BR122019027913B1 - Partícula vírus-like, composição farmacêutica compreendendo a referida partícula e método para produção da mesma - Google Patents

Partícula vírus-like, composição farmacêutica compreendendo a referida partícula e método para produção da mesma Download PDF

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Publication number
BR122019027913B1
BR122019027913B1 BR122019027913-6A BR122019027913A BR122019027913B1 BR 122019027913 B1 BR122019027913 B1 BR 122019027913B1 BR 122019027913 A BR122019027913 A BR 122019027913A BR 122019027913 B1 BR122019027913 B1 BR 122019027913B1
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BR
Brazil
Prior art keywords
hcmv
polypeptide
gag
seq
protein
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BR122019027913-6A
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English (en)
Portuguese (pt)
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David E. Anderson
Anne-Catherine Fluckiger
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Variation Biotechnologies, Inc
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Publication of BR122019027913B1 publication Critical patent/BR122019027913B1/pt

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • A61K39/245Herpetoviridae, e.g. herpes simplex virus
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • A61P31/22Antivirals for DNA viruses for herpes viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525Virus
    • A61K2039/5258Virus-like particles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/70Multivalent vaccine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/01Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011Details
    • C12N2710/16011Herpesviridae
    • C12N2710/16111Cytomegalovirus, e.g. human herpesvirus 5
    • C12N2710/16134Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00Reverse transcribing RNA viruses
    • C12N2740/00011Details
    • C12N2740/10011Retroviridae
    • C12N2740/13011Gammaretrovirus, e.g. murine leukeamia virus
    • C12N2740/13023Virus like particles [VLP]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011Details
    • C12N2760/20011Rhabdoviridae
    • C12N2760/20211Vesiculovirus, e.g. vesicular stomatitis Indiana virus
    • C12N2760/20234Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011Details
    • C12N2760/20011Rhabdoviridae
    • C12N2760/20211Vesiculovirus, e.g. vesicular stomatitis Indiana virus
    • C12N2760/20241Use of virus, viral particle or viral elements as a vector
    • C12N2760/20245Special targeting system for viral vectors

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Lubricants (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
BR122019027913-6A 2011-11-11 2012-11-09 Partícula vírus-like, composição farmacêutica compreendendo a referida partícula e método para produção da mesma BR122019027913B1 (pt)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201161558800P 2011-11-11 2011-11-11
US61/558,800 2011-11-11
US201261654157P 2012-06-01 2012-06-01
US61/654,157 2012-06-01
PCT/IB2012/002854 WO2013068847A2 (en) 2011-11-11 2012-11-09 Compositions and methods for treatment of cytomegalovirus
BR112014011229-0A BR112014011229B1 (pt) 2011-11-11 2012-11-09 Partículas vírus-like (vlp), composição farmacêutica compreendendo a referida partícula, método de produção e uso da mesma

Publications (1)

Publication Number Publication Date
BR122019027913B1 true BR122019027913B1 (pt) 2021-11-30

Family

ID=48290708

Family Applications (2)

Application Number Title Priority Date Filing Date
BR122019027913-6A BR122019027913B1 (pt) 2011-11-11 2012-11-09 Partícula vírus-like, composição farmacêutica compreendendo a referida partícula e método para produção da mesma
BR112014011229-0A BR112014011229B1 (pt) 2011-11-11 2012-11-09 Partículas vírus-like (vlp), composição farmacêutica compreendendo a referida partícula, método de produção e uso da mesma

Family Applications After (1)

Application Number Title Priority Date Filing Date
BR112014011229-0A BR112014011229B1 (pt) 2011-11-11 2012-11-09 Partículas vírus-like (vlp), composição farmacêutica compreendendo a referida partícula, método de produção e uso da mesma

Country Status (14)

Country Link
US (3) US9777043B2 (ja)
EP (2) EP2776567B1 (ja)
JP (2) JP6232544B2 (ja)
KR (2) KR102340558B1 (ja)
CN (3) CN107875382B (ja)
AU (3) AU2012335277B2 (ja)
BR (2) BR122019027913B1 (ja)
CA (2) CA3166278A1 (ja)
DK (1) DK2776567T3 (ja)
ES (1) ES2874233T3 (ja)
MX (1) MX353189B (ja)
PT (1) PT2776567T (ja)
RU (2) RU2737530C1 (ja)
WO (1) WO2013068847A2 (ja)

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US9777043B2 (en) 2011-11-11 2017-10-03 Variation Biotechnologies Inc. Compositions and methods for treatment of cytomegalovirus
CN104114572A (zh) 2011-12-16 2014-10-22 现代治疗公司 经修饰的核苷、核苷酸和核酸组合物
CA2867789C (en) * 2012-03-27 2022-06-14 Variation Biotechnologies Inc. Methods for detection of anti-cytomegalovirus neutralizing antibodies
US9572897B2 (en) 2012-04-02 2017-02-21 Modernatx, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
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DE18200782T1 (de) 2012-04-02 2021-10-21 Modernatx, Inc. Modifizierte polynukleotide zur herstellung von proteinen im zusammenhang mit erkrankungen beim menschen
US9303079B2 (en) 2012-04-02 2016-04-05 Moderna Therapeutics, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
EP3269388A1 (en) * 2012-10-30 2018-01-17 Pfizer Inc. Recombinant particle based vaccines against human cytomegalovirus infection
EP4074834A1 (en) 2012-11-26 2022-10-19 ModernaTX, Inc. Terminally modified rna
US8980864B2 (en) 2013-03-15 2015-03-17 Moderna Therapeutics, Inc. Compositions and methods of altering cholesterol levels
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MX2016004249A (es) 2013-10-03 2016-11-08 Moderna Therapeutics Inc Polinulcleotidos que codifican el receptor de lipoproteina de baja densidad.
EP3158058B1 (en) 2014-06-18 2019-04-17 MorphoSys AG Fusion proteins and uses thereof
KR101678740B1 (ko) * 2014-10-24 2016-11-23 단국대학교 천안캠퍼스 산학협력단 세포 부착활성 및 골분화 촉진활성을 나타내는 피브로넥틴 융합단백질
WO2016149426A1 (en) * 2015-03-16 2016-09-22 The Broad Institute, Inc. Constructs for continuous monitoring of live cells
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US20210047626A1 (en) * 2018-04-24 2021-02-18 Merck Sharp & Dohme Corp. Scalable chromatography process for purification of human cytomegalovirus
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US11629172B2 (en) 2018-12-21 2023-04-18 Pfizer Inc. Human cytomegalovirus gB polypeptide
KR20220038608A (ko) * 2019-05-31 2022-03-29 배리에이션 바이오테크놀로지스 아이엔씨. 다형성 교모세포종의 치료를 위한 면역치료 조성물
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Also Published As

Publication number Publication date
JP2015505299A (ja) 2015-02-19
MX353189B (es) 2018-01-05
AU2012335277A1 (en) 2014-06-12
WO2013068847A3 (en) 2014-10-30
BR112014011229B1 (pt) 2021-10-13
CA2889659C (en) 2023-03-14
EP2776567B1 (en) 2021-01-20
EP3854416A1 (en) 2021-07-28
CA2889659A1 (en) 2013-05-16
US20170349634A1 (en) 2017-12-07
PT2776567T (pt) 2021-05-25
KR102301463B1 (ko) 2021-09-14
AU2018203538A1 (en) 2018-06-07
US11248026B2 (en) 2022-02-15
CN111995664A (zh) 2020-11-27
CN107875382A (zh) 2018-04-06
JP2018023374A (ja) 2018-02-15
CN104271745A (zh) 2015-01-07
AU2012335277B2 (en) 2018-06-14
KR20140095556A (ko) 2014-08-01
EP2776567A2 (en) 2014-09-17
US9777043B2 (en) 2017-10-03
DK2776567T3 (da) 2021-04-26
AU2020264275A1 (en) 2020-11-26
EP2776567A4 (en) 2015-12-30
AU2020264275B2 (en) 2023-12-14
ES2874233T3 (es) 2021-11-04
JP6232544B2 (ja) 2017-11-22
US20140308308A1 (en) 2014-10-16
CA3166278A1 (en) 2013-05-16
BR112014011229A2 (pt) 2017-05-09
CN107875382B (zh) 2024-03-08
WO2013068847A2 (en) 2013-05-16
US20230272013A1 (en) 2023-08-31
MX2014005653A (es) 2014-09-04
RU2737530C1 (ru) 2020-12-03
KR102340558B1 (ko) 2021-12-21
RU2019139064A (ru) 2020-01-27
JP6657150B2 (ja) 2020-03-04
KR20190104644A (ko) 2019-09-10

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B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B25G Requested change of headquarter approved

Owner name: VARIATION BIOTECHNOLOGIES, INC. (CA)

B350 Update of information on the portal [chapter 15.35 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 09/11/2012, OBSERVADAS AS CONDICOES LEGAIS.

B25D Requested change of name of applicant approved

Owner name: VARIATION BIOTECHNOLOGIES INC. (CA)

B25A Requested transfer of rights approved

Owner name: SORBONNE UNIVERSITE (FR)

B25K Entry of change of name and/or headquarter and transfer of application, patent and certificate of addition of invention: republication

Owner name: SORBONNE UNIVERSITE (FR) ; VARIATION BIOTECHNOLOGIES INC. (CA)

Free format text: RETIFICADO O DESPACHO 25.1 PUBLICADO NA RPI 2685 DE 21/06/2022:ONDE SE LE: ?EM ATENDIMENTO AO SOLICITADO NA PETICAO EM EPIGRAFE, INFORMO QUE A MESMA ATENDE A TODOS OS REQUISITOS FORMAIS, SENDO ASSIM, DEFIRO A SEGUINTE TRANSFERENCIA ? LEIA-SE: ?EM ATENDIMENTO AO SOLICITADO NA PETICAO EM EPIGRAFE, INFORMO QUE A MESMA ATENDE A TODOS OS REQUISITOS FORMAIS, SENDO ASSIM, DEFIRO A SEGUINTE TRANSFERENCIA PARCIAL?