JP7759326B2 - 培養乳製品産生のための生細胞構築物およびその使用方法 - Google Patents

培養乳製品産生のための生細胞構築物およびその使用方法

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JP7759326B2
JP7759326B2 JP2022540761A JP2022540761A JP7759326B2 JP 7759326 B2 JP7759326 B2 JP 7759326B2 JP 2022540761 A JP2022540761 A JP 2022540761A JP 2022540761 A JP2022540761 A JP 2022540761A JP 7759326 B2 JP7759326 B2 JP 7759326B2
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cells
mammary
live
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scaffold
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ストリックランド,レイラ
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バイオミルク,インク.
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    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0625Epidermal cells, skin cells; Cells of the oral mucosa
    • C12N5/0631Mammary cells
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23CDAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; PREPARATION THEREOF
    • A23C23/00Other dairy products
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23CDAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; PREPARATION THEREOF
    • A23C9/00Milk preparations; Milk powder or milk powder preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/20Milk; Whey; Colostrum
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    • C12M25/00Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/14Scaffolds; Matrices
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  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
JP2022540761A 2020-01-08 2020-12-18 培養乳製品産生のための生細胞構築物およびその使用方法 Active JP7759326B2 (ja)

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US202062958407P 2020-01-08 2020-01-08
US62/958,407 2020-01-08
US202063199164P 2020-12-10 2020-12-10
US63/199,164 2020-12-10
PCT/US2020/066209 WO2021141762A1 (en) 2020-01-08 2020-12-18 Live cell constructs for production of cultured milk product and methods using the same

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KR (1) KR20220125295A (https=)
CN (2) CN115279892B (https=)
AU (1) AU2020420671A1 (https=)
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CA (1) CA3164017A1 (https=)
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Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL294496A (en) 2020-01-08 2022-09-01 Biomilq Inc Structures suitable for living for the production of a cultured milk product and methods for use
AU2021205324A1 (en) * 2020-01-08 2022-08-18 Shayne Guiliano Live cell constructs for biosynthetic milk production and related products and methods
US11206843B1 (en) 2020-05-26 2021-12-28 BIOMILQ, Inc. Milk product compositions
US11236299B1 (en) * 2020-09-08 2022-02-01 Biomilk Ltd. Methods and systems for in-vitro milk production
US20250223550A1 (en) * 2021-10-27 2025-07-10 Societe Des Produits Nestle S.A. Method for producing milk like products
WO2023097012A1 (en) * 2021-11-23 2023-06-01 BIOMILQ, Inc. Milk product compositions
KR20240114773A (ko) 2021-12-14 2024-07-24 인바이오스 엔.브이. 알파-1,3-푸코실화된 화합물의 생산
US20240417768A1 (en) 2021-12-14 2024-12-19 Inbiose N.V. Production of alpha-1,4-fucosylated compounds
AU2022416822A1 (en) 2021-12-15 2024-07-11 Inbiose N.V. Sialyltransferases for the production of sialylated oligosaccharides
WO2023137465A1 (en) * 2022-01-13 2023-07-20 BIOMILQ, Inc. Optimization of live cell constructs for production of cultured milk product and methods of using the same
WO2023175079A1 (en) 2022-03-16 2023-09-21 Inbiose N.V. Sialyltransferases for the production of sialylated oligosaccharides
AU2023246643A1 (en) 2022-04-01 2024-10-10 Inbiose N.V. Sialyltransferases for the production of sialylated oligosaccharides
IL318164A (en) * 2022-07-05 2025-03-01 Senara Gmbh Pulsed flow culture of milk-producing cell types for milk secretion
WO2024047096A1 (en) 2022-08-30 2024-03-07 Inbiose N.V. Process for purification of an oligosaccharide
WO2024165525A1 (en) 2023-02-06 2024-08-15 Inbiose N.V. Production of a saccharide, lactobionic acid and/or glycosylated forms of lactobionic acid
CN120641559A (zh) 2023-02-07 2025-09-12 因比奥斯公司 由具有降低的UDP-GlcNAc合成的细胞来产生二糖和/或乳寡糖
WO2024223815A1 (en) 2023-04-26 2024-10-31 Inbiose N.V. Production of a negatively charged oligosaccharide by a cell
EP4720280A2 (en) * 2023-06-02 2026-04-08 Biomilq, Inc. Exosome compositions and methods of use
WO2024261312A2 (en) 2023-06-21 2024-12-26 Inbiose N.V. Sialyltransferases for the production of sialylated oligosaccharides
WO2025088103A1 (en) 2023-10-26 2025-05-01 Inbiose N.V. Production of a sialylated compound
WO2025088102A1 (en) 2023-10-26 2025-05-01 Inbiose N.V. PRODUCTION OF A SIALYLATED OLIGOSACCHARIDE COMPRISING GAL-β1,3-[NEU5AC-A2,6]-HEXNAC-R
WO2025120607A1 (en) * 2023-12-08 2025-06-12 Senara Gmbh Cell-cultivated milk for confectionery and dairy product uses
EP4570821A1 (en) * 2023-12-11 2025-06-18 Senara GmbH Milk producing cells
WO2025172603A1 (en) 2024-02-16 2025-08-21 Inbiose N.V. Method for importing a disaccharide inside a cell
WO2025224348A1 (en) 2024-04-26 2025-10-30 Inbiose N.V. Production of a milk oligosaccharide mixture
WO2025262230A1 (en) 2024-06-19 2025-12-26 Mumilk In vitro method of producing milk
WO2026052789A1 (en) 2024-09-05 2026-03-12 Inbiose N.V. Fucosyltransferase mutants
CN120591197A (zh) * 2025-05-30 2025-09-05 中国农业大学 一种奶牛乳腺上皮细胞3d球体模型的建立方法及应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170267970A1 (en) 2016-02-29 2017-09-21 Whitehead Institute For Biomedical Research Three-Dimensional Hydrogels that Support Growth of Physiologically Relevant Tissue and Methods of Use Thereof

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3186849A (en) * 1959-11-02 1965-06-01 Radiation Applic Inc Removal of contaminants from milk
NL293759A (https=) * 1962-06-08 1900-01-01
DE4326665C2 (de) * 1993-08-09 1995-07-13 Biotest Pharma Gmbh Verfahren zur Sterilfiltration von Milch
US6074874A (en) 1997-08-29 2000-06-13 University Of Pittsburgh Epithelial cell cultures for in vitro testing
US6472367B1 (en) 1998-05-05 2002-10-29 Adherex Technologies, Inc. Compounds and methods for modulating OB-cadherin mediated cell adhesion
US20070005006A1 (en) * 2005-06-15 2007-01-04 Rosenfeld Paul E Methods and devices for removal of toxic compounds from breast milk
CN101422240A (zh) * 2008-05-05 2009-05-06 蒋来高 人体母乳(含初乳)冻干粉生产工艺及其制品和作用
US20130344490A1 (en) * 2012-04-27 2013-12-26 Min Peter Kim Neoplastic cells grown on decellularized biomatrix
US20150079584A1 (en) * 2013-03-15 2015-03-19 Kiyatec Inc. Bioreactor system
CN103355405A (zh) * 2013-04-07 2013-10-23 苏州旭优食品科技有限公司 一种低过敏性含乳制品的加工工艺
EP3491122A4 (en) * 2016-07-27 2020-04-08 The University of North Carolina at Chapel Hill METHOD FOR PRODUCING POLYMER SCAFFOLDINGS WITH A GRADIENT OF CROSSLINKING DENSITY
US10982181B2 (en) * 2016-09-07 2021-04-20 Triad National Security, Llc Devices for cell culture and methods of making and using the same
IL294496A (en) 2020-01-08 2022-09-01 Biomilq Inc Structures suitable for living for the production of a cultured milk product and methods for use
AU2021205324A1 (en) 2020-01-08 2022-08-18 Shayne Guiliano Live cell constructs for biosynthetic milk production and related products and methods
WO2022115033A1 (en) 2020-11-24 2022-06-02 Turtletree Labs Pte. Ltd. Bioreactor systems and methods for culturing cells

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170267970A1 (en) 2016-02-29 2017-09-21 Whitehead Institute For Biomedical Research Three-Dimensional Hydrogels that Support Growth of Physiologically Relevant Tissue and Methods of Use Thereof

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IL294496A (en) 2022-09-01
CN121227621A (zh) 2025-12-30
US20250179431A1 (en) 2025-06-05
WO2021141762A1 (en) 2021-07-15
ES2909832T3 (es) 2022-05-10
JP2026021344A (ja) 2026-02-10
US20210207090A1 (en) 2021-07-08
EP3848454B1 (en) 2022-02-09
CA3164017A1 (en) 2021-07-15
US20210403865A1 (en) 2021-12-30
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