BR112022012179A2 - Compostos de quinazolina substituída úteis como ativadores de célula t - Google Patents
Compostos de quinazolina substituída úteis como ativadores de célula tInfo
- Publication number
- BR112022012179A2 BR112022012179A2 BR112022012179A BR112022012179A BR112022012179A2 BR 112022012179 A2 BR112022012179 A2 BR 112022012179A2 BR 112022012179 A BR112022012179 A BR 112022012179A BR 112022012179 A BR112022012179 A BR 112022012179A BR 112022012179 A2 BR112022012179 A2 BR 112022012179A2
- Authority
- BR
- Brazil
- Prior art keywords
- compounds
- cell activators
- substituted quinazoline
- compounds useful
- quinazoline compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
- C07D239/80—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Dispersion Chemistry (AREA)
- Virology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN201911053553 | 2019-12-23 | ||
| PCT/US2020/066508 WO2021133751A1 (en) | 2019-12-23 | 2020-12-22 | Substituted quinazolinyl compounds useful as t cell activators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112022012179A2 true BR112022012179A2 (pt) | 2022-09-06 |
Family
ID=74195154
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112022012179A BR112022012179A2 (pt) | 2019-12-23 | 2020-12-22 | Compostos de quinazolina substituída úteis como ativadores de célula t |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US12492172B2 (https=) |
| EP (1) | EP4081516B1 (https=) |
| JP (1) | JP2023507847A (https=) |
| KR (1) | KR20220119454A (https=) |
| CN (1) | CN114846007B (https=) |
| AU (1) | AU2020415377A1 (https=) |
| BR (1) | BR112022012179A2 (https=) |
| CA (1) | CA3162985A1 (https=) |
| ES (1) | ES3038401T3 (https=) |
| IL (1) | IL294148A (https=) |
| MX (1) | MX2022006958A (https=) |
| WO (1) | WO2021133751A1 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL294032A (en) | 2019-12-24 | 2022-08-01 | Carna Biosciences Inc | Compounds that regulate diacylglycerol kinase |
| MX2023014762A (es) * | 2021-06-23 | 2024-01-15 | Gilead Sciences Inc | Compuestos moduladores de diacilglicerol quinasa. |
| JP7686091B2 (ja) | 2021-06-23 | 2025-05-30 | ギリアード サイエンシーズ， インコーポレイテッド | ジアシルグリセロールキナーゼ調節化合物 |
| JP7651018B2 (ja) | 2021-06-23 | 2025-03-25 | ギリアード サイエンシーズ， インコーポレイテッド | ジアシルグリセロールキナーゼ調節化合物 |
| AU2022299051B2 (en) | 2021-06-23 | 2025-03-13 | Gilead Sciences, Inc. | Diacylglyercol kinase modulating compounds |
| WO2023122777A1 (en) * | 2021-12-22 | 2023-06-29 | Gossamer Bio Services, Inc. | Oxime derivatives useful as t cell activators |
| WO2023122772A1 (en) * | 2021-12-22 | 2023-06-29 | Gossamer Bio Services, Inc. | Oxime derivatives useful as t cell activators |
| JP2025507915A (ja) * | 2022-03-01 | 2025-03-21 | インシリコ メディスン アイピー リミティド | ジアシルグリセロールキナーゼ（ＤＧＫ）α阻害剤及びその使用 |
| EP4486741A4 (en) | 2022-03-01 | 2026-04-08 | Insilico Medicine Ip Ltd | Diacylglycerol Kinase (DGK) Alpha Inhibitors and Their Uses |
| WO2023175185A1 (en) | 2022-03-17 | 2023-09-21 | Forx Therapeutics Ag | 2,4-dioxo-1,4-dihydroquinazoline derivatives as parg inhibitors for the treatment of cancer |
| WO2023175184A1 (en) | 2022-03-17 | 2023-09-21 | Forx Therapeutics Ag | 2,4-dioxo-1,4-dihydroquinazoline derivatives as parg inhibitors for the treatment of cancer |
| US20250215014A1 (en) * | 2022-03-31 | 2025-07-03 | InventisBio Co., Ltd. | Kinase inhibitors, preparation methods and uses thereof |
| US12600723B2 (en) | 2022-07-18 | 2026-04-14 | Incyte Corporation | Tetracyclic compounds as DGK inhibitors |
| US12600722B2 (en) | 2022-07-18 | 2026-04-14 | Incyte Corporation | Tetracyclic compounds as DGK inhibitors |
| EP4661869A1 (en) | 2023-02-06 | 2025-12-17 | Bayer Aktiengesellschaft | Combinations of dgk (diacylglycerol kinase) inhibitors and immune checkpoint inhibitors and modulators |
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| TW200418829A (en) | 2003-02-14 | 2004-10-01 | Avanir Pharmaceutics | Inhibitors of macrophage migration inhibitory factor and methods for identifying the same |
| WO2004087880A2 (en) | 2003-03-26 | 2004-10-14 | Bayer Pharmaceuticals Corporation | Compounds and their use to treat diabetes and related disorders |
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| US7381401B2 (en) | 2004-01-08 | 2008-06-03 | The University Of Chicago | T cell anergy is reversed by active Ras and regulated by diacylglycerol kinase |
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| AR119821A1 (es) | 2019-08-28 | 2022-01-12 | Bristol Myers Squibb Co | Compuestos de piridopirimidinonilo sustituidos útiles como activadores de células t |
| US20230064809A1 (en) | 2019-11-28 | 2023-03-02 | Bayer Aktiengesellschaft | Substituted aminoquinolones as dgkalpha inhibitors for immune activation |
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-
2020
- 2020-12-22 BR BR112022012179A patent/BR112022012179A2/pt not_active IP Right Cessation
- 2020-12-22 MX MX2022006958A patent/MX2022006958A/es unknown
- 2020-12-22 WO PCT/US2020/066508 patent/WO2021133751A1/en not_active Ceased
- 2020-12-22 KR KR1020227025284A patent/KR20220119454A/ko active Pending
- 2020-12-22 JP JP2022538730A patent/JP2023507847A/ja active Pending
- 2020-12-22 ES ES20845304T patent/ES3038401T3/es active Active
- 2020-12-22 AU AU2020415377A patent/AU2020415377A1/en not_active Abandoned
- 2020-12-22 CA CA3162985A patent/CA3162985A1/en active Pending
- 2020-12-22 IL IL294148A patent/IL294148A/en unknown
- 2020-12-22 US US17/785,648 patent/US12492172B2/en active Active
- 2020-12-22 CN CN202080089197.4A patent/CN114846007B/zh active Active
- 2020-12-22 EP EP20845304.3A patent/EP4081516B1/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20230094758A1 (en) | 2023-03-30 |
| US12492172B2 (en) | 2025-12-09 |
| IL294148A (en) | 2022-08-01 |
| JP2023507847A (ja) | 2023-02-27 |
| ES3038401T3 (en) | 2025-10-13 |
| KR20220119454A (ko) | 2022-08-29 |
| MX2022006958A (es) | 2022-07-12 |
| AU2020415377A1 (en) | 2022-08-18 |
| CN114846007A (zh) | 2022-08-02 |
| EP4081516A1 (en) | 2022-11-02 |
| CA3162985A1 (en) | 2021-07-01 |
| EP4081516B1 (en) | 2025-07-30 |
| CN114846007B (zh) | 2024-11-22 |
| WO2021133751A1 (en) | 2021-07-01 |
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