BR9406931A - Oligonucleotideo composição farmacêutica olignucleotideo quimérico processos para modular a expressão de PKC em células para detectar em uma amostra a presença de um gene PKC ou MRNA PKC para diagnosticar uma condição associada com PKC molécula de ácido nucleico isolada oligonucleotideo anti-sentido tendo 5 a 50 nucleotideos de comprinento sonda de polinucleotideos rocessos para detectar um gene codificando para PKCA humano em uma amostra para detectar o transcrito de MRNA longo de PKCA humano - Google Patents

Oligonucleotideo composição farmacêutica olignucleotideo quimérico processos para modular a expressão de PKC em células para detectar em uma amostra a presença de um gene PKC ou MRNA PKC para diagnosticar uma condição associada com PKC molécula de ácido nucleico isolada oligonucleotideo anti-sentido tendo 5 a 50 nucleotideos de comprinento sonda de polinucleotideos rocessos para detectar um gene codificando para PKCA humano em uma amostra para detectar o transcrito de MRNA longo de PKCA humano

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Publication number
BR9406931A
BR9406931A BR9406931A BR9406931A BR9406931A BR 9406931 A BR9406931 A BR 9406931A BR 9406931 A BR9406931 A BR 9406931A BR 9406931 A BR9406931 A BR 9406931A BR 9406931 A BR9406931 A BR 9406931A
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BR
Brazil
Prior art keywords
pkc
detect
sample
gene
pkca
Prior art date
Application number
BR9406931A
Other languages
English (en)
Inventor
Frank C Bennett
Russell T Boggs
Nicholas M Dean
Original Assignee
Isis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/089,996 external-priority patent/US5703054A/en
Application filed by Isis Pharmaceuticals Inc filed Critical Isis Pharmaceuticals Inc
Publication of BR9406931A publication Critical patent/BR9406931A/pt

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
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    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
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    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/11—Protein-serine/threonine kinases (2.7.11)
    • C12Y207/11013—Protein kinase C (2.7.11.13)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C12N2310/32—Chemical structure of the sugar
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    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/341—Gapmers, i.e. of the type ===---===
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/352—Nature of the modification linked to the nucleic acid via a carbon atom
    • C12N2310/3521—Methyl
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    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/352—Nature of the modification linked to the nucleic acid via a carbon atom
    • C12N2310/3527—Other alkyl chain
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
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    • C12N2310/3533—Halogen
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

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  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
BR9406931A 1993-07-09 1994-07-08 Oligonucleotideo composição farmacêutica olignucleotideo quimérico processos para modular a expressão de PKC em células para detectar em uma amostra a presença de um gene PKC ou MRNA PKC para diagnosticar uma condição associada com PKC molécula de ácido nucleico isolada oligonucleotideo anti-sentido tendo 5 a 50 nucleotideos de comprinento sonda de polinucleotideos rocessos para detectar um gene codificando para PKCA humano em uma amostra para detectar o transcrito de MRNA longo de PKCA humano BR9406931A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/089,996 US5703054A (en) 1992-03-16 1993-07-09 Oligonucleotide modulation of protein kinase C
US08/199,779 US5681747A (en) 1992-03-16 1994-02-22 Nucleic acid sequences encoding protein kinase C and antisense inhibition of expression thereof
PCT/US1994/007770 WO1995002069A1 (en) 1993-07-09 1994-07-08 Oligonucleotide modulation of protein kinase c

Publications (1)

Publication Number Publication Date
BR9406931A true BR9406931A (pt) 1996-09-10

Family

ID=26781147

Family Applications (1)

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BR9406931A BR9406931A (pt) 1993-07-09 1994-07-08 Oligonucleotideo composição farmacêutica olignucleotideo quimérico processos para modular a expressão de PKC em células para detectar em uma amostra a presença de um gene PKC ou MRNA PKC para diagnosticar uma condição associada com PKC molécula de ácido nucleico isolada oligonucleotideo anti-sentido tendo 5 a 50 nucleotideos de comprinento sonda de polinucleotideos rocessos para detectar um gene codificando para PKCA humano em uma amostra para detectar o transcrito de MRNA longo de PKCA humano

Country Status (12)

Country Link
US (2) US5681747A (pt)
EP (1) EP0714449A4 (pt)
JP (4) JP3553068B2 (pt)
KR (1) KR100211424B1 (pt)
AU (1) AU688354B2 (pt)
BR (1) BR9406931A (pt)
CA (1) CA2166058A1 (pt)
FI (1) FI960089A (pt)
HU (1) HU219017B (pt)
NO (1) NO960079L (pt)
NZ (1) NZ269653A (pt)
WO (1) WO1995002069A1 (pt)

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US6015892A (en) 2000-01-18
EP0714449A4 (en) 1998-12-02
AU7398194A (en) 1995-02-06
CA2166058A1 (en) 1995-01-19
US5681747A (en) 1997-10-28
JP2001224387A (ja) 2001-08-21
FI960089A0 (fi) 1996-01-08
KR100211424B1 (ko) 1999-08-02
FI960089A (fi) 1996-03-07
NO960079D0 (no) 1996-01-08
EP0714449A1 (en) 1996-06-05
NO960079L (no) 1996-02-29
HU9600050D0 (en) 1996-03-28
HU219017B (hu) 2001-01-29
JP2001224386A (ja) 2001-08-21
JP3349502B2 (ja) 2002-11-25
JP2001231579A (ja) 2001-08-28
JP3349501B2 (ja) 2002-11-25
HUT75834A (en) 1997-05-28
WO1995002069A1 (en) 1995-01-19
JP3349500B2 (ja) 2002-11-25
JPH08507929A (ja) 1996-08-27
JP3553068B2 (ja) 2004-08-11
NZ269653A (en) 1997-12-19

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