JP7695339B2 - インフルエンザを治療又は予防するための多環式キャップ依存性エンドヌクレアーゼ阻害薬 - Google Patents
インフルエンザを治療又は予防するための多環式キャップ依存性エンドヌクレアーゼ阻害薬 Download PDFInfo
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- JP7695339B2 JP7695339B2 JP2023505421A JP2023505421A JP7695339B2 JP 7695339 B2 JP7695339 B2 JP 7695339B2 JP 2023505421 A JP2023505421 A JP 2023505421A JP 2023505421 A JP2023505421 A JP 2023505421A JP 7695339 B2 JP7695339 B2 JP 7695339B2
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063056861P | 2020-07-27 | 2020-07-27 | |
| US63/056,861 | 2020-07-27 | ||
| PCT/US2021/042711 WO2022026285A1 (en) | 2020-07-27 | 2021-07-22 | Polycyclic cap-dependent endonuclease inhibitors for treating or preventing influenza |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2023535771A JP2023535771A (ja) | 2023-08-21 |
| JPWO2022026285A5 JPWO2022026285A5 (https=) | 2024-06-17 |
| JP2023535771A5 JP2023535771A5 (https=) | 2024-06-17 |
| JP7695339B2 true JP7695339B2 (ja) | 2025-06-18 |
Family
ID=80038102
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023505421A Active JP7695339B2 (ja) | 2020-07-27 | 2021-07-22 | インフルエンザを治療又は予防するための多環式キャップ依存性エンドヌクレアーゼ阻害薬 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20240018145A1 (https=) |
| EP (1) | EP4188379B1 (https=) |
| JP (1) | JP7695339B2 (https=) |
| KR (1) | KR20230044252A (https=) |
| CN (1) | CN116490190A (https=) |
| AU (1) | AU2021315475A1 (https=) |
| BR (1) | BR112023001325A2 (https=) |
| CA (1) | CA3187516A1 (https=) |
| MX (1) | MX2023001194A (https=) |
| WO (1) | WO2022026285A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN118804908A (zh) * | 2022-03-01 | 2024-10-18 | 弗门尼舍有限公司 | 制备γ,δ-不饱和醛衍生物的方法 |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007049675A1 (ja) | 2005-10-27 | 2007-05-03 | Shionogi & Co., Ltd. | Ｈｉｖインテグラーゼ阻害活性を有する多環性カルバモイルピリドン誘導体 |
| WO2012039414A1 (ja) | 2010-09-24 | 2012-03-29 | 塩野義製薬株式会社 | 置換された多環性カルバモイルピリドン誘導体のプロドラッグ |
| JP2017538713A (ja) | 2014-12-23 | 2017-12-28 | ギリアード サイエンシーズ， インコーポレイテッド | 多環式カルバモイルピリドン化合物およびそれらの薬学的使用 |
| WO2019230857A1 (ja) | 2018-05-31 | 2019-12-05 | 塩野義製薬株式会社 | 多環性ピリドン誘導体 |
| WO2019230858A1 (ja) | 2018-05-31 | 2019-12-05 | 塩野義製薬株式会社 | 多環性カルバモイルピリドン誘導体 |
| WO2020055858A1 (en) | 2018-09-10 | 2020-03-19 | Cocrystal Pharma, Inc. | Pyridopyrazine and pyridotriazine inhibitors of influenza virus replication |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5475109A (en) * | 1994-10-17 | 1995-12-12 | Merck & Co., Inc. | Dioxobutanoic acid derivatives as inhibitors of influenza endonuclease |
-
2021
- 2021-07-22 KR KR1020237006229A patent/KR20230044252A/ko active Pending
- 2021-07-22 EP EP21848925.0A patent/EP4188379B1/en active Active
- 2021-07-22 CA CA3187516A patent/CA3187516A1/en active Pending
- 2021-07-22 JP JP2023505421A patent/JP7695339B2/ja active Active
- 2021-07-22 CN CN202180065598.0A patent/CN116490190A/zh active Pending
- 2021-07-22 BR BR112023001325A patent/BR112023001325A2/pt unknown
- 2021-07-22 US US18/015,465 patent/US20240018145A1/en active Pending
- 2021-07-22 MX MX2023001194A patent/MX2023001194A/es unknown
- 2021-07-22 AU AU2021315475A patent/AU2021315475A1/en active Pending
- 2021-07-22 WO PCT/US2021/042711 patent/WO2022026285A1/en not_active Ceased
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007049675A1 (ja) | 2005-10-27 | 2007-05-03 | Shionogi & Co., Ltd. | Ｈｉｖインテグラーゼ阻害活性を有する多環性カルバモイルピリドン誘導体 |
| WO2012039414A1 (ja) | 2010-09-24 | 2012-03-29 | 塩野義製薬株式会社 | 置換された多環性カルバモイルピリドン誘導体のプロドラッグ |
| JP2017538713A (ja) | 2014-12-23 | 2017-12-28 | ギリアード サイエンシーズ， インコーポレイテッド | 多環式カルバモイルピリドン化合物およびそれらの薬学的使用 |
| WO2019230857A1 (ja) | 2018-05-31 | 2019-12-05 | 塩野義製薬株式会社 | 多環性ピリドン誘導体 |
| WO2019230858A1 (ja) | 2018-05-31 | 2019-12-05 | 塩野義製薬株式会社 | 多環性カルバモイルピリドン誘導体 |
| WO2020055858A1 (en) | 2018-09-10 | 2020-03-19 | Cocrystal Pharma, Inc. | Pyridopyrazine and pyridotriazine inhibitors of influenza virus replication |
Also Published As
| Publication number | Publication date |
|---|---|
| CN116490190A (zh) | 2023-07-25 |
| KR20230044252A (ko) | 2023-04-03 |
| EP4188379B1 (en) | 2026-02-25 |
| US20240018145A1 (en) | 2024-01-18 |
| EP4188379A4 (en) | 2024-08-28 |
| MX2023001194A (es) | 2023-04-20 |
| EP4188379A1 (en) | 2023-06-07 |
| CA3187516A1 (en) | 2022-02-03 |
| BR112023001325A2 (pt) | 2023-02-14 |
| AU2021315475A1 (en) | 2023-03-02 |
| WO2022026285A1 (en) | 2022-02-03 |
| AU2021315475A8 (en) | 2023-04-06 |
| JP2023535771A (ja) | 2023-08-21 |
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