BR112023001325A2 - Composto, composição farmacêutica, e, métodos para tratar uma doença causada por um vírus, para inibir a endonuclease dependente de cápsula, para tratar influenza em um mamífero e para prevenir influenza em um mamífero - Google Patents

Composto, composição farmacêutica, e, métodos para tratar uma doença causada por um vírus, para inibir a endonuclease dependente de cápsula, para tratar influenza em um mamífero e para prevenir influenza em um mamífero

Info

Publication number
BR112023001325A2
BR112023001325A2 BR112023001325A BR112023001325A BR112023001325A2 BR 112023001325 A2 BR112023001325 A2 BR 112023001325A2 BR 112023001325 A BR112023001325 A BR 112023001325A BR 112023001325 A BR112023001325 A BR 112023001325A BR 112023001325 A2 BR112023001325 A2 BR 112023001325A2
Authority
BR
Brazil
Prior art keywords
mammal
influenza
compound
methods
pharmaceutical composition
Prior art date
Application number
BR112023001325A
Other languages
English (en)
Portuguese (pt)
Inventor
J Morriello Gregori
W Embrey Mark
Zhang Yonglian
A Mccauley John
Man-Chu Lo Michael
Guo Liangqin
Zhao Kake
Bennett Frank
m kim Ronald
Keh Dejesus Reynalda
W Shurtleff Valerie
De Lera Ruiz Manuel
A Plotkin Michael
Su Hua
Fells James
M Crowley Brendan
R Chobanian Harry
Original Assignee
Merck Sharp & Dohme Llc
Cocrystal Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme Llc, Cocrystal Pharma Inc filed Critical Merck Sharp & Dohme Llc
Publication of BR112023001325A2 publication Critical patent/BR112023001325A2/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/16Antivirals for RNA viruses for influenza or rhinoviruses
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18Bridged systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
BR112023001325A 2020-07-27 2021-07-22 Composto, composição farmacêutica, e, métodos para tratar uma doença causada por um vírus, para inibir a endonuclease dependente de cápsula, para tratar influenza em um mamífero e para prevenir influenza em um mamífero BR112023001325A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202063056861P 2020-07-27 2020-07-27
PCT/US2021/042711 WO2022026285A1 (en) 2020-07-27 2021-07-22 Polycyclic cap-dependent endonuclease inhibitors for treating or preventing influenza

Publications (1)

Publication Number Publication Date
BR112023001325A2 true BR112023001325A2 (pt) 2023-02-14

Family

ID=80038102

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112023001325A BR112023001325A2 (pt) 2020-07-27 2021-07-22 Composto, composição farmacêutica, e, métodos para tratar uma doença causada por um vírus, para inibir a endonuclease dependente de cápsula, para tratar influenza em um mamífero e para prevenir influenza em um mamífero

Country Status (10)

Country Link
US (1) US20240018145A1 (https=)
EP (1) EP4188379B1 (https=)
JP (1) JP7695339B2 (https=)
KR (1) KR20230044252A (https=)
CN (1) CN116490190A (https=)
AU (1) AU2021315475A1 (https=)
BR (1) BR112023001325A2 (https=)
CA (1) CA3187516A1 (https=)
MX (1) MX2023001194A (https=)
WO (1) WO2022026285A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN118804908A (zh) * 2022-03-01 2024-10-18 弗门尼舍有限公司 制备γ,δ-不饱和醛衍生物的方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5475109A (en) * 1994-10-17 1995-12-12 Merck & Co., Inc. Dioxobutanoic acid derivatives as inhibitors of influenza endonuclease
EA200801144A1 (ru) 2005-10-27 2008-10-30 Сионоги Энд Ко., Лтд. Полициклическое карбамоилпиридоновое производное, обладающее ингибиторной активностью в отношении интегразы вич
MX2013003139A (es) 2010-09-24 2013-06-18 Shionogi & Co Profarmaco de derivado de carbamoilpiridona policiclica substituida.
TWI695003B (zh) 2014-12-23 2020-06-01 美商基利科學股份有限公司 多環胺甲醯基吡啶酮化合物及其醫藥用途
EP4257137A3 (en) * 2018-05-31 2023-11-01 Shionogi & Co., Ltd Polycyclic carbamoylpyridone derivatives for the treatment of hiv
AU2019277547B2 (en) 2018-05-31 2024-10-10 Shionogi & Co., Ltd. Polycyclic pyridone derivative
CN113286793B (zh) 2018-09-10 2024-04-05 共结晶制药公司 吡咯并吡嗪和吡啶并三嗪类流感病毒复制抑制剂

Also Published As

Publication number Publication date
CN116490190A (zh) 2023-07-25
KR20230044252A (ko) 2023-04-03
EP4188379B1 (en) 2026-02-25
US20240018145A1 (en) 2024-01-18
JP7695339B2 (ja) 2025-06-18
EP4188379A4 (en) 2024-08-28
MX2023001194A (es) 2023-04-20
EP4188379A1 (en) 2023-06-07
CA3187516A1 (en) 2022-02-03
AU2021315475A1 (en) 2023-03-02
WO2022026285A1 (en) 2022-02-03
AU2021315475A8 (en) 2023-04-06
JP2023535771A (ja) 2023-08-21

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