BR112022018287A2 - Compostos moduladores de gpr52 - Google Patents
Compostos moduladores de gpr52Info
- Publication number
- BR112022018287A2 BR112022018287A2 BR112022018287A BR112022018287A BR112022018287A2 BR 112022018287 A2 BR112022018287 A2 BR 112022018287A2 BR 112022018287 A BR112022018287 A BR 112022018287A BR 112022018287 A BR112022018287 A BR 112022018287A BR 112022018287 A2 BR112022018287 A2 BR 112022018287A2
- Authority
- BR
- Brazil
- Prior art keywords
- gpr52
- modulating compounds
- report
- compounds
- modulating
- Prior art date
Links
- 102100033046 G-protein coupled receptor 52 Human genes 0.000 title abstract 3
- 101000871149 Homo sapiens G-protein coupled receptor 52 Proteins 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/16—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Amplifiers (AREA)
- Optical Modulation, Optical Deflection, Nonlinear Optics, Optical Demodulation, Optical Logic Elements (AREA)
Abstract
COMPOSTOS MODULADORES DE GPR52. As divulgações neste relatório referem-se a novos compostos da Fórmula (1):(1) e sais dos mesmos, em que X, Y, R1, R2, R3 e R4 são definidos neste relatório, e seu uso no tratamento, prevenção, melhoria, controle ou redução do risco de transtornos associados aos receptores de GPR52.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB2003668.7A GB202003668D0 (en) | 2020-03-13 | 2020-03-13 | GPR52 Modulator compounds |
| PCT/GB2021/050638 WO2021181122A1 (en) | 2020-03-13 | 2021-03-15 | Gpr52 modulator compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112022018287A2 true BR112022018287A2 (pt) | 2022-11-22 |
Family
ID=70453676
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112022018287A BR112022018287A2 (pt) | 2020-03-13 | 2021-03-15 | Compostos moduladores de gpr52 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20240254101A1 (pt) |
| EP (1) | EP4117784B1 (pt) |
| JP (1) | JP7492597B2 (pt) |
| KR (1) | KR20220152296A (pt) |
| CN (1) | CN115515681B (pt) |
| AU (1) | AU2021235257A1 (pt) |
| BR (1) | BR112022018287A2 (pt) |
| CA (1) | CA3175429A1 (pt) |
| DK (1) | DK4117784T3 (pt) |
| FI (1) | FI4117784T3 (pt) |
| GB (1) | GB202003668D0 (pt) |
| IL (1) | IL296413A (pt) |
| MX (1) | MX2022011333A (pt) |
| WO (1) | WO2021181122A1 (pt) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20240208907A1 (en) * | 2021-04-26 | 2024-06-27 | Neurocrine Biosciences, Inc. | Gpr52 modulators and methods of use |
| GB202113186D0 (en) | 2021-09-15 | 2021-10-27 | Heptares Therapeutics Ltd | GPR52 Modulator compounds |
| WO2024091542A1 (en) * | 2022-10-26 | 2024-05-02 | Neurocrine Biosciences, Inc. | Compounds and compositions as gpr52 modulators |
| WO2024091538A1 (en) * | 2022-10-26 | 2024-05-02 | Neurocrine Biosciences, Inc. | Compounds and compositions as gpr52 modulators |
| WO2024091541A1 (en) * | 2022-10-26 | 2024-05-02 | Neurocrine Biosciences, Inc. | Compounds and compositions as gpr52 modulators |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005037797A1 (en) * | 2003-10-21 | 2005-04-28 | Pharmacia Corporation | Substituted pyrazole urea compounds for the treatment of inflammation |
| JPWO2009107391A1 (ja) | 2008-02-27 | 2011-06-30 | 武田薬品工業株式会社 | ６員芳香環含有化合物 |
| JPWO2011078360A1 (ja) | 2009-12-24 | 2013-05-09 | 武田薬品工業株式会社 | アミド化合物 |
| WO2011093352A1 (ja) | 2010-01-27 | 2011-08-04 | 武田薬品工業株式会社 | チアゾール誘導体 |
| ES2784316T3 (es) | 2015-04-29 | 2020-09-24 | Arena Pharm Inc | 1-Heteroaril-indolin-4-carboxamidas como moduladores de GPR52 útiles para el tratamiento o la prevención de trastornos relacionados con el mismo |
| JP7394747B2 (ja) * | 2017-09-13 | 2023-12-08 | ノバルティス アーゲー | ジフェニル誘導体及びその使用 |
-
2020
- 2020-03-13 GB GBGB2003668.7A patent/GB202003668D0/en not_active Ceased
-
2021
- 2021-03-15 WO PCT/GB2021/050638 patent/WO2021181122A1/en active Application Filing
- 2021-03-15 DK DK21713103.6T patent/DK4117784T3/da active
- 2021-03-15 MX MX2022011333A patent/MX2022011333A/es unknown
- 2021-03-15 BR BR112022018287A patent/BR112022018287A2/pt unknown
- 2021-03-15 AU AU2021235257A patent/AU2021235257A1/en active Pending
- 2021-03-15 FI FIEP21713103.6T patent/FI4117784T3/fi active
- 2021-03-15 KR KR1020227035100A patent/KR20220152296A/ko unknown
- 2021-03-15 CN CN202180033813.9A patent/CN115515681B/zh active Active
- 2021-03-15 CA CA3175429A patent/CA3175429A1/en active Pending
- 2021-03-15 US US17/909,792 patent/US20240254101A1/en active Pending
- 2021-03-15 IL IL296413A patent/IL296413A/en unknown
- 2021-03-15 EP EP21713103.6A patent/EP4117784B1/en active Active
- 2021-03-15 JP JP2022555137A patent/JP7492597B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN115515681A (zh) | 2022-12-23 |
| IL296413A (en) | 2022-11-01 |
| WO2021181122A1 (en) | 2021-09-16 |
| KR20220152296A (ko) | 2022-11-15 |
| FI4117784T3 (fi) | 2024-10-10 |
| CN115515681B (zh) | 2024-09-03 |
| AU2021235257A1 (en) | 2022-10-06 |
| JP7492597B2 (ja) | 2024-05-29 |
| MX2022011333A (es) | 2022-12-08 |
| CA3175429A1 (en) | 2021-09-16 |
| US20240254101A1 (en) | 2024-08-01 |
| GB202003668D0 (en) | 2020-04-29 |
| EP4117784B1 (en) | 2024-08-28 |
| EP4117784A1 (en) | 2023-01-18 |
| JP2023519666A (ja) | 2023-05-12 |
| DK4117784T3 (da) | 2024-10-14 |
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