BR9007789A - Derivados de acido 2-anilino fenilacetico como inibidores de pla2 e lipoxigenase - Google Patents
Derivados de acido 2-anilino fenilacetico como inibidores de pla2 e lipoxigenaseInfo
- Publication number
- BR9007789A BR9007789A BR909007789A BR9007789A BR9007789A BR 9007789 A BR9007789 A BR 9007789A BR 909007789 A BR909007789 A BR 909007789A BR 9007789 A BR9007789 A BR 9007789A BR 9007789 A BR9007789 A BR 9007789A
- Authority
- BR
- Brazil
- Prior art keywords
- anyline
- pla2
- acid derivatives
- phenylacetic acid
- lipoxygenase inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/40—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/42—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton with carboxyl groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D215/14—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/18—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/12—Radicals substituted by oxygen atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/428,092 US5021576A (en) | 1989-10-27 | 1989-10-27 | 2-Anilino phenylacetic acid derivatives |
| PCT/US1990/006253 WO1991006539A1 (en) | 1989-10-27 | 1990-10-27 | 2-anilino phenylacetic acid derivatives as inhibitors of pla2 and lipoxygenase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9007789A true BR9007789A (pt) | 1992-09-15 |
Family
ID=23697520
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR909007789A BR9007789A (pt) | 1989-10-27 | 1990-10-27 | Derivados de acido 2-anilino fenilacetico como inibidores de pla2 e lipoxigenase |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5021576A (pt) |
| EP (1) | EP0523046A1 (pt) |
| JP (1) | JPH05502022A (pt) |
| KR (1) | KR927003528A (pt) |
| AU (1) | AU640429B2 (pt) |
| BR (1) | BR9007789A (pt) |
| CA (1) | CA2067135A1 (pt) |
| FI (1) | FI921863A0 (pt) |
| HU (1) | HUT64751A (pt) |
| IE (1) | IE903873A1 (pt) |
| PT (1) | PT95691A (pt) |
| WO (1) | WO1991006539A1 (pt) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5190968A (en) * | 1991-09-30 | 1993-03-02 | Merck Frosst Canada, Inc. | (Polycyclic-arylmethoxy) indoles as inhibitors of leukotriene biosynthesis |
| US5290798A (en) * | 1991-09-30 | 1994-03-01 | Merck Frosst Canada, Inc. | (hetero-arylmethoxy)indoles as inhibitors of leukotriene biosynthesis |
| US5308850A (en) * | 1991-09-30 | 1994-05-03 | Merck Frosst Canada, Inc. | (Bicyclic-hetero-arylmethoxy)indoles as inhibitors of leukotriene biosynthesis |
| IT1256345B (it) * | 1992-08-20 | 1995-12-01 | Esteri nitrici di derivati dell'acido 2-(2,6-di-alo-fenilammino) fenilacetico e procedimento per la loro preparazione | |
| US5374635A (en) * | 1993-03-29 | 1994-12-20 | Merck Frosst Canada, Inc. | Furo[3,2-b]pyridines and thieno[3,2-b]pyridines as inhibitors of leukotriene biosynthesis |
| IT1270203B (it) * | 1994-06-09 | 1997-04-29 | Fisons Instr Spa | Procedimento e dispositivo per l'introduzione di liquidi in spettrometri di massa mediante nebulizzazione elettrostatica |
| US6355680B1 (en) | 1996-02-20 | 2002-03-12 | Exocell, Inc. | Albumin-binding compounds that prevent nonenzymatic glycation and that may be used for treatment of glycation-related pathologies |
| US5756518A (en) * | 1996-04-02 | 1998-05-26 | Kowa Co., Ltd. | Phenylene derivatives |
| TW200508197A (en) * | 2003-03-31 | 2005-03-01 | Ucb Sa | Indolone-acetamide derivatives, processes for preparing them and their uses |
| WO2018214959A1 (zh) | 2017-05-26 | 2018-11-29 | 南京明德新药研发股份有限公司 | 作为fxr受体激动剂的内酰胺类化合物 |
| CN115417751A (zh) * | 2022-06-13 | 2022-12-02 | 中山大学 | 一种苯环c-h酚羟基化的方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3558690A (en) * | 1965-04-08 | 1971-01-26 | Gelgy Chemical Corp | Substituted derivatives of 2-anilinophenylacetic acids and a process of preparation |
| IE58870B1 (en) * | 1985-03-08 | 1993-11-17 | Leo Pharm Prod Ltd | Pyridine derivatives |
| EP0219307A3 (en) * | 1985-10-16 | 1987-10-14 | Merck Frosst Canada Inc. | 2-substituted quinolines |
| GB2185741B (en) * | 1986-01-27 | 1989-10-25 | American Home Prod | Heterocyclic sulphonamides |
| JPH01502755A (ja) * | 1987-03-18 | 1989-09-21 | アメリカン・ホーム・プロダクツ・コーポレイション | スルホニルカルボキシアミド |
| JPS6429363A (en) * | 1987-07-23 | 1989-01-31 | Yoshitomi Pharmaceutical | Heterocyclic derivative |
| US4826990A (en) * | 1987-09-30 | 1989-05-02 | American Home Products Corporation | 2-aryl substituted heterocyclic compounds as antiallergic and antiinflammatory agents |
| IL88433A0 (en) * | 1987-11-25 | 1989-06-30 | Merck Frosst Canada Inc | Diarylstyrylquinoline diacids and pharmaceutical compositions containing them |
| AU617386B2 (en) * | 1987-12-01 | 1991-11-28 | Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Produktionsaktieselskab) | Substituted quinolines |
| GB8728051D0 (en) * | 1987-12-01 | 1988-01-06 | Leo Pharm Prod Ltd | Chemical compounds |
| DE3814504A1 (de) * | 1988-04-29 | 1989-11-09 | Bayer Ag | (alpha)-substituierte 4-(chinolin-2-yl-methoxy)phenylessigsaeuren und -ester, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln |
| DE3927931A1 (de) * | 1989-08-24 | 1991-02-28 | Bayer Ag | Disubstituierte (chinolin-2-yl-methoxy)phenylessigsaeure-derivate |
| PT95690A (pt) * | 1989-10-27 | 1991-09-13 | American Home Prod | Processo para a preparacao de derivados substituidos de acidos benzoilbenzo-, bifenil- e 2-oxazol-alcanoicos, uteis como inibidores de pla2 e da lipoxigenase |
-
1989
- 1989-10-27 US US07/428,092 patent/US5021576A/en not_active Expired - Fee Related
-
1990
- 1990-10-25 PT PT95691A patent/PT95691A/pt not_active Application Discontinuation
- 1990-10-26 IE IE387390A patent/IE903873A1/en not_active Application Discontinuation
- 1990-10-27 HU HU9201406A patent/HUT64751A/hu unknown
- 1990-10-27 JP JP2515688A patent/JPH05502022A/ja active Pending
- 1990-10-27 BR BR909007789A patent/BR9007789A/pt not_active Application Discontinuation
- 1990-10-27 KR KR1019920700972A patent/KR927003528A/ko not_active Application Discontinuation
- 1990-10-27 CA CA002067135A patent/CA2067135A1/en not_active Abandoned
- 1990-10-27 WO PCT/US1990/006253 patent/WO1991006539A1/en not_active Application Discontinuation
- 1990-10-27 EP EP19900916932 patent/EP0523046A1/en not_active Withdrawn
- 1990-10-27 AU AU67247/90A patent/AU640429B2/en not_active Ceased
-
1992
- 1992-04-24 FI FI921863A patent/FI921863A0/fi not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| IE903873A1 (en) | 1991-05-08 |
| WO1991006539A1 (en) | 1991-05-16 |
| JPH05502022A (ja) | 1993-04-15 |
| HU9201406D0 (en) | 1992-07-28 |
| FI921863A (fi) | 1992-04-24 |
| HUT64751A (en) | 1994-02-28 |
| CA2067135A1 (en) | 1991-04-28 |
| KR927003528A (ko) | 1992-12-18 |
| AU6724790A (en) | 1991-05-31 |
| US5021576A (en) | 1991-06-04 |
| FI921863A0 (fi) | 1992-04-24 |
| AU640429B2 (en) | 1993-08-26 |
| PT95691A (pt) | 1991-09-13 |
| EP0523046A1 (en) | 1993-01-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EG | Technical examination (opinion): publication of technical examination (opinion) | ||
| FC | Decision: refusal |