MX2023001194A - Inhibidores de la endonucleasa policiclicos dependientes de la capside para el tratamiento o la prevencion de la influenza. - Google Patents

Inhibidores de la endonucleasa policiclicos dependientes de la capside para el tratamiento o la prevencion de la influenza.

Info

Publication number
MX2023001194A
MX2023001194A MX2023001194A MX2023001194A MX2023001194A MX 2023001194 A MX2023001194 A MX 2023001194A MX 2023001194 A MX2023001194 A MX 2023001194A MX 2023001194 A MX2023001194 A MX 2023001194A MX 2023001194 A MX2023001194 A MX 2023001194A
Authority
MX
Mexico
Prior art keywords
cap
treating
polycyclic
preventing influenza
dependent endonuclease
Prior art date
Application number
MX2023001194A
Other languages
English (en)
Inventor
Kake Zhao
Liangqin Guo
Ronald M Kim
Yonglian Zhang
John A Mccauley
Reynalda Keh Dejesus
Brendan M Crowley
Lera Ruiz Manuel De
Gregori J Morriello
Michael Man - Chu Lo
Frank Bennett
Valerie W Shurtleff
Michael A Plotkin
Hua Su
James Fells
Harry R Chobanian
Mark W Embrey
Original Assignee
Merck Sharp & Dohme Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme Llc filed Critical Merck Sharp & Dohme Llc
Publication of MX2023001194A publication Critical patent/MX2023001194A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente invención proporciona un compuesto de la fórmula (I): (ver Fórmula) (I) y composiciones farmacéuticas que comprenden uno o más de dichos compuestos, y métodos para utilizar dichos compuestos para el tratamiento o la prevención de la influenza. Los compuestos son inhibidores de la endonucleasa dependientes de la cápside.
MX2023001194A 2020-07-27 2021-07-22 Inhibidores de la endonucleasa policiclicos dependientes de la capside para el tratamiento o la prevencion de la influenza. MX2023001194A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202063056861P 2020-07-27 2020-07-27
PCT/US2021/042711 WO2022026285A1 (en) 2020-07-27 2021-07-22 Polycyclic cap-dependent endonuclease inhibitors for treating or preventing influenza

Publications (1)

Publication Number Publication Date
MX2023001194A true MX2023001194A (es) 2023-04-20

Family

ID=80038102

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2023001194A MX2023001194A (es) 2020-07-27 2021-07-22 Inhibidores de la endonucleasa policiclicos dependientes de la capside para el tratamiento o la prevencion de la influenza.

Country Status (10)

Country Link
US (1) US20240018145A1 (es)
EP (1) EP4188379A4 (es)
JP (1) JP2023535771A (es)
KR (1) KR20230044252A (es)
CN (1) CN116490190A (es)
AU (1) AU2021315475A1 (es)
BR (1) BR112023001325A2 (es)
CA (1) CA3187516A1 (es)
MX (1) MX2023001194A (es)
WO (1) WO2022026285A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023166004A1 (en) * 2022-03-01 2023-09-07 Firmenich Sa Process for preparing gamma,delta-unsaturated aldehydes derivatives

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5553393B2 (ja) * 2010-09-24 2014-07-16 塩野義製薬株式会社 置換された多環性カルバモイルピリドン誘導体のプロドラッグ
EP4257137A3 (en) * 2018-05-31 2023-11-01 Shionogi & Co., Ltd Polycyclic carbamoylpyridone derivatives for the treatment of hiv
US12037333B2 (en) * 2018-09-10 2024-07-16 Cocrystal Pharma, Inc. Pyridopyrazine and pyridotriazine inhibitors of influenza virus replication

Also Published As

Publication number Publication date
CN116490190A (zh) 2023-07-25
EP4188379A4 (en) 2024-08-28
AU2021315475A1 (en) 2023-03-02
JP2023535771A (ja) 2023-08-21
BR112023001325A2 (pt) 2023-02-14
US20240018145A1 (en) 2024-01-18
AU2021315475A8 (en) 2023-04-06
WO2022026285A1 (en) 2022-02-03
KR20230044252A (ko) 2023-04-03
CA3187516A1 (en) 2022-02-03
EP4188379A1 (en) 2023-06-07

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