BR9608449A - Vìrus recombinante defeituoso, adenovìrus, uso de um vìrus, e, composição farmacêutica. - Google Patents
Vìrus recombinante defeituoso, adenovìrus, uso de um vìrus, e, composição farmacêutica.Info
- Publication number
- BR9608449A BR9608449A BR9608449-9A BR9608449A BR9608449A BR 9608449 A BR9608449 A BR 9608449A BR 9608449 A BR9608449 A BR 9608449A BR 9608449 A BR9608449 A BR 9608449A
- Authority
- BR
- Brazil
- Prior art keywords
- virus
- defective recombinant
- pharmaceutical composition
- adenoviruses
- recombinant virus
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4703—Inhibitors; Suppressors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/022—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from an adenovirus
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Public Health (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Immunology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biotechnology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
"VìRUS RECOMBINANTE DEFEITUOSO, ADENOVìRUS, USO DE UM VìRUS, E, COMPOSIçãO FARMACêUTICA". A presente invenção refere-se a vírus recombinantes defeituosos, que contêm pelo menos um gene inserido codificando toda ou parte da proteína GAX ou de uma variante desta proteína, e a seu uso terapêutico, em particular para tratar restenose pós-angioplástica.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9504234A FR2732357B1 (fr) | 1995-03-31 | 1995-03-31 | Vecteurs viraux et utilisation pour le traitement des desordres hyperproliferatifs, notamment de la restenose |
PCT/US1996/004493 WO1996030385A1 (en) | 1995-03-31 | 1996-03-28 | Viral vectors and their use for treating hyperproliferative disorders, in particular restenosis |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9608449A true BR9608449A (pt) | 1999-11-30 |
Family
ID=9477928
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9608449-9A BR9608449A (pt) | 1995-03-31 | 1996-03-28 | Vìrus recombinante defeituoso, adenovìrus, uso de um vìrus, e, composição farmacêutica. |
Country Status (16)
Country | Link |
---|---|
US (2) | US5851521A (pt) |
EP (1) | EP0817791A4 (pt) |
JP (1) | JPH11503314A (pt) |
KR (1) | KR19980703454A (pt) |
CN (1) | CN1190402A (pt) |
AP (1) | AP1011A (pt) |
AU (1) | AU701345B2 (pt) |
BR (1) | BR9608449A (pt) |
CA (1) | CA2216878A1 (pt) |
CZ (1) | CZ308897A3 (pt) |
FR (1) | FR2732357B1 (pt) |
HU (1) | HUP9801767A3 (pt) |
OA (1) | OA10516A (pt) |
SI (1) | SI9620059A (pt) |
SK (1) | SK132797A3 (pt) |
WO (1) | WO1996030385A1 (pt) |
Families Citing this family (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5856121A (en) * | 1994-02-24 | 1999-01-05 | Case Western Reserve University | Growth arrest homebox gene |
US7423125B2 (en) | 1995-08-01 | 2008-09-09 | Vegenics Limited | Antibodies to VEGF-C |
FR2740344B1 (fr) * | 1995-10-31 | 1997-11-21 | Rhone Poulenc Rorer Sa | Application de la proteine gax au traitement de cancers |
FR2754822B1 (fr) * | 1996-10-18 | 1998-11-27 | Rhone Poulenc Rorer Sa | Polypeptides comprenant des domaines de la proteine gax, impliques dans la repression de transcription et/ou interagissant avec d'autres proteines, acides nucleiques correspondants et leurs utilisations |
US6335010B1 (en) * | 1996-11-08 | 2002-01-01 | University Of California At San Diego | Gene therapy in coronary angioplasty and bypass |
WO2000041732A1 (en) | 1999-01-19 | 2000-07-20 | The Children's Hospital Of Philadelphia | Hydrogel compositions for controlled delivery of virus vectors and methods of use thereof |
CA2396628A1 (en) | 2000-01-25 | 2001-08-02 | Edwards Lifesciences Corporation | Delivery systems for treatment of restenosis and anastomotic intimal hyperplasia |
AU3988401A (en) * | 2000-02-25 | 2001-09-03 | Ludwig Inst Cancer Res | Materials and methods involving hybrid vascular endothelial growth factor dnas and proteins |
US20030100889A1 (en) * | 2001-07-05 | 2003-05-29 | Nicolas Duverger | Method of administration of a gene of interest to a vascular tissue |
US20030180936A1 (en) * | 2002-03-15 | 2003-09-25 | Memarzadeh Bahram Eric | Method for the purification, production and formulation of oncolytic adenoviruses |
US20040220656A1 (en) * | 2003-04-30 | 2004-11-04 | Epstein Samuel J. | Coated medical devices and methods of making the same |
US20080215137A1 (en) * | 2003-04-30 | 2008-09-04 | Boston Scientific Scimed, Inc. | Therapeutic driving layer for a medical device |
US20050120398A1 (en) * | 2003-09-12 | 2005-06-02 | Vertex Pharmaceuticals Incorporated | Animal model for HCV infection |
DE602005027673D1 (de) * | 2004-03-05 | 2011-06-09 | Vegenics Pty Ltd | Materialien und verfahren für wachstumsfaktorbindende konstrukte |
US7582442B2 (en) * | 2004-03-16 | 2009-09-01 | The Regents Of The University Of Michigan | Methods and compositions for using aleveolar macrophage phospholipase A2 |
US7319015B2 (en) * | 2004-03-16 | 2008-01-15 | The Regents Of The University Of Michigan | Methods and compositions for using alveolar macrophage phospholipase A2 |
GB0416487D0 (en) | 2004-07-23 | 2004-08-25 | Isis Innovation | Modified virus |
WO2006014798A2 (en) * | 2004-07-27 | 2006-02-09 | Mount Sinai School Of Medicine | Methods and compositions for using sax2 |
FI20050753A (fi) | 2004-09-03 | 2006-03-04 | Licentia Oy | Uudet peptidit |
WO2006101629A2 (en) | 2005-02-17 | 2006-09-28 | Vertex Pharmaceuticals Incorporated | SODIUM CHANNEL PROTEIN TYPE III α-SUBUNIT SPLICE VARIANT |
KR100747646B1 (ko) | 2005-02-25 | 2007-08-08 | 연세대학교 산학협력단 | 데코린 유전자를 포함하는 유전자 전달 시스템 및 이를 포함하는 약제학적 항종양 조성물 |
ATE502956T1 (de) | 2005-08-15 | 2011-04-15 | Vegenics Pty Ltd | Modifizierte vegf und pdgf mit verbesserten angiogenen eigenschaften |
US20080200408A1 (en) * | 2005-09-30 | 2008-08-21 | Mccormack Kenneth | Deletion mutants of tetrodotoxin-resistant sodium channel alpha subunit |
US7972813B2 (en) * | 2005-09-30 | 2011-07-05 | Vertex Pharmaceuticals Incorporated | Tetrodotoxin-resistant sodium channel alpha subunit |
DE602005023550D1 (de) | 2005-12-14 | 2010-10-21 | Licentia Ltd | Verwendungen eines neurotrophischen Faktors |
WO2007089780A2 (en) * | 2006-01-30 | 2007-08-09 | Licentia, Ltd. | Bmx/etk tyrosine kinase gene therapy materials and methods |
AU2007254243B2 (en) | 2006-05-17 | 2013-06-13 | Ludwig Institute For Cancer Research | Targeting VEGF-B regulation of fatty acid transporters to modulate human diseases |
FI20070808A0 (fi) | 2007-10-25 | 2007-10-25 | Mart Saarma | GDNF:n silmukointivariantit ja niiden käytöt |
WO2009088256A2 (ko) | 2008-01-09 | 2009-07-16 | Konkuk University Industrial Cooperation Corp | 배큘로바이러스-기반 백신 |
US20090196854A1 (en) * | 2008-02-04 | 2009-08-06 | Kytos Biosystems S.A. | Methods and compositions for use of crl 5803 cells for expression of biotherapeutics and encapsulated cell-based delivery |
FI20080326A0 (fi) | 2008-04-30 | 2008-04-30 | Licentia Oy | Neurotroofinen tekijä MANF ja sen käytöt |
EP2318036B1 (en) | 2008-06-30 | 2015-06-03 | The Regents of the University of Michigan | Lysosomal phospholipase a2 (lpla2) activity as a diagnostic and therapeutic target for identifying and treating systemic lupus erythematosis |
KR101230913B1 (ko) | 2009-11-06 | 2013-02-07 | 중앙대학교 산학협력단 | 나노입자-기반된 유전자 운반체 |
KR101232123B1 (ko) | 2010-10-08 | 2013-02-12 | 연세대학교 산학협력단 | 재조합된 유전자발현 조절서열을 가지는 종양 특이적 발현이 개선된 유전자 전달체 |
CA2840175C (en) | 2011-05-19 | 2021-11-16 | The Regents Of The University Of Michigan | Integrin alpha-2 binding agents and use thereof to inhibit cancer cell proliferation |
US9404090B2 (en) | 2011-11-24 | 2016-08-02 | Viromed Co., Ltd. | Adenovirus producing novel cell line and the use thereof |
DK2785683T3 (da) | 2011-11-30 | 2020-04-14 | Ludwig Inst For Cancer Res Ltd | Inkt-cellemodulatorer og fremgangsmåder til anvendelse heraf |
GB201120860D0 (en) | 2011-12-05 | 2012-01-18 | Cambridge Entpr Ltd | Cancer immunotherapy |
WO2013184209A1 (en) | 2012-06-04 | 2013-12-12 | Ludwig Institute For Cancer Research Ltd. | Mif for use in methods of treating subjects with a neurodegenerative disorder |
PL3421602T3 (pl) | 2012-09-06 | 2021-10-25 | The University Of Chicago | Polinukleotydy antysensowne wywołujące pominięcie egzonu i sposoby leczenia dystrofii |
KR101429696B1 (ko) | 2012-11-21 | 2014-08-13 | 국립암센터 | 안전성 및 항암활성이 증가된 재조합 아데노바이러스 및 이의 용도 |
AU2014218318B2 (en) | 2013-02-18 | 2018-02-15 | Vegenics Pty Limited | Ligand binding molecules and uses thereof |
WO2014191630A2 (en) | 2013-05-28 | 2014-12-04 | Helsingin Yliopisto | Non-human animal model encoding a non-functional manf gene |
DK3283500T3 (en) | 2015-04-08 | 2020-11-16 | Univ Chicago | Compositions and methods for correcting limb girdle muscular dystrophy type 2C using exon skipping |
CN108289920A (zh) | 2015-10-12 | 2018-07-17 | 汉阳大学校产学协力团 | 用于基因转移和基因治疗的腺病毒复合物 |
JP6913747B2 (ja) | 2016-09-20 | 2021-08-04 | ベーリンガー インゲルハイム フェトメディカ ゲーエムベーハーBoehringer Ingelheim Vetmedica GmbH | イヌアデノウイルスベクター |
AU2017329672B2 (en) | 2016-09-20 | 2023-07-27 | Boehringer Ingelheim Vetmedica Gmbh | New promoters |
US10619169B2 (en) | 2016-09-20 | 2020-04-14 | Boehringer Ingelheim Vetmedica Gmbh | EHV insertion site ORF70 |
KR102566066B1 (ko) | 2016-09-20 | 2023-08-16 | 베링거잉겔하임베트메디카게엠베하 | 신규한 돼지 인플루엔자 백신 |
CN111630159A (zh) | 2017-12-13 | 2020-09-04 | 基因药物株式会社 | 重组腺病毒及包含此病毒的干细胞 |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8424757D0 (en) * | 1984-10-01 | 1984-11-07 | Pasteur Institut | Retroviral vector |
FR2573436B1 (fr) * | 1984-11-20 | 1989-02-17 | Pasteur Institut | Adn recombinant comportant une sequence nucleotidique codant pour un polypeptide determine sous le controle d'un promoteur d'adenovirus, vecteurs contenant cet adn recombinant, cellules eucaryotes transformees par cet adn recombinant, produits d'excretion de ces cellules transformees et leurs applications, notamment a la constitution de vaccins |
US4797368A (en) * | 1985-03-15 | 1989-01-10 | The United States Of America As Represented By The Department Of Health And Human Services | Adeno-associated virus as eukaryotic expression vector |
US5139941A (en) * | 1985-10-31 | 1992-08-18 | University Of Florida Research Foundation, Inc. | AAV transduction vectors |
US4861719A (en) * | 1986-04-25 | 1989-08-29 | Fred Hutchinson Cancer Research Center | DNA constructs for retrovirus packaging cell lines |
CA1339354C (en) * | 1988-09-01 | 1997-08-26 | The Whitehead Institute For Biomedical Research | Recombinant retroviruses with amphotropic and ecotropic host ranges |
US5585362A (en) * | 1989-08-22 | 1996-12-17 | The Regents Of The University Of Michigan | Adenovirus vectors for gene therapy |
CA2039921A1 (en) * | 1990-04-16 | 1991-10-17 | Xandra O. Breakefield | Transfer and expression of gene sequences into central nervous system cells using herpes simplex virus mutants with deletions in genes for viral replication |
WO1991018088A1 (en) * | 1990-05-23 | 1991-11-28 | The United States Of America, Represented By The Secretary, United States Department Of Commerce | Adeno-associated virus (aav)-based eucaryotic vectors |
US5173414A (en) * | 1990-10-30 | 1992-12-22 | Applied Immune Sciences, Inc. | Production of recombinant adeno-associated virus vectors |
US5252479A (en) * | 1991-11-08 | 1993-10-12 | Research Corporation Technologies, Inc. | Safe vector for gene therapy |
DE69333886T2 (de) * | 1992-11-18 | 2006-07-27 | Arch Development Corp., Chicago | Adenovirus-gelenkter Gen-Transfer zum Herz-und glattem vaskulären Muskel |
EP0911413A3 (en) * | 1992-12-03 | 2000-11-15 | Genzyme Corporation | Minimal adenovirus-based gene therapy vector |
FR2705361B1 (fr) * | 1993-05-18 | 1995-08-04 | Centre Nat Rech Scient | Vecteurs viraux et utilisation en thérapie génique. |
FR2705686B1 (fr) * | 1993-05-28 | 1995-08-18 | Transgene Sa | Nouveaux adénovirus défectifs et lignées de complémentation correspondantes. |
SK282843B6 (sk) * | 1993-07-13 | 2002-12-03 | Rhone-Poulenc Rorer S. A. | Defektný rekombinantný adenovírus a farmaceutický prostriedok s jeho obsahom |
US5856121A (en) * | 1994-02-24 | 1999-01-05 | Case Western Reserve University | Growth arrest homebox gene |
-
1995
- 1995-03-31 FR FR9504234A patent/FR2732357B1/fr not_active Expired - Fee Related
-
1996
- 1996-03-28 SI SI9620059A patent/SI9620059A/sl not_active IP Right Cessation
- 1996-03-28 CN CN96193929A patent/CN1190402A/zh active Pending
- 1996-03-28 SK SK1327-97A patent/SK132797A3/sk unknown
- 1996-03-28 WO PCT/US1996/004493 patent/WO1996030385A1/en not_active Application Discontinuation
- 1996-03-28 BR BR9608449-9A patent/BR9608449A/pt not_active Application Discontinuation
- 1996-03-28 JP JP8529747A patent/JPH11503314A/ja not_active Ceased
- 1996-03-28 EP EP96912530A patent/EP0817791A4/en not_active Withdrawn
- 1996-03-28 CA CA002216878A patent/CA2216878A1/en not_active Abandoned
- 1996-03-28 AU AU55315/96A patent/AU701345B2/en not_active Ceased
- 1996-03-28 CZ CZ973088A patent/CZ308897A3/cs unknown
- 1996-03-28 AP APAP/P/1997/001117A patent/AP1011A/en active
- 1996-03-28 HU HU9801767A patent/HUP9801767A3/hu unknown
- 1996-03-28 KR KR1019970706858A patent/KR19980703454A/ko not_active Application Discontinuation
- 1996-09-30 US US08/723,726 patent/US5851521A/en not_active Ceased
-
1997
- 1997-09-29 OA OA70089A patent/OA10516A/en unknown
-
2000
- 2000-12-21 US US09/740,876 patent/USRE37933E1/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
CZ308897A3 (cs) | 1998-03-18 |
USRE37933E1 (en) | 2002-12-10 |
FR2732357A1 (fr) | 1996-10-04 |
HUP9801767A2 (hu) | 1998-10-28 |
AP1011A (en) | 2001-09-22 |
AP9701117A0 (en) | 1996-03-28 |
EP0817791A1 (en) | 1998-01-14 |
JPH11503314A (ja) | 1999-03-26 |
AU701345B2 (en) | 1999-01-28 |
EP0817791A4 (en) | 1998-07-15 |
MX9707549A (es) | 1998-07-31 |
CN1190402A (zh) | 1998-08-12 |
AU5531596A (en) | 1996-10-16 |
CA2216878A1 (en) | 1996-10-03 |
HUP9801767A3 (en) | 1999-04-28 |
SK132797A3 (en) | 1998-07-08 |
SI9620059A (sl) | 1998-06-30 |
FR2732357B1 (fr) | 1997-04-30 |
KR19980703454A (ko) | 1998-11-05 |
WO1996030385A1 (en) | 1996-10-03 |
OA10516A (en) | 2002-04-22 |
US5851521A (en) | 1998-12-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EG | Technical examination (opinion): publication of technical examination (opinion) | ||
B09B | Patent application refused [chapter 9.2 patent gazette] | ||
B09T | Decision of refusal: decision cancelled [chapter 9.2.1 patent gazette] | ||
B09B | Patent application refused [chapter 9.2 patent gazette] |