BR112022019821A2 - Método para produção de heparosano e bactéria do gênero escherichia com capacidade de produção de heparosano - Google Patents

Método para produção de heparosano e bactéria do gênero escherichia com capacidade de produção de heparosano

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Publication number
BR112022019821A2
BR112022019821A2 BR112022019821A BR112022019821A BR112022019821A2 BR 112022019821 A2 BR112022019821 A2 BR 112022019821A2 BR 112022019821 A BR112022019821 A BR 112022019821A BR 112022019821 A BR112022019821 A BR 112022019821A BR 112022019821 A2 BR112022019821 A2 BR 112022019821A2
Authority
BR
Brazil
Prior art keywords
heparosan
production
genus escherichia
bacteria
production capacity
Prior art date
Application number
BR112022019821A
Other languages
English (en)
Inventor
Komine Ayano
Hayashi Mikiro
Original Assignee
Rensselaer Polytech Inst
Otsuka Pharma Factory Inc
Kirin Biomaterials Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rensselaer Polytech Inst, Otsuka Pharma Factory Inc, Kirin Biomaterials Co Ltd filed Critical Rensselaer Polytech Inst
Publication of BR112022019821A2 publication Critical patent/BR112022019821A2/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/185—Escherichia
    • C12R2001/19—Escherichia coli
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

MÉTODO PARA PRODUÇÃO DE HEPAROSANO E BACTÉRIA DO GÊNERO ESCHERICHIA COM CAPACIDADE DE PRODUÇÃO DE HEPAROSANO. A presente invenção refere-se a um método para produzir heparosano com eficiência ao aperfeiçoar uma capacidade de produção de heparosano por meio de modificação genética de uma bactéria do gênero Escherichia que tem capacidade de produção de heparosano. A presente invenção refere-se a uma bactéria do gênero Escherichia que tem uma modificação genética que aumenta uma expressão de um gene kpsS e que tem capacidade de produção de heparosano; a um método para produção de heparosano utilizando a bactéria.
BR112022019821A 2020-04-03 2021-04-02 Método para produção de heparosano e bactéria do gênero escherichia com capacidade de produção de heparosano BR112022019821A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/JP2020/015384 WO2021199444A1 (en) 2020-04-03 2020-04-03 Method for producing heparosan and bacterium of genus escherichia having heparosan-producing ability
PCT/JP2021/014335 WO2021201281A1 (en) 2020-04-03 2021-04-02 Method for producing heparosan and bacterium of genus escherichia having heparosan-producing ability

Publications (1)

Publication Number Publication Date
BR112022019821A2 true BR112022019821A2 (pt) 2023-02-23

Family

ID=77927161

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112022019821A BR112022019821A2 (pt) 2020-04-03 2021-04-02 Método para produção de heparosano e bactéria do gênero escherichia com capacidade de produção de heparosano

Country Status (9)

Country Link
US (1) US20230175028A1 (pt)
EP (1) EP4127203A4 (pt)
JP (1) JP7464921B2 (pt)
KR (1) KR20230005137A (pt)
CN (1) CN115605602A (pt)
BR (1) BR112022019821A2 (pt)
CA (1) CA3174036A1 (pt)
TW (1) TW202204631A (pt)
WO (2) WO2021199444A1 (pt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK202201117A1 (en) * 2022-12-09 2024-08-08 Dsm Ip Assets Bv Genetically modified udp-n-acetylgalactosamine producing cells

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5830464B2 (ja) 1980-04-07 1983-06-29 株式会社 河原 作業台
EP1885865A4 (en) 2005-05-12 2010-12-22 Univ North Carolina ENZYMATIC SYNTHESIS OF SULFATED POLYSACCHARIDES
WO2011028668A2 (en) * 2009-09-01 2011-03-10 Zhenyu Wang K5 heparosan fermentation and purification
JP6569530B2 (ja) * 2013-10-02 2019-09-04 味の素株式会社 ヘパロサン生産細菌及びヘパロサンの製造法
TWI769176B (zh) 2016-09-07 2022-07-01 瑞瑟勒綜合技術協會 生合成肝素

Also Published As

Publication number Publication date
TW202204631A (zh) 2022-02-01
EP4127203A1 (en) 2023-02-08
WO2021199444A1 (en) 2021-10-07
WO2021201281A1 (en) 2021-10-07
JP2023519632A (ja) 2023-05-11
KR20230005137A (ko) 2023-01-09
JP7464921B2 (ja) 2024-04-10
US20230175028A1 (en) 2023-06-08
CA3174036A1 (en) 2021-10-07
EP4127203A4 (en) 2024-04-17
CN115605602A (zh) 2023-01-13

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