BR112021002565A8 - Composto, sal farmaceuticamente aceitável, tautômero ou estereoisômero do mesmo, composição farmacêutica, processo para a síntese e uso do dito composto - Google Patents
Composto, sal farmaceuticamente aceitável, tautômero ou estereoisômero do mesmo, composição farmacêutica, processo para a síntese e uso do dito compostoInfo
- Publication number
- BR112021002565A8 BR112021002565A8 BR112021002565A BR112021002565A BR112021002565A8 BR 112021002565 A8 BR112021002565 A8 BR 112021002565A8 BR 112021002565 A BR112021002565 A BR 112021002565A BR 112021002565 A BR112021002565 A BR 112021002565A BR 112021002565 A8 BR112021002565 A8 BR 112021002565A8
- Authority
- BR
- Brazil
- Prior art keywords
- compound
- tautomer
- stereoisomer
- synthesis
- pharmaceutically acceptable
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 7
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 title abstract 2
- 238000003786 synthesis reaction Methods 0.000 title abstract 2
- 241000700721 Hepatitis B virus Species 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
- C07D513/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D515/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D515/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D515/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D515/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D515/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
- C07D515/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D515/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
- C07D515/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
COMPOSTO, SAL FARMACEUTICAMENTE ACEITÁVEL, TAUTÔMERO OU ESTEREOISÔMERO DO MESMO, COMPOSIÇÃO FARMACÊUTICA, PROCESSO PARA A SÍNTESE E USO DO DITO COMPOSTO A presente invenção refere-se a compostos que são inibidores do vírus da hepatite B (HBV). Os compostos da presente invenção são úteis sozinhos ou em combinação com outros agentes para tratamento, melhora, prevenção ou cura da infecção por HBV e condições relacionadas. A presente invenção também se refere a composições farmacêuticas contendo os ditos compostos.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP18188409.9A EP3608326A1 (en) | 2018-08-10 | 2018-08-10 | Tricyclic inhibitors of hepatitis b virus |
EP18188409.9 | 2018-08-10 | ||
PCT/EP2019/071408 WO2020030781A1 (en) | 2018-08-10 | 2019-08-09 | Tricyclic inhibitors of hepatitis b virus |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112021002565A2 BR112021002565A2 (pt) | 2021-05-11 |
BR112021002565A8 true BR112021002565A8 (pt) | 2022-10-18 |
Family
ID=63209240
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112021002565A BR112021002565A8 (pt) | 2018-08-10 | 2019-08-09 | Composto, sal farmaceuticamente aceitável, tautômero ou estereoisômero do mesmo, composição farmacêutica, processo para a síntese e uso do dito composto |
Country Status (7)
Country | Link |
---|---|
US (2) | US11504382B2 (pt) |
EP (2) | EP3608326A1 (pt) |
JP (1) | JP7436454B2 (pt) |
CN (1) | CN113272309B (pt) |
BR (1) | BR112021002565A8 (pt) |
CA (1) | CA3110098A1 (pt) |
WO (1) | WO2020030781A1 (pt) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3597637A1 (en) * | 2018-07-19 | 2020-01-22 | Irbm S.P.A. | Inhibitors of hepatitis b virus |
UY38705A (es) | 2019-05-23 | 2020-12-31 | Irbm S P A | Inhibidores tricíclicos sustituidos con oxalamido del virus de hepatitis b |
WO2022206879A1 (zh) * | 2021-03-31 | 2022-10-06 | 苏州晶云药物科技股份有限公司 | 氨磺酰基吡咯酰胺类化合物的晶型及其制备方法 |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1587473A4 (en) * | 2002-12-27 | 2008-08-13 | Novartis Vaccines & Diagnostic | THIOSEMICARBAZONES ANTIVIRAL AND IMMUNOSTIMULANTS |
US7361743B2 (en) | 2004-02-11 | 2008-04-22 | Pfizer Inc | Lincomycin derivatives possessing antibacterial activity |
EP2328890B1 (en) | 2008-08-06 | 2012-01-25 | Pfizer Inc. | 6 substituted 2-heterocyclylamino pyrazine compounds as chk-1 inhibitors |
US9073940B2 (en) * | 2009-11-13 | 2015-07-07 | Merck Serono Sa | Tricyclic pyrazol amine derivatives |
CN103889953B (zh) | 2011-07-01 | 2016-06-08 | 巴鲁﹒S﹒布隆伯格研究所 | 作为防乙型肝炎病毒感染的抗病毒剂的氨磺酰苯甲酰胺衍生物 |
JP2014534206A (ja) * | 2011-10-17 | 2014-12-18 | エナンタ ファーマシューティカルズ インコーポレイテッド | C型肝炎ウイルス阻害剤 |
SG10201608528YA (en) | 2011-12-21 | 2016-12-29 | Novira Therapeutics Inc | Hepatitis b antiviral agents |
EP2938338A4 (en) | 2012-12-27 | 2016-11-23 | Univ Drexel | NOVEL ANTIVIRAL AGENTS AGAINST HBV INFECTION |
US8993771B2 (en) | 2013-03-12 | 2015-03-31 | Novira Therapeutics, Inc. | Hepatitis B antiviral agents |
US9169212B2 (en) | 2014-01-16 | 2015-10-27 | Novira Therapeutics, Inc. | Azepane derivatives and methods of treating hepatitis B infections |
KR20160128305A (ko) | 2014-02-05 | 2016-11-07 | 노비라 테라퓨틱스, 인코포레이티드 | Hbv 감염의 치료를 위한 병용 요법 |
US9400280B2 (en) | 2014-03-27 | 2016-07-26 | Novira Therapeutics, Inc. | Piperidine derivatives and methods of treating hepatitis B infections |
US9597332B2 (en) | 2014-12-02 | 2017-03-21 | Novira Therapeutics, Inc. | Sulfide alkyl compounds for HBV treatment |
AU2015358561A1 (en) | 2014-12-02 | 2017-06-08 | Novira Therapeutics, Inc. | Sulfide alkyl and pyridyl reverse sulfonamide compounds for HBV treatment |
US9765050B2 (en) | 2014-12-30 | 2017-09-19 | Novira Therapeutics, Inc. | Pyridyl reverse sulfonamides for HBV treatment |
US10875876B2 (en) | 2015-07-02 | 2020-12-29 | Janssen Sciences Ireland Uc | Cyclized sulfamoylarylamide derivatives and the use thereof as medicaments for the treatment of hepatitis B |
NZ739139A (en) | 2015-08-05 | 2023-01-27 | Indivior Uk Ltd | Dopamine d3 receptor antagonists having a bicyclo moiety |
WO2018053157A1 (en) * | 2016-09-15 | 2018-03-22 | Assembly Biosciences, Inc. | Hepatitis b core protein modulators |
AU2017353986B2 (en) * | 2016-11-07 | 2021-08-19 | Arbutus Biopharma Corporation | Substituted pyridinone-containing tricyclic compounds, and methods using same |
CN108264520B (zh) * | 2017-01-03 | 2021-12-07 | 上海长森药业有限公司 | 用于治疗乙型肝炎的化合物及其用途 |
-
2018
- 2018-08-10 EP EP18188409.9A patent/EP3608326A1/en not_active Withdrawn
-
2019
- 2019-08-09 JP JP2021506990A patent/JP7436454B2/ja active Active
- 2019-08-09 EP EP19749375.2A patent/EP3833672A1/en active Pending
- 2019-08-09 WO PCT/EP2019/071408 patent/WO2020030781A1/en unknown
- 2019-08-09 CN CN201980067267.3A patent/CN113272309B/zh active Active
- 2019-08-09 BR BR112021002565A patent/BR112021002565A8/pt unknown
- 2019-08-09 US US17/267,693 patent/US11504382B2/en active Active
- 2019-08-09 CA CA3110098A patent/CA3110098A1/en active Pending
-
2022
- 2022-10-04 US US17/937,841 patent/US20230076319A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CN113272309B (zh) | 2024-02-23 |
CA3110098A1 (en) | 2020-02-13 |
BR112021002565A2 (pt) | 2021-05-11 |
WO2020030781A1 (en) | 2020-02-13 |
US20230076319A1 (en) | 2023-03-09 |
CN113272309A (zh) | 2021-08-17 |
EP3608326A1 (en) | 2020-02-12 |
JP2021534132A (ja) | 2021-12-09 |
EP3833672A1 (en) | 2021-06-16 |
US20220110943A1 (en) | 2022-04-14 |
JP7436454B2 (ja) | 2024-02-21 |
US11504382B2 (en) | 2022-11-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B25A | Requested transfer of rights approved |
Owner name: ANTIOS THERAPEUTICS, INC. (US) |
|
B25C | Requirement related to requested transfer of rights |
Owner name: ANTIOS THERAPEUTICS, INC. (US) Free format text: A FIM DE ATENDER A TRANSFERENCIA REQUERIDA ATRAVES DA PETICAO 870230031080 DE 13/04/2023 E NECESSARIO GRU 248 PARA ALTERACAO DE SEDE DO DEPOSITANTE ?ANTIOS THERAPEUTICS, INC.? PELA DIVERGENCIA ENTRE O ATUAL ENDERECO E O CONSTANTE NO DOCUMENTO DE CESSAO. |
|
B25G | Requested change of headquarter approved |
Owner name: ANTIOS THERAPEUTICS, INC. (US) |
|
B06W | Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette] | ||
B25A | Requested transfer of rights approved |
Owner name: OSPEDALE SAN RAFFAELE S.R.L. (IT) ; ISTITUTO NAZIONALE DI GENETICA MOLECOLARE - INGM (IT) ; IRBM S.P.A. (IT) |