BR112022015727A2 - Métodos para a preparação de uma quitosana reticulada, para a preparação de um sistema de liberação de fármacos, para prevenir, tratar ou melhorar um distúrbio médico e para identificar uma quitosana reticulada, quitosana reticulada, composição, enchimento de tecido mole, curativo para ferimentos ou tecido de reconstrução, nanopartículas, meio de cultura para células ou tecido biológico, uso de quitosana reticulada, e, kit - Google Patents

Métodos para a preparação de uma quitosana reticulada, para a preparação de um sistema de liberação de fármacos, para prevenir, tratar ou melhorar um distúrbio médico e para identificar uma quitosana reticulada, quitosana reticulada, composição, enchimento de tecido mole, curativo para ferimentos ou tecido de reconstrução, nanopartículas, meio de cultura para células ou tecido biológico, uso de quitosana reticulada, e, kit

Info

Publication number
BR112022015727A2
BR112022015727A2 BR112022015727A BR112022015727A BR112022015727A2 BR 112022015727 A2 BR112022015727 A2 BR 112022015727A2 BR 112022015727 A BR112022015727 A BR 112022015727A BR 112022015727 A BR112022015727 A BR 112022015727A BR 112022015727 A2 BR112022015727 A2 BR 112022015727A2
Authority
BR
Brazil
Prior art keywords
chitosan
cross
crossed
preparation
tissue
Prior art date
Application number
BR112022015727A
Other languages
English (en)
Inventor
Kargapolov Yuriy
Fomenko Vladislav
Original Assignee
Novochizol Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP20156732.8A external-priority patent/EP3865535A1/en
Priority claimed from RU2020106398A external-priority patent/RU2020106398A/ru
Application filed by Novochizol Sa filed Critical Novochizol Sa
Publication of BR112022015727A2 publication Critical patent/BR112022015727A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0024—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
    • C08B37/0027—2-Acetamido-2-deoxy-beta-glucans; Derivatives thereof
    • C08B37/003—Chitin, i.e. 2-acetamido-2-deoxy-(beta-1,4)-D-glucan or N-acetyl-beta-1,4-D-glucosamine; Chitosan, i.e. deacetylated product of chitin or (beta-1,4)-D-glucosamine; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
    • A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
    • A01N43/14—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings
    • A01N43/16—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings with oxygen as the ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/722—Chitin, chitosan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/736—Chitin; Chitosan; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5161—Polysaccharides, e.g. alginate, chitosan, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5192—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/28—Polysaccharides or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/08—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/20—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/12—Acyclic radicals, not substituted by cyclic structures attached to a nitrogen atom of the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/24—Crosslinking, e.g. vulcanising, of macromolecules
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/34—Materials or treatment for tissue regeneration for soft tissue reconstruction
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2305/00—Characterised by the use of polysaccharides or of their derivatives not provided for in groups C08J2301/00 or C08J2303/00
    • C08J2305/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/34—Sugars
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/70—Polysaccharides
    • C12N2533/72—Chitin, chitosan

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Materials Engineering (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Dermatology (AREA)
  • Optics & Photonics (AREA)
  • Nanotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Transplantation (AREA)
  • Birds (AREA)
  • Microbiology (AREA)
  • Developmental Biology & Embryology (AREA)
  • General Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Agronomy & Crop Science (AREA)
  • Environmental Sciences (AREA)
  • Immunology (AREA)

Abstract

MÉTODOS PARA A PREPARAÇÃO DE UMA QUITOSANA RETICULADA, PARA A PREPARAÇÃO DE UM SISTEMA DE LIBERAÇÃO DE FÁRMACOS, PARA PREVENIR, TRATAR OU MELHORAR UM DISTÚRBIO MÉDICO E PARA IDENTIFICAR UMA QUITOSANA RETICULADA, QUITOSANA RETICULADA, COMPOSIÇÃO, ENCHIMENTO DE TECIDO MOLE, CURATIVO PARA FERIMENTOS OU TECIDO DE RECONSTRUÇÃO, NANOPARTÍCULAS, MEIO DE CULTURA PARA CÉLULAS OU TECIDO BIOLÓGICO, USO DE QUITOSANA RETICULADA, E, KIT. A presente invenção é direcionada a uma nova quitosana reticulada, preparações, composições e usos da mesma. Em particular, a invenção refere-se a nanopartículas e composições das mesmas úteis como agentes ativos e sistemas de liberação para pelo menos um agente bioativo.
BR112022015727A 2020-02-11 2021-02-10 Métodos para a preparação de uma quitosana reticulada, para a preparação de um sistema de liberação de fármacos, para prevenir, tratar ou melhorar um distúrbio médico e para identificar uma quitosana reticulada, quitosana reticulada, composição, enchimento de tecido mole, curativo para ferimentos ou tecido de reconstrução, nanopartículas, meio de cultura para células ou tecido biológico, uso de quitosana reticulada, e, kit BR112022015727A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP20156732.8A EP3865535A1 (en) 2020-02-11 2020-02-11 New method of synthesis of chitosan derivatives and uses thereof
RU2020106398A RU2020106398A (ru) 2020-02-11 2020-02-11 Новый способ синтеза производных хитозана и их применение
PCT/EP2021/053204 WO2021160667A1 (en) 2020-02-11 2021-02-10 New method of synthesis of chitosan derivatives and uses thereof

Publications (1)

Publication Number Publication Date
BR112022015727A2 true BR112022015727A2 (pt) 2023-01-17

Family

ID=74661348

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112022015727A BR112022015727A2 (pt) 2020-02-11 2021-02-10 Métodos para a preparação de uma quitosana reticulada, para a preparação de um sistema de liberação de fármacos, para prevenir, tratar ou melhorar um distúrbio médico e para identificar uma quitosana reticulada, quitosana reticulada, composição, enchimento de tecido mole, curativo para ferimentos ou tecido de reconstrução, nanopartículas, meio de cultura para células ou tecido biológico, uso de quitosana reticulada, e, kit

Country Status (11)

Country Link
US (1) US20230096466A1 (pt)
EP (1) EP4103640A1 (pt)
JP (1) JP2023513924A (pt)
KR (1) KR20220140580A (pt)
CN (1) CN115516012A (pt)
AU (1) AU2021220596A1 (pt)
BR (1) BR112022015727A2 (pt)
CA (1) CA3167628A1 (pt)
IL (1) IL295319A (pt)
TW (1) TW202144465A (pt)
WO (1) WO2021160667A1 (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR126678A1 (es) 2021-08-06 2023-11-01 Novochizol Sa Composiciones para el cuidado de las plantas y usos de las mismas
CN114369175B (zh) * 2022-01-13 2022-12-13 福州大学 一种低氧响应的壳聚糖聚合物及其制备方法与应用
CN116023525B (zh) * 2023-02-13 2024-03-15 湖北工程学院 一种2-位(1,4-二取代-1,2,3-三唑)修饰的壳聚糖衍生物及其制备方法和应用
CN116463885B (zh) * 2023-03-29 2024-04-05 郑州大学 一种用于纸质文物保护的CS-FEC/CS-Arg-FEC多功能保护液

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5770712A (en) 1997-03-14 1998-06-23 Virginia Tech Intellectual Properties, Inc. Crosslinked hydrogel beads from chitosan
US9956291B2 (en) * 2012-07-10 2018-05-01 Shaker A. Mousa Nanoformulation and methods of use of thyroid receptor beta1 agonists for liver targeting
CN105017256A (zh) 2014-04-29 2015-11-04 浙江导明医药科技有限公司 多氟化合物作为布鲁顿酪氨酸激酶抑制剂
EP3684374A4 (en) 2017-09-21 2021-06-16 Riboscience LLC 4'-FLUORO-2'-METHYL SUBSTITUTE NUCLEOSIDE DERIVATIVES USED AS HCV RNA REPLICATION INHIBITORS

Also Published As

Publication number Publication date
TW202144465A (zh) 2021-12-01
KR20220140580A (ko) 2022-10-18
IL295319A (en) 2022-10-01
WO2021160667A1 (en) 2021-08-19
CN115516012A (zh) 2022-12-23
CA3167628A1 (en) 2021-08-19
EP4103640A1 (en) 2022-12-21
JP2023513924A (ja) 2023-04-04
US20230096466A1 (en) 2023-03-30
AU2021220596A1 (en) 2022-09-08

Similar Documents

Publication Publication Date Title
BR112022015727A2 (pt) Métodos para a preparação de uma quitosana reticulada, para a preparação de um sistema de liberação de fármacos, para prevenir, tratar ou melhorar um distúrbio médico e para identificar uma quitosana reticulada, quitosana reticulada, composição, enchimento de tecido mole, curativo para ferimentos ou tecido de reconstrução, nanopartículas, meio de cultura para células ou tecido biológico, uso de quitosana reticulada, e, kit
ES2911647T3 (es) Composición
Holmes IV et al. Demonstration of the safety and effectiveness of the RECELL® System combined with split-thickness meshed autografts for the reduction of donor skin to treat mixed-depth burn injuries
Vanscheidt et al. Effectiveness and tissue compatibility of a 12‐week treatment of chronic venous leg ulcers with an octenidine based antiseptic–a randomized, double‐blind controlled study
ES2330801T3 (es) Aposito para heridas que comprende un agente antiinflamatorio analgesico y un complejo de iones de plata y un elemento de transicion de grupo iv de la tabla periodica de elementos.
BR112014018421A8 (pt) Composições antimicrobianas compreendendo dgla, 15-ohepa e/ou 15-hetre e métodos de uso das mesmas
ES2530417T3 (es) Dispositivo de apósito para su uso con una cánula o un catéter
KR20120022930A (ko) 은 설파디아진 및 키토산을 사용하여 제조한 약용 크림 및 이의 제조 방법
BRPI0601330A (pt) composição tópica de biocelulose em forma de gel, spray-aerosol, creme e ou suspensão aquosa para tratamento de lesões epiteliais
Shoma et al. Pentoxifylline and local honey for radiation-induced burn following breast conservative surgery
CA2815810C (en) Compositions with antibacterial and wound healing activity
De Silva et al. “Smart” polymer enhances the efficacy of topical antimicrobial agents
Putri et al. Efficacy of tilapia skin xenograft compared to paraffin-impregnated gauze as a full-thickness burn dressing after excisional debridement: A case series
JP6725108B2 (ja) ユニチオール及びジメチルスルホキシドを含む消毒組成物、その組成物の使用並びにそれを使用した創傷治療方法
CN111481733B (zh) 一种生物医药创面敷料
WHITE Would malodour and the role of ACTISORB© Silver 220.
Shirah et al. Effect of surgical wound care methods of the lay open technique on the outcome of chronic sacrococcygeal pilonidal sinus management
KR20190099338A (ko) 폴리비닐피롤리돈 및 유니티올을 포함하는 방부제 조성물 및 조성물의 용도
Glat et al. The use of Suprathel® in the treatment of pediatric burns: Retrospective review of first pilot trial in a burn unit in the United States
CN107789350A (zh) 包含硫辛酸及/或其衍生物的组合物及其应用
RU2403014C1 (ru) Средство для лечения ран
RU2404751C2 (ru) Ранозаживляющее средство
Shekokar et al. A case control study of Tilkalka (Sesamum paste) Madhusarpivarti in the management of Vidradhi Bhedana and Vistravana (i & d)
Nguyen et al. Controlled release of vancomycin from PEGylated fibrinogen polyethylene glycol diacrylate hydrogel
CN117838723A (zh) 一种含锶祛疤痕凝胶及其制备方法和应用