do hcv de comprimento natural, linhagem de célula hospedeira transfectada e in vitro infectada com o hcv, animal não humano infectado com o hcv, partìcula viral do hcv, sistema de teste in vitro, isento de célula para o hcv, vacina do hcv e conjunto de teste para o hcv e processos para identificar uma linhagem de célula que é permissiva e um animal que é permissivo para a infecção por hcv, para selecionar hcv com mutações adaptativas que permitem nìveis mais altos de replicação do hcv em uma linhagem de célula permissiva, para infectar uma animal com o hcv, para propagar o hcv in vitro, para transduzir um animal suscetìvel à infecção por hcv com um gene heterólogo, para produzir partìculas virais do hcv, proteìnas de partìcula do hcv e anticorpos do hcv, para separar agentes capazes de modular a replicação do hcv, para preparar um ácido nucleico do hcv e para detectar anticorpos do hcv em uma amostra biológica de um paciente. - Google Patents

Clone de ácido nucleico do vìrus da hepatite c (hcv) geneticamente engenheirado, clone plasmìdeo que abriga uma cdna do hcv de tamanho natural, dna ou rna do hcv transcrito do cdna do hcv de comprimento natural, linhagem de célula hospedeira transfectada e in vitro infectada com o hcv, animal não humano infectado com o hcv, partìcula viral do hcv, sistema de teste in vitro, isento de célula para o hcv, vacina do hcv e conjunto de teste para o hcv e processos para identificar uma linhagem de célula que é permissiva e um animal que é permissivo para a infecção por hcv, para selecionar hcv com mutações adaptativas que permitem nìveis mais altos de replicação do hcv em uma linhagem de célula permissiva, para infectar uma animal com o hcv, para propagar o hcv in vitro, para transduzir um animal suscetìvel à infecção por hcv com um gene heterólogo, para produzir partìculas virais do hcv, proteìnas de partìcula do hcv e anticorpos do hcv, para separar agentes capazes de modular a replicação do hcv, para preparar um ácido nucleico do hcv e para detectar anticorpos do hcv em uma amostra biológica de um paciente.

Info

Publication number
BR9808147A
BR9808147A BR9808147-0A BR9808147A BR9808147A BR 9808147 A BR9808147 A BR 9808147A BR 9808147 A BR9808147 A BR 9808147A BR 9808147 A BR9808147 A BR 9808147A
Authority
BR
Brazil
Prior art keywords
hcv
animal
permissive
cell line
vitro
Prior art date
Application number
BR9808147-0A
Other languages
English (en)
Portuguese (pt)
Inventor
Charles M Rice Iii
Alexander A Kolykhalov
Original Assignee
Univ Washington
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Washington filed Critical Univ Washington
Publication of BR9808147A publication Critical patent/BR9808147A/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/29—Hepatitis virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/706—Specific hybridization probes for hepatitis
    • C12Q1/707—Specific hybridization probes for hepatitis non-A, non-B Hepatitis, excluding hepatitis D
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
    • C12N2770/24221—Viruses as such, e.g. new isolates, mutants or their genomic sequences
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
    • C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
    • C12N2770/24234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
    • C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
    • C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES
    • C12N2840/206—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES having multiple IRES

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
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  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
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  • Immunology (AREA)
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  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Physics & Mathematics (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Plant Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
BR9808147-0A 1997-03-04 1998-02-26 Clone de ácido nucleico do vìrus da hepatite c (hcv) geneticamente engenheirado, clone plasmìdeo que abriga uma cdna do hcv de tamanho natural, dna ou rna do hcv transcrito do cdna do hcv de comprimento natural, linhagem de célula hospedeira transfectada e in vitro infectada com o hcv, animal não humano infectado com o hcv, partìcula viral do hcv, sistema de teste in vitro, isento de célula para o hcv, vacina do hcv e conjunto de teste para o hcv e processos para identificar uma linhagem de célula que é permissiva e um animal que é permissivo para a infecção por hcv, para selecionar hcv com mutações adaptativas que permitem nìveis mais altos de replicação do hcv em uma linhagem de célula permissiva, para infectar uma animal com o hcv, para propagar o hcv in vitro, para transduzir um animal suscetìvel à infecção por hcv com um gene heterólogo, para produzir partìculas virais do hcv, proteìnas de partìcula do hcv e anticorpos do hcv, para separar agentes capazes de modular a replicação do hcv, para preparar um ácido nucleico do hcv e para detectar anticorpos do hcv em uma amostra biológica de um paciente. BR9808147A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/811,566 US6127116A (en) 1995-08-29 1997-03-04 Functional DNA clone for hepatitis C virus (HCV) and uses thereof
PCT/US1998/004428 WO1998039031A1 (en) 1997-03-04 1998-02-26 Functional dna clone for hepatitis c virus (hcv) and uses thereof

Publications (1)

Publication Number Publication Date
BR9808147A true BR9808147A (pt) 2000-03-28

Family

ID=25206905

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9808147-0A BR9808147A (pt) 1997-03-04 1998-02-26 Clone de ácido nucleico do vìrus da hepatite c (hcv) geneticamente engenheirado, clone plasmìdeo que abriga uma cdna do hcv de tamanho natural, dna ou rna do hcv transcrito do cdna do hcv de comprimento natural, linhagem de célula hospedeira transfectada e in vitro infectada com o hcv, animal não humano infectado com o hcv, partìcula viral do hcv, sistema de teste in vitro, isento de célula para o hcv, vacina do hcv e conjunto de teste para o hcv e processos para identificar uma linhagem de célula que é permissiva e um animal que é permissivo para a infecção por hcv, para selecionar hcv com mutações adaptativas que permitem nìveis mais altos de replicação do hcv em uma linhagem de célula permissiva, para infectar uma animal com o hcv, para propagar o hcv in vitro, para transduzir um animal suscetìvel à infecção por hcv com um gene heterólogo, para produzir partìculas virais do hcv, proteìnas de partìcula do hcv e anticorpos do hcv, para separar agentes capazes de modular a replicação do hcv, para preparar um ácido nucleico do hcv e para detectar anticorpos do hcv em uma amostra biológica de um paciente.

Country Status (9)

Country Link
US (4) US6127116A (https=)
EP (1) EP1005366A4 (https=)
JP (2) JP4094679B2 (https=)
AU (1) AU742175B2 (https=)
BR (1) BR9808147A (https=)
CA (1) CA2283464C (https=)
IL (2) IL131688A0 (https=)
WO (1) WO1998039031A1 (https=)
ZA (1) ZA981838B (https=)

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