BRPI0815673A2 - Sulfonas cíclicas substituídas por aminobenzila úteis como inibidores de bace. - Google Patents

Sulfonas cíclicas substituídas por aminobenzila úteis como inibidores de bace.

Info

Publication number
BRPI0815673A2
BRPI0815673A2 BRPI0815673-5A2A BRPI0815673A BRPI0815673A2 BR PI0815673 A2 BRPI0815673 A2 BR PI0815673A2 BR PI0815673 A BRPI0815673 A BR PI0815673A BR PI0815673 A2 BRPI0815673 A2 BR PI0815673A2
Authority
BR
Brazil
Prior art keywords
aminobenzile
sulphones
cycle
replaced
useful
Prior art date
Application number
BRPI0815673-5A2A
Other languages
English (en)
Inventor
Emmanuelle Briard
Rainer Martin Lueoend
Rainer Machauer
Henrik Moebitz
Olivier Rogel
Jean-Michel Rondeau
Heinrich Rueeger
Marina Tintelnot-Blomley
Siem Jacob Veenstra
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of BRPI0815673A2 publication Critical patent/BRPI0815673A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/02—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
BRPI0815673-5A2A 2007-08-23 2008-08-22 Sulfonas cíclicas substituídas por aminobenzila úteis como inibidores de bace. BRPI0815673A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP07114881 2007-08-23
EP08160123 2008-07-10
PCT/EP2008/061030 WO2009024615A1 (en) 2007-08-23 2008-08-22 Aminobenzyl-substituted cyclic sulfones useful as bace inhibitors

Publications (1)

Publication Number Publication Date
BRPI0815673A2 true BRPI0815673A2 (pt) 2015-02-18

Family

ID=39789883

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0815673-5A2A BRPI0815673A2 (pt) 2007-08-23 2008-08-22 Sulfonas cíclicas substituídas por aminobenzila úteis como inibidores de bace.

Country Status (15)

Country Link
US (1) US20090054427A1 (pt)
EP (1) EP2190833A1 (pt)
JP (1) JP2010536831A (pt)
KR (1) KR20100061805A (pt)
CN (1) CN101835771A (pt)
AR (1) AR068062A1 (pt)
AU (1) AU2008290561A1 (pt)
BR (1) BRPI0815673A2 (pt)
CA (1) CA2697254A1 (pt)
CL (1) CL2008002480A1 (pt)
EA (1) EA201000340A1 (pt)
MX (1) MX2010002007A (pt)
PE (1) PE20090953A1 (pt)
TW (1) TW200916097A (pt)
WO (1) WO2009024615A1 (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102076678A (zh) * 2008-07-10 2011-05-25 诺瓦提斯公司 作为bace抑制剂的具有氨基苄基取代基的环砜类化合物
EP2593106A4 (en) 2010-07-16 2014-01-01 Univ Rockefeller ORGANIC CONNECTIONS
US9242943B2 (en) * 2011-01-18 2016-01-26 Siena Biotech S.P.A. 1,4 oxazines as BACE1 and/or BACE2 inhibitors
DK2804610T3 (en) 2012-01-16 2019-02-25 Univ Rockefeller ORGANIC COMPOUNDS
EP2956443B1 (en) 2013-02-12 2019-09-25 Buck Institute For Research On Aging Hydantoins that modulate bace-mediated app processing
CN106674264A (zh) * 2016-12-20 2017-05-17 苏州汉德创宏生化科技有限公司 (2,2,2‑三氟乙氧基)苯硼酸类化合物的合成方法
US11684622B2 (en) 2018-06-19 2023-06-27 Celecor Therapeutics, Inc. Deuterated RUC-4

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA001534B1 (ru) * 1996-02-07 2001-04-23 Варнер-Ламберт Компани Производные циклической аминокислоты или их фармацевтически приемлемые соли, фармацевтическая композиция и способ лечения депрессии, состояний паники, страха и болевых ощущений
KR20010033153A (ko) * 1997-12-16 2001-04-25 로즈 암스트롱, 크리스틴 에이. 트러트웨인 4(3)-치환-4(3)-아미노메틸-(티오)피란 또는 -피페리딘유도체(=가바펜틴 동족체), 그의 제법 및 신경 질환 치료용도
GB0602951D0 (en) * 2006-02-14 2006-03-29 Novartis Ag Organic Compounds

Also Published As

Publication number Publication date
CN101835771A (zh) 2010-09-15
WO2009024615A1 (en) 2009-02-26
PE20090953A1 (es) 2009-08-10
TW200916097A (en) 2009-04-16
CL2008002480A1 (es) 2009-05-15
JP2010536831A (ja) 2010-12-02
EP2190833A1 (en) 2010-06-02
AR068062A1 (es) 2009-11-04
KR20100061805A (ko) 2010-06-09
CA2697254A1 (en) 2009-02-26
MX2010002007A (es) 2010-03-10
EA201000340A1 (ru) 2010-08-30
US20090054427A1 (en) 2009-02-26
AU2008290561A1 (en) 2009-02-26

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]