BR112022013569A2 - Construções de célula viva para produção de produto lácteo cultivado e métodos usando as mesmas - Google Patents

Construções de célula viva para produção de produto lácteo cultivado e métodos usando as mesmas

Info

Publication number
BR112022013569A2
BR112022013569A2 BR112022013569A BR112022013569A BR112022013569A2 BR 112022013569 A2 BR112022013569 A2 BR 112022013569A2 BR 112022013569 A BR112022013569 A BR 112022013569A BR 112022013569 A BR112022013569 A BR 112022013569A BR 112022013569 A2 BR112022013569 A2 BR 112022013569A2
Authority
BR
Brazil
Prior art keywords
methods
same
living cell
cell constructions
dairy products
Prior art date
Application number
BR112022013569A
Other languages
English (en)
Portuguese (pt)
Inventor
Strickland Leila
Original Assignee
Biomilq Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=74095691&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112022013569(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Biomilq Inc filed Critical Biomilq Inc
Publication of BR112022013569A2 publication Critical patent/BR112022013569A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0625—Epidermal cells, skin cells; Cells of the oral mucosa
    • C12N5/0631—Mammary cells
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; PREPARATION THEREOF
    • A23C23/00—Other dairy products
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; PREPARATION THEREOF
    • A23C9/00—Milk preparations; Milk powder or milk powder preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/20—Milk; Whey; Colostrum
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M21/00—Bioreactors or fermenters specially adapted for specific uses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/34—Internal compartments or partitions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/14—Scaffolds; Matrices
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/02—Atmosphere, e.g. low oxygen conditions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/315—Prolactin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2513/00—3D culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2523/00—Culture process characterised by temperature
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/30—Synthetic polymers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/52—Fibronectin; Laminin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/54—Collagen; Gelatin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/70—Polysaccharides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/70—Polysaccharides
    • C12N2533/72—Chitin, chitosan
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/70—Polysaccharides
    • C12N2533/74—Alginate
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/70—Polysaccharides
    • C12N2533/76—Agarose, agar-agar
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/70—Polysaccharides
    • C12N2533/78—Cellulose
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/70—Polysaccharides
    • C12N2533/80—Hyaluronan
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/90—Substrates of biological origin, e.g. extracellular matrix, decellularised tissue

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Dermatology (AREA)
  • Sustainable Development (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Clinical Laboratory Science (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
BR112022013569A 2020-01-08 2020-12-18 Construções de célula viva para produção de produto lácteo cultivado e métodos usando as mesmas BR112022013569A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202062958407P 2020-01-08 2020-01-08
US202063199164P 2020-12-10 2020-12-10
PCT/US2020/066209 WO2021141762A1 (en) 2020-01-08 2020-12-18 Live cell constructs for production of cultured milk product and methods using the same

Publications (1)

Publication Number Publication Date
BR112022013569A2 true BR112022013569A2 (pt) 2022-09-13

Family

ID=74095691

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112022013569A BR112022013569A2 (pt) 2020-01-08 2020-12-18 Construções de célula viva para produção de produto lácteo cultivado e métodos usando as mesmas

Country Status (12)

Country Link
US (3) US11111477B2 (https=)
EP (3) EP3848453A1 (https=)
JP (2) JP7759326B2 (https=)
KR (1) KR20220125295A (https=)
CN (2) CN115279892B (https=)
AU (1) AU2020420671A1 (https=)
BR (1) BR112022013569A2 (https=)
CA (1) CA3164017A1 (https=)
ES (1) ES2909832T3 (https=)
IL (1) IL294496A (https=)
MX (1) MX2022008483A (https=)
WO (1) WO2021141762A1 (https=)

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IL294496A (en) 2020-01-08 2022-09-01 Biomilq Inc Structures suitable for living for the production of a cultured milk product and methods for use
AU2021205324A1 (en) * 2020-01-08 2022-08-18 Shayne Guiliano Live cell constructs for biosynthetic milk production and related products and methods
US11206843B1 (en) 2020-05-26 2021-12-28 BIOMILQ, Inc. Milk product compositions
US11236299B1 (en) * 2020-09-08 2022-02-01 Biomilk Ltd. Methods and systems for in-vitro milk production
US20250223550A1 (en) * 2021-10-27 2025-07-10 Societe Des Produits Nestle S.A. Method for producing milk like products
WO2023097012A1 (en) * 2021-11-23 2023-06-01 BIOMILQ, Inc. Milk product compositions
KR20240114773A (ko) 2021-12-14 2024-07-24 인바이오스 엔.브이. 알파-1,3-푸코실화된 화합물의 생산
US20240417768A1 (en) 2021-12-14 2024-12-19 Inbiose N.V. Production of alpha-1,4-fucosylated compounds
AU2022416822A1 (en) 2021-12-15 2024-07-11 Inbiose N.V. Sialyltransferases for the production of sialylated oligosaccharides
WO2023137465A1 (en) * 2022-01-13 2023-07-20 BIOMILQ, Inc. Optimization of live cell constructs for production of cultured milk product and methods of using the same
WO2023175079A1 (en) 2022-03-16 2023-09-21 Inbiose N.V. Sialyltransferases for the production of sialylated oligosaccharides
AU2023246643A1 (en) 2022-04-01 2024-10-10 Inbiose N.V. Sialyltransferases for the production of sialylated oligosaccharides
IL318164A (en) * 2022-07-05 2025-03-01 Senara Gmbh Pulsed flow culture of milk-producing cell types for milk secretion
WO2024047096A1 (en) 2022-08-30 2024-03-07 Inbiose N.V. Process for purification of an oligosaccharide
WO2024165525A1 (en) 2023-02-06 2024-08-15 Inbiose N.V. Production of a saccharide, lactobionic acid and/or glycosylated forms of lactobionic acid
CN120641559A (zh) 2023-02-07 2025-09-12 因比奥斯公司 由具有降低的UDP-GlcNAc合成的细胞来产生二糖和/或乳寡糖
WO2024223815A1 (en) 2023-04-26 2024-10-31 Inbiose N.V. Production of a negatively charged oligosaccharide by a cell
EP4720280A2 (en) * 2023-06-02 2026-04-08 Biomilq, Inc. Exosome compositions and methods of use
WO2024261312A2 (en) 2023-06-21 2024-12-26 Inbiose N.V. Sialyltransferases for the production of sialylated oligosaccharides
WO2025088103A1 (en) 2023-10-26 2025-05-01 Inbiose N.V. Production of a sialylated compound
WO2025088102A1 (en) 2023-10-26 2025-05-01 Inbiose N.V. PRODUCTION OF A SIALYLATED OLIGOSACCHARIDE COMPRISING GAL-β1,3-[NEU5AC-A2,6]-HEXNAC-R
WO2025120607A1 (en) * 2023-12-08 2025-06-12 Senara Gmbh Cell-cultivated milk for confectionery and dairy product uses
EP4570821A1 (en) * 2023-12-11 2025-06-18 Senara GmbH Milk producing cells
WO2025172603A1 (en) 2024-02-16 2025-08-21 Inbiose N.V. Method for importing a disaccharide inside a cell
WO2025224348A1 (en) 2024-04-26 2025-10-30 Inbiose N.V. Production of a milk oligosaccharide mixture
WO2025262230A1 (en) 2024-06-19 2025-12-26 Mumilk In vitro method of producing milk
WO2026052789A1 (en) 2024-09-05 2026-03-12 Inbiose N.V. Fucosyltransferase mutants
CN120591197A (zh) * 2025-05-30 2025-09-05 中国农业大学 一种奶牛乳腺上皮细胞3d球体模型的建立方法及应用

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AU2021205324A1 (en) 2020-01-08 2022-08-18 Shayne Guiliano Live cell constructs for biosynthetic milk production and related products and methods
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Also Published As

Publication number Publication date
CN115279892B (zh) 2025-09-23
IL294496A (en) 2022-09-01
CN121227621A (zh) 2025-12-30
US20250179431A1 (en) 2025-06-05
WO2021141762A1 (en) 2021-07-15
ES2909832T3 (es) 2022-05-10
JP2026021344A (ja) 2026-02-10
US20210207090A1 (en) 2021-07-08
EP3848454B1 (en) 2022-02-09
CA3164017A1 (en) 2021-07-15
US20210403865A1 (en) 2021-12-30
KR20220125295A (ko) 2022-09-14
JP7759326B2 (ja) 2025-10-23
US11111477B2 (en) 2021-09-07
EP4052583A1 (en) 2022-09-07
JP2023515749A (ja) 2023-04-14
EP3848453A1 (en) 2021-07-14
MX2022008483A (es) 2022-09-07
AU2020420671A1 (en) 2022-07-28
CN115279892A (zh) 2022-11-01
EP3848454A1 (en) 2021-07-14

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