BR9807383A - Formulação farmacêutica que compreende amoxicilina e clavulanato - Google Patents
Formulação farmacêutica que compreende amoxicilina e clavulanatoInfo
- Publication number
- BR9807383A BR9807383A BR9807383-4A BR9807383A BR9807383A BR 9807383 A BR9807383 A BR 9807383A BR 9807383 A BR9807383 A BR 9807383A BR 9807383 A BR9807383 A BR 9807383A
- Authority
- BR
- Brazil
- Prior art keywords
- amoxicillin
- clavulanate
- pharmaceutical formulation
- formulations
- granules
- Prior art date
Links
- LSQZJLSUYDQPKJ-NJBDSQKTSA-N amoxicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=C(O)C=C1 LSQZJLSUYDQPKJ-NJBDSQKTSA-N 0.000 title abstract 4
- 229960003022 amoxicillin Drugs 0.000 title abstract 4
- LSQZJLSUYDQPKJ-UHFFFAOYSA-N p-Hydroxyampicillin Natural products O=C1N2C(C(O)=O)C(C)(C)SC2C1NC(=O)C(N)C1=CC=C(O)C=C1 LSQZJLSUYDQPKJ-UHFFFAOYSA-N 0.000 title abstract 4
- HZZVJAQRINQKSD-UHFFFAOYSA-N Clavulanic acid Natural products OC(=O)C1C(=CCO)OC2CC(=O)N21 HZZVJAQRINQKSD-UHFFFAOYSA-N 0.000 title abstract 2
- 229940090805 clavulanate Drugs 0.000 title abstract 2
- HZZVJAQRINQKSD-PBFISZAISA-N clavulanic acid Chemical compound OC(=O)[C@H]1C(=C/CO)/O[C@@H]2CC(=O)N21 HZZVJAQRINQKSD-PBFISZAISA-N 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 238000009472 formulation Methods 0.000 abstract 4
- 239000000203 mixture Substances 0.000 abstract 4
- 239000008187 granular material Substances 0.000 abstract 2
- QJVHTELASVOWBE-AGNWQMPPSA-N (2s,5r,6r)-6-[[(2r)-2-amino-2-(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid;(2r,3z,5r)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic acid Chemical compound OC(=O)[C@H]1C(=C/CO)/O[C@@H]2CC(=O)N21.C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=C(O)C=C1 QJVHTELASVOWBE-AGNWQMPPSA-N 0.000 abstract 1
- ABVRVIZBZKUTMK-JSYANWSFSA-M potassium clavulanate Chemical compound [K+].[O-]C(=O)[C@H]1C(=C/CO)/O[C@@H]2CC(=O)N21 ABVRVIZBZKUTMK-JSYANWSFSA-M 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0007—Effervescent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9703101.7A GB9703101D0 (en) | 1997-02-14 | 1997-02-14 | Formulations |
| GBGB9703099.3A GB9703099D0 (en) | 1997-02-14 | 1997-02-14 | Formulations |
| GBGB9703100.9A GB9703100D0 (en) | 1997-02-14 | 1997-02-14 | Formulations |
| PCT/EP1998/000811 WO1998035672A1 (en) | 1997-02-14 | 1998-02-10 | Pharmaceutical formulations comprising amoxocyllin and clavulanate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9807383A true BR9807383A (pt) | 2000-03-14 |
Family
ID=27268719
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9807383-4A BR9807383A (pt) | 1997-02-14 | 1998-02-10 | Formulação farmacêutica que compreende amoxicilina e clavulanato |
Country Status (25)
| Country | Link |
|---|---|
| EP (2) | EP1142574A1 (OSRAM) |
| JP (1) | JP2001512451A (OSRAM) |
| KR (1) | KR100499812B1 (OSRAM) |
| CN (1) | CN1194687C (OSRAM) |
| AP (1) | AP1253A (OSRAM) |
| AT (1) | ATE243516T1 (OSRAM) |
| AU (1) | AU728526B2 (OSRAM) |
| BG (1) | BG103664A (OSRAM) |
| BR (1) | BR9807383A (OSRAM) |
| CA (1) | CA2280857A1 (OSRAM) |
| DE (1) | DE69815833T2 (OSRAM) |
| DZ (1) | DZ2420A1 (OSRAM) |
| EA (1) | EA002595B1 (OSRAM) |
| ES (1) | ES2201468T3 (OSRAM) |
| HK (1) | HK1043041A1 (OSRAM) |
| ID (1) | ID23673A (OSRAM) |
| IL (1) | IL131201A (OSRAM) |
| MA (1) | MA24473A1 (OSRAM) |
| NO (1) | NO993887L (OSRAM) |
| NZ (1) | NZ337043A (OSRAM) |
| OA (1) | OA11087A (OSRAM) |
| PL (1) | PL334976A1 (OSRAM) |
| SK (1) | SK110299A3 (OSRAM) |
| TR (1) | TR199901961T2 (OSRAM) |
| WO (1) | WO1998035672A1 (OSRAM) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9416600D0 (en) * | 1994-08-17 | 1994-10-12 | Smithkline Beecham Plc | Pharmaceutical formulation |
| EP1093812A3 (en) | 1995-09-07 | 2001-06-06 | SmithKline Beecham Corporation | Amoxycillin and clavulanate containing pharmaceutical formulation |
| GB9815532D0 (en) | 1998-07-17 | 1998-09-16 | Lek Pharmaceutical & Cvhemical | Pharmaceutical suspension formulation |
| WO2000050036A1 (en) * | 1999-02-26 | 2000-08-31 | Biovail International Ltd. | Storage stable amoxycillin and clavulanate suspension composition |
| KR100634937B1 (ko) * | 1999-04-13 | 2006-10-17 | 비참 파마슈티컬스 (피티이) 리미티드 | 신규한 치료 방법 |
| US6878386B1 (en) | 1999-04-13 | 2005-04-12 | Beecham Pharmaceuticals (Pte) Limited | Method of treating a bacterial infection comprising amoxycillin and potassium clavulanate |
| US7250176B1 (en) | 1999-04-13 | 2007-07-31 | Beecham Pharmaceuticals (Pte) Limited | Method of treating a bacterial infection |
| US6294199B1 (en) | 1999-04-13 | 2001-09-25 | Beecham Pharmaceuticals (Pte) Limited | Method of treating a bacterial infection comprising administering amoxycillin |
| FR2797588B1 (fr) * | 1999-08-20 | 2003-08-01 | Smithkline Beecham Lab | Formulation pharmaceutique a base d'amoxycilline et de clavulanate |
| PT1078627E (pt) * | 1999-08-20 | 2006-10-31 | Glaxosmithkline Lab Sas | Formulacao farmaceutica compreendendo amoxicilina e clavulanato |
| US6541025B1 (en) * | 1999-12-30 | 2003-04-01 | Shear/Kershman Laboratories, Inc. | Method for preparing solid delivery system for encapsulated and non-encapsulated pharmaceuticals |
| US6375982B1 (en) * | 2000-07-05 | 2002-04-23 | Capricorn Pharma, Inc. | Rapid-melt semi-solid compositions, methods of making same and method of using same |
| US6756057B2 (en) | 2000-10-12 | 2004-06-29 | Beecham Pharmaceuticals (Pte) Limited | Amoxicillin and potassium clavulanate dosage form |
| WO2002030392A2 (en) | 2000-10-12 | 2002-04-18 | Beecham Pharmaceuticals (Pte) Limited | Formulation containing amoxicillin |
| AT413983B (de) * | 2001-04-12 | 2006-08-15 | Sandoz Ag | K-clavulanat in der form eines granulates |
| AT412344B (de) * | 2001-04-12 | 2005-01-25 | Sandoz Ag | Hydrophobisierte teilchen von k-clavulanat |
| EP1474104A2 (en) * | 2002-02-01 | 2004-11-10 | Sandoz Ag | Demixing-stable granulate |
| DE60323474D1 (de) * | 2002-04-09 | 2008-10-23 | Flamel Tech Sa | Orale pharmazeutische formulierung in form einer wässrigen suspension von mikrokapseln zur modifizierten freisetzung von amoxicillin |
| KR20050062514A (ko) * | 2002-07-16 | 2005-06-23 | 랜박시 래보러터리스 리미티드 | 경구 투여용 분산성 정제 |
| AU2004246811A1 (en) * | 2003-06-16 | 2004-12-23 | Glaxo Group Limited | Pharmaceutical formulations comprising amoxicillin and clavulanate |
| CN1968682A (zh) * | 2004-06-18 | 2007-05-23 | 株式会社柳韩洋行 | 包含表面改性的碳酸氢钠的阿莫西林和/或克拉维酸口服分散片组合物 |
| SI21912A (sl) * | 2004-12-24 | 2006-06-30 | Lek Farmacevtska Druzba D.D. | Stabilne farmacevtske oblike, ki vsebujejo amoksicilin in klavulansko kislino |
| DE102006007830A1 (de) * | 2006-02-17 | 2007-08-30 | Grünenthal GmbH | Lagerstabile orale Darreichungsform von Amoxicillin und Clavulansäure |
| CN100464750C (zh) * | 2006-02-23 | 2009-03-04 | 珠海联邦制药股份有限公司 | 一种制备含阿莫西林钠和克拉维酸钾的药物混合物的方法 |
| FI20080351A0 (fi) * | 2008-05-09 | 2008-05-09 | Atacama Labs Oy | Prosessi matalan lääkepitoisuuden tabletin valmistamiseksi |
| FI20080352A0 (fi) * | 2008-05-09 | 2008-05-09 | Atacama Labs Oy | Prosessi korkean lääkepitoisuuden tabletin valmistamiseksi |
| US8951562B2 (en) | 2006-11-10 | 2015-02-10 | Atacama Labs Oy | Method and apparatus or dry granulation |
| FI20070521A7 (fi) | 2006-11-10 | 2008-05-11 | Atacama Labs Oy | Rakeita, tabletteja ja rakeistusmenetelmä |
| CA2723409C (en) | 2008-05-09 | 2016-11-08 | Atacama Labs Oy | Method and apparatus for dry granulation |
| CN102861015B (zh) * | 2011-07-05 | 2015-07-08 | 北京乐维生物技术有限公司 | 一种稳定的阿莫西林克拉维酸钾缓释制剂及其制备工艺 |
| WO2014065769A1 (en) * | 2012-10-22 | 2014-05-01 | Bilgiç Mahmut | Formulations for oral suspensions comprising antibiotics |
| EP3046548B1 (en) * | 2013-09-20 | 2020-02-12 | Centrient Pharmaceuticals Netherlands B.V. | Tablet comprising crospovidone |
| US9254261B2 (en) * | 2014-03-03 | 2016-02-09 | Sandoz Ag | Stable quick dissolving dosage form comprising amoxicillin and clavulanic acid |
| KR102002906B1 (ko) * | 2016-10-18 | 2019-07-23 | 경동제약 주식회사 | 셀레콕시브를 포함하는 정제 |
| EP3994154A1 (en) | 2019-07-05 | 2022-05-11 | GlaxoSmithKline Intellectual Property (No.2) Limited | Streptomyces clavuligerus |
| CN113274357B (zh) * | 2021-05-28 | 2022-12-27 | 广州白云山医药集团股份有限公司白云山制药总厂 | 一种阿莫西林药物及其制备方法 |
| CN114869884A (zh) * | 2021-07-30 | 2022-08-09 | 江苏恒丰强生物技术有限公司 | 一种用于猪呼吸道疾病的复方阿莫西林粉及其制备方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4110165A (en) * | 1974-04-20 | 1978-08-29 | Beecham Group Limited | Process for the production of clavulanic acid |
| US4140764A (en) * | 1974-12-18 | 1979-02-20 | Beecham Group Limited | β-Lactamase inhibitors and process for their preparation |
| JO984B1 (en) * | 1977-10-11 | 1979-12-01 | بيتشام غروب ليمتد | A dry pharmaceutical compound with a suitable dosage unit for oral administration |
| NZ198241A (en) * | 1980-09-27 | 1983-12-16 | Beecham Group Ltd | Tablet containing amoxycillin and potassium clavulanate |
| GB9109862D0 (en) * | 1991-05-08 | 1991-07-03 | Beecham Lab Sa | Pharmaceutical formulations |
| AU5863894A (en) * | 1993-01-22 | 1994-08-15 | Smithkline Beecham Plc | Pharmaceutical formulations comprising clavulanic acid alone or in combination with other beta-lactam antibiotics |
| IL109770A0 (en) * | 1993-05-29 | 1994-11-28 | Smithkline Beecham Corp | Thermal infusion process for preparing controlled release solid dosage forms of medicaments for oral administration and controlled release solid dosage forms of medicaments prepared thereby |
| GB9402203D0 (en) * | 1994-02-04 | 1994-03-30 | Smithkline Beecham Plc | Pharmaceutical formulation |
| GB9405856D0 (en) * | 1994-03-24 | 1994-05-11 | Smithkline Beecham Plc | Pharmaceutical formulation |
| GB9407386D0 (en) * | 1994-04-14 | 1994-06-08 | Smithkline Beecham Plc | Pharmaceutical formulation |
| GB9408117D0 (en) * | 1994-04-23 | 1994-06-15 | Smithkline Beecham Corp | Pharmaceutical formulations |
| DZ1926A1 (fr) * | 1994-09-03 | 2002-02-17 | Smithkline Beckman P L C | Formulations pharmaceutiques. |
-
1998
- 1998-02-10 IL IL13120198A patent/IL131201A/xx not_active IP Right Cessation
- 1998-02-10 JP JP53535198A patent/JP2001512451A/ja not_active Ceased
- 1998-02-10 CA CA002280857A patent/CA2280857A1/en not_active Abandoned
- 1998-02-10 ES ES98912303T patent/ES2201468T3/es not_active Expired - Lifetime
- 1998-02-10 EP EP01201884A patent/EP1142574A1/en not_active Ceased
- 1998-02-10 TR TR1999/01961T patent/TR199901961T2/xx unknown
- 1998-02-10 WO PCT/EP1998/000811 patent/WO1998035672A1/en not_active Ceased
- 1998-02-10 DE DE69815833T patent/DE69815833T2/de not_active Expired - Lifetime
- 1998-02-10 NZ NZ337043A patent/NZ337043A/en unknown
- 1998-02-10 CN CNB988040956A patent/CN1194687C/zh not_active Expired - Fee Related
- 1998-02-10 SK SK1102-99A patent/SK110299A3/sk unknown
- 1998-02-10 EP EP98912303A patent/EP0975342B1/en not_active Expired - Lifetime
- 1998-02-10 PL PL98334976A patent/PL334976A1/xx unknown
- 1998-02-10 AT AT98912303T patent/ATE243516T1/de not_active IP Right Cessation
- 1998-02-10 AP APAP/P/1999/001623A patent/AP1253A/en active
- 1998-02-10 AU AU67196/98A patent/AU728526B2/en not_active Ceased
- 1998-02-10 ID IDW990859D patent/ID23673A/id unknown
- 1998-02-10 BR BR9807383-4A patent/BR9807383A/pt not_active Application Discontinuation
- 1998-02-10 KR KR10-1999-7007362A patent/KR100499812B1/ko not_active Expired - Fee Related
- 1998-02-10 EA EA199900647A patent/EA002595B1/ru not_active IP Right Cessation
- 1998-02-11 DZ DZ980030A patent/DZ2420A1/xx active
- 1998-02-12 MA MA24964A patent/MA24473A1/fr unknown
-
1999
- 1999-08-12 NO NO993887A patent/NO993887L/no unknown
- 1999-08-13 OA OA9900181A patent/OA11087A/en unknown
- 1999-08-13 BG BG103664A patent/BG103664A/xx unknown
-
2000
- 2000-07-26 HK HK02102072.5A patent/HK1043041A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN1194687C (zh) | 2005-03-30 |
| DE69815833T2 (de) | 2004-05-19 |
| CN1251990A (zh) | 2000-05-03 |
| CA2280857A1 (en) | 1998-08-20 |
| HK1043041A1 (en) | 2002-09-06 |
| SK110299A3 (en) | 2000-08-14 |
| DZ2420A1 (fr) | 2003-01-04 |
| EA002595B1 (ru) | 2002-06-27 |
| TR199901961T2 (xx) | 1999-11-22 |
| EP0975342A1 (en) | 2000-02-02 |
| JP2001512451A (ja) | 2001-08-21 |
| NO993887D0 (no) | 1999-08-12 |
| IL131201A0 (en) | 2001-01-28 |
| AP1253A (en) | 2004-03-17 |
| NO993887L (no) | 1999-08-12 |
| WO1998035672A1 (en) | 1998-08-20 |
| PL334976A1 (en) | 2000-03-27 |
| EP1142574A1 (en) | 2001-10-10 |
| AP9901623A0 (en) | 1999-09-30 |
| AU728526B2 (en) | 2001-01-11 |
| ATE243516T1 (de) | 2003-07-15 |
| KR100499812B1 (ko) | 2005-07-08 |
| DE69815833D1 (de) | 2003-07-31 |
| MA24473A1 (fr) | 1998-10-01 |
| EP0975342B1 (en) | 2003-06-25 |
| KR20000071076A (ko) | 2000-11-25 |
| OA11087A (en) | 2003-03-13 |
| IL131201A (en) | 2005-06-19 |
| ID23673A (id) | 2000-05-11 |
| ES2201468T3 (es) | 2004-03-16 |
| EA199900647A1 (ru) | 2000-06-26 |
| BG103664A (en) | 2000-03-31 |
| AU6719698A (en) | 1998-09-08 |
| NZ337043A (en) | 2001-02-23 |
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