BR9707366A - Novos aminoácidos ciclicos como agentes farmacéuticos - Google Patents
Novos aminoácidos ciclicos como agentes farmacéuticosInfo
- Publication number
- BR9707366A BR9707366A BR9707366A BR9707366A BR9707366A BR 9707366 A BR9707366 A BR 9707366A BR 9707366 A BR9707366 A BR 9707366A BR 9707366 A BR9707366 A BR 9707366A BR 9707366 A BR9707366 A BR 9707366A
- Authority
- BR
- Brazil
- Prior art keywords
- pct
- amino acids
- cyclic amino
- pharmaceutical agents
- date
- Prior art date
Links
- -1 cyclic amino acids Chemical class 0.000 title abstract 2
- 239000008177 pharmaceutical agent Substances 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 208000035475 disorder Diseases 0.000 abstract 2
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 208000006083 Hypokinesia Diseases 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 208000002173 dizziness Diseases 0.000 abstract 1
- 206010015037 epilepsy Diseases 0.000 abstract 1
- 230000003483 hypokinetic effect Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 230000002981 neuropathic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
- C07D335/02—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/04—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1127896P | 1996-02-07 | 1996-02-07 | |
| PCT/US1997/000255 WO1997029101A1 (en) | 1996-02-07 | 1997-01-02 | Novel cyclic amino acids as pharmaceutical agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9707366A true BR9707366A (pt) | 1999-07-20 |
Family
ID=21749660
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9707366A BR9707366A (pt) | 1996-02-07 | 1997-01-02 | Novos aminoácidos ciclicos como agentes farmacéuticos |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US5929088A (cg-RX-API-DMAC7.html) |
| EP (1) | EP0888325B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2000511877A (cg-RX-API-DMAC7.html) |
| KR (1) | KR19990082349A (cg-RX-API-DMAC7.html) |
| AT (1) | ATE218135T1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU720628B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BR9707366A (cg-RX-API-DMAC7.html) |
| CA (1) | CA2244708A1 (cg-RX-API-DMAC7.html) |
| CZ (1) | CZ296052B6 (cg-RX-API-DMAC7.html) |
| DE (1) | DE69712877T2 (cg-RX-API-DMAC7.html) |
| DK (1) | DK0888325T3 (cg-RX-API-DMAC7.html) |
| EA (1) | EA001534B1 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2176668T3 (cg-RX-API-DMAC7.html) |
| HU (1) | HUP9901074A3 (cg-RX-API-DMAC7.html) |
| IL (1) | IL125562A (cg-RX-API-DMAC7.html) |
| NO (1) | NO983612L (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ326669A (cg-RX-API-DMAC7.html) |
| PL (1) | PL328432A1 (cg-RX-API-DMAC7.html) |
| PT (1) | PT888325E (cg-RX-API-DMAC7.html) |
| SK (1) | SK282665B6 (cg-RX-API-DMAC7.html) |
| WO (1) | WO1997029101A1 (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA97991B (cg-RX-API-DMAC7.html) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL126999A (en) | 1996-07-24 | 2002-03-10 | Warner Lambert Co | Pharmaceutical preparations containing isobutylgaba and its history for use in the treatment of pain |
| PT1015415E (pt) | 1997-09-18 | 2003-09-30 | Warner Lambert Co | Novos processos estereosselectivos para a preparacao de analogos de gabapentina |
| US6984659B2 (en) | 1997-11-18 | 2006-01-10 | Klinikum Der Albert-Ludwigs Universitaet | 2-pyrrolidinone derivatives substituted at position 4 for reducing the extracellular glutamate level |
| DE19751062A1 (de) | 1997-11-18 | 1999-07-08 | Univ Ludwigs Albert | An 4-Stellung substituierte 2-Pyrrolidinon-Derivate zur Verringerung des extrazellulären Glutamat-Spiegels |
| TR200001800T2 (tr) * | 1997-12-16 | 2001-03-21 | Warner-Lambert Company | -4(3)-İkameli -4(3)- aminometil-(tio) piran veya- piperidin türevleri (=Gabapentin analogları), hazırlanmaları ve nörolojik hastalıkların tedavisinde kullanımları |
| CA2404157A1 (en) * | 2000-03-28 | 2001-10-04 | Robert J. Delorenzo | Inhibition of a novel calcium injury current that forms in neurons during injury prevents neuronal cell death |
| WO2002032376A2 (en) | 2000-10-06 | 2002-04-25 | Xenoport, Inc. | Bile-acid conjugates for providing sustained systemic concentrations of drugs |
| US6992076B2 (en) | 2000-10-06 | 2006-01-31 | Xenoport, Inc. | Bile-acid derived compounds for providing sustained systemic concentrations of drugs after oral administration |
| GB2368579A (en) * | 2000-10-31 | 2002-05-08 | Parke Davis & Co Ltd | Azole pharmaceutical agents |
| US6818787B2 (en) | 2001-06-11 | 2004-11-16 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| ATE380029T1 (de) | 2001-06-11 | 2007-12-15 | Xenoport Inc | Prodrugs von gaba-analoga, zusammensetzungen und ihre verwendungszwecke |
| US8048917B2 (en) | 2005-04-06 | 2011-11-01 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| US7186855B2 (en) | 2001-06-11 | 2007-03-06 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| US7232924B2 (en) | 2001-06-11 | 2007-06-19 | Xenoport, Inc. | Methods for synthesis of acyloxyalkyl derivatives of GABA analogs |
| EP1412324A4 (en) | 2001-06-11 | 2004-09-29 | Xenoport Inc | AMINO ACID CONJUGATES THAT RESULT IN GABA ANALOGA LASTING SYSTEMIC CONCENTRATIONS |
| AU2002316231A1 (en) | 2002-02-19 | 2003-09-29 | Xenoport, Inc. | Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof |
| WO2003080588A1 (en) | 2002-03-20 | 2003-10-02 | Xenoport | Cyclic 1-(acyloxy)-alkyl prodrugs of gaba analogs, compositions and uses thereof |
| AU2003243180A1 (en) | 2002-05-17 | 2003-12-12 | Xenoport, Inc. | Amino acid conjugates providing for sustained systemic concentrations of gaba analogues |
| US20040092498A1 (en) * | 2002-08-16 | 2004-05-13 | David Blakemore | Substituted glycine derivatives for use as medicaments |
| US7060727B2 (en) | 2002-12-11 | 2006-06-13 | Xenoport, Inc. | Prodrugs of fused GABA analogs, pharmaceutical compositions and uses thereof |
| CA2451267A1 (en) | 2002-12-13 | 2004-06-13 | Warner-Lambert Company Llc | Pharmaceutical uses for alpha2delta ligands |
| PT1572173E (pt) | 2002-12-13 | 2010-05-10 | Warner Lambert Co | Ligando alfa-2-delta para tratar sintomas do tracto urinário inferior |
| EP1670451A4 (en) | 2003-09-11 | 2009-10-21 | Xenoport Inc | TREATMENT AND / OR PREVENTION OF URINARY INCONTINENCE AND PROMOTERS OF GABA ANALOGS |
| CA2537402C (en) | 2003-09-12 | 2009-05-05 | Pfizer Inc. | Combinations comprising alpha-2-delta ligands and serotonin / noradrenaline re-uptake inhibitors |
| NZ545989A (en) | 2003-09-17 | 2009-10-30 | Xenoport Inc | Treating or preventing restless legs syndrome using prodrugs of gaba analogs |
| ATE516801T1 (de) | 2003-10-14 | 2011-08-15 | Xenoport Inc | Kristalline form eines gamma-aminobuttersäure- analogons |
| US20050176680A1 (en) | 2003-12-11 | 2005-08-11 | Sepracor, Inc. | Combination of sedative and a neurotransmitter modulator, and methods for improving sleep quality and treating depression |
| CN102429882B (zh) | 2004-11-04 | 2015-03-25 | 什诺波特有限公司 | 加巴喷丁前体药物持续释放口服剂型 |
| JP5308350B2 (ja) | 2006-12-22 | 2013-10-09 | レコルダーティ アイルランド リミテッド | α２δリガンドおよびＮＳＡＩＤを用いた下部尿路機能障害の併用療法 |
| CA2697254A1 (en) * | 2007-08-23 | 2009-02-26 | Novartis Ag | Aminobenzyl-substituted cyclic sulfones useful as bace inhibitors |
| US7868043B2 (en) | 2008-01-25 | 2011-01-11 | Xenoport, Inc. | Mesophasic forms of (3S)-aminomethyl-5-methyl-hexanoic acid prodrugs and methods of use |
| ES2601852T3 (es) | 2008-01-25 | 2017-02-16 | Xenoport, Inc. | Forma cristalina de sales de calcio de ácidos (3S)-aminometil-5-metil-hexanoicos y métodos de uso |
| WO2009094563A2 (en) | 2008-01-25 | 2009-07-30 | Xenoport, Inc. | Crystalline form of calcium-salts of (3s)-aminomethyl-b-methyl-hexanoic acids and methods of use |
| WO2010042759A2 (en) | 2008-10-08 | 2010-04-15 | Kyphia Pharmaceuticals Inc | Gaba conjugates and methods of use thereof |
| WO2010084797A1 (ja) * | 2009-01-21 | 2010-07-29 | 第一三共株式会社 | 含ヘテロ原子化合物 |
| US9066853B2 (en) | 2013-01-15 | 2015-06-30 | Warsaw Orthopedic, Inc. | Clonidine compounds in a biodegradable fiber |
| CA2903000C (en) | 2013-01-28 | 2021-10-12 | Hector L. Lopez | Methods of improving tolerability, pharmacodynamics, and efficacy of .beta.-alanine and use therefor |
| CN114621119A (zh) | 2018-05-14 | 2022-06-14 | 昌郁医药公司 | 萘普生和普瑞巴林的1-(酰氧基)-烷基氨基甲酸酯药物缀合物的结晶形式 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4087544A (en) * | 1974-12-21 | 1978-05-02 | Warner-Lambert Company | Treatment of cranial dysfunctions using novel cyclic amino acids |
| DE2460891C2 (de) * | 1974-12-21 | 1982-09-23 | Gödecke AG, 1000 Berlin | 1-Aminomethyl-1-cycloalkanessigsäuren und deren Ester, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel |
| US5270317A (en) * | 1990-03-20 | 1993-12-14 | Elf Sanofi | N-substituted heterocyclic derivatives, their preparation and the pharmaceutical compositions in which they are present |
| EP0641780A1 (en) * | 1991-07-09 | 1995-03-08 | Nippon Soda Co., Ltd. | Heterocyclic cyclohexanedione derivative, production thereof, and herbicide |
| US5514801A (en) * | 1992-12-29 | 1996-05-07 | Monsanto Company | Cyclic sulfone containing retroviral protease inhibitors |
| GB9314758D0 (en) * | 1993-07-16 | 1993-08-25 | Wyeth John & Brother Ltd | Heterocyclic derivatives |
| US5527194A (en) * | 1994-02-02 | 1996-06-18 | Brunswick Corporation | Thrust sensor for marine drives |
| US5491152A (en) * | 1994-03-23 | 1996-02-13 | The Du Pont Merck Pharmaceutical Company | Derivatives of cyclic ethers and sulfides for the treatment of atherosclerosis |
| US5760006A (en) * | 1997-06-23 | 1998-06-02 | Ortho Pharmaceutical Corporation | Anticonvulsant derivatives useful in treating psoriasis |
-
1997
- 1997-01-02 EA EA199800682A patent/EA001534B1/ru not_active IP Right Cessation
- 1997-01-02 BR BR9707366A patent/BR9707366A/pt not_active Application Discontinuation
- 1997-01-02 JP JP09528505A patent/JP2000511877A/ja not_active Abandoned
- 1997-01-02 EP EP97901385A patent/EP0888325B1/en not_active Expired - Lifetime
- 1997-01-02 KR KR1019980706079A patent/KR19990082349A/ko not_active Ceased
- 1997-01-02 CZ CZ19982452A patent/CZ296052B6/cs not_active IP Right Cessation
- 1997-01-02 AT AT97901385T patent/ATE218135T1/de not_active IP Right Cessation
- 1997-01-02 US US09/077,053 patent/US5929088A/en not_active Expired - Fee Related
- 1997-01-02 DK DK97901385T patent/DK0888325T3/da active
- 1997-01-02 DE DE69712877T patent/DE69712877T2/de not_active Expired - Fee Related
- 1997-01-02 PL PL97328432A patent/PL328432A1/xx unknown
- 1997-01-02 SK SK1067-98A patent/SK282665B6/sk unknown
- 1997-01-02 WO PCT/US1997/000255 patent/WO1997029101A1/en not_active Ceased
- 1997-01-02 NZ NZ326669A patent/NZ326669A/en unknown
- 1997-01-02 IL IL12556297A patent/IL125562A/en not_active IP Right Cessation
- 1997-01-02 ES ES97901385T patent/ES2176668T3/es not_active Expired - Lifetime
- 1997-01-02 HU HU9901074A patent/HUP9901074A3/hu unknown
- 1997-01-02 CA CA002244708A patent/CA2244708A1/en not_active Abandoned
- 1997-01-02 PT PT97901385T patent/PT888325E/pt unknown
- 1997-01-02 AU AU15295/97A patent/AU720628B2/en not_active Ceased
- 1997-02-06 ZA ZA9700991A patent/ZA97991B/xx unknown
-
1998
- 1998-08-06 NO NO983612A patent/NO983612L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| HUP9901074A2 (hu) | 2001-04-28 |
| SK106798A3 (en) | 1999-07-12 |
| DE69712877T2 (de) | 2002-11-14 |
| HUP9901074A3 (en) | 2001-08-28 |
| EA001534B1 (ru) | 2001-04-23 |
| CZ245298A3 (cs) | 1998-11-11 |
| ATE218135T1 (de) | 2002-06-15 |
| PT888325E (pt) | 2002-10-31 |
| ZA97991B (en) | 1997-08-15 |
| ES2176668T3 (es) | 2002-12-01 |
| DK0888325T3 (da) | 2002-09-16 |
| PL328432A1 (en) | 1999-02-01 |
| JP2000511877A (ja) | 2000-09-12 |
| CA2244708A1 (en) | 1997-08-14 |
| AU720628B2 (en) | 2000-06-08 |
| NO983612L (no) | 1998-10-06 |
| DE69712877D1 (de) | 2002-07-04 |
| AU1529597A (en) | 1997-08-28 |
| EA199800682A1 (ru) | 1999-02-25 |
| US5929088A (en) | 1999-07-27 |
| EP0888325A1 (en) | 1999-01-07 |
| WO1997029101A1 (en) | 1997-08-14 |
| SK282665B6 (sk) | 2002-11-06 |
| NO983612D0 (no) | 1998-08-06 |
| IL125562A (en) | 2001-08-08 |
| EP0888325B1 (en) | 2002-05-29 |
| KR19990082349A (ko) | 1999-11-25 |
| CZ296052B6 (cs) | 2005-12-14 |
| NZ326669A (en) | 2001-05-25 |
| IL125562A0 (en) | 1999-03-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: INDEFIRO O PRESENTE PEDIDO DE PATENTE DE ACORDO COM ART. 36 DA LPI . |